ATE532787T1 - Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus - Google Patents

Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus

Info

Publication number
ATE532787T1
ATE532787T1 AT07815246T AT07815246T ATE532787T1 AT E532787 T1 ATE532787 T1 AT E532787T1 AT 07815246 T AT07815246 T AT 07815246T AT 07815246 T AT07815246 T AT 07815246T AT E532787 T1 ATE532787 T1 AT E532787T1
Authority
AT
Austria
Prior art keywords
treatment
respiratory syncytial
syncytial virus
virus infections
polycyclic
Prior art date
Application number
AT07815246T
Other languages
English (en)
Inventor
Jeffrey Peter Mitchell
Alistair George Draffan
Vanessa Anne Sanford
Silas Bond
Chin Yu Lim
Penelope Anne Mayes
Original Assignee
Biota Scient Management
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scient Management filed Critical Biota Scient Management
Application granted granted Critical
Publication of ATE532787T1 publication Critical patent/ATE532787T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07815246T 2006-09-28 2007-09-26 Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus ATE532787T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84807306P 2006-09-28 2006-09-28
PCT/AU2007/001429 WO2008037011A1 (en) 2006-09-28 2007-09-26 Polycyclic agents for the treatment of respiratory syncytial virus infections

Publications (1)

Publication Number Publication Date
ATE532787T1 true ATE532787T1 (de) 2011-11-15

Family

ID=39229629

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07815246T ATE532787T1 (de) 2006-09-28 2007-09-26 Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus

Country Status (22)

Country Link
US (2) US8598194B2 (de)
EP (1) EP2069353B1 (de)
JP (1) JP5340943B2 (de)
KR (1) KR101488826B1 (de)
CN (1) CN101583614B (de)
AR (1) AR063038A1 (de)
AT (1) ATE532787T1 (de)
AU (1) AU2007302611C1 (de)
BR (1) BRPI0717536A2 (de)
CA (1) CA2664376C (de)
DK (1) DK2069353T3 (de)
ES (1) ES2376915T3 (de)
HK (1) HK1131988A1 (de)
IL (1) IL197783A (de)
MX (1) MX2009003336A (de)
NO (1) NO20091521L (de)
NZ (1) NZ575805A (de)
PL (1) PL2069353T3 (de)
PT (1) PT2069353E (de)
TW (1) TWI423972B (de)
WO (1) WO2008037011A1 (de)
ZA (1) ZA200901983B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1697377B1 (de) * 2003-12-24 2011-01-26 Biota Scientific Management Pty. Ltd. Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
TWI508968B (zh) * 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
US8796303B2 (en) * 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
AU2012292947B2 (en) * 2011-08-05 2017-02-16 Biota Scientific Management Pty Ltd Compounds for treating respiratory syncytial virus infections
MX2014005197A (es) * 2011-11-04 2014-05-28 Syngenta Participations Ag Compuestos plaguicidas.
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137586C (de) 1963-04-11
US3507863A (en) * 1963-12-18 1970-04-21 Sandoz Ag Isoindolones and method for preparing same
NL126596C (de) 1964-02-11
NL129866C (de) 1965-09-21
CH480350A (de) * 1965-09-21 1969-10-31 Geigy Ag J R Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
US3379733A (en) * 1965-12-07 1968-04-23 Sandoz Ag N-(omega-aminoalkyl)isoindoles and method for preparing same
CH481123A (de) 1966-09-21 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
DE1670041A1 (de) 1967-03-14 1972-03-02 American Home Prod Isoindole und Isoindoline
CH482697A (de) 1967-03-17 1969-12-15 Geigy Ag J R Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
US3885037A (en) * 1968-09-05 1975-05-20 American Home Prod Method of producing anorexia using imidazolinyl phenyl carbonyl compounds, their acid addition salts and related compounds
US3935218A (en) * 1968-09-05 1976-01-27 American Home Products Corporation Imidazolinyl phenyl carbonyl compounds acid addition salts and related compounds
US3657221A (en) * 1969-02-19 1972-04-18 American Home Prod Process for preparing 9b-substituted-1 - sulfonyl - 1 2 3 9b - tetrahydro-5h-imidazo(2 1-a)isoindol-5-ones
US3770766A (en) * 1970-03-10 1973-11-06 American Home Prod 2-(2-amino-2,2-dialkylamino-3-hydroxy-3-phenyl-1h-benz(f)isoindole-1-ones
GB1322339A (en) 1970-03-10 1973-07-04 American Home Prod Imidazoline derivatives
US3624101A (en) * 1970-03-10 1971-11-30 American Home Prod 2,3-DIHYDRO-5-ARYL-5H-BENZ{8 f{9 IMIDAZO{8 2,1-a{9 ISOINDOL-5-OLS
US3966955A (en) * 1974-08-07 1976-06-29 American Home Products Corporation Anti-ulcer therapy
US4056536A (en) * 1976-06-29 1977-11-01 Merck & Co., Inc. Pyrrolo[2,1-b][3]benzazepines
US4701208A (en) * 1983-08-02 1987-10-20 American Cyanamid Company Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof
DE3520390A1 (de) * 1984-07-07 1986-02-06 Bayer Ag, 5090 Leverkusen Imidazo-pyrrolo-pyridin-derivate
EP0183993A3 (de) 1984-11-16 1987-12-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2H-Imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine und deren Verwendung als Unkrautbekämpfungsmittel
DE3674028D1 (de) * 1985-03-12 1990-10-18 Ciba Geigy Ag Heterocyclisch kondensierte pyridin-verbindungen als herbizide.
DE3534948A1 (de) * 1985-10-01 1987-04-09 Bayer Ag Fungizide und wachstumsregulatorische mittel
US4717414A (en) * 1986-08-08 1988-01-05 Ppg Industries, Inc. Herbicidally active imidazopyrrolo-pyridine (or benzene) derivatives
DE3634952A1 (de) * 1986-10-14 1988-04-21 Bayer Ag Imidazo-pyrrolo-pyridin-derivate
EP0475908A1 (de) * 1990-09-14 1992-03-18 Ciba-Geigy Ag Chromogene Lactamverbindungen und ihre Herstellung und Verwendung
DE4103177A1 (de) 1991-02-02 1992-08-06 Boehringer Mannheim Gmbh Thiazolo-(2,3-a)isoindol-derivate und diese enthaltende arzneimittel
CA2104963A1 (en) 1991-02-28 1992-08-29 Harald Zilch Use of tricyclic isoindolinones as anti-viral medicaments as well as new optically-active isoindolinones
DE4108395A1 (de) 1991-03-15 1993-01-28 Boehringer Mannheim Gmbh Verwendung von oxazolo-(2,3-a)isoindol-und imidazo(2,1-a)-isoindol-derivaten als antivirale arzneimittel sowie neue oxazolo(2,3-a)isoindol-derivaten
DE4129779A1 (de) * 1991-09-07 1993-03-11 Boehringer Mannheim Gmbh Neue tricyclische thiazol- und oxazol-derivate und diese enthaltende arzneimittel
JPH0780886B2 (ja) * 1992-05-15 1995-08-30 ナショナル・サイエンス・カウンシル 三環結合ヒドロキシグアニジン、その製造法及びそれを含む抗癌組成物
AU6729600A (en) 1999-08-25 2001-03-19 Banyu Pharmaceutical Co., Ltd. Novel isoindole derivatives
CA2347869C (en) * 2000-02-14 2004-01-06 Mobility Electronics, Inc. Linked bridge
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
JP4058663B2 (ja) * 2000-09-22 2008-03-12 有機合成薬品工業株式会社 リボース1−リン酸類及びヌクレオシド化合物の製造方法
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US20040161846A1 (en) 2000-11-22 2004-08-19 Mason Anthony John Method of expression and agents identified thereby
WO2002066479A1 (fr) 2001-02-23 2002-08-29 Banyu Pharmaceutical Co.,Ltd. Derives de l'isoindole
AUPR878401A0 (en) 2001-11-09 2001-12-06 Biota Holdings Ltd Methods for identifying or screening anti-viral agents
EP1697377B1 (de) * 2003-12-24 2011-01-26 Biota Scientific Management Pty. Ltd. Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus
LT3284520T (lt) 2005-04-28 2019-09-25 Viiv Healthcare Company Policiklinis karbamoilpiridono darinys, turintis živ integrazę slopinantį poveikį
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑

Also Published As

Publication number Publication date
AR063038A1 (es) 2008-12-23
KR101488826B1 (ko) 2015-02-03
AU2007302611A1 (en) 2008-04-03
RU2009115872A (ru) 2010-11-10
KR20090073212A (ko) 2009-07-02
ES2376915T3 (es) 2012-03-20
IL197783A (en) 2014-01-30
PL2069353T3 (pl) 2012-04-30
DK2069353T3 (da) 2012-02-20
EP2069353A4 (de) 2010-09-15
TW200831505A (en) 2008-08-01
US9675694B2 (en) 2017-06-13
WO2008037011A1 (en) 2008-04-03
BRPI0717536A2 (pt) 2013-10-22
ZA200901983B (en) 2010-03-31
EP2069353B1 (de) 2011-11-09
CA2664376C (en) 2015-06-02
TWI423972B (zh) 2014-01-21
HK1131988A1 (en) 2010-02-12
EP2069353A1 (de) 2009-06-17
AU2007302611B2 (en) 2013-06-20
JP5340943B2 (ja) 2013-11-13
CA2664376A1 (en) 2008-04-03
US8598194B2 (en) 2013-12-03
CN101583614B (zh) 2014-01-22
US20140004111A1 (en) 2014-01-02
NZ575805A (en) 2012-03-30
JP2010504915A (ja) 2010-02-18
MX2009003336A (es) 2009-05-28
CN101583614A (zh) 2009-11-18
NO20091521L (no) 2009-04-21
AU2007302611C1 (en) 2013-11-21
PT2069353E (pt) 2012-02-06
IL197783A0 (en) 2009-12-24
US20100021458A1 (en) 2010-01-28

Similar Documents

Publication Publication Date Title
ATE541845T1 (de) 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen
ATE545418T1 (de) Zusammensetzungen und kits zur behandlung von influenza
ATE434620T1 (de) Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
IL209380A0 (en) Small molecule inhibitors for the treatment or prevention of dengue virus infection
ATE527241T1 (de) Pyridiazinonderivate zur behandlung von tumoren
ATE429218T1 (de) Pinolensäure zur behandlung von übergewicht
DE602005026984D1 (de) Chinolin-derivate zur behandlung von latenter tuberkulose
ATE476414T1 (de) Biphenyloxyessigsäurederivate zur behandlung von atemwegserkrankungen
DE602005017503D1 (de) Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
ATE521365T1 (de) Kinin-antagonisten zur behandlung von blasenfunktionsstörung
ATE532507T1 (de) Neramexane zur behandlung von subakuten tinnitus
ATE482939T1 (de) Neue antimikrobielle verbindungen, ihre synthese und ihre verwendung zur behandlung von säugetierinfektionen
ATE482709T1 (de) Neue arzneimittelkombinationen zur behandlung von atemwegserkrankungen
ATE534633T1 (de) Indazolderivate zur behandlung von hsp90- induzierten krankheiten
ATE533774T1 (de) Neuartige nukleosidanaloge zur behandlung von virusinfektionen
ATE532787T1 (de) Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus
DE502006008804D1 (de) Neue, langwirksame betamimetika zur behandlung von atemwegserkrankungen
DE602006003094D1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
DE602006021192D1 (de) Visnadin zur Behandlung von Kopfhautjucken
ATE517877T1 (de) Neue arzneimittel zur behandlung von atemwegserkrankungen
DE602005016141D1 (de) S-mirtazapin zur behandlung von hitzewallungen
BRPI0720323A2 (pt) composto, método de tratamento, composição farmacêutica e uso do composto
ATE482707T1 (de) 1-ä2h-1-benzopyran-2-on-8-ylü- piperazin- derivate zur behandlung von schmerzen
DE602007008759D1 (de) Pyrroloä1,2-aüimidazoldion zur behandlung von peripherer neurotoxizität durch chemotherapeutische mittel
DE502005002104D1 (de) Hesperidin zur Behandlung von Epilepsie