ATE515494T1 - Neue verbindungen, deren herstellung und verwendung - Google Patents

Neue verbindungen, deren herstellung und verwendung

Info

Publication number
ATE515494T1
ATE515494T1 AT05742978T AT05742978T ATE515494T1 AT E515494 T1 ATE515494 T1 AT E515494T1 AT 05742978 T AT05742978 T AT 05742978T AT 05742978 T AT05742978 T AT 05742978T AT E515494 T1 ATE515494 T1 AT E515494T1
Authority
AT
Austria
Prior art keywords
compounds
production
new compounds
pharmaceutical compositions
treatment
Prior art date
Application number
AT05742978T
Other languages
English (en)
Inventor
Zdenek Polivka
Original Assignee
High Point Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc
Application granted granted Critical
Publication of ATE515494T1 publication Critical patent/ATE515494T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes
AT05742978T 2004-05-05 2005-05-03 Neue verbindungen, deren herstellung und verwendung ATE515494T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200400718 2004-05-05
PCT/EP2005/052013 WO2005105736A1 (en) 2004-05-05 2005-05-03 Novel compounds, their preparation and use

Publications (1)

Publication Number Publication Date
ATE515494T1 true ATE515494T1 (de) 2011-07-15

Family

ID=34993286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05742978T ATE515494T1 (de) 2004-05-05 2005-05-03 Neue verbindungen, deren herstellung und verwendung

Country Status (5)

Country Link
US (1) US8053598B2 (de)
EP (1) EP1745014B1 (de)
JP (1) JP4981662B2 (de)
AT (1) ATE515494T1 (de)
WO (1) WO2005105736A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105735A1 (en) * 2004-05-05 2005-11-10 Novo Nordisk A/S Phenoxyacetic acid derivatives as ppar agonists
EP2386540A1 (de) 2005-12-22 2011-11-16 High Point Pharmaceuticals, LLC Neue Verbindungen, ihre Herstellung und Verwendung
JP4866901B2 (ja) * 2007-02-07 2012-02-01 協和発酵キリン株式会社 ３環系化合物
US8486980B2 (en) 2008-08-06 2013-07-16 Kyowa Hakko Kirin Co., Ltd. Tricyclic compound
KR101898610B1 (ko) 2010-08-31 2018-09-14 서울대학교산학협력단 ＰＰＡＲδ 활성물질의 태자 재프로그래밍 용도
CN103874697A (zh) 2011-08-03 2014-06-18 协和发酵麒麟株式会社 二苯并氧杂*衍生物
CA3185909A1 (en) 2020-07-22 2022-01-27 Reneo Pharmaceuticals, Inc. Crystalline ppar-delta agonist
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US414891A (en) * 1889-11-12 Teen twenty-fourths to bernard j
FR2331336A1 (fr) 1975-11-14 1977-06-10 Rolland Sa A Acides oxy-4,4' bis(phenoxy-2 alcanocarboxyliques), leurs derives et leur application comme medicament
US4920132A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US5324743A (en) 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
IL109451A0 (en) 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
AU1856997A (en) 1996-02-02 1997-08-22 Merck & Co., Inc. Method for raising hdl cholesterol levels
ES2202582T3 (es) 1996-02-02 2004-04-01 MERCK & CO., INC. Agentes antidiabeticos.
DE69733154T2 (de) 1996-02-02 2006-03-09 Merck & Co., Inc. Verfahren zur behandlung von diabetes und verwandter krankheitszustände.
DE69728267T2 (de) 1996-02-02 2005-02-24 Merck & Co., Inc. Antidiabetisches mittel
WO1997028137A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Heterocyclic derivatives as antidiabetic and antiobesity agents
WO1997043241A1 (fr) 1996-05-13 1997-11-20 Nippon Shinyaku Co., Ltd. Composes d'ethylene substitue et medicaments
US5773469A (en) 1996-06-18 1998-06-30 Ortho Pharmaceutical Corporation Diaryl antimicrobial agents
EP0948327B1 (de) 1996-12-23 2006-03-08 Merck & Co., Inc. Antidiabetische mittel
ES2320181T3 (es) 1997-07-24 2009-05-19 Astellas Pharma Inc. Composiciones farmaceuticas que tienen un efecto reductor del colesterol.
HUP0101022A1 (hu) 1997-10-17 2001-10-28 Aventis Pharmaceuticals Products Inc. Kinolinszármazékok gyógyászati alkalmazása
WO2000023416A1 (en) * 1998-10-21 2000-04-27 Novo Nordisk A/S New compounds, their preparation and use
WO2000023415A1 (en) * 1998-10-21 2000-04-27 Novo Nordisk A/S New compounds, their preparation and use
JP2002542218A (ja) * 1999-04-20 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 新規な化合物、それらの製造および使用
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
JP2003500432A (ja) 1999-06-01 2003-01-07 ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター ジフェニルエーテル誘導体を用いて脱毛症を処置する方法
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
US6369098B1 (en) 1999-10-05 2002-04-09 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
PL356745A1 (en) 1999-11-10 2004-06-28 Takeda Chemical Industries, Ltd Body weight gain inhibitors
CN1390139A (zh) 1999-11-11 2003-01-08 伊莱利利公司 用于治疗癌症的肿瘤细胞溶解组合物
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
WO2001055086A1 (en) 2000-01-28 2001-08-02 Novo Nordisk A/S Alkynylsubstituted propionic acid derivatives and their use against diabetes and obesity
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
JP2003520838A (ja) 2000-01-28 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造および使用。
CA2400021A1 (en) 2000-02-18 2001-08-23 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
KR20020081424A (ko) 2000-03-09 2002-10-26 아벤티스 파마 도이칠란트 게엠베하 Ｐｐａｒ 매개인자의 치료학적 용도
US6448293B1 (en) 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
JP2001354671A (ja) 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
AU2001277723A1 (en) 2000-08-11 2002-02-25 Nippon Chemiphar Co., Ltd. Ppardelta activators
ATE368653T1 (de) 2000-08-23 2007-08-15 Lilly Co Eli Oxazolylaryloxyessigsäure derivate und ihre verwendung als ppar agonisten
US6630504B2 (en) 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
GB0024361D0 (en) 2000-10-05 2000-11-22 Glaxo Group Ltd Medicaments
WO2002046154A1 (en) 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Peroxisome proliferator activated receptor d activators
GB0031107D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031103D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
CA2433573A1 (en) 2000-12-28 2002-07-11 Takeda Chemical Industries, Ltd. Alkanoic acid derivatives, process for their production and use thereof
EP1357914A2 (de) 2001-02-02 2003-11-05 SmithKline Beecham Corporation Verfahren zur behandlung von ppar vermittelten krankheiten
WO2002076957A1 (fr) 2001-03-23 2002-10-03 Nippon Chemiphar Co.,Ltd. Activateur de recepteur active par les proliferateurs du peroxysome
JP4256166B2 (ja) 2001-03-28 2009-04-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルボン酸化合物
WO2002080899A1 (fr) 2001-03-30 2002-10-17 Eisai Co., Ltd. Agent de traitement de maladie digestive
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2002098840A1 (fr) 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
DE10130812A1 (de) 2001-06-26 2003-01-02 Zf Lenksysteme Gmbh Hilfskraftlenkung
FR2826574B1 (fr) 2001-06-29 2005-08-26 Oreal Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles
JP2004536152A (ja) 2001-07-30 2004-12-02 ノボ　ノルディスク　アクティーゼルスカブ 新規ビニルｎ−（２−ベンゾイルフェニル）−ｌ−チロシン誘導体及び抗糖尿病剤等へのそれらの使用
JP2004536150A (ja) 2001-07-30 2004-12-02 ノボ　ノルディスク　アクティーゼルスカブ 新規なビニル、カルボン酸誘導体および抗生物質などとしてのそれらの使用
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
ATE526319T1 (de) 2001-08-10 2011-10-15 Nippon Chemiphar Co Aktivator für den peroxisome proliferator- responsiven rezeptor delta
WO2003016265A1 (fr) 2001-08-17 2003-02-27 Eisai Co., Ltd. Compose cyclique et agoniste du recepteur ppar
MXPA04002330A (es) 2001-09-14 2005-04-08 Japan Tobacco Inc Compuestos biarilo ligados.
IL161351A0 (en) 2001-10-12 2004-09-27 Nippon Chemiphar Co ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR delta
DE10151390A1 (de) 2001-10-18 2003-05-08 Bayer Ag Essigsäurederivate
JP2003171275A (ja) 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト
WO2003072100A1 (en) 2002-02-25 2003-09-04 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
WO2003074495A1 (en) 2002-03-01 2003-09-12 Smithkline Beecham Corporation Hppars activators
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
US20030207924A1 (en) 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) * 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
DE10222034A1 (de) 2002-05-17 2003-11-27 Bayer Ag Tetrahydroisochinolin-Derivate
GB0214149D0 (en) 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
GB0214254D0 (en) 2002-06-20 2002-07-31 Glaxo Group Ltd Chemical compounds
DE10229777A1 (de) 2002-07-03 2004-01-29 Bayer Ag Indolin-Phenylsulfonamid-Derivate
AU2003281040A1 (en) 2002-07-10 2004-02-02 Sumitomo Pharmaceuticals Co., Ltd. Biaryl derivatives
PL375700A1 (en) * 2002-09-05 2005-12-12 Novo Nordisk A/S Novel vinyl carboxylic acid derivatives and their therapeutical use
EP1558572B1 (de) * 2002-10-28 2010-06-30 High Point Pharmaceuticals, LLC Neue verbindungen und deren verwendung als ppar-modulatoren
US7129268B2 (en) 2002-10-28 2006-10-31 Novo Nordisk A/S Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
US20050080115A1 (en) 2002-10-28 2005-04-14 Lone Jeppesen Novel compounds, their preparation and use
KR20050055790A (ko) * 2002-10-28 2005-06-13 노보 노르디스크 에이/에스 Ｐｐａｒ 매개 질환의 치료에 유용한 신규 화합물
US7396850B2 (en) 2003-01-06 2008-07-08 Eli Lilly And Company Pyrazole derivative as PPAR modulator
DE10300099A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Indol-Phenylsulfonamid-Derivate
BRPI0407180A (pt) 2003-02-14 2006-02-07 Lilly Co Eli Composto, composição farmacêutica, métodos para modular um receptor ativado pelo proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição, para diminuir a glicose no sangue em um mamìfero, para tratar ou prevenir diabetes mellitus, doença cardiovascular e sìndrome x em um mamìfero, e, uso de um composto
JPWO2004080943A1 (ja) 2003-03-11 2006-06-08 小野薬品工業株式会社 シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤
CA2518986A1 (en) 2003-03-13 2004-09-23 Ono Pharmaceutical Co., Ltd. Imino ether derivative compounds and drugs containing the compounds as the active ingredient
CA2521175A1 (en) 2003-04-07 2004-10-28 Kalypsys, Inc. Para-sulfonyl substituted phenyl compounds as modulators of ppars
US20050070532A1 (en) 2003-04-17 2005-03-31 Liu Kevin Aryl compounds as modulators of PPARS and methods of treating metabolic disorders
CN1812978A (zh) 2003-04-30 2006-08-02 药物研发有限责任公司 作为蛋白酪氨酸磷酸酶－1b抑制剂的苯基取代羧酸
ES2299906T3 (es) 2003-11-25 2008-06-01 Eli Lilly And Company Moduladores de receptores activados por proliferadores de peroxisomas.
EP1737440A2 (de) 2004-04-01 2007-01-03 Aventis Pharmaceuticals, Inc. Verwendung von ppar delta agonisten zur behandlung von demyelisierenden erkrankungen
DE602005027677D1 (de) 2004-04-01 2011-06-09 Aventis Pharma Inc 1,3,4-oxadiazol-2-one als ppar-delta-modulatoren und deren verwendung
CN1956984B (zh) 2004-04-01 2010-06-09 安万特药物公司 1,3,4-二唑-2-酮作为PPAR-δ调节剂
WO2005105725A1 (en) 2004-05-05 2005-11-10 Novo Nordisk A/S Novel compounds, their preparation and use
WO2005105735A1 (en) 2004-05-05 2005-11-10 Novo Nordisk A/S Phenoxyacetic acid derivatives as ppar agonists
EP2386540A1 (de) 2005-12-22 2011-11-16 High Point Pharmaceuticals, LLC Neue Verbindungen, ihre Herstellung und Verwendung
US7943612B2 (en) 2006-03-09 2011-05-17 High Point Pharmaceuticals, Llc Compounds that modulate PPAR activity, their preparation and use
WO2007141295A1 (en) 2006-06-08 2007-12-13 High Point Pharmaceuticals, Llc Process for preparing phenoxy acetic acid derivatives

Also Published As

Publication number Publication date
EP1745014B1 (de) 2011-07-06
WO2005105736A1 (en) 2005-11-10
JP2007536342A (ja) 2007-12-13
JP4981662B2 (ja) 2012-07-25
EP1745014A1 (de) 2007-01-24
US8053598B2 (en) 2011-11-08
US20090012171A1 (en) 2009-01-08

Similar Documents

Publication Publication Date Title
EA200870103A1 (ru) Феноксиуксусные кислоты в качестве активаторов ppar дельта
ATE515494T1 (de) Neue verbindungen, deren herstellung und verwendung
NO20052575L (no) Nye forbindelser, deres fremstilling og anvendelse
MX2007005205A (es) Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma.
WO2006100081A3 (de) Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
NO20082096L (no) Azaindol-2-karboksamidderivativer
PE20110547A1 (es) Compuestos de isoindolina con actividad anticancerigena
EA201070422A1 (ru) Производные оксадиазола
DE60330757D1 (de) Verwendung von pyridylamiden als angiogenesehemmer
EA201100007A1 (ru) Производные хиноксалиндиона
DE502005010170D1 (de) Neue langwirksame beta-2-agonisten, und deren verwendung als arzneimittel
CL2008002689A1 (es) Compuestos derivados de heterociclo 1,4 piperidina sustituida; compuestos intermediarios; composicion farmaceutica; proceso de preparacion; y su uso en el tratamiento del alzheimer y esquizofrenia.
BRPI0519292A2 (pt) compostos orgÂnicos
MA32544B1 (fr) Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
MX2007011698A (es) Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
DE602006010738D1 (de) Pyrroloä2,3-cüpyridinderivate
WO2006125181A3 (en) Piperidine derivatives and their use as stearoyl-coa desaturase modulators
ATE412636T1 (de) Piperazinylpyridinderivate als mittel gegen adipositas
ATE486838T1 (de) Neue verbindungen, ihre herstellung und verwendung
BRPI0417858A (pt) composto, composição farmacêutica, e, uso de uma composição farmacêutica
ATE478056T1 (de) Oxazol- und thiazol-verbindungen als ppar- modulatoren
ATE486055T1 (de) Neue verbindungen, ihre herstellung und verwendung
ATE475642T1 (de) Phenoxyessigsäurederivate als ppar-agonisten
ATE469882T1 (de) Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen
TW200800960A (en) Novel 2,3-dihydroindole compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties