ATE486613T1 - Mit nucleinsäure complexierte block-copolymere - Google Patents
Mit nucleinsäure complexierte block-copolymereInfo
- Publication number
- ATE486613T1 ATE486613T1 AT03712331T AT03712331T ATE486613T1 AT E486613 T1 ATE486613 T1 AT E486613T1 AT 03712331 T AT03712331 T AT 03712331T AT 03712331 T AT03712331 T AT 03712331T AT E486613 T1 ATE486613 T1 AT E486613T1
- Authority
- AT
- Austria
- Prior art keywords
- zwitterionic
- copolymer
- monomers
- polymer
- active compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Graft Or Block Polymers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02251605 | 2002-03-07 | ||
PCT/GB2003/000992 WO2003074090A2 (en) | 2002-03-07 | 2003-03-07 | Compositions of polymers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE486613T1 true ATE486613T1 (de) | 2010-11-15 |
Family
ID=27771938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03712331T ATE486613T1 (de) | 2002-03-07 | 2003-03-07 | Mit nucleinsäure complexierte block-copolymere |
Country Status (6)
Country | Link |
---|---|
US (1) | US8182802B2 (de) |
EP (1) | EP1480680B1 (de) |
AT (1) | ATE486613T1 (de) |
AU (1) | AU2003217009A1 (de) |
DE (1) | DE60334779D1 (de) |
WO (1) | WO2003074090A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8048408B2 (en) | 2002-01-16 | 2011-11-01 | Biocompatibles Uk Limited | Polymer conjugates |
WO2003074026A1 (en) | 2002-03-07 | 2003-09-12 | Biocompatibles Uk Limited | Drug carriers comprising amphiphilic block copolymers |
GB0301014D0 (en) | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
JP2006517793A (ja) * | 2003-01-31 | 2006-08-03 | ノバルティス アクチエンゲゼルシャフト | スクリーニングアッセイ |
WO2004069888A2 (en) * | 2003-02-05 | 2004-08-19 | Biocompatibles Uk Limited | Block copolymers |
US7786213B2 (en) * | 2003-10-15 | 2010-08-31 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
JP2005234584A (ja) * | 2004-02-22 | 2005-09-02 | Rohm & Haas Electronic Materials Llc | フォトレジスト組成物 |
EP3222142A1 (de) | 2006-02-28 | 2017-09-27 | Kodiak Sciences Inc. | Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und deren herstellung |
US20080207822A1 (en) * | 2007-02-22 | 2008-08-28 | General Electric Company | Composition and associated method |
US9732142B2 (en) * | 2008-05-15 | 2017-08-15 | Biocompatibles Uk Limited | Intracellular antibody delivery |
US9254258B2 (en) | 2008-05-15 | 2016-02-09 | Biocompatibles Uk Limited | Amphiphilic block copolymers for nucleic acid delivery |
DK2260873T3 (da) | 2009-06-08 | 2019-09-16 | Biocompatibles Uk Ltd | Pcylering af proteiner |
US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
US9393194B2 (en) * | 2010-11-23 | 2016-07-19 | Chung Yuan Christian University | Biocarrier and method of using the same |
ES2819217T3 (es) | 2013-09-08 | 2021-04-15 | Kodiak Sciences Inc | Conjugados de polímeros iónicos dipolares y factor VIII |
US9309336B2 (en) | 2013-11-27 | 2016-04-12 | King Fahd University Of Petroleum And Minerals | Synthesis and antiscalant behavior of a novel polyzwitterionic acid |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP3207128B1 (de) | 2014-10-17 | 2022-07-27 | Kodiak Sciences Inc. | Zwitterionische butyrylcholinesterasepolymerkonjugate |
RU2744860C2 (ru) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Антитела и их конъюгаты |
GB201603296D0 (en) | 2016-02-25 | 2016-04-13 | Ucl Business Plc | Chemotactic,drug-containing polymersomes |
GB201604553D0 (en) | 2016-03-17 | 2016-05-04 | Ucl Business Plc | Fumarate polymersomes |
GB201608737D0 (en) | 2016-05-18 | 2016-06-29 | Ucl Business Plc | Polymersomes |
JP2022522940A (ja) | 2019-01-07 | 2022-04-21 | ユーシーエル ビジネス リミテッド | 複数のリガンドで機能化されたポリマーソーム |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
CA3238273A1 (en) | 2021-11-24 | 2023-06-01 | Giuseppe Battaglia | Polymersomes for clearance of amyloid beta and/or tau proteins |
WO2024147020A1 (en) | 2023-01-06 | 2024-07-11 | Vianautis Bio Limited | Polymersomes for delivery of nucleic acid cargoes |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317178D0 (en) | 1993-08-18 | 1993-10-06 | Biocompatibles Ltd | Polymer surface coatings |
US6291620B1 (en) * | 1994-11-09 | 2001-09-18 | E. I. Du Pont De Nemours And Company | Polymer synthesis |
US6221959B1 (en) * | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
US6353055B1 (en) | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
GB9624130D0 (en) * | 1996-11-20 | 1997-01-08 | Biocompatibles Ltd | Biocompatible compositions |
CA2294334A1 (en) * | 1997-06-13 | 1998-12-17 | Adi Eisenberg | Compositions for delivery of biological agents and methods for the preparation thereof |
WO1998056348A1 (en) | 1997-06-13 | 1998-12-17 | University Of Nebraska Board Of Regents | Compositions for delivery of biological agents and methods for the preparation thereof |
US6258371B1 (en) * | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
WO2000028920A1 (en) * | 1998-11-13 | 2000-05-25 | Biocompatibles Limited | Therapeutic use of polymers |
CN1129646C (zh) * | 1998-11-13 | 2003-12-03 | 生物相容英国有限公司 | 包含两性离子单体组分的阴离子-阳离子的多离子配合物 |
GB9924502D0 (en) * | 1999-10-15 | 1999-12-15 | Biocompatibles Ltd | Polymer blend materials |
US6310175B1 (en) * | 1999-10-23 | 2001-10-30 | Nippon Shokubai Co., Ltd. | Star-shaped block copolymer and production process therefor |
US6852816B2 (en) | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
US8048408B2 (en) | 2002-01-16 | 2011-11-01 | Biocompatibles Uk Limited | Polymer conjugates |
WO2003074026A1 (en) | 2002-03-07 | 2003-09-12 | Biocompatibles Uk Limited | Drug carriers comprising amphiphilic block copolymers |
GB0301014D0 (en) | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
WO2004069888A2 (en) | 2003-02-05 | 2004-08-19 | Biocompatibles Uk Limited | Block copolymers |
-
2003
- 2003-03-07 DE DE60334779T patent/DE60334779D1/de not_active Expired - Lifetime
- 2003-03-07 WO PCT/GB2003/000992 patent/WO2003074090A2/en not_active Application Discontinuation
- 2003-03-07 EP EP03712331A patent/EP1480680B1/de not_active Expired - Lifetime
- 2003-03-07 AU AU2003217009A patent/AU2003217009A1/en not_active Abandoned
- 2003-03-07 AT AT03712331T patent/ATE486613T1/de not_active IP Right Cessation
- 2003-03-07 US US10/506,814 patent/US8182802B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2003217009A1 (en) | 2003-09-16 |
EP1480680B1 (de) | 2010-11-03 |
EP1480680A2 (de) | 2004-12-01 |
US20050163743A1 (en) | 2005-07-28 |
WO2003074090A2 (en) | 2003-09-12 |
WO2003074090A3 (en) | 2003-12-18 |
DE60334779D1 (en) | 2010-12-16 |
US8182802B2 (en) | 2012-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |