ATE540122T1 - Cluster-deletion und humanisierung in zwei schritten - Google Patents
Cluster-deletion und humanisierung in zwei schrittenInfo
- Publication number
- ATE540122T1 ATE540122T1 AT08806243T AT08806243T ATE540122T1 AT E540122 T1 ATE540122 T1 AT E540122T1 AT 08806243 T AT08806243 T AT 08806243T AT 08806243 T AT08806243 T AT 08806243T AT E540122 T1 ATE540122 T1 AT E540122T1
- Authority
- AT
- Austria
- Prior art keywords
- humanization
- steps
- cluster
- cluster deletion
- relates
- Prior art date
Links
- 230000037430 deletion Effects 0.000 title 1
- 238000012217 deletion Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000006801 homologous recombination Effects 0.000 abstract 1
- 238000002744 homologous recombination Methods 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0718029.2A GB0718029D0 (en) | 2007-09-14 | 2007-09-14 | Two step cluster deletion and humanisation |
PCT/GB2008/003084 WO2009034328A2 (en) | 2007-09-14 | 2008-09-12 | Two step cluster deletion and humanisation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540122T1 true ATE540122T1 (de) | 2012-01-15 |
Family
ID=38659025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08806243T ATE540122T1 (de) | 2007-09-14 | 2008-09-12 | Cluster-deletion und humanisierung in zwei schritten |
Country Status (10)
Country | Link |
---|---|
US (1) | US20100281554A1 (de) |
EP (1) | EP2209898B8 (de) |
JP (1) | JP2010538632A (de) |
CN (1) | CN101855356A (de) |
AT (1) | ATE540122T1 (de) |
AU (1) | AU2008299636A1 (de) |
CA (1) | CA2699547A1 (de) |
ES (1) | ES2384760T3 (de) |
GB (1) | GB0718029D0 (de) |
WO (1) | WO2009034328A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010303737B2 (en) * | 2009-10-06 | 2014-05-29 | Institute For Research In Biomedicine (Irb) | Genetically modified mice and engraftment |
PT2675271T (pt) * | 2011-02-15 | 2018-10-11 | Univ Yale | Ratinhos humanizados para m-csf |
KR102287541B1 (ko) | 2012-09-07 | 2021-08-10 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
SG10201707449TA (en) | 2012-11-05 | 2017-10-30 | Regeneron Pharma | Genetically modified non-human animals and methods of use thereof |
ES2854276T3 (es) | 2014-05-19 | 2021-09-21 | Regeneron Pharma | Animales no humanos modificados genéticamente que expresan EPO humana |
SG11201708380WA (en) | 2015-04-13 | 2017-11-29 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
EP3474662A1 (de) | 2016-06-27 | 2019-05-01 | Baylor College of Medicine | Nichtmenschliches chimäres tier mit menschlicher leber mit defizienter p450-oxidoreduktase und verfahren zur verwendung davon |
CN107779462B (zh) * | 2016-08-29 | 2021-06-04 | 中国科学院分子细胞科学卓越创新中心 | 双同源重组谱系示踪技术 |
CN110129346A (zh) * | 2018-02-02 | 2019-08-16 | 杭州菁因康生物科技有限公司 | 一种高效的基因工程载体 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
EP1206906A4 (de) * | 1999-08-13 | 2004-12-29 | Kirin Brewery | Maus, die träger des menschlichen cytochrom p450 ist |
US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20050153392A1 (en) * | 2003-08-11 | 2005-07-14 | Roland Buelow | Transgenesis with humanized immunoglobulin loci |
CA2590010A1 (en) * | 2004-12-13 | 2006-06-22 | Iti Scotland Limited | Transgenic animals for assessing drug metabolism and toxicity |
GB0700194D0 (en) * | 2007-01-05 | 2007-02-14 | Univ Edinburgh | Humanisation of animals |
-
2007
- 2007-09-14 GB GBGB0718029.2A patent/GB0718029D0/en not_active Ceased
-
2008
- 2008-09-12 EP EP08806243A patent/EP2209898B8/de not_active Not-in-force
- 2008-09-12 AU AU2008299636A patent/AU2008299636A1/en not_active Abandoned
- 2008-09-12 JP JP2010524566A patent/JP2010538632A/ja active Pending
- 2008-09-12 CN CN200880106841A patent/CN101855356A/zh active Pending
- 2008-09-12 ES ES08806243T patent/ES2384760T3/es active Active
- 2008-09-12 CA CA2699547A patent/CA2699547A1/en not_active Abandoned
- 2008-09-12 WO PCT/GB2008/003084 patent/WO2009034328A2/en active Application Filing
- 2008-09-12 AT AT08806243T patent/ATE540122T1/de active
- 2008-09-12 US US12/677,777 patent/US20100281554A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20100281554A1 (en) | 2010-11-04 |
JP2010538632A (ja) | 2010-12-16 |
CA2699547A1 (en) | 2009-03-19 |
AU2008299636A1 (en) | 2009-03-19 |
GB0718029D0 (en) | 2007-10-24 |
WO2009034328A2 (en) | 2009-03-19 |
EP2209898B1 (de) | 2012-01-04 |
ES2384760T3 (es) | 2012-07-12 |
EP2209898B8 (de) | 2012-03-21 |
EP2209898A2 (de) | 2010-07-28 |
WO2009034328A3 (en) | 2009-04-30 |
CN101855356A (zh) | 2010-10-06 |
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