ATE554169T1 - Smad7-inhibitoren zur behandlung von krankheiten des zns - Google Patents
Smad7-inhibitoren zur behandlung von krankheiten des znsInfo
- Publication number
- ATE554169T1 ATE554169T1 AT02790321T AT02790321T ATE554169T1 AT E554169 T1 ATE554169 T1 AT E554169T1 AT 02790321 T AT02790321 T AT 02790321T AT 02790321 T AT02790321 T AT 02790321T AT E554169 T1 ATE554169 T1 AT E554169T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- cns diseases
- smad7 inhibitors
- diseases
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01126140 | 2001-11-02 | ||
| PCT/EP2002/012221 WO2003037368A2 (en) | 2001-11-02 | 2002-10-31 | Smad7 inhibitors for the treatment of cns diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554169T1 true ATE554169T1 (de) | 2012-05-15 |
Family
ID=8179155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02790321T ATE554169T1 (de) | 2001-11-02 | 2002-10-31 | Smad7-inhibitoren zur behandlung von krankheiten des zns |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7700572B2 (de) |
| EP (1) | EP1456380B1 (de) |
| AT (1) | ATE554169T1 (de) |
| AU (1) | AU2002363182A1 (de) |
| CY (1) | CY1112932T1 (de) |
| DK (1) | DK1456380T3 (de) |
| ES (1) | ES2388968T3 (de) |
| PT (1) | PT1456380E (de) |
| SI (1) | SI1456380T1 (de) |
| WO (1) | WO2003037368A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2388968T3 (es) * | 2001-11-02 | 2012-10-22 | Giuliani International Limited | Inhibidores de Smad7 para el tratamiento de enfermedades del SNC |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| RU2010139426A (ru) | 2008-03-17 | 2012-04-27 | Зе Скрипс Ресеч Инститьют (Us) | Комбинация химического и генетического подходов к получению индуцированных плюрипотентных стволовых клеток |
| US8912154B2 (en) | 2008-11-13 | 2014-12-16 | Nogra Pharma Limited | Antisense compositions and methods of making and using same |
| WO2010065917A1 (en) | 2008-12-05 | 2010-06-10 | The Regents Of The University Of California | Methods of treating neurological disorders |
| CN113621576A (zh) | 2009-10-16 | 2021-11-09 | 斯克里普斯研究所 | 多能细胞的诱导 |
| ES2893699T3 (es) | 2010-03-31 | 2022-02-09 | Scripps Research Inst | Reprogramación de células |
| KR102160721B1 (ko) | 2010-12-22 | 2020-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| ES2392862B1 (es) * | 2011-06-02 | 2013-11-05 | Fundación Para La Investigación Biomédica Del Hospital Universitario Ramón Y Cajal | Tgf-beta y/o smad3 como marcadores de diagnóstico y/o pronóstico de alfa-sinucleinopatías |
| EP2748611B1 (de) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Verfahren zur überwachung des ansprechens auf eine anti-smad7-therapie |
| RU2667960C2 (ru) * | 2012-04-18 | 2018-09-25 | Ногра Фарма Лимитед | Способы лечения диабета и/или улучшения выживания панкреатических островков после трансплантации |
| GB201300684D0 (en) | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| KR102670874B1 (ko) | 2014-03-04 | 2024-05-31 | 페이트 세러퓨틱스, 인코포레이티드 | 개선된 재프로그래밍 방법 및 세포 배양 플랫폼 |
| US10473669B2 (en) | 2014-05-09 | 2019-11-12 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| US10023879B2 (en) | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
| MX2017004973A (es) | 2014-10-17 | 2017-12-07 | Nogra Pharma Ltd | Metodos y composiciones para tratar a un sujeto con un oligonucleotido antisentido de smad7. |
| CN114058582A (zh) | 2015-01-26 | 2022-02-18 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| CN108291237B (zh) | 2015-10-16 | 2023-11-21 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
| CN115927199A (zh) | 2015-11-04 | 2023-04-07 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| WO2017079673A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
| EP3420082A4 (de) | 2016-02-23 | 2019-10-16 | Celgene Alpine Investment Company II, LLC | Verfahren zur behandlung von darmfibrose mittels smad7-hemmung |
| WO2019051173A1 (en) * | 2017-09-08 | 2019-03-14 | Ionis Pharmaceuticals, Inc. | MODULATORS OF SMAD7 EXPRESSION |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096722A (en) * | 1990-08-14 | 2000-08-01 | Isis Pharmaceuticals Inc. | Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases |
| RU95104940A (ru) * | 1992-07-27 | 1997-01-10 | Хайбрайдон | Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения |
| US6884787B2 (en) * | 2001-07-14 | 2005-04-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of transforming growth factor-beta 3 expression |
| EP0667148B1 (de) * | 1992-11-06 | 2002-07-03 | Hisamitsu Pharmaceutical Co., Inc. | Perorale pharmazeutische zubereitung mit freisetzung im unteren verfdauungstrakt |
| US20020177568A1 (en) * | 1992-12-07 | 2002-11-28 | Stinchcomb Dan T. | Enzymatic nucleic acid treatment of diseases or conditions related to levels of NF-kappa B |
| JP3555952B2 (ja) * | 1993-04-30 | 2004-08-18 | バイオグノスティック・ゲゼルシャフト・フュア・バイオモレキュラーレ・ダイアグノスティック・ミット・ベシュレンクテル・ハフツング | トランスフォーミング成長因子−β（ＴＧＦ‐β）の免疫抑制効果の治療用アンチセンス−オリゴヌクレオチド類 |
| GB9516268D0 (en) * | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
| CA2247246A1 (en) * | 1996-02-16 | 1997-08-21 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
| US5783566A (en) * | 1996-05-10 | 1998-07-21 | California Institute Of Technology | Method for increasing or decreasing transfection efficiency |
| US5856462A (en) * | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| CA2274608C (en) | 1996-12-11 | 2007-06-26 | Bristol-Myers Squibb Company | Prokaryotic two-hybrid system |
| JPH10295381A (ja) * | 1997-04-23 | 1998-11-10 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 新規シグナル伝達因子、およびそれをコードする遺伝子 |
| JP3431637B2 (ja) * | 1997-05-20 | 2003-07-28 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｓｍａｄ７およびその使用 |
| US6887906B1 (en) * | 1997-07-01 | 2005-05-03 | Isispharmaceuticals, Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
| JPH11335269A (ja) * | 1998-05-19 | 1999-12-07 | Hisamitsu Pharmaceut Co Inc | 遺伝子関連医薬の経口投与固形製剤 |
| JP2002521004A (ja) | 1998-07-10 | 2002-07-16 | キュラゲン コーポレイション | ヒトβアミドイド前駆体タンパク質（β−ＡＰＰ）のヒトＬＯＮプロテアーゼ様タンパク質（ＨｓＬＯＮ）との相互作用 |
| US6479465B2 (en) * | 1999-03-24 | 2002-11-12 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of treating colitis using STAT-4 anti-sense oligonucleotides |
| US6159697A (en) * | 2000-01-19 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of Smad7 expression |
| US20020147140A1 (en) * | 2000-01-31 | 2002-10-10 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| IL151345A0 (en) * | 2000-02-23 | 2003-04-10 | Univ California | Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation |
| WO2001070955A2 (en) * | 2000-03-21 | 2001-09-27 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in prokaryotes |
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| ES2388968T3 (es) * | 2001-11-02 | 2012-10-22 | Giuliani International Limited | Inhibidores de Smad7 para el tratamiento de enfermedades del SNC |
| JP2003135075A (ja) * | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長ｃＤＮＡ |
| AU2003296944A1 (en) * | 2002-12-10 | 2004-06-30 | George Koob | A method for treatment of drug addiction and for screening of pharmaceutical agents therefor |
| ITRM20030149A1 (it) * | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| US20040265833A1 (en) * | 2003-06-23 | 2004-12-30 | Cathy Lofton-Day | Methods and nucleic acids for the analysis of colorectal cell proliferative disorders |
| WO2005084712A2 (en) * | 2004-02-27 | 2005-09-15 | Antisense Pharma Gmbh | Use of an oligonucleotide or its active derivative for the preparation of a pharmaceutical composition for inhibiting the formation of metastases in cancer treatment |
| US20080032943A1 (en) * | 2005-11-04 | 2008-02-07 | Johji Inazawa | Method for detecting cancer and a method for suppressing cancer |
| WO2009151600A2 (en) * | 2008-06-10 | 2009-12-17 | Tufts University | Smad proteins control drosha-mediated mirna maturation |
| US8110355B2 (en) * | 2009-02-20 | 2012-02-07 | GenRemedy, LLC | Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis |
-
2002
- 2002-10-31 ES ES02790321T patent/ES2388968T3/es not_active Expired - Lifetime
- 2002-10-31 AT AT02790321T patent/ATE554169T1/de active
- 2002-10-31 AU AU2002363182A patent/AU2002363182A1/en not_active Abandoned
- 2002-10-31 US US10/494,333 patent/US7700572B2/en not_active Expired - Fee Related
- 2002-10-31 SI SI200230992T patent/SI1456380T1/sl unknown
- 2002-10-31 PT PT02790321T patent/PT1456380E/pt unknown
- 2002-10-31 DK DK02790321.0T patent/DK1456380T3/da active
- 2002-10-31 EP EP02790321A patent/EP1456380B1/de not_active Expired - Lifetime
- 2002-10-31 WO PCT/EP2002/012221 patent/WO2003037368A2/en not_active Application Discontinuation
-
2009
- 2009-09-23 US US12/565,629 patent/US20110207795A1/en not_active Abandoned
-
2012
- 2012-07-09 CY CY20121100612T patent/CY1112932T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20050119203A1 (en) | 2005-06-02 |
| EP1456380B1 (de) | 2012-04-18 |
| DK1456380T3 (da) | 2012-07-30 |
| WO2003037368A3 (en) | 2004-03-11 |
| WO2003037368A2 (en) | 2003-05-08 |
| ES2388968T3 (es) | 2012-10-22 |
| PT1456380E (pt) | 2012-07-23 |
| CY1112932T1 (el) | 2016-04-13 |
| EP1456380A2 (de) | 2004-09-15 |
| AU2002363182A1 (en) | 2003-05-12 |
| SI1456380T1 (sl) | 2012-11-30 |
| US7700572B2 (en) | 2010-04-20 |
| US20110207795A1 (en) | 2011-08-25 |
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