ATE509014T1 - Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren - Google Patents

Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren

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Publication number
ATE509014T1
ATE509014T1 AT02713444T AT02713444T ATE509014T1 AT E509014 T1 ATE509014 T1 AT E509014T1 AT 02713444 T AT02713444 T AT 02713444T AT 02713444 T AT02713444 T AT 02713444T AT E509014 T1 ATE509014 T1 AT E509014T1
Authority
AT
Austria
Prior art keywords
malonyl
decarboxylase
malonyl coa
decarboxylase inhibitors
compounds
Prior art date
Application number
AT02713444T
Other languages
English (en)
Inventor
Thomas Arrhenius
Mi Chen
Jie Fei Cheng
Yujin Huang
Alex Nadzan
Richard Penuliar
David Wallace
Lin Zhang
Gary Lopaschuk
Jason Dyck
Original Assignee
Chugai Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE509014T1 publication Critical patent/ATE509014T1/de

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/14—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D277/38—Nitrogen atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • C07D277/38—Nitrogen atoms
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    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
AT02713444T 2001-01-26 2002-01-22 Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren ATE509014T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26455201P 2001-01-26 2001-01-26
PCT/US2002/001789 WO2002058698A2 (en) 2001-01-26 2002-01-22 Malonyl-coa decarboxylase inhibitors useful as metabolic modulators

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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2284817T3 (es) * 2001-01-26 2007-11-16 Chugai Seiyaku Kabushiki Kaisha Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa.
WO2002066035A2 (en) 2001-02-20 2002-08-29 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
WO2003090869A1 (en) * 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha Lxr modulators
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
JP2006519229A (ja) * 2003-02-13 2006-08-24 アルバート・アインシュタイン・カレッジ・オヴ・メディシン・オヴ・イェシヴァ・ユニヴァーシティ 視床下部内の長鎖脂肪アシルＣｏＡレベルの変調による摂食量およびグルコース産生量の調節
WO2005011670A1 (en) 2003-08-01 2005-02-10 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
CA2533763C (en) 2003-08-01 2012-11-20 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors
ATE400272T1 (de) 2003-08-01 2008-07-15 Chugai Pharmaceutical Co Ltd Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
EP2208495B1 (de) 2003-08-01 2011-12-14 Chugai Seiyaku Kabushiki Kaisha Azol-Verbindungen auf Cyanoguanidin-Basis als Malonyl-Coa Decarboxylase-Hemmer
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
ATE384058T1 (de) * 2003-12-08 2008-02-15 Hoffmann La Roche Thiazolderivate
ATE462431T1 (de) 2004-05-28 2010-04-15 Expanscience Lab Verwendung von furanalkylen zur herstellung eines arzneimittels für die behandlung von adipositas sowie kosmetische behandlung von übergewicht
FR2870742B1 (fr) 2004-05-28 2008-03-14 Expanscience Laboratoires Sa Utilisation d'alkyle furannes pour la preparation d'un medicament destine au traitement du diabete, de l'obesite et pour le traitement cosmetique de la cellulite et de la surcharge ponderale
FR2870743B1 (fr) * 2005-03-21 2012-03-09 Expanscience Lab Utilisation d'alkyle furannes pour la preparation d'un medicament destine au traitement de l'obesite et pour le traitement cosmetique de la surcharge ponderale
DE602005027563D1 (de) 2004-05-28 2011-06-01 Expanscience Lab Verwendung von furanalkylen zur kosmetischen behandlung von zellulitis
US7601725B2 (en) 2004-07-16 2009-10-13 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as Aurora kinase inhibitors
WO2006041922A2 (en) * 2004-10-08 2006-04-20 Dara Biosciences, Inc. Agents and methods for administration to the central nervous system
WO2006088798A2 (en) * 2005-02-14 2006-08-24 Albert Einstein College Of Medicine Of Yeshiva University Modulation of hypothalamic atp-sensitive potassium channels
US9808544B2 (en) 2005-08-31 2017-11-07 Ultraviolet Sciences, Inc. Ultraviolet light treatment chamber
EP3178322B1 (de) * 2014-07-28 2021-11-03 Sumitomo Chemical Company, Limited Amid-verbindung und deren verwendung zur bekämpfung von schädlichen arthropoden
TWI664905B (zh) * 2014-07-29 2019-07-11 日商住友化學股份有限公司 含有醯胺化合物之有害節肢動物控制劑
CA2965467A1 (en) 2014-10-24 2016-04-28 Ono Pharmaceutical Co., Ltd. Kcnq2-5 channel activator
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物
CN111093662B (zh) 2017-06-20 2023-10-03 安布里亚制药公司 用于提高心脏代谢效率的组合物和方法
US20210353617A1 (en) 2018-10-17 2021-11-18 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
CN117242053A (zh) * 2021-05-17 2023-12-15 住友橡胶工业株式会社 氧化腈化合物和含离子官能团的聚合物

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666769A (en) 1969-10-09 1972-05-30 Du Pont Thermally stable 2-perfluoro-substituted benzothiazoles
US4381311A (en) 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols
JPS57134480A (en) 1980-12-29 1982-08-19 Du Pont Antiinflammatory 4,5-diaryl-alpha- (polyhalomethyl)-2-thiophene methanols
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
GB8714537D0 (en) 1987-06-22 1987-07-29 Ici Plc Pyrazine derivatives
EP0733366B1 (de) 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Angiotensin II-Rezeptor blockierende Imidazole und Diuretika enthaltende pharmazeutische Zusammensetzungen
US4832930A (en) * 1988-05-02 1989-05-23 Tekatch William M Decomposition of ammonium thiocyanate
HU217958B (hu) 1989-06-30 2000-05-28 E. I. Du Pont De Nemours And Co. Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
JP2568315B2 (ja) 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
US5117097A (en) * 1990-02-27 1992-05-26 Kabushiki Kaisha Tokai Rika Denki Seisakusho Key system for a vehicle
RU1743153C (ru) 1990-06-04 1995-02-27 ВНИИ химических средств защиты растений N-[4-2'-гидроксигексафторизопропил)фенил] -n-этил-n'-фенилмочевина, обладающая рострегулирующим и антидотным действием
DE69123582T2 (de) 1990-06-22 1997-05-15 Du Pont Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten
EP0480716A1 (de) 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Gesättigte Hydroxyalkylchinolinsäuren zur Verwendung als Leukotrien-Antagonisten
CA2053148A1 (en) 1990-10-16 1992-04-17 Karnail Atwal Dihydropyrimidine derivatives
US5470975A (en) 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5374615A (en) 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
SU1825496A3 (ru) 1991-04-04 1994-12-30 Всесоюзный научно-исследовательский институт химических средств защиты растений Производные n-[4-(1-гидрокси-1-трифторметил-2,2,2-трифторэтил)фенил]мочевины, обладающие антидотной активностью к 2-хлор-n-[(4-метокси-6-метил-1,3,5-триазин-2-ил)аминокарбонил] бензолсульфамиду в посевах льна
US5190942A (en) 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
US5177097A (en) 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
US5256695A (en) 1991-07-24 1993-10-26 E. R. Squibb & Sons, Inc. Acyl amidine and acyl guanidine substituted biphenyl derivatives
AU2494792A (en) 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
US5212177A (en) 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
US5350752A (en) 1991-12-16 1994-09-27 E. R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5225408A (en) 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
TW297025B (de) 1992-02-14 1997-02-01 Squibb & Sons Inc
US5208235A (en) 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole derivatives
US5208234A (en) 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Substituted imidazole phosphonic and phosphinic acid derivatives
WO1993021168A1 (en) 1992-04-10 1993-10-28 Merck Frosst Canada Inc. Thiazole-substituted benzyl alcohols as leukotriene antagonists
US5506227A (en) 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
US5378704A (en) 1992-04-15 1995-01-03 E. R. Squibb & Sons, Inc. Non-peptidic angiotensin-II-receptor-antagonists
US5534347A (en) 1992-09-04 1996-07-09 Eastman Kodak Company Fusing roll having a fluorocarbon-silicone barrier layer
JP3323500B2 (ja) 1992-10-30 2002-09-09 ロード・コーポレーション 低粘度磁気レオロジー材料
GB9226860D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
WO1994015932A1 (en) 1993-01-15 1994-07-21 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
DE4302681A1 (de) 1993-02-01 1994-08-04 Hoechst Ag Sulfonsäureester, damit hergestellte strahlungsempfindliche Gemische und deren Verwendung
DE4306152A1 (de) 1993-02-27 1994-09-01 Hoechst Ag Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
GB9408577D0 (en) 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
US5932733A (en) 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
WO1995035311A1 (en) 1994-06-17 1995-12-28 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
US5637599A (en) 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5519143A (en) 1994-09-19 1996-05-21 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitation
US5527827A (en) 1994-10-27 1996-06-18 Merck Frosst Canada, Inc. Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis
US5552437A (en) 1994-10-27 1996-09-03 Merck Frosst Canada, Inc. Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis
JPH08311036A (ja) 1995-03-14 1996-11-26 Takeda Chem Ind Ltd ピラゾール誘導体、その用途
IL117534A0 (en) 1995-03-24 1996-07-23 Rhone Poulenc Agrochimie Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
JPH0912585A (ja) 1995-06-30 1997-01-14 Ube Ind Ltd 高配位典型元素錯体
JPH0912795A (ja) 1995-06-30 1997-01-14 Sumitomo Chem Co Ltd 押出成形用エチレン系樹脂組成物及び押出成形体
GB2321244B (en) 1997-01-20 2000-11-22 Pharmacia & Upjohn Spa Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents
DE19716231A1 (de) 1997-04-18 1998-10-22 Studiengesellschaft Kohle Mbh Olefinmetathese in komprimiertem Kohlendioxid
DE19722952A1 (de) 1997-05-31 1998-12-03 Huels Chemische Werke Ag Verwendung von Polymeren zur Inhibierung der Denaturierung von adsorbierten Eiweißstoffen
US5895771A (en) 1997-06-05 1999-04-20 Akzo Nobel Nv Fluorinated alkoxy and/or aryloxy aluminates as cocatalysts for metallocene-catalyzed olefin polymerizations
US5977413A (en) 1997-08-04 1999-11-02 Nippon Kayaku Kabushiki Kaisha Method for producing bis(3-amino-4-hydroxyphenyl) compounds
AU1022999A (en) 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
KR20010086196A (ko) 1997-09-11 2001-09-10 추후보정 폴리플루오로알콕사이드 리간드를 함유한 약한 배위결합음이온
EP1071648A2 (de) 1998-03-13 2001-01-31 Merck Frosst Canada & Co. CARBONSÄUREN UND ACYLSULFONAMIDE, SOLCHE VERBINDUNGEN ENTHALTENDE Gemenge UND BEHANDLUNGSVERFAHREN
GB2337701A (en) 1998-05-26 1999-12-01 United Medical And Dental Schools Of Guys St Thomas Hospitals Treatment of ischemia with an angiotensin II antagonist
JP2002518380A (ja) * 1998-06-18 2002-06-25 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤
FR2784114B1 (fr) 1998-09-18 2001-02-02 Thomson Csf Materiaux polymeres absorbant les composes organophosphores. procede de synthese de ces materiaux. capteurs chimiques comprenant ces materiaux
EP1034196B1 (de) 1998-10-05 2005-01-12 Promerus LLC Katalysator und verfahren zur polymerisation von cycloolefinen
US6350832B1 (en) 1998-12-09 2002-02-26 The B. F. Goodrich Company Mold addition polymerization of norbornene-type monomers using group 10 metal complexes
JP2002533318A (ja) 1998-12-22 2002-10-08 ニューロサーチ、アクティーゼルスカブ イオンチャネル調節剤
WO2000046203A2 (en) 1999-02-04 2000-08-10 Millennium Pharmaceuticals, Inc. G-protein coupled heptahelical receptor binding compounds and methods of use thereof
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
AU6074700A (en) 1999-07-08 2001-01-30 Tularik Inc. Compositions and methods for raising hdl cholesterol levels
JP4267920B2 (ja) 2001-01-26 2009-05-27 中外製薬株式会社 代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤
ES2284817T3 (es) 2001-01-26 2007-11-16 Chugai Seiyaku Kabushiki Kaisha Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa.
JP4539565B2 (ja) 2006-01-13 2010-09-08 株式会社ジェイ・エム・エス 血液浄化回路

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JP5113823B2 (ja) 2013-01-09
US20100016259A1 (en) 2010-01-21
CA2735267A1 (en) 2002-08-01
CA2735478A1 (en) 2002-08-01
AU2002245294B2 (en) 2005-09-22
WO2002058698A2 (en) 2002-08-01
JP2004527475A (ja) 2004-09-09
CA2435067C (en) 2011-11-15
JP2008007510A (ja) 2008-01-17
HK1138521A1 (en) 2010-08-27
WO2002058698A8 (en) 2005-06-30
US7524969B2 (en) 2009-04-28
EP1411929B1 (de) 2011-05-11
CN101596191A (zh) 2009-12-09
HK1068285A1 (en) 2005-04-29
CA2435067A1 (en) 2002-08-01
ES2362270T3 (es) 2011-06-30
CN1537001A (zh) 2004-10-13
CN101596191B (zh) 2011-06-15
KR100637564B1 (ko) 2006-10-20
CA2735478C (en) 2014-07-08
WO2002058698A3 (en) 2004-02-12
US8119819B2 (en) 2012-02-21
JP2010065054A (ja) 2010-03-25
CA2735267C (en) 2013-05-07
EP1411929A2 (de) 2004-04-28
CN100528154C (zh) 2009-08-19
US20040082576A1 (en) 2004-04-29
KR20030070609A (ko) 2003-08-30

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