ATE86256T1 - Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. - Google Patents
Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.Info
- Publication number
- ATE86256T1 ATE86256T1 AT88904639T AT88904639T ATE86256T1 AT E86256 T1 ATE86256 T1 AT E86256T1 AT 88904639 T AT88904639 T AT 88904639T AT 88904639 T AT88904639 T AT 88904639T AT E86256 T1 ATE86256 T1 AT E86256T1
- Authority
- AT
- Austria
- Prior art keywords
- thieno
- triazolo
- diazepin
- compounds
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13205887 | 1987-05-28 | ||
JP13719587 | 1987-05-29 | ||
JP14969887 | 1987-06-16 | ||
EP88904639A EP0315698B1 (de) | 1987-05-28 | 1988-05-25 | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben |
PCT/JP1988/000506 WO1988009333A1 (en) | 1987-05-28 | 1988-05-25 | Thieno(triazolo)diazepine compound and medicinal application of the same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE86256T1 true ATE86256T1 (de) | 1993-03-15 |
Family
ID=27316424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88904639T ATE86256T1 (de) | 1987-05-28 | 1988-05-25 | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4960770A (de) |
EP (1) | EP0315698B1 (de) |
JP (1) | JP2531102B2 (de) |
AT (1) | ATE86256T1 (de) |
DE (1) | DE3878833T2 (de) |
WO (1) | WO1988009333A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
MC1999A1 (fr) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
CA1324863C (en) * | 1988-01-30 | 1993-11-30 | Minoru Moriwaki | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
US5382579A (en) * | 1988-10-31 | 1995-01-17 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5468740A (en) * | 1988-10-31 | 1995-11-21 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
US5221671A (en) * | 1988-10-31 | 1993-06-22 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5304553A (en) * | 1988-10-31 | 1994-04-19 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
EP0387613A1 (de) * | 1989-03-03 | 1990-09-19 | Boehringer Ingelheim Kg | Neue Thienodiazepine |
JP2959598B2 (ja) * | 1990-10-12 | 1999-10-06 | 吉富製薬株式会社 | 光学活性なチエノトリアゾロジアゼピン化合物 |
JPH10190985A (ja) * | 1996-12-26 | 1998-07-21 | Asahi Optical Co Ltd | カスケード走査光学系を備えた記録装置 |
AU2007325315A1 (en) * | 2006-11-28 | 2008-06-05 | Kalypsys Inc | Heterocyclic modulators of TGR5 |
JP5490811B2 (ja) * | 2008-10-30 | 2014-05-14 | スルコメッド エルエルシー | アポaに対して活性なチエノトリアゾロジアゼピン誘導体 |
WO2011143660A2 (en) | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
KR101857599B1 (ko) | 2010-05-14 | 2018-05-14 | 다나-파버 캔서 인스티튜트 인크. | 종양형성, 염증성 질환 및 다른 장애를 치료하기 위한 조성물 및 방법 |
US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
EP2705039B1 (de) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomainhemmer und ihre verwendung |
WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
DE102011082013A1 (de) * | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
EP2864336B1 (de) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazolazepinbromdomänenhemmer und verwendungen davon |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
US11446309B2 (en) | 2013-11-08 | 2022-09-20 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors |
JP2017504653A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアミノピリミジンベンゼンスルホン誘導体およびその使用 |
JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体の使用 |
US10925881B2 (en) | 2014-02-28 | 2021-02-23 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
ES2725928T3 (es) | 2014-06-20 | 2019-09-30 | Constellation Pharmaceuticals Inc | Formas cristalinas de 2-((4S)-6-(4-clorofenil)-1-metil-4H-benzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida |
WO2016022902A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
CA2955077A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
AU2015339511B2 (en) | 2014-10-27 | 2020-05-14 | Tensha Therapeutics, Inc. | Bromodomain inhibitors |
EP3307728A4 (de) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Kombinationstherapie von transkriptionshemmern und kinasehemmern |
KR20180051576A (ko) | 2015-09-11 | 2018-05-16 | 다나-파버 캔서 인스티튜트 인크. | 아세트아미드 티에노트리아졸로디아제핀 및 그의 용도 |
RU2750164C2 (ru) | 2015-09-11 | 2021-06-22 | Дана-Фарбер Кэнсер Инститьют, Инк. | Цианотиенотриазолодиазепины и пути их применения |
WO2017091673A2 (en) | 2015-11-25 | 2017-06-01 | Dana-Farber Cancer Institute, Inc. | Bivalent bromodomain inhibtors and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0137538B1 (de) * | 1983-09-09 | 1990-03-14 | Shell Internationale Researchmaatschappij B.V. | Biopolymerzusammensetzungen und Verfahren zur Herstellung derselben |
DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
ES2037013T3 (es) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
JPH06187623A (ja) * | 1992-12-15 | 1994-07-08 | Matsushita Electric Ind Co Ltd | 磁気記録再生装置 |
JPH06222718A (ja) * | 1993-01-27 | 1994-08-12 | Sekisui Chem Co Ltd | 装飾用粘着シートの貼り付け方法 |
-
1988
- 1988-05-25 EP EP88904639A patent/EP0315698B1/de not_active Expired - Lifetime
- 1988-05-25 DE DE8888904639T patent/DE3878833T2/de not_active Expired - Fee Related
- 1988-05-25 WO PCT/JP1988/000506 patent/WO1988009333A1/ja active IP Right Grant
- 1988-05-25 AT AT88904639T patent/ATE86256T1/de not_active IP Right Cessation
- 1988-05-25 US US07/304,989 patent/US4960770A/en not_active Expired - Fee Related
-
1993
- 1993-06-28 JP JP5185489A patent/JP2531102B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3878833D1 (de) | 1993-04-08 |
EP0315698A4 (de) | 1990-05-14 |
EP0315698A1 (de) | 1989-05-17 |
US4960770A (en) | 1990-10-02 |
WO1988009333A1 (en) | 1988-12-01 |
JP2531102B2 (ja) | 1996-09-04 |
JPH06157316A (ja) | 1994-06-03 |
DE3878833T2 (de) | 1993-06-09 |
EP0315698B1 (de) | 1993-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |