ATE532526T1 - Zelltherapie: verfahren und zusammensetzung zur behandlung von diabetes - Google Patents

Zelltherapie: verfahren und zusammensetzung zur behandlung von diabetes

Info

Publication number
ATE532526T1
ATE532526T1 AT07760776T AT07760776T ATE532526T1 AT E532526 T1 ATE532526 T1 AT E532526T1 AT 07760776 T AT07760776 T AT 07760776T AT 07760776 T AT07760776 T AT 07760776T AT E532526 T1 ATE532526 T1 AT E532526T1
Authority
AT
Austria
Prior art keywords
composition
cell therapy
treating diabetes
pancreases
islet cells
Prior art date
Application number
AT07760776T
Other languages
English (en)
Inventor
Vladislav Broytman
Nikanor Broytman
Nikolay Skaletskiy
Original Assignee
Philadelphia Medical Scient Ct L L C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philadelphia Medical Scient Ct L L C filed Critical Philadelphia Medical Scient Ct L L C
Application granted granted Critical
Publication of ATE532526T1 publication Critical patent/ATE532526T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/39Pancreas; Islets of Langerhans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10Mechanical dissociation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT07760776T 2006-04-17 2007-04-17 Zelltherapie: verfahren und zusammensetzung zur behandlung von diabetes ATE532526T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79292906P 2006-04-17 2006-04-17
PCT/US2007/066786 WO2007121438A2 (en) 2006-04-17 2007-04-17 Cell therapy: a method and a composition for treating diabetes

Publications (1)

Publication Number Publication Date
ATE532526T1 true ATE532526T1 (de) 2011-11-15

Family

ID=38610440

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07760776T ATE532526T1 (de) 2006-04-17 2007-04-17 Zelltherapie: verfahren und zusammensetzung zur behandlung von diabetes

Country Status (15)

Country Link
US (2) US9574180B2 (de)
EP (1) EP2013332B1 (de)
AT (1) ATE532526T1 (de)
AU (1) AU2007237934B2 (de)
CA (1) CA2649706C (de)
CY (1) CY1112307T1 (de)
ES (1) ES2377464T3 (de)
HK (1) HK1127086A1 (de)
IL (1) IL194796A (de)
NZ (1) NZ572839A (de)
PL (1) PL2013332T3 (de)
PT (1) PT2013332E (de)
RU (1) RU2450052C2 (de)
WO (1) WO2007121438A2 (de)
ZA (1) ZA200809767B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014151229A1 (en) * 2013-03-15 2014-09-25 Philadelphia Medical Scientific Center, L.L.C. Cell therapy: a method and a composition for treating diabetes
RU2534911C1 (ru) * 2013-10-29 2014-12-10 Сергей Михайлович Чудных Способ лечения сахарного диабета в эксперименте
US20200224165A1 (en) * 2016-07-22 2020-07-16 Senlin Li Methods and compositions for rejuvenation
US11617832B2 (en) 2016-08-17 2023-04-04 International Business Machines Corporation Portal system-based bionic pancreas
KR102060609B1 (ko) 2018-09-13 2019-12-30 사회복지법인 삼성생명공익재단 유도만능줄기세포 유래 내피세포와 요독 복합체를 사용한 요독성 혈관병증 모델 및 이의 이용
WO2023227068A1 (en) * 2022-05-25 2023-11-30 Hangzhou Reprogenix Bioscience, Inc. A new site for transplantation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2069563C1 (ru) * 1993-03-04 1996-11-27 Шилкин Герман Алексеевич Способ лечения диабетической ретинопатии
US5741334A (en) * 1995-06-07 1998-04-21 Circe Biomedical, Inc. Artificial pancreatic perfusion device
RU2135193C1 (ru) * 1997-10-28 1999-08-27 Скалецкий Николай Николаевич Способ получения материала, содержащего бета-клетки поджелудочной железы, для трансплантации больным сахарным диабетом с использованием феномена миграции клеток, материал, содержащий бета-клетки поджелудочной железы, для трансплантации больным сахарным диабетом и способ лечения сахарного диабета методом его трансплантации
US20020071824A1 (en) * 1999-05-27 2002-06-13 Nick Giannoukakis Gene transfer to pancreatic b cells for prevention of islet dysfunction
EP1317253A4 (de) * 2000-07-28 2006-04-26 Univ Emory Biologische komponente eine künstliche membran enthaltend
US8236771B2 (en) * 2004-05-18 2012-08-07 National Institute Of Transplantation Foundation Vectors and methods for long-term immune evasion to prolong transplant viability

Also Published As

Publication number Publication date
US9574180B2 (en) 2017-02-21
RU2008145053A (ru) 2010-05-27
PL2013332T3 (pl) 2012-04-30
WO2007121438A3 (en) 2008-03-27
PT2013332E (pt) 2012-02-20
AU2007237934A1 (en) 2007-10-25
CY1112307T1 (el) 2015-12-09
ES2377464T3 (es) 2012-03-27
US20150284687A1 (en) 2015-10-08
RU2450052C2 (ru) 2012-05-10
IL194796A0 (en) 2009-08-03
NZ572839A (en) 2011-12-22
US20080267925A1 (en) 2008-10-30
WO2007121438A2 (en) 2007-10-25
IL194796A (en) 2014-02-27
EP2013332B1 (de) 2011-11-09
CA2649706C (en) 2013-06-11
EP2013332A2 (de) 2009-01-14
ZA200809767B (en) 2009-11-25
AU2007237934B2 (en) 2012-11-01
EP2013332A4 (de) 2009-05-13
HK1127086A1 (en) 2009-09-18
CA2649706A1 (en) 2007-10-25

Similar Documents

Publication Publication Date Title
ATE532526T1 (de) Zelltherapie: verfahren und zusammensetzung zur behandlung von diabetes
ATE523585T1 (de) Differenzierung menschlicher embryonaler stammzellen
RU2012105922A (ru) Дифференцирование человеческих эмбриональных стволовых клеток
BR112015019997A2 (pt) Métodos de sacarificar e fermentar um material celulósico
WO2011082038A3 (en) Improved reprogramming compositions
RU2011121843A (ru) Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
ATE492629T1 (de) Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur
DE602006018768D1 (de) Konditionell immortalisierte adulte langzeit-stammzellen und verfahren zur herstellung und verwendung von solchen zellen
MX2010001335A (es) Diferenciacion de celulas madre embrionarias humanas.
MX2009002065A (es) Una composicion farmaceutica para tratar cancer pulmonar, un metodo para inhibir el crecimiento o invasion de cancer pulmonar y un metodo para tratar cancer pulmonar.
MX2009004640A (es) Estimulacion por litio de proliferacion de celula de tallo sanguinea de cordon y produccion de factor de crecimiento.
RU2014146170A (ru) Способы лечения диабета и/или улучшения выживания панкреатических островков после трансплантации
TW200736399A (en) Expansion and differentiation of neural stem cells under low oxygen conditions
ATE544849T1 (de) Aktivierte dendritische zellen, therapieverfahren unter verwendung der dendritischen zellen sowie verfahren zur kultivierung von gamma-delta-t- zellen
EA201300817A1 (ru) Способ улучшенного приживления гемопоэтических стволовых клеток
AR057058A1 (es) Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
MX2014001441A (es) Metodo para aumentar la asimilación de dioxido de carbono (co2) y la producción de aceite en organismos fotosinteticos.
MX2011007936A (es) Metodos para regeneracion de tejido pancreatico.
ATE519504T1 (de) Chromatin-remodellierende substanzen zur erhöhung der expression von pdx-1 und förderung der zelldifferenzierung
ATE544846T1 (de) Fusionierte mesenchymale stammzellen zur behandlung von diabetes und verfahren dafür
DK1554374T3 (da) Fremgangsmåde til storskala T-lymfocytdyrkning i et homogent system
WO2014100816A3 (en) Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
RU2008106675A (ru) Способ лечения периимплантита
ATE461994T1 (de) Verfahren und vorrichtungen zum kultivieren von stammzellen
AR050723A1 (es) Proceso para la preparacion de z-5- carboximetilen-1,3- dioxolan-4- onas