ATE544754T1 - Verfahren zur herstellung von ivabradinhydrochlorid - Google Patents
Verfahren zur herstellung von ivabradinhydrochloridInfo
- Publication number
- ATE544754T1 ATE544754T1 AT07870531T AT07870531T ATE544754T1 AT E544754 T1 ATE544754 T1 AT E544754T1 AT 07870531 T AT07870531 T AT 07870531T AT 07870531 T AT07870531 T AT 07870531T AT E544754 T1 ATE544754 T1 AT E544754T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- ivabradine hydrochloride
- ivabradine
- hydrochloride
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1966MU2006 | 2006-11-30 | ||
| PCT/IN2007/000564 WO2008065681A2 (en) | 2006-11-30 | 2007-11-30 | Process for preparation of ivabradine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE544754T1 true ATE544754T1 (de) | 2012-02-15 |
Family
ID=39468373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07870531T ATE544754T1 (de) | 2006-11-30 | 2007-11-30 | Verfahren zur herstellung von ivabradinhydrochlorid |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP2460797A3 (de) |
| AT (1) | ATE544754T1 (de) |
| ES (1) | ES2381771T3 (de) |
| WO (1) | WO2008065681A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5632279B2 (ja) | 2007-05-30 | 2014-11-26 | アイエヌディー−スイフト ラボラトリーズ リミテッド | 塩酸イバブラジンの調製方法及びポリモルフ |
| CN101723897B (zh) * | 2008-10-31 | 2011-11-16 | 齐鲁制药有限公司 | 伊伐布雷定的合成方法 |
| CN102264689B (zh) | 2008-12-22 | 2014-12-31 | 新梅斯托克尔卡公司 | 制备伊伐布雷定的方法 |
| FR2940287B1 (fr) * | 2008-12-24 | 2010-12-24 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| FR2941695B1 (fr) * | 2009-02-04 | 2011-02-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2943667B1 (fr) * | 2009-03-31 | 2011-05-06 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| WO2010128525A2 (en) | 2009-05-04 | 2010-11-11 | Dinesh Shantilal Patel | A formulation of ivabradine for treating the cardiovascular disease |
| FR2950343B1 (fr) * | 2009-09-18 | 2011-11-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| HUE035588T2 (en) | 2010-02-12 | 2018-05-28 | Krka D D Novo Mesto | Form of ivabradine hydrochloride |
| FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| HUP1000245A2 (en) | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
| EP2579860B1 (de) | 2010-06-14 | 2014-04-23 | Ratiopharm GmbH | Ivabradinhaltige pharmazeutische zusammensetzung mit modifizierter freisetzung |
| WO2012025940A1 (en) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Polymorphic form of ivabradine hydrochloride and process for preparation thereof |
| FR2971507B1 (fr) * | 2011-02-14 | 2013-01-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| CN102372642B (zh) * | 2011-07-04 | 2014-01-08 | 江苏宇田生物医药科技有限公司 | (1s)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷的制备方法 |
| EP2589594A1 (de) | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradin-Hydrochloridform IV |
| WO2013064427A1 (en) | 2011-11-04 | 2013-05-10 | Synthon Bv | A process for making crystalline delta-form of ivabradine hydrochloride |
| EP2780327A1 (de) | 2011-11-14 | 2014-09-24 | Cadila Healthcare Limited | Polymorphe formen von ivabradinhydrochlorid |
| FR2984319B1 (fr) * | 2011-12-20 | 2013-12-27 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2988720B1 (fr) * | 2012-03-27 | 2014-03-14 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| CN102827080B (zh) * | 2012-09-12 | 2014-03-19 | 江苏宇田生物医药科技有限公司 | 一种伊伐布雷定的合成方法及其中间产物 |
| FI2781509T4 (fi) | 2013-03-19 | 2023-09-07 | Ivabradiinihydrokloridin uusi polymorfi ja sen valmistusmenetelmä | |
| FR3003859B1 (fr) * | 2013-03-26 | 2015-03-13 | Servier Lab | "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine" |
| CZ305096B6 (cs) | 2013-10-02 | 2015-04-29 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice |
| CN103772281B (zh) * | 2013-12-31 | 2015-10-21 | 南京正大天晴制药有限公司 | 伊伐布雷定的制备方法 |
| CZ2014478A3 (cs) | 2014-07-10 | 2015-09-16 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice |
| WO2016102423A1 (en) | 2014-12-22 | 2016-06-30 | Ratiopharm Gmbh | Composition comprising ivabradine in a dissolved form |
| EP3101010A1 (de) * | 2015-06-03 | 2016-12-07 | Urquima S.A. | Neues verfahren zur herstellung von hochreinem ivabradine und dessen salzen |
| CN108424389A (zh) * | 2017-02-13 | 2018-08-21 | 浙江京新药业股份有限公司 | 一种伊伐布雷定杂质的制备方法 |
| CN108530359A (zh) * | 2017-03-01 | 2018-09-14 | 浙江京新药业股份有限公司 | 一种伊伐布雷定杂质的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
| FR2681862B1 (fr) | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2870537A1 (fr) * | 2004-05-19 | 2005-11-25 | Servier Lab | Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882555B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882556B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882553B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891827B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
-
2007
- 2007-11-30 AT AT07870531T patent/ATE544754T1/de active
- 2007-11-30 ES ES07870531T patent/ES2381771T3/es active Active
- 2007-11-30 EP EP11195861A patent/EP2460797A3/de not_active Withdrawn
- 2007-11-30 EP EP07870531A patent/EP2097383B1/de active Active
- 2007-11-30 WO PCT/IN2007/000564 patent/WO2008065681A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2097383A2 (de) | 2009-09-09 |
| EP2460797A3 (de) | 2012-12-05 |
| ES2381771T3 (es) | 2012-05-31 |
| WO2008065681A2 (en) | 2008-06-05 |
| EP2460797A2 (de) | 2012-06-06 |
| EP2097383B1 (de) | 2012-02-08 |
| WO2008065681A3 (en) | 2009-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE544754T1 (de) | Verfahren zur herstellung von ivabradinhydrochlorid | |
| DE602006018429D1 (de) | Verfahren zur herstellung von verschlüssen | |
| ATE408604T1 (de) | Verfahren zur herstellung von 1-alkyl-3- phenyluracilen | |
| ATE455105T1 (de) | Verfahren zur herstellung von difluormethylpyrazolylcarboxylaten | |
| ATE430480T1 (de) | Verfahren zur herstellung von nährmittelzusammensetzungen | |
| ATE408609T1 (de) | Verfahren zur herstellung von n-phenylpyrazol-1- carboxamiden | |
| ATE522488T1 (de) | Verfahren zur herstellung von 1,2-dichlorethan | |
| DE602006015090D1 (de) | Verfahren zur herstellung von gezielt durchlässigen laminaten | |
| ATE516816T1 (de) | Verfahren zur herstellung von impfstoffen | |
| DE602006018223D1 (de) | Verfahren zur Herstellung von Leuchtdioden | |
| DE602005019848D1 (de) | Verfahren zur herstellung von tad- getrocknetem ti | |
| ATE533747T1 (de) | Verfahren zur herstellung von tetrahydrochinolinderivaten | |
| ATE480531T1 (de) | Verfahren zur herstellung von benzopyran-2- olderivaten | |
| ATE524426T1 (de) | Verfahren zur herstellung von 1,2-dichlorethan | |
| ATE406801T1 (de) | Verfahren zur herstellung von sauermilchprodukten | |
| ATE376997T1 (de) | Verfahren zur herstellung von 1,4- diphenylazetidinon-derivaten | |
| ATE444303T1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
| ATE466843T1 (de) | Verfahren zur herstellung von n-piperidino-1,5- diphenylpyrazol-3-carboxamid-derivaten | |
| DE602007001567D1 (de) | Verfahren zur Herstellung von Fotomasken-Rohlingen | |
| ATE549314T1 (de) | Verfahren zur herstellung von 4-aminochinazolinen | |
| ATE554088T1 (de) | Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten | |
| DE502005007702D1 (de) | Verfahren zur herstellung von terrylen-3,4:11,12-t | |
| ATE417839T1 (de) | Verfahren zur herstellung von amorolfin | |
| DE602007000239D1 (de) | Verfahren zur Herstellung von hohlen Artikeln | |
| ATE496871T1 (de) | Verfahren zur herstellung von titanprodukten |