ATE509925T1 - Substituierte bicyclocarbonsäureamidverbindungen - Google Patents

Substituierte bicyclocarbonsäureamidverbindungen

Info

Publication number
ATE509925T1
ATE509925T1 AT07825705T AT07825705T ATE509925T1 AT E509925 T1 ATE509925 T1 AT E509925T1 AT 07825705 T AT07825705 T AT 07825705T AT 07825705 T AT07825705 T AT 07825705T AT E509925 T1 ATE509925 T1 AT E509925T1
Authority
AT
Austria
Prior art keywords
bicyclocarbonic
substituted
acid amide
amide compounds
compounds
Prior art date
Application number
AT07825705T
Other languages
English (en)
Inventor
Andrew Antony Calabrese
Matthew Alexander James Duncton
Kentaro Futatsugi
Misato Hirano
Satoshi Nagayama
Koji Ando
Original Assignee
Pfizer
Renovis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Renovis Inc filed Critical Pfizer
Application granted granted Critical
Publication of ATE509925T1 publication Critical patent/ATE509925T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
AT07825705T 2006-11-17 2007-11-09 Substituierte bicyclocarbonsäureamidverbindungen ATE509925T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86628506P 2006-11-17 2006-11-17
US94393307P 2007-06-14 2007-06-14
US98334307P 2007-10-29 2007-10-29
PCT/IB2007/003559 WO2008059370A2 (en) 2006-11-17 2007-11-09 Substituted bicyclocarboxyamide compounds

Publications (1)

Publication Number Publication Date
ATE509925T1 true ATE509925T1 (de) 2011-06-15

Family

ID=39311049

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07825705T ATE509925T1 (de) 2006-11-17 2007-11-09 Substituierte bicyclocarbonsäureamidverbindungen

Country Status (12)

Country Link
US (1) US7964732B2 (de)
EP (1) EP2091944B1 (de)
JP (1) JP2010510202A (de)
AR (1) AR064253A1 (de)
AT (1) ATE509925T1 (de)
CA (1) CA2669915C (de)
CL (1) CL2007003289A1 (de)
GT (1) GT200700103A (de)
PE (1) PE20081504A1 (de)
TW (1) TW200831089A (de)
UY (1) UY30723A1 (de)
WO (1) WO2008059370A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
NZ595759A (en) * 2009-05-07 2014-03-28 Gruenenthal Chemie Substituted phenylureas and phenylamides as vanilloid receptor ligands
SI2427436T1 (sl) * 2009-05-07 2013-04-30 Grunenthal Gmbh Substituirani aromatski karboksamidni in sečninski derivati kot ligandi vaniloidnega receptorja
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
WO2012025469A1 (en) * 2010-08-24 2012-03-01 Solvay Sa Improved process for the preparation of esters of 1-h-pyrazole-4-carboxylic acids
WO2012062463A1 (en) * 2010-11-10 2012-05-18 Grünenthal GmbH Substituted bicyclic carboxamide and urea derivatives as vanilloid receptor ligands
JP5140776B1 (ja) * 2012-09-05 2013-02-13 タマ化学工業株式会社 １−置換−３−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法
RU2687089C2 (ru) 2015-05-18 2019-05-07 Шэньян Сайнокем Агрокемикалз Р Энд Д Ко., Лтд. Соединения замещенного пиразола, содержащего пиримидинил, их получение и применение
AR112673A1 (es) 2017-08-11 2019-11-27 Syngenta Participations Ag Derivados de pirazol activos como plaguicidas
WO2020164993A1 (en) 2019-02-13 2020-08-20 Syngenta Crop Protection Ag Pesticidally active pyrazole derivatives
WO2020164994A1 (en) 2019-02-13 2020-08-20 Syngenta Crop Protection Ag Pesticidally active pyrazole derivatives
CN110256342B (zh) * 2019-07-16 2022-06-07 河南省科学院化学研究所有限公司 一种2-氰基喹啉衍生物的合成方法
CN110734401A (zh) * 2019-10-10 2020-01-31 长沙麓兴生物科技有限公司 一种氮未取代-4-甲酰基吡唑的制备方法
CN114989546B (zh) * 2022-07-05 2023-07-28 上海乐纯生物技术有限公司 一种用于细胞治疗储液袋生产的fep膜

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2671059B2 (ja) 1990-11-30 1997-10-29 富士レビオ株式会社 ナフトエ酸誘導体
AU5006693A (en) 1992-08-07 1994-03-03 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Polyhydroxylated naphthyl 2-carboxylate, and quinolyl and isoquinolyl 3-carboxylate derivatives as protein tyrosine kinase inhibitors
CN1114834A (zh) 1993-09-28 1996-01-10 大塚制药株式会社 抗糖尿病剂
DE4423353A1 (de) 1994-07-04 1996-01-11 Bayer Ag Verfahren zur Herstellung N-acylierter 2-Chlor-5-aminomethylpyridine
US5753700A (en) 1994-12-28 1998-05-19 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
AU1457299A (en) 1997-11-12 1999-05-31 Ariad Pharmaceuticals, Inc. Novel signal transduction inhibitors, compositions containing them
WO1999026927A2 (en) 1997-11-21 1999-06-03 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists for treating central nervous system diseases
AU3208200A (en) 1999-01-13 2000-08-01 Research Foundation Of The State University Of New York, The A novel method for designing protein kinase inhibitors
EP1147094A1 (de) 1999-01-15 2001-10-24 Novo Nordisk A/S Nicht-peptidische glp-1 agonisten
RU2267484C2 (ru) 1999-04-28 2006-01-10 Авентис Фарма Дойчланд Гмбх Производные диариловой кислоты и фармацевтическая композиция на их основе
JP2003500387A (ja) 1999-05-24 2003-01-07 シーオーアール セラピューティクス インコーポレイテッド Ｘａ因子の阻害剤
ES2249272T3 (es) 1999-06-02 2006-04-01 Nps Pharmaceuticals, Inc. Antagonistas de receptores de glutamato metabotropicos y su uso para el tratamiento de enfermedades del sistema nervioso central.
EP1192135A2 (de) 1999-06-14 2002-04-03 Eli Lilly And Company Inhibitoren von serin proteasen
EP1192132B1 (de) 1999-06-14 2005-09-07 Eli Lilly And Company Inhibitoren von serin proteasen
CA2380986C (en) 1999-08-07 2009-10-20 Boehringer Ingelheim Pharma Kg Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
DE19963179B4 (de) 1999-12-27 2009-02-05 Grünenthal GmbH Substituierte 1- und 2-Naphthol-Mannichbasen
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
DE60133743T2 (de) 2000-08-21 2009-07-02 Pacific Corp. Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
JP2005511478A (ja) 2001-04-03 2005-04-28 メルク　エンド　カムパニー　インコーポレーテッド Ｎ−置換非アリール複素環アミジル系ｎｍｄａ／ｎｒ２ｂ拮抗薬
DE60231868D1 (de) 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
TWI239942B (en) 2001-06-11 2005-09-21 Dainippon Pharmaceutical Co N-arylphenylacetamide derivative and pharmaceutical composition containing the same
FR2827599A1 (fr) 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
JP2005501873A (ja) 2001-07-31 2005-01-20 バイエル・ヘルスケア・アクチェンゲゼルシャフト アミン誘導体
DE60226756D1 (de) 2001-10-04 2008-07-03 Merck & Co Inc Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5
US20050009812A1 (en) 2001-10-05 2005-01-13 Takuya Seko Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
MXPA04003758A (es) 2001-10-22 2005-06-20 Univ New York State Res Found Inhibidores de proteina - cinasas y proteina-fosfatasas, metodos para disenarlos y metodos para usarlos.
EP1451156A4 (de) 2001-11-27 2005-05-25 Merck & Co Inc 4-aminochinolinverbindungen
AU2003245773A1 (en) 2002-02-15 2003-09-04 Glaxo Group Limited Vanilloid receptor modulators
US8163769B2 (en) 2002-03-12 2012-04-24 Abbott Laboratories Antibacterial compounds
TW200306159A (en) 2002-03-19 2003-11-16 Du Pont Bicyclic fused pyridinyl amides and advantageous compositions thereof for use as fungicides
GB0206876D0 (en) 2002-03-22 2002-05-01 Merck Sharp & Dohme Therapeutic agents
US7598418B2 (en) 2002-04-18 2009-10-06 Institute Of Medicinal Molecular Design, Inc. Amide derivatives
CN1675154A (zh) 2002-06-07 2005-09-28 科蒂科股份有限公司 抑制巨噬细胞移动抑制因子(mif)的细胞因子或生物活性的萘衍生物
GB2389580A (en) 2002-06-12 2003-12-17 Bayer Ag 2-Naphthamide PGI2 antagonists
AU2003262946A1 (en) 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
EP1581498A2 (de) 2002-11-22 2005-10-05 Bristol-Myers Squibb Company Pyridinyl-, pyrimidinyl-und pyrazinylamide als kaliumkanalöffner
EP1581510A4 (de) 2002-11-22 2006-08-30 Bristol Myers Squibb Co 1-aryl-2-hydroxyethylamideals kaliumkanalöffner
US7179427B2 (en) * 2002-11-25 2007-02-20 Abb Lummus Global Inc. Apparatus for countercurrent contacting of gas and solids
AU2003287880A1 (en) 2002-12-11 2004-06-30 7Tm Pharma A/S Cyclic quinoline compounds for use in mch receptor related disorders
CN100406007C (zh) 2002-12-20 2008-07-30 安姆根有限公司 哮喘和过敏性炎症调节剂
EP1572693A1 (de) 2002-12-20 2005-09-14 Pharmacia Corporation Mitogenaktivierte proteinkinaseaktivierte proteinkinase-2-inhibierende verbindungen
ATE551324T1 (de) 2003-02-03 2012-04-15 Janssen Pharmaceutica Nv Chinolin-amid-derivate als modulatoren von vanilloid-vr1-rezeptoren
WO2004078114A2 (en) 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.
JP2006519846A (ja) 2003-03-10 2006-08-31 シェーリング　コーポレイション 複素環式キナーゼインヒビター：使用および合成の方法
AU2004241242A1 (en) 2003-05-14 2004-12-02 Emisphere Technologies, Inc. Compositions for delivering peptide YY and PYY agonists
US20050004133A1 (en) 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
KR101165647B1 (ko) 2003-06-20 2012-07-17 갈데르마 리써어치 앤드 디벨로프먼트 ＰＰＡＲγ 형 수용체를 조절하는 신규 화합물, 및 미용또는 약학 조성물에서의 이의 용도
KR100707123B1 (ko) 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물
AU2004259675A1 (en) 2003-07-15 2005-02-03 Merck & Co., Inc. Hydroxypyridine CGRP receptor antagonists
SE0302323D0 (sv) 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
EP1660503A1 (de) 2003-08-29 2006-05-31 Pfizer Inc. Naphthalincarboxamide und derivate als neue anti-angiogene mittel
US20050232818A1 (en) * 2003-09-19 2005-10-20 Donald Sandell Single sheet seal applicator and cartridge
WO2005033079A1 (ja) 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
WO2005035526A1 (en) 2003-10-09 2005-04-21 Argenta Discovery Ltd. Bicyclic compounds and their therapeutic use
EP1713807A1 (de) 2004-01-23 2006-10-25 Amgen Inc. Vanilloidrezeptorliganden und deren verwendung bei behandlungen
CA2553966A1 (en) 2004-01-23 2005-08-04 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US7544803B2 (en) 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
EP1740551B9 (de) 2004-04-30 2013-01-16 Takeda Pharmaceutical Company Limited Heterocyclische amidverbindung und deren verwendung als mmp-13-inhibitor
EP1782811A4 (de) 2004-08-09 2010-09-01 Eisai R&D Man Co Ltd Neues anti-malaria-mittel mit heterozyklischer verbindung

Also Published As

Publication number Publication date
WO2008059370A2 (en) 2008-05-22
CA2669915A1 (en) 2008-05-22
CA2669915C (en) 2012-02-07
US20100267769A1 (en) 2010-10-21
AR064253A1 (es) 2009-03-25
EP2091944B1 (de) 2011-05-18
TW200831089A (en) 2008-08-01
WO2008059370A8 (en) 2009-06-04
GT200700103A (es) 2008-11-04
US7964732B2 (en) 2011-06-21
UY30723A1 (es) 2008-07-03
EP2091944A2 (de) 2009-08-26
JP2010510202A (ja) 2010-04-02
CL2007003289A1 (es) 2008-06-20
WO2008059370A3 (en) 2008-07-24
PE20081504A1 (es) 2008-10-30

Similar Documents

Publication Publication Date Title
LTC2004635I2 (lt) Pakeistieji enaminokarbonilo junginiai
ATE509925T1 (de) Substituierte bicyclocarbonsäureamidverbindungen
ATE524477T1 (de) Aziridinylepothilonverbindungen
BRPI0922904A2 (pt) "compostos"
ATE502948T1 (de) Substituierte bicyclolactamverbindungen
BRPI0719204A2 (pt) Inibidores de hdac
DK2041139T3 (da) Farmaceutiske forbindelser
BRPI0813500A2 (pt) Compostos antivirais
BRPI0821086A2 (pt) Compostos inseticidas
BRPI0714512A2 (pt) Compostos químicos
NO347644B1 (no) Polymorfer
ATE478849T1 (de) 4-anilinochinolin-3-carbonsäureamide als csf-1r- kinaseinhibitoren
AT504580A3 (de) Scan-einrichtung
BRPI0811264A2 (pt) Compostos
ATE546437T1 (de) Aminomethyl-4-imidazole
ATE443056T1 (de) Substituierte n-sulfonylaminophenylethyl-2- phenoxyacetamidverbindungen
ATE510923T1 (de) Nukleinsäure
BRPI0814424A2 (pt) Compostos heterociclila
ATE534010T1 (de) Zielfernrohr
DE602007011911D1 (de) Stark hydrophober verbundstoff
BRPI0815332A2 (pt) Composto de ácido fenilacético
BRPI0809996A2 (pt) Compostos
DE602007012490D1 (de) Herbizidzusammensetzung
DE102006045567A8 (de) Crimpstabilisierung
BRPI0815181A2 (pt) Compostos

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties