ATE555836T1 - Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffe - Google Patents
Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffeInfo
- Publication number
- ATE555836T1 ATE555836T1 AT08826080T AT08826080T ATE555836T1 AT E555836 T1 ATE555836 T1 AT E555836T1 AT 08826080 T AT08826080 T AT 08826080T AT 08826080 T AT08826080 T AT 08826080T AT E555836 T1 ATE555836 T1 AT E555836T1
- Authority
- AT
- Austria
- Prior art keywords
- density
- separation
- solid
- materials
- solids
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Fluid Mechanics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94721407P | 2007-06-29 | 2007-06-29 | |
US95248307P | 2007-07-27 | 2007-07-27 | |
US3998308P | 2008-03-27 | 2008-03-27 | |
PCT/US2008/068797 WO2009006409A2 (en) | 2007-06-29 | 2008-06-30 | Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE555836T1 true ATE555836T1 (de) | 2012-05-15 |
Family
ID=40226799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08826080T ATE555836T1 (de) | 2007-06-29 | 2008-06-30 | Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffe |
Country Status (4)
Country | Link |
---|---|
US (1) | US9551706B2 (de) |
EP (1) | EP2167216B1 (de) |
AT (1) | ATE555836T1 (de) |
WO (1) | WO2009006409A2 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1794581A2 (de) | 2004-09-15 | 2007-06-13 | Microchip Biotechnologies, Inc. | Mikrofluidische vorrichtungen |
CN101415813B (zh) | 2006-02-03 | 2013-04-10 | 微芯片生物工艺学股份有限公司 | 微流体装置 |
KR20100028526A (ko) | 2007-02-05 | 2010-03-12 | 마이크로칩 바이오테크놀로지스, 인크. | 마이크로유체 및 나노유체 장치, 시스템 및 응용 |
EP2167216B1 (de) | 2007-06-29 | 2012-05-02 | The President and Fellows of Harvard College | Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffe |
US20090253181A1 (en) | 2008-01-22 | 2009-10-08 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
WO2010077322A1 (en) | 2008-12-31 | 2010-07-08 | Microchip Biotechnologies, Inc. | Instrument with microfluidic chip |
KR20120030130A (ko) | 2009-06-02 | 2012-03-27 | 인터젠엑스 인크. | 다이아프램 밸브를 포함하는 유체 장치 |
CN102803147B (zh) | 2009-06-05 | 2015-11-25 | 尹特根埃克斯有限公司 | 通用样品准备***以及在一体化分析***中的用途 |
CN102575976B (zh) | 2009-09-28 | 2016-03-30 | 皇家飞利浦电子股份有限公司 | 物质确定设备 |
DE102009055800B4 (de) * | 2009-11-18 | 2013-01-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | System und ein Verfahren zur Detektion von in flüssigen Proben enthaltenen Analytmolekülen |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
EP2534449B1 (de) * | 2010-02-12 | 2016-07-06 | Marquardt Mechatronik GmbH | Verfahren zur positionsmessung |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
WO2012024691A1 (en) * | 2010-08-20 | 2012-02-23 | President And Fellows Of Harvard College | Multiphase systems for analysis of solid materials |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
US9322804B2 (en) | 2010-11-29 | 2016-04-26 | President And Fellows Of Harvard College | Quality control of diamagnetic materials using magnetic levitation |
WO2012166580A1 (en) | 2011-05-25 | 2012-12-06 | Cidra Corporate Services Inc. | Flotation separation using lightweight synthetic beads or bubbles |
WO2013037732A1 (en) * | 2011-09-12 | 2013-03-21 | Siemens Aktiengesellschaft | A method and a system for determining counts of a target cellular entity in a suspension using magnetic levitation |
WO2013044089A1 (en) * | 2011-09-23 | 2013-03-28 | President And Fellows Of Harvard College | Density analysis of organisms by magnetic levitation |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
US11198126B2 (en) * | 2011-10-31 | 2021-12-14 | Fluid-Screen, Inc. | Apparatus for pathogen detection |
JP5279942B1 (ja) * | 2011-11-09 | 2013-09-04 | 国立大学法人九州大学 | コバルト抽出方法 |
WO2013116696A1 (en) | 2012-02-03 | 2013-08-08 | University Of Cincinnati | Microfluidic methods for passive separation of cells and particles |
WO2013188725A1 (en) * | 2012-06-14 | 2013-12-19 | President And Fellows Of Harvard College | Levitation of materials in paramagnetic ionic liquids |
US9278353B2 (en) * | 2012-06-25 | 2016-03-08 | The General Hospital Corporation | Sorting particles using high gradient magnetic fields |
WO2014018960A1 (en) * | 2012-07-27 | 2014-01-30 | President And Fellows Of Harvard College | Density amplification in magnetic levitation to detect binding events of large molecules |
EP2720059B1 (de) * | 2012-10-15 | 2015-03-11 | MagCam NV | Vorrichtungen und Verfahren zum Bestimmen einer Magnetfeldverteilung eines Magneten entlang einer Hauptoberfläche des Magneten |
US9263669B2 (en) * | 2013-03-13 | 2016-02-16 | International Business Machines Corporation | Magnetic trap for cylindrical diamagnetic materials |
CN110560187B (zh) | 2013-11-18 | 2022-01-11 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
AU2015222978B2 (en) * | 2014-02-26 | 2021-05-13 | Beth Israel Deaconess Medical Center | System and method for cell levitation and monitoring |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
JP6511616B2 (ja) * | 2014-07-08 | 2019-05-15 | 中部キレスト株式会社 | キレート剤 |
EP3209410A4 (de) | 2014-10-22 | 2018-05-02 | IntegenX Inc. | Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben |
US11291931B2 (en) | 2014-12-15 | 2022-04-05 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
WO2016100290A1 (en) | 2014-12-15 | 2016-06-23 | Akadeum Life Sciences, LLC | Method and system for buoyant separation |
JP7219089B2 (ja) * | 2015-10-02 | 2023-02-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 磁気浮上を用いた生物学的および非生物学的な部分の選別 |
WO2017158425A1 (en) | 2016-03-18 | 2017-09-21 | Andrew Alliance S.A. | Methods and apparatus for bead manipulation in a tip of a liquid handler |
US11774444B2 (en) * | 2016-11-11 | 2023-10-03 | Beth Israel Deaconess Medical Center, Inc. | Detection and identification of cell bound and soluble antigens using magnetic levitation |
EP3351796A1 (de) * | 2017-01-23 | 2018-07-25 | Université de Strasbourg | Vorrichtung und verfahren zum zirkulieren von flüssigkeiten |
JP7189314B2 (ja) | 2018-07-09 | 2022-12-13 | アカデューム ライフ サイエンセズ,インコーポレイテッド | 浮遊性粒子を処理するシステムおよび方法 |
US11676750B2 (en) * | 2018-09-28 | 2023-06-13 | President And Fellows Of Harvard College | Magnetic levitation |
CN110346239B (zh) * | 2019-07-10 | 2022-02-11 | 国家纳米科学中心 | 一种纳米材料密度的检测方法 |
TR201910569A2 (tr) * | 2019-07-16 | 2021-02-22 | Izmir Yueksek Teknoloji Enstituesue | Hücresel uygulamalar i̇çi̇n manyeti̇k kuvvetleri̇ kullanan kismi̇ yerçeki̇mi̇ platformu tasarim ve üreti̇mi̇ |
CN111189745B (zh) * | 2020-01-15 | 2021-10-22 | 浙江大学 | 一种基于环形悬浮的磁悬浮密度检测方法 |
US11946038B1 (en) | 2020-05-29 | 2024-04-02 | 10X Genomics, Inc. | Methods and systems including flow and magnetic modules |
CN114485410B (zh) * | 2020-10-27 | 2024-03-01 | 中国烟草总公司郑州烟草研究院 | 一种基于激光测距***的烟草物料堆积度标定方法 |
CN112557258B (zh) * | 2020-11-23 | 2022-12-02 | 金发科技股份有限公司 | 一种测试高分子材料密度的溶液及其应用 |
US20220364973A1 (en) * | 2021-05-13 | 2022-11-17 | Honeywell International Inc. | In situ fluid sampling device and method of using the same |
WO2023028329A1 (en) | 2021-08-26 | 2023-03-02 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
DE102021129034B3 (de) | 2021-11-08 | 2023-01-26 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | Messanordnungen und verfahren zum bestimmen einer magnetischen gradientenkraft und deren verteilung |
WO2023200777A1 (en) * | 2022-04-12 | 2023-10-19 | Massachusetts Institute Of Technology | Device and method for isolation and detection of targets in a sample |
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US4062765A (en) | 1975-12-29 | 1977-12-13 | Union Carbide Corporation | Apparatus and process for the separation of particles of different density with magnetic fluids |
US4049398A (en) | 1976-05-28 | 1977-09-20 | Vaseen Vesper A | Separating oxygen from the air by means of dissolving air in a nonmagnetic, inert liquid and then paramagnetically collecting the oxygen from the liquid |
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EP0571858B1 (de) | 1992-05-18 | 1996-08-14 | Mitsubishi Cable Industries, Ltd. | Sekundäre Lithiumbatterie |
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AU2001261463A1 (en) | 2000-05-12 | 2001-11-26 | University Of Cincinnati | Magnetic bead-based arrays |
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WO2002061392A2 (en) * | 2001-01-31 | 2002-08-08 | Board Of Regents, The University Of Texas System | Method and apparatus for the confinement of materials in a micromachined chemical sensor array |
JP3418381B2 (ja) | 2001-02-07 | 2003-06-23 | 日本学術振興会 | 高分子球状体の製造方法 |
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GB0404713D0 (en) | 2004-03-02 | 2004-04-07 | Isis Innovation | Separation of carbon nanotubes |
GB0409987D0 (en) * | 2004-05-05 | 2004-06-09 | Univ Nottingham | A method for materials separation in an inhomogeneous magnetic field using vibration |
US20050274650A1 (en) * | 2004-06-09 | 2005-12-15 | Georgia Tech Research Corporation | Blood separation systems in micro device format and fabrication methods |
US20060223178A1 (en) | 2005-04-05 | 2006-10-05 | Tom Barber | Devices and methods for magnetic enrichment of cells and other particles |
EP2167216B1 (de) | 2007-06-29 | 2012-05-02 | The President and Fellows of Harvard College | Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffe |
-
2008
- 2008-06-30 EP EP08826080A patent/EP2167216B1/de active Active
- 2008-06-30 WO PCT/US2008/068797 patent/WO2009006409A2/en active Application Filing
- 2008-06-30 US US12/666,132 patent/US9551706B2/en active Active
- 2008-06-30 AT AT08826080T patent/ATE555836T1/de active
Also Published As
Publication number | Publication date |
---|---|
EP2167216A4 (de) | 2011-03-09 |
WO2009006409A3 (en) | 2009-02-26 |
EP2167216B1 (de) | 2012-05-02 |
US20100285606A1 (en) | 2010-11-11 |
WO2009006409A2 (en) | 2009-01-08 |
US9551706B2 (en) | 2017-01-24 |
EP2167216A2 (de) | 2010-03-31 |
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