ATE489475T1 - Stammzellen von langerhans-inseln und ihre verwendung bei der behandlung von diabetes mellitus - Google Patents

Stammzellen von langerhans-inseln und ihre verwendung bei der behandlung von diabetes mellitus

Info

Publication number: ATE489475T1
Authority: AT; Austria
Prior art keywords: stem cells; cells; pancreatic; methods; islet
Prior art date: 2001-09-26

Application number

AT02768905T

Other languages

English (en)

Inventor

Joel Habener

Henryk Zulewski

Melissa Thomas

Elizabeth Abraham

Mario Vallejo

Colin Leech

Anna Nolan

Andreas Lechner

Original Assignee

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-26

Filing date

2002-09-26

Publication date

2010-12-15

2001-09-26 Priority claimed from US09/963,875 external-priority patent/US20020164307A1/en

2002-05-02 Priority claimed from US10/136,891 external-priority patent/US6923959B2/en

2002-09-26 Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE489475T1 publication Critical patent/ATE489475T1/de

Links

210000000130 stem cell Anatomy 0.000 title abstract 7
206010012601 diabetes mellitus Diseases 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 3
108010090306 Member 2 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 abstract 2
102000013013 Member 2 Subfamily G ATP Binding Cassette Transporter Human genes 0.000 abstract 2
102000008730 Nestin Human genes 0.000 abstract 2
108010088225 Nestin Proteins 0.000 abstract 2
230000004069 differentiation Effects 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
210000004153 islets of langerhan Anatomy 0.000 abstract 2
210000005055 nestin Anatomy 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 abstract 1
108010066302 Keratin-19 Proteins 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 abstract 1
210000003494 hepatocyte Anatomy 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
210000002660 insulin-secreting cell Anatomy 0.000 abstract 1
239000003550 marker Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Environmental Sciences (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Cell Biology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Developmental Biology & Embryology (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Prostheses (AREA)

AT02768905T 2001-09-26 2002-09-26 Stammzellen von langerhans-inseln und ihre verwendung bei der behandlung von diabetes mellitus ATE489475T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US09/963,875 US20020164307A1 (en)	1999-12-06	2001-09-26	Stem cells of the islets of langerhans and their use in treating diabetes mellitus
US10/120,687 US20030082155A1 (en)	1999-12-06	2002-04-11	Stem cells of the islets of langerhans and their use in treating diabetes mellitus
US10/136,891 US6923959B2 (en)	1999-12-06	2002-05-02	Method of pre-inducing a state of immune tolerance before organ transplantation
PCT/US2002/030700 WO2003026584A2 (en)	2001-09-26	2002-09-26	Stem cells of the islets of langerhans and their use in treating diabetes mellitus

Publications (1)

Publication Number	Publication Date
ATE489475T1 true ATE489475T1 (de)	2010-12-15

Family

ID=38596629

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02768905T ATE489475T1 (de)	2001-09-26	2002-09-26	Stammzellen von langerhans-inseln und ihre verwendung bei der behandlung von diabetes mellitus

Country Status (11)

Country	Link
US (2)	US20030082155A1 (de)
EP (1)	EP1438418B1 (de)
JP (1)	JP2005533746A (de)
CN (1)	CN1589330A (de)
AT (1)	ATE489475T1 (de)
AU (1)	AU2002331910B2 (de)
CA (1)	CA2461861A1 (de)
DE (1)	DE60238431D1 (de)
HK (1)	HK1067155A1 (de)
IL (1)	IL161119A0 (de)
WO (1)	WO2003026584A2 (de)

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EP1438418A4 (de)	2005-12-21
CN1589330A (zh)	2005-03-02
US20030082155A1 (en)	2003-05-01
JP2005533746A (ja)	2005-11-10
WO2003026584A2 (en)	2003-04-03
HK1067155A1 (en)	2005-04-01
US20070128176A1 (en)	2007-06-07
DE60238431D1 (de)	2011-01-05
WO2003026584A3 (en)	2003-09-18
EP1438418B1 (de)	2010-11-24
CA2461861A1 (en)	2003-04-03
IL161119A0 (en)	2004-08-31
EP1438418A2 (de)	2004-07-21
AU2002331910B2 (en)	2007-10-11
US8110399B2 (en)	2012-02-07

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