ATE69168T1 - Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung. - Google Patents
Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung.Info
- Publication number
- ATE69168T1 ATE69168T1 AT87310141T AT87310141T ATE69168T1 AT E69168 T1 ATE69168 T1 AT E69168T1 AT 87310141 T AT87310141 T AT 87310141T AT 87310141 T AT87310141 T AT 87310141T AT E69168 T1 ATE69168 T1 AT E69168T1
- Authority
- AT
- Austria
- Prior art keywords
- dioxacycloalkanes
- carbon atoms
- percutaneous absorption
- therapeutic agents
- preferred compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/931,653 US4861764A (en) | 1986-11-17 | 1986-11-17 | Percutaneous absorption enhancers, compositions containing same and method of use |
EP87310141A EP0268460B1 (de) | 1986-11-17 | 1987-11-17 | Mittel zur Verbesserung der perkutanen Absorption, diese enthaltende Arzneimittel und Methode zu ihrer Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE69168T1 true ATE69168T1 (de) | 1991-11-15 |
Family
ID=25461144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT87310141T ATE69168T1 (de) | 1986-11-17 | 1987-11-17 | Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4861764A (de) |
EP (1) | EP0268460B1 (de) |
AT (1) | ATE69168T1 (de) |
CA (1) | CA1313619C (de) |
DE (1) | DE3774398D1 (de) |
ES (1) | ES2038676T3 (de) |
GR (1) | GR3003238T3 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06509559A (ja) * | 1991-03-19 | 1994-10-27 | セラピューティック パッチ リサーチ エヌ.ブイ. | 膜透過エンハンサーとしてのアミノアルコール誘導体組成物及び方法 |
DE69320378T2 (de) * | 1992-01-21 | 1999-04-29 | Macrochem Corp | Iontophoretische verbesserte Verabreichung von Medikamenten |
EP0656356A1 (de) * | 1992-08-21 | 1995-06-07 | Japan Tobacco Inc. | Dioxacycloalkanverbindung mit reninhemmender wirkung |
US5334615A (en) * | 1992-12-17 | 1994-08-02 | Walles Wilhelm E | Oil with bactericidal and virucidal properties |
US5637616A (en) * | 1993-06-18 | 1997-06-10 | Arcturus Pharmaceutical Corporation | Method for treating diseases mediated by proteases |
US5620980A (en) | 1995-02-22 | 1997-04-15 | Macrochem Corporation | Method for treating hair loss |
AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
AU4136697A (en) * | 1996-09-10 | 1998-04-02 | Daiso Co. Ltd. | Process for preparing 1,3-dioxolane-4-methanol compounds |
EP0930311B1 (de) * | 1996-09-10 | 2003-11-26 | Daiso Co., Ltd. | Verfahren zur herstellung von 1,3-dioxolan-4-methanol-verbindungen |
DE19711758C2 (de) * | 1997-03-21 | 2003-06-18 | Degussa | Verfahren zur Herstellung von 1,3-Dioxanverbindungen |
US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
US5968919A (en) * | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
US6153769A (en) * | 1997-11-27 | 2000-11-28 | Roche Vitamins Inc. | Manufacture of polyene aldehydes |
ATE238751T1 (de) * | 1998-02-09 | 2003-05-15 | Macrochem Corp | Antimykotischer nagellack |
US5942545A (en) * | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
PL346238A1 (en) * | 1998-08-20 | 2002-01-28 | 3M Innovative Properties Co | Spray on bandage and drug delivery system |
US7537773B1 (en) * | 1998-08-25 | 2009-05-26 | Botulinum Toxin Research Associates, Inc. | Chemodenervating pharmaceutical as anti-inflammatory agent |
US6825234B2 (en) | 1998-12-10 | 2004-11-30 | Nexmed (Holdings) , Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
US20070191320A1 (en) * | 1998-12-10 | 2007-08-16 | Nexmed Holdings, Inc. | Methods of treatment for female sexual arousal disorder |
US6486207B2 (en) | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
US6596266B2 (en) | 2000-02-18 | 2003-07-22 | Natural Science, Inc. | Compositions containing minoxidil and saw palmetto for treating baldness |
US7241731B2 (en) | 2000-06-05 | 2007-07-10 | Sumitomo Electric Industries, Ltd. | Oligopeptides for promoting hair growth |
US20050008602A1 (en) * | 2000-06-05 | 2005-01-13 | Sumitomo Electric Industries, Ltd. | Oligopeptides for promoting hair growth |
US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
CA2466425A1 (en) * | 2001-11-09 | 2003-05-15 | Qlt Inc. | Photodynamic therapy for the treatment of hair loss |
TWI339122B (en) * | 2002-03-15 | 2011-03-21 | Lab Besins Iscovesco | Androgen pharmaceutical composition,kit containing the same and method for using the same |
EP2106805B1 (de) | 2003-03-21 | 2011-06-15 | Nexmed Holdings, Inc. | Antimykotischer Nagellack und Verfahren zu seiner Verwendung |
KR20050119134A (ko) * | 2003-03-21 | 2005-12-20 | 넥스메드 홀딩스 인코포레이티드 | 발기 부전 치료용 프로스타글란딘 조성물 |
DE10314976A1 (de) * | 2003-04-02 | 2004-10-14 | Bayer Healthcare Ag | Verbesserte Penetration von Wirkstoffen in Zellen und Organe |
KR20050041815A (ko) * | 2003-10-31 | 2005-05-04 | 싸이토팜(주) | 자외선에 의한 피부손상을 경감시키는 항산화 조성물 |
CA2457214A1 (en) | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
FR2869232B1 (fr) * | 2004-04-21 | 2007-09-21 | Gattefosse Sas Soc Par Actions | Nouveaux excipients pharmaceutiques ou cosmetiques a base d'acetals cyliques |
JP2008533153A (ja) * | 2005-03-14 | 2008-08-21 | マクロケム コーポレイション | ヒトの皮膚を介したマクロライドの浸透増強 |
JP2009504566A (ja) * | 2005-05-11 | 2009-02-05 | マクロケム コーポレイション | 局所用組成物の低投薬量投与 |
GT200600397A (es) * | 2005-09-07 | 2007-08-28 | Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales | |
GT200600396A (es) * | 2005-09-07 | 2007-04-23 | Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales | |
JP5505760B2 (ja) | 2005-09-27 | 2014-05-28 | ティッシュテク・インコーポレーテッド | 羊膜調製物及び精製組成物及びその使用方法 |
US8187639B2 (en) | 2005-09-27 | 2012-05-29 | Tissue Tech, Inc. | Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment |
BRPI0617294B8 (pt) | 2005-10-12 | 2021-05-25 | Besins Healthcare Lu Sarl | composição farmacêutica em gel hidroalcóolico e uso de testosterona |
US20080319370A1 (en) | 2005-11-04 | 2008-12-25 | Acrux Dds Pty Ltd. | Method and System for Transdermal Drug Delivery |
JP5570992B2 (ja) | 2007-10-10 | 2014-08-13 | セラメティックス エルエルシー | 皮膚病又は皮膚病変の治療方法及び組成物 |
US8962669B2 (en) | 2010-06-11 | 2015-02-24 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
EP2717888B1 (de) | 2011-06-10 | 2020-09-09 | Tissuetech, Inc. | Verfahren zur verarbeitung fötaler gewebesubstrate |
CA3133869A1 (en) | 2011-08-26 | 2013-03-07 | Tissuetech, Inc. | Methods of sterilizing fetal support tissues |
WO2014066916A2 (en) | 2012-10-28 | 2014-05-01 | Revance Therapeutics, Inc. | Compositions and methods for safe treatment of rhinitis |
CN107205971A (zh) | 2014-11-18 | 2017-09-26 | 罗格斯,新泽西州立大学 | 用于治疗代谢疾病和癌症的新的线粒体解偶联剂 |
EP3458454B1 (de) | 2016-05-18 | 2021-11-24 | Rutgers, The State University of New Jersey | 2-hydroxy-n-(benzo[d]thiazol-2-yl)benzamid-derivate als mitochondrien-entkoppler zur behandlung von stoffwechselerkrankungen und krebs |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1082370B (de) * | 1958-01-18 | 1960-05-25 | C F Asche & Co Ag | Verfahren zur Herstellung von verformbaren Massen fuer kosmetische und pharmazeutische Zwecke |
GB1385914A (en) * | 1971-10-19 | 1975-03-05 | Wigglesworth Ltd | Compositions having bactericidal activity |
US4012520A (en) * | 1973-08-08 | 1977-03-15 | The Upjohn Company | Composition and method of producing infertility in male rodents |
GB1448458A (en) * | 1973-11-21 | 1976-09-08 | Allen & Hanburys Ltd | 1,3-dioxan derivatives and pharmaceutical compositions thereof |
IT1037122B (it) * | 1975-04-01 | 1979-11-10 | Maggioni E C S P A | Derivati alogenati dell 1 3 dios solano ad attivita mucolitica |
DE2965405D1 (en) * | 1978-11-30 | 1983-06-16 | Ici Plc | Compositions containing 1,3-dioxolanes as emollients |
CA1225594A (en) * | 1983-05-20 | 1987-08-18 | Jourge Heller | Method for percutaneously administering physiologically active agents |
US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
-
1986
- 1986-11-17 US US06/931,653 patent/US4861764A/en not_active Expired - Lifetime
-
1987
- 1987-11-16 CA CA000551898A patent/CA1313619C/en not_active Expired - Lifetime
- 1987-11-17 AT AT87310141T patent/ATE69168T1/de not_active IP Right Cessation
- 1987-11-17 EP EP87310141A patent/EP0268460B1/de not_active Expired
- 1987-11-17 ES ES198787310141T patent/ES2038676T3/es not_active Expired - Lifetime
- 1987-11-17 DE DE8787310141T patent/DE3774398D1/de not_active Expired - Lifetime
-
1991
- 1991-11-29 GR GR91401841T patent/GR3003238T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3003238T3 (en) | 1993-02-17 |
US4861764A (en) | 1989-08-29 |
EP0268460A1 (de) | 1988-05-25 |
EP0268460B1 (de) | 1991-11-06 |
CA1313619C (en) | 1993-02-16 |
DE3774398D1 (de) | 1991-12-12 |
ES2038676T3 (es) | 1993-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |