ATE546444T1 - Amidophenoxyindazole als c-met-hemmer - Google Patents
Amidophenoxyindazole als c-met-hemmerInfo
- Publication number
- ATE546444T1 ATE546444T1 AT09790440T AT09790440T ATE546444T1 AT E546444 T1 ATE546444 T1 AT E546444T1 AT 09790440 T AT09790440 T AT 09790440T AT 09790440 T AT09790440 T AT 09790440T AT E546444 T1 ATE546444 T1 AT E546444T1
- Authority
- AT
- Austria
- Prior art keywords
- amidophenoxyindazoles
- met inhibitors
- inhibitors
- met
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8329408P | 2008-07-24 | 2008-07-24 | |
| US8508208P | 2008-07-31 | 2008-07-31 | |
| US10865908P | 2008-10-27 | 2008-10-27 | |
| PCT/US2009/050640 WO2010011538A1 (en) | 2008-07-24 | 2009-07-15 | Amidophenoxyindazoles useful as inhibitors of c-met |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE546444T1 true ATE546444T1 (de) | 2012-03-15 |
Family
ID=41010247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09790440T ATE546444T1 (de) | 2008-07-24 | 2009-07-15 | Amidophenoxyindazole als c-met-hemmer |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US8030302B2 (de) |
| EP (1) | EP2310382B1 (de) |
| JP (1) | JP5414794B2 (de) |
| KR (1) | KR101334456B1 (de) |
| CN (1) | CN102105462B (de) |
| AR (1) | AR074632A1 (de) |
| AT (1) | ATE546444T1 (de) |
| AU (1) | AU2009274256B2 (de) |
| BR (1) | BRPI0916286B8 (de) |
| CA (1) | CA2731773C (de) |
| CL (1) | CL2011000134A1 (de) |
| CO (1) | CO6351737A2 (de) |
| CR (1) | CR20110046A (de) |
| CY (1) | CY1112595T1 (de) |
| DK (1) | DK2310382T3 (de) |
| DO (1) | DOP2011000009A (de) |
| EA (1) | EA018385B1 (de) |
| EC (1) | ECSP11010778A (de) |
| ES (1) | ES2379587T3 (de) |
| HK (1) | HK1155172A1 (de) |
| HR (1) | HRP20120202T1 (de) |
| IL (1) | IL210490A (de) |
| JO (1) | JO2788B1 (de) |
| MA (1) | MA32594B1 (de) |
| MX (1) | MX2011000925A (de) |
| MY (1) | MY163852A (de) |
| NZ (1) | NZ590013A (de) |
| PE (1) | PE20110150A1 (de) |
| PL (1) | PL2310382T3 (de) |
| PT (1) | PT2310382E (de) |
| RS (1) | RS52261B (de) |
| SI (1) | SI2310382T1 (de) |
| SV (1) | SV2011003816A (de) |
| TW (1) | TWI365185B (de) |
| WO (1) | WO2010011538A1 (de) |
| ZA (1) | ZA201100219B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2532657B9 (de) | 2008-10-14 | 2017-04-19 | Sunshine Lake Pharma Co., Ltd. | Verbindungen und anwendungsverfahren |
| CA2752421C (en) | 2009-03-21 | 2013-08-06 | Ning Xi | Amino ester derivatives, salts thereof and methods of use |
| MX352844B (es) | 2011-02-28 | 2017-12-11 | Calitor Sciences Llc | Compuestos de quinolina sustituidos y metodos de uso. |
| JP5970003B2 (ja) * | 2011-03-04 | 2016-08-17 | ローカス ファーマシューティカルズ インコーポレイテッド | アミノピラジン化合物 |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| CN104334581B (zh) * | 2012-05-09 | 2018-02-02 | 伊莱利利公司 | 抗‑c‑Met抗体 |
| WO2014134313A1 (en) * | 2013-02-27 | 2014-09-04 | Array Biopharma Inc. | Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof |
| CN104140393B (zh) * | 2013-12-10 | 2016-09-21 | 郑州泰基鸿诺医药股份有限公司 | 一种芳环/芳杂环叔丁醇酯类化合物的制备方法 |
| WO2015164161A1 (en) | 2014-04-22 | 2015-10-29 | Calitor Sciences, Llc | Bicylcic pyrazolone compounds and methods of use |
| TW201716085A (zh) * | 2015-08-12 | 2017-05-16 | 應克隆公司 | 癌症之組合療法 |
| JP2019511541A (ja) * | 2016-04-15 | 2019-04-25 | イーライ リリー アンド カンパニー | 結腸直腸癌の処置における使用のためのラムシルマブとメレスチニブとの組み合わせ |
| WO2017208018A1 (en) | 2016-06-02 | 2017-12-07 | Immunocore Limited | Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein |
| CN109562282A (zh) * | 2016-07-29 | 2019-04-02 | 伊莱利利公司 | 用于治疗癌症的使用merestinib和抗-pd-l1或抗-pd-1抑制剂的组合疗法 |
| CN108069938A (zh) * | 2016-11-15 | 2018-05-25 | 中国药科大学 | 2,4-二取代吡啶类化合物及其制备方法和应用 |
| EP3541384A1 (de) * | 2016-11-16 | 2019-09-25 | Eli Lilly and Company | Behandlung von krebs mit exon-14-skipping mutation(en) oder exon-14-skipping phänotyp |
| ES2866348T3 (es) | 2016-11-16 | 2021-10-19 | Lilly Co Eli | Terapia de combinación para el cáncer con mutación o mutaciones de omisión del exón 14 o fenotipo de omisión del exón 14 |
| CN107382968A (zh) * | 2017-07-06 | 2017-11-24 | 北京万全德众医药生物技术有限公司 | 一种吲哚类c‑Met抑制剂的制备方法 |
| CN107311983A (zh) * | 2017-07-06 | 2017-11-03 | 北京万全德众医药生物技术有限公司 | 吲哚类小分子c‑met抑制剂 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| EP3480201A1 (de) | 2017-11-06 | 2019-05-08 | Oncostellae, S.L. | Neue analoga als androgen-rezeptor und glucocorticoid-rezeptor-modulatoren |
| EP3719012B1 (de) | 2017-11-24 | 2024-03-06 | Medshine Discovery Inc. | N-[4-[(2-amino-4-pyridinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidincarboxamid-derivate als c-meth/axl-inhibitoren zur behandlung von tumoren |
| WO2019141202A1 (zh) * | 2018-01-17 | 2019-07-25 | 南京药捷安康生物科技有限公司 | Tam家族激酶/和csf1r激酶抑制剂及其用途 |
| CN111295386B (zh) | 2018-03-08 | 2022-09-06 | 伟迈可生物有限公司 | 噻吩并吡啶衍生物及含有该衍生物的药物组合物 |
| BR112021003447A2 (pt) * | 2018-08-24 | 2021-05-18 | Nanjing Transthera Biosciences Co., Ltd. | inibidor derivado de quinolina inovador |
| AU2019335450A1 (en) | 2018-09-03 | 2021-05-06 | Tyligand Bioscience (Shanghai) Limited | TRK inhibitor as anti-cancer drug |
| CN112771053A (zh) | 2019-09-06 | 2021-05-07 | 伟迈可生物有限公司 | 基于生物标志物的治疗组合物 |
| CN117355533A (zh) * | 2021-06-22 | 2024-01-05 | 株式会社Lg化学 | 作为蛋白激酶抑制剂的新型化合物 |
| WO2023110936A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Reversible macrocyclic kinase inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
| US5484681A (en) * | 1994-10-31 | 1996-01-16 | Xerox Corporation | Conductive composite particles and processes for the preparation thereof |
| IL114149A0 (en) * | 1995-06-14 | 1995-10-31 | Yeda Res & Dev | Modified avidin and streptavidin molecules and use thereof |
| US5747577A (en) * | 1995-12-27 | 1998-05-05 | Xerox Corporation | Conductive particles containing carbon black and processes for the preparation thereof |
| DE10046029A1 (de) | 2000-09-18 | 2002-03-28 | Bayer Ag | Indazole |
| ES2268015T3 (es) * | 2001-05-18 | 2007-03-16 | Srl, Inc. | Procedimiento de inmunoensayo. |
| US6956084B2 (en) * | 2001-10-04 | 2005-10-18 | Bridgestone Corporation | Nano-particle preparation and applications |
| JP2004067703A (ja) * | 2002-04-24 | 2004-03-04 | Japan Science & Technology Corp | 架橋ポリマー、微粒子および製造方法 |
| US7192780B2 (en) * | 2002-10-23 | 2007-03-20 | Evident Technologies | Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| EP1649284B1 (de) * | 2003-07-17 | 2007-12-05 | Invitrogen Dynal AS | Verfahren zur herstellung von ummantelten magnetischen teilchen |
| US7163998B2 (en) * | 2003-09-09 | 2007-01-16 | Eastman Kodak Company | Stabilized polymer beads and method of preparation |
| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| ME02736B (de) | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolpyridazine als tyrosinkinasehemmer |
| JP2009529047A (ja) | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| CN101511892B (zh) * | 2006-06-29 | 2012-02-29 | 英维特罗根戴内尔公司 | 含有多嵌段聚合物的颗粒 |
| PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| KR20090071612A (ko) | 2006-10-23 | 2009-07-01 | 에스지엑스 파마슈티컬스, 인코포레이티드 | 단백질 키나제 조정제로서의 바이시클릭 트리아졸 |
| EP2170785B1 (de) | 2007-06-27 | 2018-09-12 | Arkema Inc. | Verfahren zur herstellung von hydrofluorolefinen |
-
2009
- 2009-07-10 TW TW098123519A patent/TWI365185B/zh not_active IP Right Cessation
- 2009-07-12 JO JO2009256A patent/JO2788B1/en active
- 2009-07-13 AR ARP090102636A patent/AR074632A1/es active IP Right Grant
- 2009-07-15 CN CN200980128694.4A patent/CN102105462B/zh not_active Expired - Fee Related
- 2009-07-15 MY MYPI2011000343A patent/MY163852A/en unknown
- 2009-07-15 PE PE2011000061A patent/PE20110150A1/es active IP Right Grant
- 2009-07-15 EA EA201170252A patent/EA018385B1/ru not_active IP Right Cessation
- 2009-07-15 BR BRPI0916286A patent/BRPI0916286B8/pt not_active IP Right Cessation
- 2009-07-15 US US12/503,223 patent/US8030302B2/en not_active Ceased
- 2009-07-15 DK DK09790440.3T patent/DK2310382T3/da active
- 2009-07-15 CA CA2731773A patent/CA2731773C/en not_active Expired - Fee Related
- 2009-07-15 NZ NZ590013A patent/NZ590013A/en not_active IP Right Cessation
- 2009-07-15 JP JP2011520095A patent/JP5414794B2/ja not_active Expired - Fee Related
- 2009-07-15 MX MX2011000925A patent/MX2011000925A/es active IP Right Grant
- 2009-07-15 SI SI200930193T patent/SI2310382T1/sl unknown
- 2009-07-15 WO PCT/US2009/050640 patent/WO2010011538A1/en active Application Filing
- 2009-07-15 AU AU2009274256A patent/AU2009274256B2/en not_active Ceased
- 2009-07-15 EP EP09790440A patent/EP2310382B1/de active Active
- 2009-07-15 AT AT09790440T patent/ATE546444T1/de active
- 2009-07-15 RS RS20120176A patent/RS52261B/en unknown
- 2009-07-15 PL PL09790440T patent/PL2310382T3/pl unknown
- 2009-07-15 ES ES09790440T patent/ES2379587T3/es active Active
- 2009-07-15 PT PT09790440T patent/PT2310382E/pt unknown
- 2009-07-15 KR KR1020117001628A patent/KR101334456B1/ko active IP Right Grant
-
2011
- 2011-01-06 IL IL210490A patent/IL210490A/en active IP Right Grant
- 2011-01-07 DO DO2011000009A patent/DOP2011000009A/es unknown
- 2011-01-07 ZA ZA2011/00219A patent/ZA201100219B/en unknown
- 2011-01-19 CO CO11005437A patent/CO6351737A2/es not_active Application Discontinuation
- 2011-01-21 SV SV2011003816A patent/SV2011003816A/es active IP Right Grant
- 2011-01-21 CL CL2011000134A patent/CL2011000134A1/es unknown
- 2011-01-21 EC EC2011010778A patent/ECSP11010778A/es unknown
- 2011-01-24 MA MA33555A patent/MA32594B1/fr unknown
- 2011-01-24 CR CR20110046A patent/CR20110046A/es unknown
- 2011-09-08 HK HK11109520.7A patent/HK1155172A1/xx not_active IP Right Cessation
- 2011-12-08 US US13/374,053 patent/USRE43878E1/en not_active Expired - Fee Related
-
2012
- 2012-03-01 HR HR20120202T patent/HRP20120202T1/hr unknown
- 2012-04-04 CY CY20121100337T patent/CY1112595T1/el unknown
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