ATE483714T1 - Podophyllotoxine als antiproliferative mittel - Google Patents
Podophyllotoxine als antiproliferative mittelInfo
- Publication number
- ATE483714T1 ATE483714T1 AT02791768T AT02791768T ATE483714T1 AT E483714 T1 ATE483714 T1 AT E483714T1 AT 02791768 T AT02791768 T AT 02791768T AT 02791768 T AT02791768 T AT 02791768T AT E483714 T1 ATE483714 T1 AT E483714T1
- Authority
- AT
- Austria
- Prior art keywords
- podophyllotoxins
- antiproliferative agents
- antiproliferative
- agents
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10160515 | 2001-12-03 | ||
PCT/EP2002/013669 WO2003048166A1 (en) | 2001-12-03 | 2002-12-03 | Podophyllotoxins as antiproliferative agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE483714T1 true ATE483714T1 (de) | 2010-10-15 |
Family
ID=7708614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02791768T ATE483714T1 (de) | 2001-12-03 | 2002-12-03 | Podophyllotoxine als antiproliferative mittel |
Country Status (10)
Country | Link |
---|---|
US (1) | US7582778B2 (de) |
EP (2) | EP1451193B1 (de) |
JP (2) | JP4527978B2 (de) |
AT (1) | ATE483714T1 (de) |
AU (1) | AU2002358086B2 (de) |
CA (1) | CA2468479C (de) |
DE (1) | DE60237915D1 (de) |
DK (1) | DK2327705T3 (de) |
ES (2) | ES2545393T3 (de) |
WO (1) | WO2003048166A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
JP4527978B2 (ja) * | 2001-12-03 | 2010-08-18 | ウニベルジテートスクリーニクム シャリテー デア フンボルト−ウニベルジテート ツー ベルリン テクノロジー トランスファーステラ | ポドフィロトキシン |
DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
US20110191868A1 (en) | 2008-04-10 | 2011-08-04 | Massachusetts Institute Of Technology | Methods for identification and use of agents targeting cancer stem cells |
US20100256385A1 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Prostaglandin e receptor antagonists |
JP5727000B2 (ja) * | 2010-04-16 | 2015-06-03 | ツェルアクト ファーマ ゲーエムベーハー | 腫瘍の処置のためのエポトシドのアナログ |
CN102070645B (zh) * | 2011-01-07 | 2015-04-22 | 兰州大学 | 一种脱氧鬼臼毒素类化合物及其制备与应用 |
US10106778B2 (en) | 2012-11-08 | 2018-10-23 | Whitehead Institute For Biomedical Research | Selective targeting of cancer stem cells |
GB2513299A (en) | 2013-03-12 | 2014-10-29 | Cellact Pharma Gmbh Biomedizinzentrum | Compounds for targeting cancer stem cells |
US10398672B2 (en) | 2014-04-29 | 2019-09-03 | Whitehead Institute For Biomedical Research | Methods and compositions for targeting cancer stem cells |
EP3211091A1 (de) * | 2016-02-24 | 2017-08-30 | CellAct Pharma GmbH | Verfahren zur diagnose von mit etoposid-prodrug behandelbarem krebs |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
ZA886810B (en) * | 1987-12-18 | 1989-08-30 | Bristol Myers Co | Epipodophyllotoxin glucoside 4'-acyl derivatives |
US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
DE3935016A1 (de) | 1989-10-20 | 1991-04-25 | Behringwerke Ag | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten |
US6610841B1 (en) | 1997-12-18 | 2003-08-26 | Gilead Sciences, Inc. | Nucleotide-based prodrugs |
JP4115514B2 (ja) | 1991-10-23 | 2008-07-09 | キャンサー・リサーチ・キヤンペーン・テクノロジー・リミテツド | Cb 1954およびその類似体を細胞障害性の形態に還元するための細菌のニトロリダクターゼ |
DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
US5605976A (en) | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
CA2264227A1 (en) | 1996-09-27 | 1998-04-02 | Raymond A. Firestone | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
JP4527978B2 (ja) * | 2001-12-03 | 2010-08-18 | ウニベルジテートスクリーニクム シャリテー デア フンボルト−ウニベルジテート ツー ベルリン テクノロジー トランスファーステラ | ポドフィロトキシン |
-
2002
- 2002-12-03 JP JP2003549356A patent/JP4527978B2/ja not_active Expired - Lifetime
- 2002-12-03 EP EP02791768A patent/EP1451193B1/de not_active Expired - Lifetime
- 2002-12-03 US US10/497,521 patent/US7582778B2/en not_active Expired - Lifetime
- 2002-12-03 WO PCT/EP2002/013669 patent/WO2003048166A1/en active Application Filing
- 2002-12-03 AT AT02791768T patent/ATE483714T1/de not_active IP Right Cessation
- 2002-12-03 ES ES10010826.5T patent/ES2545393T3/es not_active Expired - Lifetime
- 2002-12-03 EP EP10010826.5A patent/EP2327705B1/de not_active Expired - Lifetime
- 2002-12-03 ES ES02791768T patent/ES2354065T3/es not_active Expired - Lifetime
- 2002-12-03 DK DK10010826.5T patent/DK2327705T3/en active
- 2002-12-03 CA CA2468479A patent/CA2468479C/en not_active Expired - Lifetime
- 2002-12-03 DE DE60237915T patent/DE60237915D1/de not_active Expired - Lifetime
- 2002-12-03 AU AU2002358086A patent/AU2002358086B2/en not_active Expired
-
2009
- 2009-11-27 JP JP2009269930A patent/JP5302862B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1451193B1 (de) | 2010-10-06 |
AU2002358086A1 (en) | 2003-06-17 |
EP1451193A1 (de) | 2004-09-01 |
ES2545393T3 (es) | 2015-09-10 |
JP4527978B2 (ja) | 2010-08-18 |
EP2327705A1 (de) | 2011-06-01 |
DE60237915D1 (en) | 2010-11-18 |
AU2002358086B2 (en) | 2009-06-04 |
CA2468479C (en) | 2010-04-27 |
ES2354065T3 (es) | 2011-03-09 |
US20060293254A1 (en) | 2006-12-28 |
JP2005517645A (ja) | 2005-06-16 |
JP5302862B2 (ja) | 2013-10-02 |
WO2003048166A1 (en) | 2003-06-12 |
CA2468479A1 (en) | 2003-06-12 |
DK2327705T3 (en) | 2015-08-24 |
US7582778B2 (en) | 2009-09-01 |
EP2327705B1 (de) | 2015-05-27 |
JP2010120943A (ja) | 2010-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |