ATE534900T1 - Verfahren zum testen einer protein-protein- wechselwirkung - Google Patents
Verfahren zum testen einer protein-protein- wechselwirkungInfo
- Publication number
- ATE534900T1 ATE534900T1 AT04756784T AT04756784T ATE534900T1 AT E534900 T1 ATE534900 T1 AT E534900T1 AT 04756784 T AT04756784 T AT 04756784T AT 04756784 T AT04756784 T AT 04756784T AT E534900 T1 ATE534900 T1 AT E534900T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- interaction
- testing
- activator
- molecule
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48596803P | 2003-07-09 | 2003-07-09 | |
US51191803P | 2003-10-15 | 2003-10-15 | |
US56611304P | 2004-04-27 | 2004-04-27 | |
PCT/US2004/021887 WO2005007822A2 (en) | 2003-07-09 | 2004-07-09 | Method for assaying protein-protein interaction |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE534900T1 true ATE534900T1 (de) | 2011-12-15 |
Family
ID=34084516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04756784T ATE534900T1 (de) | 2003-07-09 | 2004-07-09 | Verfahren zum testen einer protein-protein- wechselwirkung |
Country Status (9)
Country | Link |
---|---|
US (3) | US7049076B2 (de) |
EP (2) | EP2336768A1 (de) |
JP (1) | JP4734498B2 (de) |
CN (1) | CN1894581B (de) |
AT (1) | ATE534900T1 (de) |
AU (1) | AU2004257228B8 (de) |
CA (1) | CA2531698A1 (de) |
IL (1) | IL173023A0 (de) |
WO (1) | WO2005007822A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7049076B2 (en) * | 2003-07-09 | 2006-05-23 | Sentigen Biosciences, Inc. | Method for assaying protein—protein interaction |
US20070224615A1 (en) * | 2003-07-09 | 2007-09-27 | Invitrogen Corporation | Methods for assaying protein-protein interactions |
EP1893627A4 (de) * | 2005-05-27 | 2009-11-11 | Sentigen Biosciences Inc | Für die untersuchung von protein-protein-wechselwirkungen geeigneter multiplexarray |
WO2007010525A2 (en) | 2005-07-21 | 2007-01-25 | Aebi Ltd. | Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest |
WO2007092938A2 (en) * | 2006-02-08 | 2007-08-16 | Invitrogen Corporation | Cellular assays for signaling receptors |
NZ597557A (en) | 2006-03-02 | 2013-10-25 | Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
ATE528647T1 (de) * | 2006-03-16 | 2011-10-15 | Life Technologies Corp | Verfahren zur untersuchung von protein-protein- interaktionen |
WO2007149807A1 (en) * | 2006-06-20 | 2007-12-27 | Invitrogen Corporation | Methods for identifying modifiers of gpr1 activity |
AU2007317204A1 (en) * | 2006-11-10 | 2008-05-15 | Dimerix Bioscience Pty Ltd | Thyrotropin releasing hormone receptor-orexin receptor hetero-dimers/-oligomers |
US9026409B2 (en) | 2007-08-06 | 2015-05-05 | Design Ready Controls, Inc. | Systems, methods, and software for automated design and manufacturing of HVAC control panels |
KR101636306B1 (ko) * | 2007-09-04 | 2016-07-05 | 사노피 | 프로테아제 활성화된 리포터를 사용한 단백질-단백질 상호작용 조절 분자의 확인 방법 |
FR2934684B1 (fr) | 2008-07-31 | 2012-11-16 | Cis Bio Int | Methode de detection de l'internalisation de proteines membranaires. |
US20110177973A1 (en) * | 2008-09-25 | 2011-07-21 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Combinatorial synthesis and use of libraries of short expressed nucleic acid sequences for the analysis of cellular events |
JP5586285B2 (ja) * | 2009-03-18 | 2014-09-10 | オリンパス株式会社 | 受容体相互作用検出方法およびサイクリックampセンサータンパク質 |
CA2821985C (en) | 2011-01-11 | 2019-07-09 | Dimerix Bioscience Pty Ltd | Combination therapy |
GB201103453D0 (en) * | 2011-03-01 | 2011-04-13 | Vib Vzw | Kinase substrate sensor |
TW201302779A (zh) | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
US9804160B2 (en) | 2011-09-28 | 2017-10-31 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Protein-protein interaction as biomarkers |
WO2014153044A1 (en) * | 2013-03-14 | 2014-09-25 | Temple University Of The Commonwealth System Of Higher Education | Treatment of patients with hyponatremia and cardiac disease |
CN105101995A (zh) | 2013-03-15 | 2015-11-25 | 宾夕法尼亚大学理事会 | 具有生物分子佐剂的疫苗 |
GB201310008D0 (en) | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
KR101733609B1 (ko) * | 2014-02-07 | 2017-05-08 | 한국생명공학연구원 | 단백질 융합 디스플레이 기술을 이용한 물질 간 상호작용 고속분석 방법 |
WO2016149274A1 (en) * | 2015-03-17 | 2016-09-22 | Brown University | Methods for labeling and manipulating a cellular circuit |
CN104991072B (zh) * | 2015-06-16 | 2017-03-29 | 西北农林科技大学 | 一种昆虫体外蛋白质相互作用检测***的制备方法及应用 |
BR112018013663A2 (pt) | 2016-01-11 | 2019-01-22 | Univ Leland Stanford Junior | proteínas quiméricas e métodos de imunoterapia |
SG11201805792PA (en) | 2016-01-11 | 2018-08-30 | Univ Leland Stanford Junior | Chimeric proteins and methods of regulating gene expression |
GB201609604D0 (en) * | 2016-06-01 | 2016-07-13 | Ucl Business Plc | Cell |
CN107976411B (zh) * | 2016-10-25 | 2020-10-23 | 中国科学院微生物研究所 | 包含别构转录因子调控***的生物传感器、试剂盒及其在小分子检测中的用途 |
WO2019062744A1 (zh) * | 2017-09-27 | 2019-04-04 | 北京大学 | 融合多肽 |
CN108191979B (zh) * | 2017-12-08 | 2021-01-01 | 上海晶诺生物科技有限公司 | 一种荧光互补检测人趋化因子生物学活性的方法 |
WO2020026979A1 (ja) * | 2018-07-31 | 2020-02-06 | 国立大学法人東京大学 | 膜タンパク質活性測定法 |
CN110853712B (zh) * | 2018-08-01 | 2022-06-07 | 清华大学 | 鉴定多对生物分子间相互作用调控因子的方法 |
KR102317202B1 (ko) * | 2018-10-19 | 2021-10-25 | 주식회사 프로티나 | 유방암 재발 예측 방법 |
US20230043198A1 (en) * | 2018-12-10 | 2023-02-09 | Yale University | Microbiota metabolites that shape host physiology |
WO2022271264A1 (en) * | 2021-06-21 | 2022-12-29 | Massachusetts Institute Of Technology | Real-time g-protein coupled receptor (gpcr) linked bioluminescent sensing of biological targets and processes |
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EP1353182A3 (de) | 2002-04-12 | 2004-02-04 | Smithkline Beecham Corporation | Verfahren zur Vorhersage von Zell-basierten Assay Resultaten mit Hilfe von Bindungsprofilen |
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KR100890579B1 (ko) * | 2002-08-19 | 2009-04-27 | 프로테온 주식회사 | Rna 결합 단백질의 유전자를 융합파트너로 이용한재조합 단백질의 제조방법 |
EP1579212B1 (de) * | 2002-10-25 | 2008-12-31 | MDS Analytical Technologies (US) Inc. | Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung |
US7049076B2 (en) * | 2003-07-09 | 2006-05-23 | Sentigen Biosciences, Inc. | Method for assaying protein—protein interaction |
-
2004
- 2004-07-09 US US10/888,313 patent/US7049076B2/en not_active Expired - Lifetime
- 2004-07-09 CN CN2004800248641A patent/CN1894581B/zh not_active Expired - Lifetime
- 2004-07-09 AT AT04756784T patent/ATE534900T1/de active
- 2004-07-09 EP EP10186070A patent/EP2336768A1/de not_active Withdrawn
- 2004-07-09 WO PCT/US2004/021887 patent/WO2005007822A2/en active Application Filing
- 2004-07-09 AU AU2004257228A patent/AU2004257228B8/en not_active Expired
- 2004-07-09 CA CA002531698A patent/CA2531698A1/en not_active Abandoned
- 2004-07-09 JP JP2006518902A patent/JP4734498B2/ja not_active Expired - Lifetime
- 2004-07-09 EP EP04756784A patent/EP1644734B1/de not_active Expired - Lifetime
-
2006
- 2006-01-08 IL IL173023A patent/IL173023A0/en unknown
- 2006-02-02 US US11/346,759 patent/US8017398B2/en active Active
-
2011
- 2011-08-18 US US13/212,965 patent/US20120077706A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2004257228B2 (en) | 2008-12-18 |
EP1644734A4 (de) | 2007-04-25 |
EP1644734B1 (de) | 2011-11-23 |
EP2336768A1 (de) | 2011-06-22 |
EP2336768A9 (de) | 2011-08-10 |
IL173023A0 (en) | 2006-06-11 |
US7049076B2 (en) | 2006-05-23 |
WO2005007822A3 (en) | 2005-03-31 |
CN1894581B (zh) | 2012-02-01 |
WO2005007822A2 (en) | 2005-01-27 |
US20050100934A1 (en) | 2005-05-12 |
US8017398B2 (en) | 2011-09-13 |
EP1644734A2 (de) | 2006-04-12 |
US20060147975A1 (en) | 2006-07-06 |
AU2004257228B8 (en) | 2009-01-08 |
JP4734498B2 (ja) | 2011-07-27 |
CN1894581A (zh) | 2007-01-10 |
CA2531698A1 (en) | 2005-01-27 |
US20120077706A1 (en) | 2012-03-29 |
AU2004257228A1 (en) | 2005-01-27 |
JP2007528713A (ja) | 2007-10-18 |
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