ATE485394T1 - Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai - Google Patents
Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnaiInfo
- Publication number
- ATE485394T1 ATE485394T1 AT04753972T AT04753972T ATE485394T1 AT E485394 T1 ATE485394 T1 AT E485394T1 AT 04753972 T AT04753972 T AT 04753972T AT 04753972 T AT04753972 T AT 04753972T AT E485394 T1 ATE485394 T1 AT E485394T1
- Authority
- AT
- Austria
- Prior art keywords
- sirna duplex
- antisense strand
- fnai
- specificity
- effectiveness
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/331—Universal or degenerate base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47533103P | 2003-06-02 | 2003-06-02 | |
| US50792803P | 2003-09-30 | 2003-09-30 | |
| US57526804P | 2004-05-28 | 2004-05-28 | |
| PCT/US2004/017256 WO2005001043A2 (en) | 2003-06-02 | 2004-06-02 | METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE485394T1 true ATE485394T1 (de) | 2010-11-15 |
Family
ID=33556382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04753972T ATE485394T1 (de) | 2003-06-02 | 2004-06-02 | Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8309704B2 (de) |
| EP (2) | EP2314692B1 (de) |
| AT (1) | ATE485394T1 (de) |
| AU (2) | AU2004252442B2 (de) |
| CA (1) | CA2527958C (de) |
| DE (1) | DE602004029678D1 (de) |
| ES (2) | ES2864206T3 (de) |
| WO (1) | WO2005001043A2 (de) |
Families Citing this family (122)
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| US9879266B2 (en) | 2002-11-14 | 2018-01-30 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7781575B2 (en) | 2002-11-14 | 2010-08-24 | Dharmacon, Inc. | siRNA targeting tumor protein 53 (p53) |
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| US7612196B2 (en) | 2002-11-14 | 2009-11-03 | Dharmacon, Inc. | siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
| US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
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| EP1666593A4 (de) * | 2003-08-18 | 2009-07-15 | Japan Health Science Found | Verbessertes sirna-molekül und verfahren zur hemmung der genexpression unter verwendung davon |
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- 2004-06-02 DE DE602004029678T patent/DE602004029678D1/de not_active Expired - Lifetime
- 2004-06-02 EP EP10181632.0A patent/EP2314692B1/de not_active Expired - Lifetime
- 2004-06-02 ES ES10181632T patent/ES2864206T3/es not_active Expired - Lifetime
- 2004-06-02 CA CA2527958A patent/CA2527958C/en not_active Expired - Lifetime
- 2004-06-02 ES ES04753972T patent/ES2357116T5/es not_active Expired - Lifetime
- 2004-06-02 EP EP04753972.1A patent/EP1633890B2/de not_active Expired - Lifetime
- 2004-06-02 WO PCT/US2004/017256 patent/WO2005001043A2/en active Application Filing
- 2004-06-02 AT AT04753972T patent/ATE485394T1/de not_active IP Right Cessation
- 2004-06-02 US US10/859,321 patent/US8309704B2/en active Active
- 2004-06-02 AU AU2004252442A patent/AU2004252442B2/en not_active Expired
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| DE602004029678D1 (de) | 2010-12-02 |
| CA2527958C (en) | 2014-04-08 |
| US20050181382A1 (en) | 2005-08-18 |
| ES2357116T3 (es) | 2011-04-18 |
| CA2527958A1 (en) | 2005-01-06 |
| ES2864206T3 (es) | 2021-10-13 |
| EP2314692B1 (de) | 2021-02-24 |
| EP1633890B2 (de) | 2020-11-18 |
| AU2010202861A1 (en) | 2010-08-05 |
| WO2005001043A3 (en) | 2005-12-29 |
| AU2004252442B2 (en) | 2010-04-08 |
| EP1633890B1 (de) | 2010-10-20 |
| WO2005001043A2 (en) | 2005-01-06 |
| US8309704B2 (en) | 2012-11-13 |
| EP2314692A3 (de) | 2011-08-03 |
| EP1633890A2 (de) | 2006-03-15 |
| EP1633890A4 (de) | 2006-11-29 |
| ES2357116T5 (es) | 2021-09-03 |
| AU2010202861B2 (en) | 2013-05-23 |
| AU2004252442A1 (en) | 2005-01-06 |
| EP2314692A2 (de) | 2011-04-27 |
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