ATE543810T1 - Hemmer des 5-lipoxygenase aktivierenden proteins (flap) - Google Patents

Hemmer des 5-lipoxygenase aktivierenden proteins (flap)

Info

Publication number
ATE543810T1
ATE543810T1 AT07837478T AT07837478T ATE543810T1 AT E543810 T1 ATE543810 T1 AT E543810T1 AT 07837478 T AT07837478 T AT 07837478T AT 07837478 T AT07837478 T AT 07837478T AT E543810 T1 ATE543810 T1 AT E543810T1
Authority
AT
Austria
Prior art keywords
lipoxygenase
inhibitors
flap
activate protein
formula
Prior art date
Application number
AT07837478T
Other languages
English (en)
Inventor
Anthony Ogawa
Feroze Ujjainwalla
Bunte Ellen Vande
Lin Chu
Debra Ondeyka
Ihor Kopka
Bing Li
Hyun Ok
Minal Patel
Jinyou Xu
Rosemary Sisco
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE543810T1 publication Critical patent/ATE543810T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT07837478T 2006-09-01 2007-08-29 Hemmer des 5-lipoxygenase aktivierenden proteins (flap) ATE543810T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84175806P 2006-09-01 2006-09-01
US93388607P 2007-06-08 2007-06-08
US96159807P 2007-07-23 2007-07-23
PCT/US2007/018991 WO2008030369A1 (en) 2006-09-01 2007-08-29 Inhibitors of 5 -lipoxygenase activating protein ( flap)

Publications (1)

Publication Number Publication Date
ATE543810T1 true ATE543810T1 (de) 2012-02-15

Family

ID=38925607

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07837478T ATE543810T1 (de) 2006-09-01 2007-08-29 Hemmer des 5-lipoxygenase aktivierenden proteins (flap)

Country Status (7)

Country Link
US (1) US8440672B2 (de)
EP (1) EP2064204B1 (de)
JP (1) JP2010502615A (de)
AT (1) ATE543810T1 (de)
AU (1) AU2007293373A1 (de)
CA (1) CA2666686A1 (de)
WO (1) WO2008030369A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101466677A (zh) 2006-04-11 2009-06-24 默克公司 二芳基取代的烷烃
WO2008030369A1 (en) 2006-09-01 2008-03-13 Merck & Co., Inc. Inhibitors of 5 -lipoxygenase activating protein ( flap)
US20100190761A1 (en) * 2007-06-20 2010-07-29 Anthony Ogawa Diphenyl substituted alkanes
WO2010027762A1 (en) 2008-09-04 2010-03-11 Boehringer Ingelheim International Gmbh Indolizine inhibitors of leukotriene production
EP2345328A4 (de) * 2008-09-19 2014-06-25 Sumitomo Chemical Co Zusammensetzung zur verwendung in der landwirtschaft
EP2509975B1 (de) 2009-12-04 2014-04-23 Boehringer Ingelheim International GmbH Benzimidazolhemmer der leukotrienproduktion
CA2797719C (en) 2010-04-30 2019-11-26 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
EP2606045B1 (de) * 2010-08-16 2016-01-06 Boehringer Ingelheim International GmbH Oxadiazolhemmer der leukotrienproduktion
EP2609092B1 (de) 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Oxadiazolhemmer der leukotrienproduktion
WO2012040137A1 (en) * 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
CA2812449A1 (en) * 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
WO2012058254A1 (en) 2010-10-29 2012-05-03 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
JP5789888B2 (ja) 2010-11-01 2015-10-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
US9073895B2 (en) 2010-12-16 2015-07-07 Boehringer Ingelheim International Gmbh Biarylamide inhibitors of leukotriene production
US9174980B2 (en) 2012-01-31 2015-11-03 Boehringer Ingelheim International Gmbh Heterocyclic compounds as inhibitors of leukotriene production
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
EP2865756A1 (de) 2013-10-22 2015-04-29 Sylentis, S.A.U. siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des FLAP-Gens
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
WO2016065584A1 (en) * 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Piperidine oxadiazole and thiadiazole orexin receptor antagonists
WO2016149126A1 (en) 2015-03-13 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186654B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them
US4853398A (en) * 1987-04-13 1989-08-01 Eli Lilly And Company Leukotriene antagonists and use thereas
US6051573A (en) * 1994-06-28 2000-04-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists
US5795900A (en) * 1995-10-03 1998-08-18 Abbott Laboratories Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
US5668146A (en) * 1995-10-03 1997-09-16 Abbott Laboratories Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis
CA2337230A1 (en) * 1998-07-15 2000-01-27 Bristol-Myers Squibb Company Stereoselective reductive amination of ketones
US6468781B1 (en) * 1999-07-08 2002-10-22 Bristol-Myers Squibb Company Stereoselective reductive amination of ketones
CA2364653A1 (en) 1999-02-25 2000-08-31 Merck Frosst Canada & Co. Pde iv inhibiting compounds, compositions and methods of treatment
DE60128581T2 (de) * 2000-10-17 2008-02-14 Excelsyn Molecular Develpopment Ltd., Holywell Herstellung von alpha -hydroxy-carboxy säure mit hilfe von einem gekoppelten enzym system
DE10112401A1 (de) * 2001-03-13 2002-09-19 Degussa Alkohol-Dehydrogenase und deren Verwendung
WO2002077789A1 (en) 2001-03-26 2002-10-03 Hyun-Gi An Multimedia calendar system
WO2005007672A2 (en) 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Small molecule toll-like receptor (tlr) antagonists
AU2004259747B2 (en) 2003-07-24 2009-02-19 Merck Frosst Canada Ltd Diphenyl substituted Cycloalkanes, compositions containing such compounds and methods of use
AU2005230878A1 (en) 2004-03-30 2005-10-20 Merck & Co., Inc. 2-aminothiazole compounds useful as aspartyl protease inhibitors
US20070287736A1 (en) * 2004-10-18 2007-12-13 Lin Chu Diphenyl Substituted Alkanes as Flap Inhibitors
JP2008537930A (ja) * 2005-03-09 2008-10-02 メルク エンド カムパニー インコーポレーテッド ジフェニル置換シクロアルカン、前記化合物を含む組成物及び使用方法
UY29610A1 (es) * 2005-06-21 2007-01-31 Cancer Rec Tech Ltd Aril-alquilaminas y heteroaril-alquilaminas como inhibidores de la quinasa proteínica
JPWO2007013694A1 (ja) * 2005-07-29 2009-02-12 武田薬品工業株式会社 フェノキシアルカン酸化合物
WO2007056210A2 (en) 2005-11-04 2007-05-18 Merck & Co., Inc. Diphenylmethane derivatives as inhibitors of leukotriene biosynthesis
CN101466677A (zh) 2006-04-11 2009-06-24 默克公司 二芳基取代的烷烃
WO2008030369A1 (en) 2006-09-01 2008-03-13 Merck & Co., Inc. Inhibitors of 5 -lipoxygenase activating protein ( flap)
US20100190761A1 (en) * 2007-06-20 2010-07-29 Anthony Ogawa Diphenyl substituted alkanes
CA2702225A1 (en) * 2007-10-10 2009-04-16 Merck Sharp & Dohme Corp. Diphenyl substituted cycloalkanes
CA2714058A1 (en) 2008-02-28 2009-09-03 Ivory D. Hills 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease

Also Published As

Publication number Publication date
US8440672B2 (en) 2013-05-14
EP2064204B1 (de) 2012-02-01
CA2666686A1 (en) 2008-03-13
EP2064204A1 (de) 2009-06-03
JP2010502615A (ja) 2010-01-28
US20100168076A1 (en) 2010-07-01
WO2008030369A1 (en) 2008-03-13
AU2007293373A1 (en) 2008-03-13

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