AU1952697A - Inhibitors of farnesyl-protein transferase - Google Patents

Inhibitors of farnesyl-protein transferase

Info

Publication number
AU1952697A
AU1952697A AU19526/97A AU1952697A AU1952697A AU 1952697 A AU1952697 A AU 1952697A AU 19526/97 A AU19526/97 A AU 19526/97A AU 1952697 A AU1952697 A AU 1952697A AU 1952697 A AU1952697 A AU 1952697A
Authority
AU
Australia
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU19526/97A
Other versions
AU703988B2 (en
Inventor
Christopher J. Dinsmore
George D. Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607124.6A external-priority patent/GB9607124D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1952697A publication Critical patent/AU1952697A/en
Application granted granted Critical
Publication of AU703988B2 publication Critical patent/AU703988B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU19526/97A 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase Ceased AU703988B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1108196P 1996-01-30 1996-01-30
US60/011081 1996-01-30
GB9607124 1996-04-04
GBGB9607124.6A GB9607124D0 (en) 1996-04-04 1996-04-04 Inhibitors of farnesyl-protein transferase
PCT/US1997/001455 WO1997027853A1 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
AU1952697A true AU1952697A (en) 1997-08-22
AU703988B2 AU703988B2 (en) 1999-04-01

Family

ID=26309063

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19526/97A Ceased AU703988B2 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Country Status (4)

Country Link
EP (1) EP0877610A4 (en)
JP (1) JP2000505797A (en)
AU (1) AU703988B2 (en)
WO (1) WO1997027853A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712504B2 (en) * 1996-01-30 1999-11-11 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU760027B2 (en) 1998-07-02 2003-05-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
CA2336448A1 (en) 1998-07-02 2000-01-13 Christopher J. Dinsmore Inhibitors of prenyl-protein transferase
US7049324B1 (en) 1999-11-15 2006-05-23 Ashis Kumar Saha Triazoles as farnesyl transferase inhibitors
DE60038498T2 (en) 1999-11-15 2009-05-07 Janssen Pharmaceutica N.V. Triazoles as farnesyl transferase inhibitors
US6380228B1 (en) 2000-04-10 2002-04-30 Merck & Co., Inc. Inhibitors of prenyl-protein transferase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
US5534537A (en) * 1995-03-29 1996-07-09 Merck & Co., Inc. Prodrugs of inhibitors of farnesyl-protein transferase
US5578629A (en) * 1995-03-29 1996-11-26 Merck & Co., Inc. Benzamide-containing inhibitors of farnesyl-protein transferase

Also Published As

Publication number Publication date
EP0877610A1 (en) 1998-11-18
JP2000505797A (en) 2000-05-16
EP0877610A4 (en) 1999-09-15
WO1997027853A1 (en) 1997-08-07
AU703988B2 (en) 1999-04-01

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired