ATE195867T1
(de)
*
|
1991-09-20 |
2000-09-15 |
Glaxo Group Ltd |
Neue medizinische indikation für tachykinin- antagonisten
|
AU675786B2
(en)
*
|
1992-04-15 |
1997-02-20 |
Merck Sharp & Dohme Limited |
Azacyclic compounds
|
US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
US5637699A
(en)
*
|
1992-06-29 |
1997-06-10 |
Merck & Co., Inc. |
Process for preparing morpholine tachykinin receptor antagonists
|
US6048859A
(en)
|
1992-06-29 |
2000-04-11 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
JP2683783B2
(ja)
*
|
1992-07-10 |
1997-12-03 |
雪印乳業株式会社 |
シェーグレン症候群治療剤
|
GB2268931A
(en)
*
|
1992-07-22 |
1994-01-26 |
Merck Sharp & Dohme |
Azabicyclic tachykinin-receptor antagonists
|
ATE173725T1
(de)
*
|
1992-07-28 |
1998-12-15 |
Merck Sharp & Dohme |
Azazyklische verbindungen
|
GB2269170A
(en)
*
|
1992-07-29 |
1994-02-02 |
Merck Sharp & Dohme |
Azatricyclic tachykinin antagonists
|
US5387595A
(en)
*
|
1992-08-26 |
1995-02-07 |
Merck & Co., Inc. |
Alicyclic compounds as tachykinin receptor antagonists
|
GB9220286D0
(en)
*
|
1992-09-25 |
1992-11-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5837711A
(en)
*
|
1992-10-28 |
1998-11-17 |
Pfizer Inc. |
Substituted quinuclidines as substance P antagonists
|
WO1994013663A1
(en)
*
|
1992-12-10 |
1994-06-23 |
Pfizer Inc. |
Aminomethylene substituted non-aromatic heterocycles and use as substance p antagonists
|
US5344830A
(en)
*
|
1992-12-10 |
1994-09-06 |
Merck & Co., Inc. |
N,N-diacylpiperazine tachykinin antagonists
|
US5830854A
(en)
*
|
1992-12-14 |
1998-11-03 |
Merck Sharp & Dohme, Limited |
Method of treating cystic fibrosis using a tachykinin receptor antagonist
|
GB9226581D0
(en)
*
|
1992-12-21 |
1993-02-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9300051D0
(en)
*
|
1993-01-04 |
1993-03-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
FR2700472B1
(fr)
|
1993-01-19 |
1995-02-17 |
Rhone Poulenc Rorer Sa |
Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
|
AU679207B2
(en)
*
|
1993-02-18 |
1997-06-26 |
Merck Sharp & Dohme Limited |
Azacyclic compounds, compositions containing them and their use as tachykinin antagonists
|
US6060473A
(en)
*
|
1993-04-01 |
2000-05-09 |
Ucb S.A. - Dtb |
7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
|
US5817679A
(en)
*
|
1993-04-01 |
1998-10-06 |
University Of Virginia |
7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
|
WO1995002595A1
(en)
*
|
1993-07-15 |
1995-01-26 |
Pfizer Inc. |
Benzyloxyquinuclidines as substance p antagonists
|
US6077846A
(en)
*
|
1993-09-10 |
2000-06-20 |
Ucb, S.A. |
Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
|
US5610165A
(en)
*
|
1994-02-17 |
1997-03-11 |
Merck & Co., Inc. |
N-acylpiperidine tachykinin antagonists
|
IL112778A0
(en)
*
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
US6117889A
(en)
*
|
1994-04-01 |
2000-09-12 |
University Of Virginia |
7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
|
FR2725900B1
(fr)
*
|
1994-10-21 |
1997-07-18 |
Sanofi Sa |
Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
|
FR2728166A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Composition topique contenant un antagoniste de substance p
|
FR2728169A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
|
FR2728165A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
|
TW458774B
(en)
|
1995-10-20 |
2001-10-11 |
Pfizer |
Antiemetic pharmaceutical compositions
|
FR2741262B1
(fr)
|
1995-11-20 |
1999-03-05 |
Oreal |
Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
|
AU3716997A
(en)
*
|
1996-07-17 |
1998-02-09 |
Merck & Co., Inc. |
Alteration of circadian rhythmicity with a tachykinin antagonist
|
MX9706944A
(es)
*
|
1996-09-12 |
1998-08-30 |
Pfizer |
Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
RU2309953C2
(ru)
|
1999-11-03 |
2007-11-10 |
Эймр Текнолоджи, Инк. |
Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе
|
BR0112350A
(pt)
|
2000-07-11 |
2003-06-24 |
Albany Molecular Res Inc |
Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico
|
GB0108982D0
(en)
|
2001-04-10 |
2001-05-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6709651B2
(en)
|
2001-07-03 |
2004-03-23 |
B.M.R.A. Corporation B.V. |
Treatment of substance P-related disorders
|
NZ552397A
(en)
|
2004-07-15 |
2011-04-29 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
US20080027095A1
(en)
*
|
2005-01-07 |
2008-01-31 |
Priya Kunapuli |
Use Of 3-Substituted-2-(Diphenylmethy)-1-Azabicyclo[2.2.2]Octanes For Treating Mrg-X1 Receptor Mediated Diseases
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
EP1904069B1
(de)
|
2005-07-15 |
2018-06-13 |
Albany Molecular Research, Inc. |
Aryl- und heteroarylsubstituierte tetrahydrobenzazepine und verwendung damit zur wiederaufnahmeblockierung von norepinephrin, dopamin und serotonin
|
BRPI0616463A2
(pt)
|
2005-09-29 |
2011-06-21 |
Merck & Co Inc |
composto, composição farmacêutica, e, uso de um composto
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
WO2008039327A2
(en)
|
2006-09-22 |
2008-04-03 |
Merck & Co., Inc. |
Method of treatment using fatty acid synthesis inhibitors
|
JP5172124B2
(ja)
|
2006-09-29 |
2013-03-27 |
関東化学株式会社 |
2位に置換基を有する光学活性キヌクリジノール類の製造方法
|
JP5232374B2
(ja)
*
|
2006-09-29 |
2013-07-10 |
関東化学株式会社 |
2位に置換基を有する光学活性キヌクリジノール類の製造方法
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
AU2008204380B2
(en)
|
2007-01-10 |
2013-08-15 |
Msd Italia S.R.L. |
Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
|
JP2010516734A
(ja)
|
2007-01-24 |
2010-05-20 |
グラクソ グループ リミテッド |
3,5−ジアミノ−6−(2,3−ジクロロフェニル)−1,2,4−トリアジンまたはr(−)−2,4−ジアミノ−5−(2,3−ジクロロフェニル)−6−フルオロメチルピリミジンを含む医薬組成物
|
EP2145884B1
(de)
|
2007-04-02 |
2014-08-06 |
Msd K.K. |
Indoledionderivat
|
US8389553B2
(en)
|
2007-06-27 |
2013-03-05 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
AR071997A1
(es)
|
2008-06-04 |
2010-07-28 |
Bristol Myers Squibb Co |
Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
UA105182C2
(ru)
|
2008-07-03 |
2014-04-25 |
Ньюрексон, Інк. |
Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
|
KR101320245B1
(ko)
|
2008-10-30 |
2013-10-30 |
머크 샤프 앤드 돔 코포레이션 |
이소니코틴아미드 오렉신 수용체 길항제
|
EP2413932A4
(de)
|
2009-04-01 |
2012-09-19 |
Merck Sharp & Dohme |
Hemmer der akt-aktivität
|
KR20120023072A
(ko)
|
2009-05-12 |
2012-03-12 |
브리스톨-마이어스 스큅 컴퍼니 |
(S)-7-(〔1,2,4〕트리아졸〔1,5-a〕피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
|
NZ596104A
(en)
|
2009-05-12 |
2014-01-31 |
Albany Molecular Res Inc |
7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
|
KR20120034644A
(ko)
|
2009-05-12 |
2012-04-12 |
알바니 몰레큘라 리써치, 인크. |
아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
|
BR112012008849A2
(pt)
|
2009-10-14 |
2015-09-22 |
Schering Corp |
composto, composição farmacêutica, e, uso de um composto
|
EP2584903B1
(de)
|
2010-06-24 |
2018-10-24 |
Merck Sharp & Dohme Corp. |
Neue heterozyklische verbindungen als erk-hemmer
|
JP6043285B2
(ja)
|
2010-08-02 |
2016-12-14 |
サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. |
低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害
|
HUE044815T2
(hu)
|
2010-08-17 |
2019-11-28 |
Sirna Therapeutics Inc |
Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával
|
EP2608669B1
(de)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
Neue pyrazolo-[1,5-a-]pyrimidinderivate als mtor-hemmer
|
EP2613782B1
(de)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Indazolderivate als erk-hemmer
|
WO2012036997A1
(en)
|
2010-09-16 |
2012-03-22 |
Schering Corporation |
Fused pyrazole derivatives as novel erk inhibitors
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
US20140045847A1
(en)
|
2011-04-21 |
2014-02-13 |
Piramal Enterprises Limited |
Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
EP3919620A1
(de)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Zusammensetzungen mit kurzer interferierender nukleinsäure (sina)
|
US9233979B2
(en)
|
2012-09-28 |
2016-01-12 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
BR112015012295A8
(pt)
|
2012-11-28 |
2023-03-14 |
Merck Sharp & Dohme |
Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer
|
BR112015013611A2
(pt)
|
2012-12-20 |
2017-11-14 |
Merck Sharp & Dohme |
composto, e, composição farmacêutica
|
EP2951180B1
(de)
|
2013-01-30 |
2018-05-02 |
Merck Sharp & Dohme Corp. |
2,6,7,8-substituierte purine als hdm2-inhibitoren
|
EP3041938A1
(de)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Kreisförmige polynukleotide
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
EP3833667B1
(de)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5-inhibitoren
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
WO2020167706A1
(en)
|
2019-02-13 |
2020-08-20 |
Merck Sharp & Dohme Corp. |
5-alkyl pyrrolidine orexin receptor agonists
|
EP4010314B1
(de)
|
2019-08-08 |
2024-02-28 |
Merck Sharp & Dohme LLC |
Heteroaryl-pyrrolidin- und piperidinorexinrezeptor-agonisten
|
CA3189908A1
(en)
|
2020-08-18 |
2022-02-24 |
Stephane L. Bogen |
Bicycloheptane pyrrolidine orexin receptor agonists
|