ATE484596T1 - Mutantes herpes-simplex-virus und verwendung davon bei der behandlung von plattenepithelkarzinom - Google Patents
Mutantes herpes-simplex-virus und verwendung davon bei der behandlung von plattenepithelkarzinomInfo
- Publication number
- ATE484596T1 ATE484596T1 AT04798619T AT04798619T ATE484596T1 AT E484596 T1 ATE484596 T1 AT E484596T1 AT 04798619 T AT04798619 T AT 04798619T AT 04798619 T AT04798619 T AT 04798619T AT E484596 T1 ATE484596 T1 AT E484596T1
- Authority
- AT
- Austria
- Prior art keywords
- herpes simplex
- simplex virus
- cell carcinoma
- squamous cell
- treatment
- Prior art date
Links
- 241000700584 Simplexvirus Species 0.000 title abstract 5
- 206010041823 squamous cell carcinoma Diseases 0.000 title 1
- 102100026982 DCN1-like protein 1 Human genes 0.000 abstract 3
- 101000911746 Homo sapiens DCN1-like protein 1 Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000030279 gene silencing Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000000754 repressing effect Effects 0.000 abstract 1
- 229920002477 rna polymer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0326798.6A GB0326798D0 (en) | 2003-11-17 | 2003-11-17 | Methods for generating mutant virus |
US54130804P | 2004-02-03 | 2004-02-03 | |
PCT/GB2004/004908 WO2005049846A2 (en) | 2003-11-17 | 2004-11-17 | Mutant herpes simplex virus and use thereof in the treatment of squamous cell cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE484596T1 true ATE484596T1 (de) | 2010-10-15 |
Family
ID=29763982
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04798569T ATE433493T1 (de) | 2003-11-17 | 2004-11-17 | Für eine heterologe nitroreduktase kodierender onkolytischer herpes simplex virus |
AT04798619T ATE484596T1 (de) | 2003-11-17 | 2004-11-17 | Mutantes herpes-simplex-virus und verwendung davon bei der behandlung von plattenepithelkarzinom |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04798569T ATE433493T1 (de) | 2003-11-17 | 2004-11-17 | Für eine heterologe nitroreduktase kodierender onkolytischer herpes simplex virus |
Country Status (7)
Country | Link |
---|---|
US (3) | US7498161B2 (de) |
EP (3) | EP1692294A2 (de) |
JP (1) | JP2007511215A (de) |
AT (2) | ATE433493T1 (de) |
DE (2) | DE602004021496D1 (de) |
GB (1) | GB0326798D0 (de) |
WO (2) | WO2005049845A2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9415320D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | Cancer treatment |
EP1694852B1 (de) | 2003-11-17 | 2010-10-13 | Crusade Laboratories Limited | Mutantes herpes-simplex-virus und verwendung davon bei der behandlung von plattenepithelkarzinom |
WO2007026146A1 (en) * | 2005-08-30 | 2007-03-08 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
US7897146B2 (en) | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
GB0409596D0 (en) * | 2004-04-29 | 2004-06-02 | Crusade Lab Ltd | Novel herpes simplex viruses and uses thereof |
US20120301506A1 (en) * | 2010-11-23 | 2012-11-29 | Xiaoliu Zhang | Oncolytic Virus as an Inducer for Innate Antitumor Immunity |
US8163292B2 (en) | 2007-02-16 | 2012-04-24 | Virttu Biologics Limited | Herpes simplex viruses and methods of viral replication |
US20090081639A1 (en) * | 2007-05-31 | 2009-03-26 | Phil Hill | Assay for sensitivity to chemotherapeutic agents |
GB0714578D0 (en) * | 2007-07-26 | 2007-09-05 | Crusade Lab Ltd | Viruses |
US8334097B2 (en) * | 2009-05-01 | 2012-12-18 | Vivebio, Llc | Method of pooling and/or concentrating biological specimens for analysis |
WO2011119925A2 (en) * | 2010-03-25 | 2011-09-29 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses for treatment of cancers |
EP2593796A4 (de) * | 2010-07-16 | 2016-07-27 | Auckland Uniservices Ltd | Bakterielle nitroreduktase-enzyme und verfahren dafür |
US9447156B2 (en) | 2011-05-17 | 2016-09-20 | St. Jude Children's Research Hospital | Methods and compositions for inhibiting neddylation of proteins |
WO2013052915A2 (en) | 2011-10-05 | 2013-04-11 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
US20140087362A1 (en) | 2012-03-16 | 2014-03-27 | Aladar A. Szalay | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
EP2662117A1 (de) | 2012-05-11 | 2013-11-13 | Virttu Biologics Limited | Herpes Simplex Virus zur Behandlung von Leberkrebs |
WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
CA3126536C (en) | 2014-10-14 | 2023-07-25 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
KR102536850B1 (ko) | 2016-04-15 | 2023-05-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
KR20190006495A (ko) | 2016-04-15 | 2019-01-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Cd80 변이체 면역조절 단백질 및 그의 용도 |
US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
WO2018022946A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
SG11201903407XA (en) | 2016-10-20 | 2019-05-30 | Alpine Immune Sciences Inc | Secretable variant immunomodulatory proteins and engineered cell therapy |
CN110869052A (zh) | 2016-12-23 | 2020-03-06 | 维图生物制剂公司 | 癌症的治疗 |
WO2018148462A1 (en) | 2017-02-09 | 2018-08-16 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
WO2018170023A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Pd-l2 variant immunomodulatory proteins and uses thereof |
CA3054068A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
KR20240039221A (ko) | 2017-03-16 | 2024-03-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Pd-l1 리간드 변이체 면역조절 단백질 및 그의 용도 |
MA50404A (fr) | 2017-10-18 | 2020-08-26 | Alpine Immune Sciences Inc | Protéines immunomodulatrices à variants de ligand de icos variant, compositions et méthodes associées |
CN110117577B (zh) * | 2018-02-05 | 2023-10-24 | 中国科学院武汉物理与数学研究所 | 低毒单纯疱疹病毒***及其构建方法和应用 |
CA3098572A1 (en) * | 2018-05-01 | 2019-11-07 | Albert Einstein College Of Medicine | Hsv-2-delta-gd vaccines and methods for their production and use |
US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
CA3177467A1 (en) | 2018-06-04 | 2019-12-12 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
US20210363219A1 (en) | 2018-06-15 | 2021-11-25 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
US11242528B2 (en) | 2018-08-28 | 2022-02-08 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
EP3876951A1 (de) | 2018-11-06 | 2021-09-15 | Calidi Biotherapeutics, Inc. | Verbesserte systeme für zellvermittelte onkolytische virustherapie |
WO2020107002A2 (en) | 2018-11-21 | 2020-05-28 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (nk) cell subset and related compositions and methods |
TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
CA3120868A1 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
EP3931210A1 (de) | 2019-02-27 | 2022-01-05 | Actym Therapeutics, Inc. | Zur besiedlung von tumoren, tumorresidenten immunzellen und der mikroumgebung des tumors entwickelte immunstimulatorische bakterien |
US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
EP4139439A1 (de) | 2020-04-22 | 2023-03-01 | Indapta Therapeutics, Inc. | Zusammensetzungen natürlicher killerzellen (nk) und verfahren zur erzeugung davon |
TW202241479A (zh) | 2020-12-30 | 2022-11-01 | 美商安迅生物製藥公司 | 遞送外來抗原之溶瘤病毒及表現靶向外來抗原之嵌合受體之經工程化免疫細胞之組合療法 |
LT7046B (lt) | 2022-04-15 | 2024-02-12 | Vilniaus Universitetas | Hidrolazės ir jų panaudojimas |
Family Cites Families (26)
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US5965138A (en) | 1985-09-06 | 1999-10-12 | Syntro Corporation | Recombinant chimeric virus and uses thereof |
DE68912441T2 (de) | 1988-06-24 | 1994-05-11 | British Tech Group | Nichtessentielle Geflügelpockenvirus-Regionen. |
GB9102126D0 (en) | 1991-01-31 | 1991-03-13 | Smithkline Beecham Biolog | Novel vaccine |
ES2212795T3 (es) | 1991-08-26 | 2004-08-01 | Baxter Healthcare S.A. | Virus de la viruela de las aves de corral recombinante. |
AU681337B2 (en) * | 1991-10-23 | 1997-08-28 | Cancer Research Campaign Technology Limited | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form |
DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
CA2167706A1 (en) | 1993-07-27 | 1995-02-09 | Nigel Fraser | Modified dna virus vectors and uses therefor |
AT403167B (de) * | 1994-11-14 | 1997-11-25 | Immuno Ag | Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems |
EP0753581A1 (de) | 1995-07-10 | 1997-01-15 | Immuno Ag | Verbesserte rekombinante eukaryotische zytoplasmatische Viren, Methode ihrer Herstellung und ihrer Verwendung als Impfstoffe |
ZA966287B (en) | 1995-07-27 | 1998-03-09 | American Cyanamid Co | Avirulent herpetic viruses useful as tumoricidal agents and vaccines. |
WO1997014808A2 (en) | 1995-10-19 | 1997-04-24 | St. Jude Children's Research Hospital | Herpesvirus vectors and their uses |
US5998174A (en) | 1997-05-12 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Multigene vectors |
GB9801930D0 (en) * | 1998-01-29 | 1998-03-25 | Univ London | Mutant herpes simplex viruses and uses thereof |
US5922576A (en) * | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
CA2327506A1 (en) * | 1998-04-30 | 1999-11-04 | The General Hospital Corporation | Combination viral-based and gene-based therapy of tumors |
EP1153136A2 (de) * | 1998-12-09 | 2001-11-14 | The General Hospital Corporation | Verbessertes verpacken von hsv-amplikons und herstellung von rekombinanten viralen vektoren |
ES2233349T3 (es) * | 1999-08-31 | 2005-06-16 | The General Hospital Corporation | Reordenacion por promotores especificos para una celula y/o especificos para un tumor de la expresion del gen gamma 34,5 herpetico. |
EP1111061A1 (de) * | 1999-12-20 | 2001-06-27 | Universite Libre De Bruxelles | Vektor mit doppelter Selektion |
GB9930418D0 (en) | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
EP1568779A1 (de) * | 2000-01-21 | 2005-08-31 | BioVex Limited | hsv-stämme für die onkolytische behandlung von krebs |
CA2452653A1 (en) * | 2001-07-17 | 2003-01-30 | Anne Josephine Milner | Silencing of gene expression by sirna |
NZ531413A (en) | 2001-08-21 | 2006-01-27 | Innovata Plc | Improved nitroreductase enzymes |
US7348418B2 (en) | 2002-02-08 | 2008-03-25 | Memorial Sloan-Kettering Cancer Center | Carcinoma-related genes and polypeptides and methods of use thereof |
GB0203285D0 (en) * | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
JP2005519091A (ja) * | 2002-03-01 | 2005-06-30 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 癌の再発及び転移の予防 |
US7288529B2 (en) * | 2003-04-24 | 2007-10-30 | New York University | ALK protein tyrosine kinase, cells and methods embodying and using same |
-
2003
- 2003-11-17 GB GBGB0326798.6A patent/GB0326798D0/en not_active Ceased
-
2004
- 2004-11-17 EP EP04798558A patent/EP1692294A2/de not_active Withdrawn
- 2004-11-17 DE DE602004021496T patent/DE602004021496D1/de active Active
- 2004-11-17 US US10/579,606 patent/US7498161B2/en active Active
- 2004-11-17 EP EP10186056A patent/EP2281897A3/de not_active Withdrawn
- 2004-11-17 AT AT04798569T patent/ATE433493T1/de not_active IP Right Cessation
- 2004-11-17 US US10/579,607 patent/US20070110720A1/en not_active Abandoned
- 2004-11-17 JP JP2006538966A patent/JP2007511215A/ja active Pending
- 2004-11-17 DE DE602004029608T patent/DE602004029608D1/de active Active
- 2004-11-17 WO PCT/GB2004/004851 patent/WO2005049845A2/en active Application Filing
- 2004-11-17 WO PCT/GB2004/004839 patent/WO2005049844A2/en active Application Filing
- 2004-11-17 EP EP04798569A patent/EP1685254B1/de active Active
- 2004-11-17 AT AT04798619T patent/ATE484596T1/de not_active IP Right Cessation
-
2009
- 2009-01-21 US US12/357,123 patent/US20090208460A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE602004029608D1 (de) | 2010-11-25 |
WO2005049845A2 (en) | 2005-06-02 |
US20090208460A1 (en) | 2009-08-20 |
US7498161B2 (en) | 2009-03-03 |
WO2005049844A3 (en) | 2005-10-20 |
WO2005049844A2 (en) | 2005-06-02 |
GB0326798D0 (en) | 2003-12-24 |
EP1685254B1 (de) | 2009-06-10 |
ATE433493T1 (de) | 2009-06-15 |
EP1685254A2 (de) | 2006-08-02 |
EP2281897A3 (de) | 2011-11-30 |
EP1692294A2 (de) | 2006-08-23 |
US20070110720A1 (en) | 2007-05-17 |
US20070098689A1 (en) | 2007-05-03 |
WO2005049845A3 (en) | 2005-10-27 |
WO2005049845A9 (en) | 2006-08-17 |
DE602004021496D1 (de) | 2009-07-23 |
EP2281897A2 (de) | 2011-02-09 |
JP2007511215A (ja) | 2007-05-10 |
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