ATE48643T1 - Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm. - Google Patents

Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm.

Info

Publication number: ATE48643T1
Authority: AT; Austria
Prior art keywords: derivatives; glucagon; yeast strain; production; transformed yeast
Prior art date: 1985-01-22

Application number

AT86300384T

Other languages

English (en)

Inventor

Kjeld Norris

Lars Thim

Fanny Norris

Mogens Trier Hansen

Alister James Moody

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-22

Filing date

1986-01-20

Publication date

1989-12-15

1986-01-20 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1989-12-15 Application granted granted Critical

1989-12-15 Publication of ATE48643T1 publication Critical patent/ATE48643T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Endocrinology (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Diabetes (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Emergency Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT86300384T 1985-01-22 1986-01-20 Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm. ATE48643T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK27885A DK27885A (da)	1985-01-22	1985-01-22	Fremstilling af peptider
EP86300384A EP0189998B1 (de)	1985-01-22	1986-01-20	Verfahren zur Herstellung von Glucagon oder dessen Derivaten in einem transformierten Hefestamm

Publications (1)

Publication Number	Publication Date
ATE48643T1 true ATE48643T1 (de)	1989-12-15

Family

ID=8091749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86300384T ATE48643T1 (de)	1985-01-22	1986-01-20	Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm.

Country Status (17)

Country	Link
US (1)	US4826763A (de)
EP (1)	EP0189998B1 (de)
JP (2)	JPH0720435B2 (de)
AT (1)	ATE48643T1 (de)
AU (1)	AU587218B2 (de)
CA (1)	CA1294232C (de)
DE (1)	DE3667488D1 (de)
DK (1)	DK27885A (de)
ES (1)	ES8708250A1 (de)
FI (1)	FI87800C (de)
GR (1)	GR860149B (de)
IE (1)	IE58726B1 (de)
MX (1)	MX163776B (de)
NO (1)	NO172185C (de)
NZ (1)	NZ214883A (de)
PT (1)	PT81872B (de)
ZA (1)	ZA86393B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5151354A (en) *	1986-08-21	1992-09-29	Cornelius Hollenberg	Fermentation processes using amylolytic enzyme producing microorganisms
EP0268772B1 (de) *	1986-09-19	1995-04-26	ZymoGenetics, Inc.	Expression des biologisch aktiven Faktors XIII
JPH01187499A (ja) *	1988-01-21	1989-07-26	Science & Tech Agency	原子炉解体用ロボット
IL93173A0 (en) *	1989-02-01	1990-11-05	Shionogi & Co	Production of glucagon
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5234906A (en) *	1991-01-10	1993-08-10	Amylin Pharmaceuticals, Inc.	Hyperglycemic compositions
US5510459A (en) *	1991-01-17	1996-04-23	Zymogenetics, Inc.	Glucagon antagonists
US5408037A (en) *	1991-01-17	1995-04-18	Zymogenetics, Inc.	Methods for detecting glucagon antagonists
EP0653965B1 (de) *	1992-07-06	1996-05-15	Beckman Instruments, Inc.	Flüssigkeitsversorgungssystem mit Mehrwegventil
DK144093D0 (de) *	1993-12-23	1993-12-23	Novo Nordisk As
US5652216A (en) *	1994-05-26	1997-07-29	Novo Nordisk A/S	Pharmaceutical preparation
AU746633B2 (en) *	1997-05-16	2002-05-02	1149336 Ontario Inc.	Methods of enhancing functioning of the upper gastrointestinal tract
WO2004060387A1 (en) *	2002-12-27	2004-07-22	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en)	2002-12-27	2010-02-02	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
MX362028B (es)	2009-02-03	2019-01-04	Amunix Pharmaceuticals Inc	Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos.
ES2705249T3 (es)	2009-06-08	2019-03-22	Amunix Operating Inc	Polipéptidos reguladores de glucosa y métodos para su producción y uso
MX366864B (es)	2012-02-27	2019-07-26	Amunix Operating Inc	Composiciones de conjugados de xten y métodos para realizarlas.
WO2020074583A1 (en)	2018-10-09	2020-04-16	Fresenius Kabi Ipsum S.R.L.	Process for the manufacture of glp-1 analogues
EP3753946A1 (de)	2019-06-18	2020-12-23	Fresenius Kabi iPSUM S.r.l.	Verbessertes verfahren zur herstellung von hochreinem glucagon
EP3986919A1 (de)	2019-06-18	2022-04-27	Fresenius Kabi iPSUM S.r.l.	Verfahren zur herstellung von glucagon
US20230287040A1 (en)	2019-11-13	2023-09-14	Amunix Pharmaceuticals, Inc.	Barcoded xten polypeptides and compositions thereof, and methods for making and using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4401759A (en) *	1980-05-01	1983-08-30	Harvey Rubin	Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
DK283180A (da) *	1980-07-01	1982-01-02	Novo Industri As	Polypeptider og derivater deraf
US4546082A (en) *	1982-06-17	1985-10-08	Regents Of The Univ. Of California	E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

1985
- 1985-01-22 DK DK27885A patent/DK27885A/da unknown
1986
- 1986-01-20 NO NO860178A patent/NO172185C/no not_active IP Right Cessation
- 1986-01-20 GR GR860149A patent/GR860149B/el active IP Right Revival
- 1986-01-20 CA CA000499911A patent/CA1294232C/en not_active Expired - Lifetime
- 1986-01-20 ES ES551042A patent/ES8708250A1/es not_active Expired
- 1986-01-20 AT AT86300384T patent/ATE48643T1/de not_active IP Right Cessation
- 1986-01-20 FI FI860251A patent/FI87800C/fi not_active IP Right Cessation
- 1986-01-20 DE DE8686300384T patent/DE3667488D1/de not_active Expired - Lifetime
- 1986-01-20 PT PT81872A patent/PT81872B/pt active IP Right Revival
- 1986-01-20 IE IE16286A patent/IE58726B1/en not_active IP Right Cessation
- 1986-01-20 JP JP61009822A patent/JPH0720435B2/ja not_active Expired - Lifetime
- 1986-01-20 MX MX1277A patent/MX163776B/es unknown
- 1986-01-20 AU AU52472/86A patent/AU587218B2/en not_active Expired
- 1986-01-20 ZA ZA86393A patent/ZA86393B/xx unknown
- 1986-01-20 EP EP86300384A patent/EP0189998B1/de not_active Expired
- 1986-01-21 US US06/820,144 patent/US4826763A/en not_active Expired - Lifetime
- 1986-01-21 NZ NZ214883A patent/NZ214883A/en unknown
1993
- 1993-10-13 JP JP5255433A patent/JPH0746986B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GR860149B (en)	1986-05-21
FI87800C (fi)	1993-02-25
AU587218B2 (en)	1989-08-10
JPH06292594A (ja)	1994-10-21
AU5247286A (en)	1986-07-31
FI860251A0 (fi)	1986-01-20
FI87800B (fi)	1992-11-13
FI860251A (fi)	1986-07-23
NO860178L (no)	1986-07-23
ES551042A0 (es)	1987-10-01
DK27885D0 (da)	1985-01-22
DE3667488D1 (de)	1990-01-18
NO172185B (no)	1993-03-08
NZ214883A (en)	1988-04-29
JPS61181398A (ja)	1986-08-14
MX163776B (es)	1992-06-22
IE860162L (en)	1986-07-22
EP0189998B1 (de)	1989-12-13
ES8708250A1 (es)	1987-10-01
IE58726B1 (en)	1993-11-03
JPH0746986B2 (ja)	1995-05-24
US4826763A (en)	1989-05-02
PT81872A (en)	1986-02-01
DK27885A (da)	1986-07-23
CA1294232C (en)	1992-01-14
PT81872B (pt)	1988-05-27
JPH0720435B2 (ja)	1995-03-08
EP0189998A1 (de)	1986-08-06
NO172185C (no)	1993-06-16
ZA86393B (en)	1987-03-25

Legal Events

Date	Code	Title	Description
1990-05-15	UEP	Publication of translation of european patent specification
2006-04-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE48643T1 (de)	1989-12-15	Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm.
DE3856505T2 (de)	2002-08-08	Proteine mit Faktor VIII Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende Zusammensetzungen
AU2790292A (en)	1993-04-27	Viral recombinant vectors for expression in muscle cells
IT8167406A0 (it)	1981-03-23	Procedimento e veicolo per la produzione di polipeptidi mediante espressione nei batteri di un codice genetico di struttura
AU573768B2 (en)	1988-06-23	Hyaluronic acid from streptococci
DE3578435D1 (de)	1990-08-02	Promotoren fuer die expression von fremden genen in hefe, plasmide, die diese promotoren enthalten, sowie deren verwendung zur herstellung von polypeptiden.
ATE78055T1 (de)	1992-07-15	Verfahren zur herstellung von proteinen und transformierten zellen und dna-konstruktionen zur korrektur von mankos und wirtszellen sowie deren herstellung und verwendung.
EP0139878A3 (de)	1985-10-02	Herstellung von Immun-Interferon und seiner m-RNS
EP0196879A3 (de)	1988-03-16	Verfahren zur Erzeugung von unbehaarten Schweinen
EP0592685A4 (de)	1995-07-12	Planze resistent gegen mindestens zwei viren und dessen preparation.
EP0422217A4 (en)	1992-08-19	Human recombinant placental ribonuclease inhibitor and method of production
GB1221235A (en)	1971-02-03	A process for the production of uricase
EP0343388A3 (de)	1990-09-12	Expression von Gamma-Interferon in methylotrophischen Hefen
ATE50453T1 (de)	1990-03-15	Spezifisches polypeptid produzierende hybridzellinien, erhaeltlich aus primaerzellen, die spontan faehig sind zur expres sion dieses polypeptids oder eines aehnlichen polypeptids, verfahren zum erhalten dieser hybridzellen und deren verwendung zur herstellung dieses polypeptids.
DE3853590D1 (de)	1995-05-18	Rinder granulocyt-makrophagenkolonie stimulierender faktor.
EP0369229A3 (de)	1991-07-03	Verfahren zur Herstellung von Kunststoffen nach dem Polyisocyanatpolyadditionsverfahren sowie dafür geeignete Katalysatoren
DE3684560D1 (de)	1992-04-30	Verwendung von ergolinderivaten zur herstellung eines arzneimittels zum schutz der nerven.
ATE48985T1 (de)	1990-01-15	Verfahren zur herstellung von organotonen mit gelbildungseigenschaften.