ATE493134T1 - Gefriergetrocknetes präparat mit methylcobalamin und verfahren zu seiner herstellung - Google Patents

Gefriergetrocknetes präparat mit methylcobalamin und verfahren zu seiner herstellung

Info

Publication number
ATE493134T1
ATE493134T1 AT04731472T AT04731472T ATE493134T1 AT E493134 T1 ATE493134 T1 AT E493134T1 AT 04731472 T AT04731472 T AT 04731472T AT 04731472 T AT04731472 T AT 04731472T AT E493134 T1 ATE493134 T1 AT E493134T1
Authority
AT
Austria
Prior art keywords
freeze
dried preparation
methylcobalamin
preparation containing
excipient
Prior art date
Application number
AT04731472T
Other languages
English (en)
Inventor
Akira Kato
Teruko Nomura
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of ATE493134T1 publication Critical patent/ATE493134T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
AT04731472T 2003-05-07 2004-05-06 Gefriergetrocknetes präparat mit methylcobalamin und verfahren zu seiner herstellung ATE493134T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003129251 2003-05-07
PCT/JP2004/005973 WO2004098614A1 (ja) 2003-05-07 2004-05-06 メチルコバラミン含有凍結乾燥製剤及びその製造方法

Publications (1)

Publication Number Publication Date
ATE493134T1 true ATE493134T1 (de) 2011-01-15

Family

ID=33432069

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04731472T ATE493134T1 (de) 2003-05-07 2004-05-06 Gefriergetrocknetes präparat mit methylcobalamin und verfahren zu seiner herstellung

Country Status (11)

Country Link
US (1) US20060247203A1 (de)
EP (1) EP1621202B1 (de)
JP (1) JP4753717B2 (de)
KR (1) KR100732100B1 (de)
CN (1) CN100376251C (de)
AT (1) ATE493134T1 (de)
AU (1) AU2004236603B2 (de)
CA (1) CA2521928A1 (de)
DE (1) DE602004030781D1 (de)
ES (1) ES2356242T3 (de)
WO (1) WO2004098614A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI334866B (en) * 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
CN101500571A (zh) * 2006-08-14 2009-08-05 卫材R&D管理有限公司 稳定的冻干制剂
CN101616912A (zh) * 2007-01-29 2009-12-30 卫材R&D管理有限公司 大环内酯系化合物的固体及其制造方法及其药物组合物
CU24142B1 (es) * 2010-10-29 2015-12-23 Troikaa Pharmaceuticals Ltd Composiciones nasales de vitamina b12
CN102895200B (zh) * 2012-11-02 2014-04-02 湖北人民制药有限公司 甲钴胺冻干组合物及其制备方法
CN107595877B (zh) * 2016-07-12 2020-08-28 石药集团恩必普药业有限公司 一种含有丁苯酞的药物组合物及其在治疗als病药物中的应用
CN111556752A (zh) 2017-12-28 2020-08-18 富士胶片富山化学株式会社 冻干制剂的制造方法
JP7436151B2 (ja) * 2019-05-31 2024-02-21 小林製薬株式会社 ビタミンb12類の光安定化方法
CN112494436A (zh) * 2020-12-14 2021-03-16 卓和药业集团有限公司 一种注射用甲钴胺及其制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7028M (de) * 1966-06-23 1969-06-09
JPS55113721A (en) * 1979-02-27 1980-09-02 Eisai Co Ltd Immunity regulator
JPS59152327A (ja) * 1983-02-16 1984-08-31 Otsuka Pharmaceut Co Ltd 安定な静注用総合ビタミン製剤
JPS62149619A (ja) * 1985-09-05 1987-07-03 Teijin Ltd 活性型ビタミンd3類注射用組成物
FR2740686B1 (fr) * 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
FR2740973B1 (fr) * 1995-11-15 1998-02-06 Lipha Nouvelle forme d'administration de l'hydroxocobalamine et son utilisation dans les intoxications par les cyanures
CA2266412A1 (en) * 1996-09-18 1998-03-26 William J. Sarill Compositions containing cobalamin and amino acids
JP3889844B2 (ja) * 1997-02-10 2007-03-07 龍兒 梶 筋萎縮性側索硬化症治療剤
WO2001092288A2 (en) * 2000-05-31 2001-12-06 Mayo Foundation For Medical Education And Research Cobalamin compounds useful as antibiotic agents and as imaging agents

Also Published As

Publication number Publication date
US20060247203A1 (en) 2006-11-02
CN100376251C (zh) 2008-03-26
AU2004236603A1 (en) 2004-11-18
ES2356242T3 (es) 2011-04-06
WO2004098614A1 (ja) 2004-11-18
EP1621202B1 (de) 2010-12-29
AU2004236603B2 (en) 2006-12-07
JPWO2004098614A1 (ja) 2006-07-13
KR100732100B1 (ko) 2007-06-27
EP1621202A1 (de) 2006-02-01
CN1784237A (zh) 2006-06-07
DE602004030781D1 (de) 2011-02-10
EP1621202A4 (de) 2007-10-31
CA2521928A1 (en) 2004-11-18
JP4753717B2 (ja) 2011-08-24
KR20060011987A (ko) 2006-02-06

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