ATE485059T1 - Tumortherapie mit vektoren auf sindbis virus- basis - Google Patents
Tumortherapie mit vektoren auf sindbis virus- basisInfo
- Publication number
- ATE485059T1 ATE485059T1 AT02728587T AT02728587T ATE485059T1 AT E485059 T1 ATE485059 T1 AT E485059T1 AT 02728587 T AT02728587 T AT 02728587T AT 02728587 T AT02728587 T AT 02728587T AT E485059 T1 ATE485059 T1 AT E485059T1
- Authority
- AT
- Austria
- Prior art keywords
- vectors
- sindbis virus
- based vectors
- tumor therapy
- alphavirus
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 241000710929 Alphavirus Species 0.000 abstract 2
- 102000002297 Laminin Receptors Human genes 0.000 abstract 1
- 108010000851 Laminin Receptors Proteins 0.000 abstract 1
- 241000710960 Sindbis virus Species 0.000 abstract 1
- 206010054094 Tumour necrosis Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27905101P | 2001-03-27 | 2001-03-27 | |
US31137301P | 2001-08-10 | 2001-08-10 | |
PCT/US2002/009432 WO2002076468A1 (en) | 2001-03-27 | 2002-03-27 | Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE485059T1 true ATE485059T1 (de) | 2010-11-15 |
Family
ID=26959427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02728587T ATE485059T1 (de) | 2001-03-27 | 2002-03-27 | Tumortherapie mit vektoren auf sindbis virus- basis |
Country Status (9)
Country | Link |
---|---|
US (5) | US7306792B2 (de) |
EP (1) | EP1383513B1 (de) |
JP (1) | JP5089847B2 (de) |
CN (1) | CN1520303B (de) |
AT (1) | ATE485059T1 (de) |
AU (1) | AU2002258631B2 (de) |
CA (1) | CA2440890C (de) |
DE (1) | DE60238044D1 (de) |
WO (1) | WO2002076468A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1520303B (zh) * | 2001-03-27 | 2013-04-24 | 纽约大学 | 利用基于α病毒且靶向高亲和性层粘连蛋白受体的载体进行肿瘤治疗 |
CA2575591A1 (en) | 2003-08-08 | 2005-02-17 | Yuji Shino | A pharmaceutical composition for treatment of cancers |
US7910093B2 (en) * | 2003-08-19 | 2011-03-22 | New York University | Method for detecting cancer cells and monitoring cancer therapy |
WO2005118802A2 (en) | 2004-06-03 | 2005-12-15 | The Regents Of The University Of California | Targeting pseudotyped retroviral vectors |
US7303898B2 (en) | 2005-03-29 | 2007-12-04 | New York University | Defective sindbis viral vectors |
WO2009105673A2 (en) * | 2008-02-21 | 2009-08-27 | New York University | Tumor therapy with replication competent sindbis viral vectors |
WO2010005704A2 (en) * | 2008-06-13 | 2010-01-14 | New York University | Novel helper plasmid, defective sindbis viral vectors and methods of use thereof |
US20110010782A1 (en) * | 2009-07-09 | 2011-01-13 | Microsoft Corporation | Adapting parasites to combat disease |
JP5817053B2 (ja) * | 2010-04-02 | 2015-11-18 | 国立大学法人 千葉大学 | 腫瘍特異性を有するリポソーム |
JP2016530300A (ja) * | 2013-09-06 | 2016-09-29 | ニューヨーク・ユニバーシティ | シンドビスウイルスベクター及び腫瘍関連抗原を用いる抗腫瘍免疫誘導法 |
CA3015530A1 (en) * | 2016-03-04 | 2017-09-08 | New York University | Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity |
US20200377598A1 (en) | 2017-03-03 | 2020-12-03 | New York University | Induction and Enhancement of Antitumor Immunity Involving Virus Vectors Expressing Multiple Epitopes of Tumor Associated Antigens and Immune Checkpoint Inhibitors or Proteins |
US20200407401A1 (en) * | 2018-01-04 | 2020-12-31 | Washington University | Compositions and methods for inhibition of alphavirus infection |
EP3997125A1 (de) | 2019-07-08 | 2022-05-18 | New York University | Tumorimmuntherapie unter verwendung von viralen sindbis-vektoren und agonistischen monoklonalen antikörpern |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
US6770283B1 (en) | 1990-12-13 | 2004-08-03 | Bioption Ab | DNA expression systems based on alphaviruses |
US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
SE9401091D0 (sv) | 1994-03-31 | 1994-03-31 | Bioption Ab | Alphavirus cDNA vectors |
SE9401709D0 (sv) | 1994-05-18 | 1994-05-18 | Mathilda Sjoeberg | Improved alphavirus vectors for expression of heterologous DNA |
FR2746110B1 (fr) * | 1996-03-14 | 1998-04-17 | Methode de traitement par therapie genique des tumeurs humaines et virus recombinants correspondants | |
US6458560B1 (en) | 1996-04-05 | 2002-10-01 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
AU742365B2 (en) * | 1997-03-14 | 2002-01-03 | Selective Genetics, Inc. | Adenoviral vectors with modified tropism |
US7470426B1 (en) * | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
AU9603898A (en) * | 1997-10-09 | 1999-05-03 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
AU2796799A (en) * | 1998-03-03 | 1999-09-20 | Uab Research Foundation, The | Amplification of gene transfer and gene therapy by controlled replication |
CN1230595A (zh) * | 1998-04-02 | 1999-10-06 | 武汉大学 | 缺失调亡抑制基因病毒的构建及在肿瘤基因治疗中的应用 |
CN1258742A (zh) * | 1998-12-25 | 2000-07-05 | 华西医科大学 | ***抑制基因p53缺陷肿瘤的重组毒素腺病毒突变体 |
US6329201B1 (en) | 1998-12-31 | 2001-12-11 | Chiron Corporation | Compositions and methods for packaging of alphavirus vectors |
AU2220800A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Compositions and methods for packaging of alphavirus vectors |
CN1477964A (zh) * | 1999-04-15 | 2004-02-25 | 应用病毒*** | |
US6730297B1 (en) | 1999-05-28 | 2004-05-04 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders |
CA2407518A1 (en) * | 2000-04-26 | 2001-11-01 | Crucell Holland B.V. | Adenovirus vectors with knobless fibers, and their uses |
AU2002306736A1 (en) | 2001-03-16 | 2002-10-03 | Johns Hopkins University | A replication-defective alphavirus vaccine linking antigen with an immunogenicity-potentiating polypeptide and a method of delivery the same |
CN1520303B (zh) * | 2001-03-27 | 2013-04-24 | 纽约大学 | 利用基于α病毒且靶向高亲和性层粘连蛋白受体的载体进行肿瘤治疗 |
CA2575591A1 (en) * | 2003-08-08 | 2005-02-17 | Yuji Shino | A pharmaceutical composition for treatment of cancers |
-
2002
- 2002-03-27 CN CN028072286A patent/CN1520303B/zh not_active Expired - Fee Related
- 2002-03-27 US US10/473,477 patent/US7306792B2/en not_active Expired - Lifetime
- 2002-03-27 WO PCT/US2002/009432 patent/WO2002076468A1/en active IP Right Grant
- 2002-03-27 AT AT02728587T patent/ATE485059T1/de not_active IP Right Cessation
- 2002-03-27 DE DE60238044T patent/DE60238044D1/de not_active Expired - Lifetime
- 2002-03-27 JP JP2002574982A patent/JP5089847B2/ja not_active Expired - Fee Related
- 2002-03-27 AU AU2002258631A patent/AU2002258631B2/en not_active Ceased
- 2002-03-27 CA CA2440890A patent/CA2440890C/en not_active Expired - Fee Related
- 2002-03-27 EP EP02728587A patent/EP1383513B1/de not_active Expired - Lifetime
-
2007
- 2007-10-30 US US11/928,564 patent/US7807147B2/en not_active Expired - Fee Related
-
2008
- 2008-09-29 US US12/240,474 patent/US20090041726A1/en not_active Abandoned
- 2008-11-13 US US12/270,230 patent/US20090081283A1/en not_active Abandoned
- 2008-11-13 US US12/270,150 patent/US20090081131A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080125391A1 (en) | 2008-05-29 |
JP2004532832A (ja) | 2004-10-28 |
US7306792B2 (en) | 2007-12-11 |
WO2002076468A1 (en) | 2002-10-03 |
AU2002258631B2 (en) | 2007-05-17 |
CN1520303B (zh) | 2013-04-24 |
US20090041726A1 (en) | 2009-02-12 |
US20090081283A1 (en) | 2009-03-26 |
CN1520303A (zh) | 2004-08-11 |
US20090081131A1 (en) | 2009-03-26 |
EP1383513A4 (de) | 2006-03-29 |
US7807147B2 (en) | 2010-10-05 |
DE60238044D1 (de) | 2010-12-02 |
CA2440890A1 (en) | 2002-10-03 |
JP5089847B2 (ja) | 2012-12-05 |
EP1383513A1 (de) | 2004-01-28 |
US20040102410A1 (en) | 2004-05-27 |
EP1383513B1 (de) | 2010-10-20 |
CA2440890C (en) | 2011-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |