ATE82118T1 - Feste und poroese einheitsform, enthaltend mikropartikel und/oder nanopartikel und verfahren zu ihrer herstellung. - Google Patents

Feste und poroese einheitsform, enthaltend mikropartikel und/oder nanopartikel und verfahren zu ihrer herstellung.

Info

Publication number
ATE82118T1
ATE82118T1 AT89402061T AT89402061T ATE82118T1 AT E82118 T1 ATE82118 T1 AT E82118T1 AT 89402061 T AT89402061 T AT 89402061T AT 89402061 T AT89402061 T AT 89402061T AT E82118 T1 ATE82118 T1 AT E82118T1
Authority
AT
Austria
Prior art keywords
nanoparticles
solid
manufacture
containing microparticles
unit form
Prior art date
Application number
AT89402061T
Other languages
English (en)
Inventor
Frederic Courteille
Anne Coutel
Guy Lebreton
Michel Veillard
Original Assignee
Farmalyoc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmalyoc filed Critical Farmalyoc
Application granted granted Critical
Publication of ATE82118T1 publication Critical patent/ATE82118T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Silicon Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
AT89402061T 1988-07-21 1989-07-20 Feste und poroese einheitsform, enthaltend mikropartikel und/oder nanopartikel und verfahren zu ihrer herstellung. ATE82118T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8809864A FR2634376B1 (fr) 1988-07-21 1988-07-21 Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
EP89402061A EP0352190B1 (de) 1988-07-21 1989-07-20 Feste und poröse Einheitsform, enthaltend Mikropartikel und/oder Nanopartikel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE82118T1 true ATE82118T1 (de) 1992-11-15

Family

ID=9368634

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89402061T ATE82118T1 (de) 1988-07-21 1989-07-20 Feste und poroese einheitsform, enthaltend mikropartikel und/oder nanopartikel und verfahren zu ihrer herstellung.

Country Status (19)

Country Link
US (1) US5384124A (de)
EP (1) EP0352190B1 (de)
JP (1) JP2812723B2 (de)
KR (1) KR0146960B1 (de)
AT (1) ATE82118T1 (de)
AU (1) AU626031B2 (de)
CA (1) CA1340576C (de)
DE (1) DE68903442T2 (de)
DK (1) DK175095B1 (de)
ES (1) ES2052947T3 (de)
FI (1) FI97275C (de)
FR (1) FR2634376B1 (de)
GR (1) GR3006518T3 (de)
IE (1) IE64907B1 (de)
IL (1) IL91010A (de)
NO (1) NO178526C (de)
NZ (1) NZ230005A (de)
PT (1) PT91237B (de)
ZA (1) ZA895546B (de)

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EP0352190B1 (de) 1992-11-11
NO892985L (no) 1990-01-22
PT91237A (pt) 1990-02-08
PT91237B (pt) 1995-03-01
IE892360L (en) 1990-01-21
FI97275B (fi) 1996-08-15
KR900001362A (ko) 1990-02-27
NZ230005A (en) 1991-08-27
NO178526C (no) 1996-04-17
DK360489A (da) 1990-01-22
IL91010A0 (en) 1990-02-09
FR2634376B1 (fr) 1992-04-17
KR0146960B1 (ko) 1998-08-17
GR3006518T3 (de) 1993-06-30
AU626031B2 (en) 1992-07-23
JP2812723B2 (ja) 1998-10-22
CA1340576C (fr) 1999-06-01
FR2634376A1 (fr) 1990-01-26
NO892985D0 (no) 1989-07-20
DE68903442D1 (de) 1992-12-17
DK360489D0 (da) 1989-07-20
FI893504A (fi) 1990-01-22
IE64907B1 (en) 1995-09-20
EP0352190A1 (de) 1990-01-24
ES2052947T3 (es) 1994-07-16
FI893504A0 (fi) 1989-07-20
NO178526B (no) 1996-01-08
ZA895546B (en) 1990-04-25
DK175095B1 (da) 2004-06-01
IL91010A (en) 1993-03-15
DE68903442T2 (de) 1993-05-06
FI97275C (fi) 1996-11-25
US5384124A (en) 1995-01-24
JPH0288520A (ja) 1990-03-28
AU3881989A (en) 1990-01-25

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