ATE543080T1 - System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie - Google Patents

System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie

Info

Publication number
ATE543080T1
ATE543080T1 AT01957072T AT01957072T ATE543080T1 AT E543080 T1 ATE543080 T1 AT E543080T1 AT 01957072 T AT01957072 T AT 01957072T AT 01957072 T AT01957072 T AT 01957072T AT E543080 T1 ATE543080 T1 AT E543080T1
Authority
AT
Austria
Prior art keywords
pump
stoke
epi
raman scattering
stokes raman
Prior art date
Application number
AT01957072T
Other languages
English (en)
Inventor
Xiaoliang Xie
Andreas Volkmer
Ji-Xin Cheng
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE543080T1 publication Critical patent/ATE543080T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT01957072T 2000-07-13 2001-06-20 System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie ATE543080T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21809100P 2000-07-13 2000-07-13
PCT/US2001/019678 WO2002006778A1 (en) 2000-07-13 2001-06-20 System and method for epi-detected coherent anti-stokes raman scattering microscopy

Publications (1)

Publication Number Publication Date
ATE543080T1 true ATE543080T1 (de) 2012-02-15

Family

ID=22813707

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01957072T ATE543080T1 (de) 2000-07-13 2001-06-20 System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie

Country Status (4)

Country Link
US (1) US6809814B2 (de)
EP (1) EP1311813B9 (de)
AT (1) ATE543080T1 (de)
WO (1) WO2002006778A1 (de)

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US7256885B2 (en) 2003-01-29 2007-08-14 Yeda Research And Development Company Ltd. Coherently controlled nonlinear Raman spectroscopy and microscopy
WO2005029149A1 (de) * 2003-09-25 2005-03-31 Leica Microsystems Cms Gmbh Mikroskop mit evaneszenter beleuchtung
EP1754033B1 (de) 2004-05-27 2011-06-22 Yeda Research And Development Co., Ltd. Kohärent gesteuerte nichtlineare raman-spektroskopie
US7388668B2 (en) * 2004-06-09 2008-06-17 President & Fellows Of Harvard College Phase sensitive heterodyne coherent anti-Stokes Raman scattering micro-spectroscopy and microscopy
JP4954452B2 (ja) 2004-07-06 2012-06-13 オリンパス株式会社 顕微鏡
WO2006078716A2 (en) 2005-01-21 2006-07-27 President And Fellows Of Harvard College Office Of Technology And Trademark Licensing Tunable optical parametric oscillator for non-linear vibrational spectroscopy
US7414729B2 (en) 2005-10-13 2008-08-19 President And Fellows Of Harvard College System and method for coherent anti-Stokes Raman scattering endoscopy
US7352458B2 (en) * 2005-10-26 2008-04-01 President And Fellows Of Harvard College System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses
CN101617407A (zh) * 2006-10-27 2009-12-30 阿里戴斯公司 使用量子***识别和量子控制技术用于医疗诊断和治疗目的
EP2076172A4 (de) * 2006-10-27 2012-03-21 Aretais Inc Verwendung kohärenter raman-verfahren für medizinische diagnostische und therapeutische zwecke sowie kalibrierverfahren dafür
US7480045B2 (en) * 2006-10-31 2009-01-20 Academia Sinica Controlling pulses in optical microscopy
DE102006056429B3 (de) 2006-11-28 2008-02-14 Leica Microsystems Cms Gmbh Lasermikroskop mit räumlich trennendem Strahlteiler
US7869051B2 (en) * 2007-01-19 2011-01-11 Stc. Unm System and method for ratiometric non-linear coherent imaging
DE102007021378A1 (de) * 2007-05-04 2008-11-06 Ape Angewandte Physik Und Elektronik Gmbh Verfahren und optische Anordnung zum Erzeugen eines nicht-linearen optischen Signals an einem durch ein Anregungsfeld angeregten Material sowie Verwendung des Verfahrens und der optischen Anordnung
KR100860947B1 (ko) * 2007-06-08 2008-09-30 한국표준과학연구원 적외선 비선형 분자진동 분광 이미징 장치
WO2009149733A1 (en) * 2008-06-13 2009-12-17 Embl Heidelberg Next generation flow cytometer sorter
US8027032B2 (en) 2008-08-22 2011-09-27 President & Fellows Of Harvard College Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism
US8120772B2 (en) * 2008-11-03 2012-02-21 The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology Method for NRB-free nonlinear vibrational spectroscopy and miscroscopy
WO2010071682A2 (en) 2008-12-20 2010-06-24 Purdue Research Foundation A multimodal platform for nonlinear optical microscopy and microspectroscopy
US9285575B2 (en) * 2009-01-26 2016-03-15 President And Fellows Of Harvard College Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping
US8248614B2 (en) * 2009-03-16 2012-08-21 Ut-Battelle, Llc Quantitative phase-imaging systems
US8264694B2 (en) * 2009-03-16 2012-09-11 Ut-Battelle, Llc Quantitative phase-contrast and excitation-emission systems
US8675201B2 (en) * 2009-06-05 2014-03-18 The Penn State Research Foundation Coherent anti-Stokes Raman holography
FR2955663B1 (fr) 2010-01-22 2014-09-12 Ct Nat De La Rech C N R S Methode pour la detection d'un signal optique non lineaire resonant et dispositif pour la mise en oeuvre de ladite methode
WO2011162787A1 (en) 2010-06-22 2011-12-29 President And Fellows Of Harvard College Systems and methods providing efficient detection of back-scattered illumination in modulation transfer microscopy or micro-spectroscopy
GB201013321D0 (en) 2010-08-06 2010-09-22 King S College London Method and apparatus for non-resonant background reduction in Coherent anti-strokes Raman Scattering (CARS) spectroscopy
US20130267855A1 (en) * 2011-10-28 2013-10-10 Kazuo Tsubota Comprehensive measuring method of biological materials and treatment method using broadly tunable laser
US9634454B1 (en) 2012-01-17 2017-04-25 President And Fellows Of Harvard College Laser illumination systems and methods for dual-excitation wavelength non-linear optical microscopy and micro-spectroscopy systems
US8792156B1 (en) 2012-01-17 2014-07-29 President And Fellows Of Harvard College Laser illumination systems and methods for dual-excitation wavelength non-linear optical microscopy and micro-spectroscopy systems
FR3003949B1 (fr) * 2013-03-26 2015-05-01 Univ Aix Marseille Dispositif et methode de detection raman stimulee.
US9506858B2 (en) * 2013-05-09 2016-11-29 The Board Of Trustees Of The University Of Illinois Optical parametric amplification of weak signals for imaging biological tissue
WO2014205007A1 (en) * 2013-06-17 2014-12-24 Invenio Imaging Inc. Methods and systems for coherent raman scattering
US9778193B2 (en) * 2013-08-22 2017-10-03 Kinetic River Corp. Methods and apparatuses for label-free particle analysis
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
CN108348224A (zh) 2015-09-25 2018-07-31 密执安州立大学董事会 用于相干拉曼成像的活检装置
CN106990089B (zh) * 2017-04-01 2019-06-04 上海理工大学 同步降频的相干反斯托克斯拉曼散射成像***及成像方法
CN109765213B (zh) * 2019-03-27 2024-03-29 苏州威邦震电光电技术有限公司 相干反斯托克斯拉曼散射显微镜成像装置
CN117413819A (zh) 2019-04-18 2024-01-19 艾步思国际有限责任公司 用于连续添加冷冻保护剂的***和工艺

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Also Published As

Publication number Publication date
EP1311813B1 (de) 2012-01-25
US6809814B2 (en) 2004-10-26
US20030160955A1 (en) 2003-08-28
WO2002006778A1 (en) 2002-01-24
EP1311813B9 (de) 2012-05-02
EP1311813A4 (de) 2006-05-10
EP1311813A1 (de) 2003-05-21

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