ATE486613T1 - Mit nucleinsäure complexierte block-copolymere - Google Patents

Mit nucleinsäure complexierte block-copolymere

Info

Publication number
ATE486613T1
ATE486613T1 AT03712331T AT03712331T ATE486613T1 AT E486613 T1 ATE486613 T1 AT E486613T1 AT 03712331 T AT03712331 T AT 03712331T AT 03712331 T AT03712331 T AT 03712331T AT E486613 T1 ATE486613 T1 AT E486613T1
Authority
AT
Austria
Prior art keywords
zwitterionic
copolymer
monomers
polymer
active compound
Prior art date
Application number
AT03712331T
Other languages
English (en)
Inventor
A Lennard Lewis
Steven Armes
Original Assignee
Biocompatibles Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd
Application granted granted Critical
Publication of ATE486613T1 publication Critical patent/ATE486613T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT03712331T 2002-03-07 2003-03-07 Mit nucleinsäure complexierte block-copolymere ATE486613T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02251605 2002-03-07
PCT/GB2003/000992 WO2003074090A2 (en) 2002-03-07 2003-03-07 Compositions of polymers

Publications (1)

Publication Number Publication Date
ATE486613T1 true ATE486613T1 (de) 2010-11-15

Family

ID=27771938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03712331T ATE486613T1 (de) 2002-03-07 2003-03-07 Mit nucleinsäure complexierte block-copolymere

Country Status (6)

Country Link
US (1) US8182802B2 (de)
EP (1) EP1480680B1 (de)
AT (1) ATE486613T1 (de)
AU (1) AU2003217009A1 (de)
DE (1) DE60334779D1 (de)
WO (1) WO2003074090A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048408B2 (en) 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
WO2003074026A1 (en) 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers
GB0301014D0 (en) 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
JP2006517793A (ja) * 2003-01-31 2006-08-03 ノバルティス アクチエンゲゼルシャフト スクリーニングアッセイ
WO2004069888A2 (en) * 2003-02-05 2004-08-19 Biocompatibles Uk Limited Block copolymers
US7786213B2 (en) * 2003-10-15 2010-08-31 The Regents Of The University Of California Biomacromolecule polymer conjugates
JP2005234584A (ja) * 2004-02-22 2005-09-02 Rohm & Haas Electronic Materials Llc フォトレジスト組成物
EP3222142A1 (de) 2006-02-28 2017-09-27 Kodiak Sciences Inc. Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und deren herstellung
US20080207822A1 (en) * 2007-02-22 2008-08-28 General Electric Company Composition and associated method
US9732142B2 (en) * 2008-05-15 2017-08-15 Biocompatibles Uk Limited Intracellular antibody delivery
US9254258B2 (en) 2008-05-15 2016-02-09 Biocompatibles Uk Limited Amphiphilic block copolymers for nucleic acid delivery
DK2260873T3 (da) 2009-06-08 2019-09-16 Biocompatibles Uk Ltd Pcylering af proteiner
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
US9393194B2 (en) * 2010-11-23 2016-07-19 Chung Yuan Christian University Biocarrier and method of using the same
ES2819217T3 (es) 2013-09-08 2021-04-15 Kodiak Sciences Inc Conjugados de polímeros iónicos dipolares y factor VIII
US9309336B2 (en) 2013-11-27 2016-04-12 King Fahd University Of Petroleum And Minerals Synthesis and antiscalant behavior of a novel polyzwitterionic acid
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
EP3207128B1 (de) 2014-10-17 2022-07-27 Kodiak Sciences Inc. Zwitterionische butyrylcholinesterasepolymerkonjugate
RU2744860C2 (ru) 2015-12-30 2021-03-16 Кодиак Сайенсиз Инк. Антитела и их конъюгаты
GB201603296D0 (en) 2016-02-25 2016-04-13 Ucl Business Plc Chemotactic,drug-containing polymersomes
GB201604553D0 (en) 2016-03-17 2016-05-04 Ucl Business Plc Fumarate polymersomes
GB201608737D0 (en) 2016-05-18 2016-06-29 Ucl Business Plc Polymersomes
JP2022522940A (ja) 2019-01-07 2022-04-21 ユーシーエル ビジネス リミテッド 複数のリガンドで機能化されたポリマーソーム
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
CA3238273A1 (en) 2021-11-24 2023-06-01 Giuseppe Battaglia Polymersomes for clearance of amyloid beta and/or tau proteins
WO2024147020A1 (en) 2023-01-06 2024-07-11 Vianautis Bio Limited Polymersomes for delivery of nucleic acid cargoes

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317178D0 (en) 1993-08-18 1993-10-06 Biocompatibles Ltd Polymer surface coatings
US6291620B1 (en) * 1994-11-09 2001-09-18 E. I. Du Pont De Nemours And Company Polymer synthesis
US6221959B1 (en) * 1994-11-18 2001-04-24 Supratek Pharma, Inc. Polynucleotide compositions
US5656611A (en) * 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
US6353055B1 (en) 1994-11-18 2002-03-05 Supratek Pharma Inc. Polynucleotide compositions
GB9624130D0 (en) * 1996-11-20 1997-01-08 Biocompatibles Ltd Biocompatible compositions
CA2294334A1 (en) * 1997-06-13 1998-12-17 Adi Eisenberg Compositions for delivery of biological agents and methods for the preparation thereof
WO1998056348A1 (en) 1997-06-13 1998-12-17 University Of Nebraska Board Of Regents Compositions for delivery of biological agents and methods for the preparation thereof
US6258371B1 (en) * 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
WO2000028920A1 (en) * 1998-11-13 2000-05-25 Biocompatibles Limited Therapeutic use of polymers
CN1129646C (zh) * 1998-11-13 2003-12-03 生物相容英国有限公司 包含两性离子单体组分的阴离子－阳离子的多离子配合物
GB9924502D0 (en) * 1999-10-15 1999-12-15 Biocompatibles Ltd Polymer blend materials
US6310175B1 (en) * 1999-10-23 2001-10-30 Nippon Shokubai Co., Ltd. Star-shaped block copolymer and production process therefor
US6852816B2 (en) 2000-10-06 2005-02-08 Biocompatibles Uk Limited Zwitterionic polymers
US8048408B2 (en) 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
WO2003074026A1 (en) 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers
GB0301014D0 (en) 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
WO2004069888A2 (en) 2003-02-05 2004-08-19 Biocompatibles Uk Limited Block copolymers

Also Published As

Publication number Publication date
AU2003217009A1 (en) 2003-09-16
EP1480680B1 (de) 2010-11-03
EP1480680A2 (de) 2004-12-01
US20050163743A1 (en) 2005-07-28
WO2003074090A2 (en) 2003-09-12
WO2003074090A3 (en) 2003-12-18
DE60334779D1 (en) 2010-12-16
US8182802B2 (en) 2012-05-22

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Legal Events

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