ATE481094T1 - Behandlung von diabetischer nephropathie - Google Patents

Behandlung von diabetischer nephropathie

Info

Publication number
ATE481094T1
ATE481094T1 AT06849559T AT06849559T ATE481094T1 AT E481094 T1 ATE481094 T1 AT E481094T1 AT 06849559 T AT06849559 T AT 06849559T AT 06849559 T AT06849559 T AT 06849559T AT E481094 T1 ATE481094 T1 AT E481094T1
Authority
AT
Austria
Prior art keywords
treatment
compositions
compounds
methods
diabetic nephropathy
Prior art date
Application number
AT06849559T
Other languages
English (en)
Inventor
Wendy Hauck
Pavel Hamet
Original Assignee
Kiacta Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kiacta Sarl filed Critical Kiacta Sarl
Application granted granted Critical
Publication of ATE481094T1 publication Critical patent/ATE481094T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06849559T 2005-12-22 2006-12-22 Behandlung von diabetischer nephropathie ATE481094T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75307205P 2005-12-22 2005-12-22
PCT/IB2006/004262 WO2007125385A2 (en) 2005-12-22 2006-12-22 Treatment of renal disorders, diabetic nephopathy and dyslipidemias

Publications (1)

Publication Number Publication Date
ATE481094T1 true ATE481094T1 (de) 2010-10-15

Family

ID=38655869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06849559T ATE481094T1 (de) 2005-12-22 2006-12-22 Behandlung von diabetischer nephropathie

Country Status (12)

Country Link
US (1) US8372886B2 (de)
EP (1) EP1968561B8 (de)
CN (1) CN101453999A (de)
AT (1) ATE481094T1 (de)
AU (1) AU2006342958A1 (de)
BR (1) BRPI0620637A2 (de)
CA (1) CA2634871A1 (de)
DE (1) DE602006016990D1 (de)
ES (1) ES2352801T3 (de)
IL (1) IL192377A0 (de)
MX (1) MX2008008213A (de)
WO (1) WO2007125385A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2352801T3 (es) 2005-12-22 2011-02-23 Kiacta Sàrl Tratamiento de nefropatía diabética.
WO2007095536A2 (en) * 2006-02-13 2007-08-23 Mount Sinai School Of Medicine Treatment and prevention of renal disease
MX2009006768A (es) * 2006-12-22 2009-08-31 Bellus Health Int Ltd Metodos, compuestos, y composiciones para tratar trastornos metabolicos y diabetes.
EP2479571A3 (de) * 2007-03-26 2012-09-26 Novartis AG Prognostische Biomarker der renalen Sicherheit und Biomarker-Signatur zur Überwachung der Nierenfunktion
SG10201600910YA (en) * 2009-08-10 2016-03-30 Bhi Ltd Partnership Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid
RU2473134C2 (ru) * 2011-03-29 2013-01-20 Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Министерства здравоохранения и социального развития РФ Способ профилактики системного амилоидоза и его нефропатической формы у экспериментальных животных
RU2473133C2 (ru) * 2011-03-30 2013-01-20 Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Министерства здравоохранения и социального развития РФ Способ профилактики системного амилоидоза и его нефропатической формы у экспериментальных животных
MX2016014261A (es) * 2014-04-30 2017-05-04 Icahn School Med Mount Sinai Uso de acido 1,3-propandisulfonico o sales farmaceuticamente aceptables del mismo para el tratamiento de sarcoidosis.
US10869884B2 (en) * 2016-09-19 2020-12-22 Aten Porus Lifesciences Cyclodextrin based polymers, methods, compositions and applications thereof
WO2019195773A1 (en) * 2018-04-05 2019-10-10 The George Washington University METHOD OF TREATING A MAMMAL WITH DIABETES ASSOCIATED KIDNEY DISEASE USING LOCAL ADMINISTRATION OF STEM CELLS WITH TRANSIENTLY REDUCED p53
CN109453191A (zh) * 2018-12-06 2019-03-12 郑州大学第附属医院 GSK-3β抑制剂及在糖尿病肾病干预新靶点的应用

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2531468A (en) * 1949-04-14 1950-11-28 Eastman Kodak Co Polyvinyl sulfonates and process for their preparation
DE1122064B (de) * 1960-01-09 1962-01-18 Basf Ag Verfahren zur Einfuehrung von alyphatischen Kohlenwasserstoffresten in organische Verbindungen, die Hydroxylgruppen, tertiaere Aminogruppen, aromatische gebundene Sulfhydrylgruppen und bzw. oder aromatisch gebundene primaere oder sekundaere Aminogruppen enthalten
US3218352A (en) * 1962-05-03 1965-11-16 Abbott Lab Homotaurine process
US3174901A (en) * 1963-01-31 1965-03-23 Jan Marcel Didier Aron Samuel Process for the oral treatment of diabetes
US3658966A (en) * 1969-09-15 1972-04-25 Kowa Co Methods of treating hypertension
US3920833A (en) * 1974-08-08 1975-11-18 Stanley Drug Products Inc Antifibrinolytic agents
CA1144937A (en) * 1977-12-22 1983-04-19 Dke J.E. Helgstrand Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections
FR2437834A1 (fr) 1978-10-04 1980-04-30 Lejeune Jerome Compositions pharmaceutiques a base de l-serine ou de glycine
FR2457281A1 (fr) * 1979-05-23 1980-12-19 Meram Lab Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee
US4255448A (en) * 1979-09-10 1981-03-10 Wisconsin Alumni Research Foundation Method for reducing epileptiform activity
US4448779A (en) 1981-07-16 1984-05-15 Sanofi Use of MS salt in geriatric medicine
JPS5879022A (ja) 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
US4448184A (en) * 1982-02-05 1984-05-15 Zmijewski Raymond W Sine bar grinding wheel dresser
US5087618A (en) * 1982-05-18 1992-02-11 University Of Florida Redox carriers for brain-specific drug delivery
US4657704A (en) * 1982-09-08 1987-04-14 Mitsui Toatsu Chemicals, Incorporated Production of aminoalkylsulfonic acids
US4737353A (en) * 1984-04-13 1988-04-12 Union Carbide Corporation Beryllium-aluminum-phosphorus-silicon-oxide molecular sieve compositions
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
JPH0733332B2 (ja) * 1985-11-19 1995-04-12 富山化学工業株式会社 痴呆症状改善・治療剤
JPH0786122B2 (ja) * 1986-05-30 1995-09-20 日本ペイント株式会社 三次元架橋された微小樹脂粒子およびその製造法
US4919915A (en) 1987-03-03 1990-04-24 Paul Averback Method for detecting the ability to prevent red-to-green congophilic birefringence
US4847082A (en) * 1987-01-21 1989-07-11 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
US4883666A (en) * 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
AU1790988A (en) 1987-05-19 1988-12-21 Baylor College Of Medicine Phosphoethanolamine for treatment of alzheimer's disease
IT1205042B (it) * 1987-05-28 1989-03-10 Crinos Industria Farmaco Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer
IT1211792B (it) 1987-09-21 1989-11-03 Sigma Tau Ind Farmaceuti O-alcanoil derivati dell'acido 3ammino-2-idrossipropansolfonico adattivita'anticonvulsivante e loro composizioni farmaceutiche per il trattamento terapeutico dell'epilessia
DK505488D0 (da) 1987-12-21 1988-09-09 Bar Shalom Daniel Middel og anvendelse af samme
IT1212000B (it) 1987-12-24 1989-11-08 Sigma Tau Ind Farmaceuti Fenilbenziliden-derivati dell'acido 3)amminopropansolfonico ad attivita' anticonvulsivante e loro composizioni farmaceutiche per il trattamento terapeutico della epilessia
US4968678A (en) 1988-02-19 1990-11-06 Eli Lilly And Company Tetrazole excitatory amino acid receptor antagonists
ATE87918T1 (de) 1988-02-19 1993-04-15 Lilly Co Eli Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren.
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
DE4004978A1 (de) 1990-02-19 1991-08-22 Nmi Naturwissenschaftl U Mediz Praeventive therapie fuer morbus alzheimer
US5091432A (en) * 1990-03-28 1992-02-25 Glasky Alvin J 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
US5242932A (en) 1991-12-17 1993-09-07 The Rockefeller University Treatment of amyloidosis associated with alzheimer disease
US5385915A (en) * 1990-05-16 1995-01-31 The Rockefeller University Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
JPH0725786A (ja) 1990-05-16 1995-01-27 Univ Rockefeller アルツハイマー病を伴うアミロイドーシスの治療
DE4021066A1 (de) 1990-07-03 1992-01-09 Hoechst Ag Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden
DE69125216T2 (de) * 1990-07-19 1997-09-25 Nippon Zoki Pharmaceutical Co Aminoalkanesulfonsäurederivate und pharmazeutische Zusammensetzungen davon zur Prävention oder Behandlung von Herzerkrankungen
US5137873A (en) 1990-07-27 1992-08-11 The Children's Medical Center Corporation Substance p and tachykinin agonists for treatment of alzheimer's disease
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US6746678B1 (en) * 1991-02-22 2004-06-08 Howard K. Shapiro Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments
CA2104594C (en) 1991-02-22 2004-05-11 Howard K. Shapiro Use of pharmaceutical compounds in the treatment of symptoms of disorders related to neurological diseases and etiologically related symptomology
US5723496A (en) * 1991-03-05 1998-03-03 The Regents Of University Of California Method for prevention and treatment of harmful effects of intracellular acidosis
US5164295A (en) * 1991-03-06 1992-11-17 The Upjohn Company Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
GB9117716D0 (en) 1991-08-16 1991-10-02 Lynxvale Ltd Gaba derivatives and their therapeutic application
AU664710B2 (en) 1991-08-27 1995-11-30 Upjohn Company, The A method for treatment of metabolic disorders
US5705401A (en) 1991-11-12 1998-01-06 The University Of Melbourne Method of assaying for alzheimer's disease
ATE147404T1 (de) * 1991-12-19 1997-01-15 Ciba Geigy Ag Aminosulfonsäurederivate und verfahren zu ihrer herstellung
EP0642337B1 (de) 1992-05-29 1997-09-03 University Of British Columbia Dapsone und promin zur behandlung der demenz
US5318958A (en) * 1992-05-29 1994-06-07 Queen's University At Kingston Amyloid precursor protein
EP0604641B1 (de) 1992-06-30 2002-03-20 SHAPIRO, Howard, K. Verwendung einer kombination bestehend aus einem aminderivat oder aminverwandten derivat der benzoesäure und einem amino-polysaccharide zur herstellung eines medikaments fuer die behandlung von entzündlichen erkrankungen
US5276059A (en) * 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
US5837672A (en) * 1992-07-10 1998-11-17 Athena Neurosciences, Inc. Methods and compositions for the detection of soluble β-amyloid peptide
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
US5972328A (en) * 1993-03-29 1999-10-26 Queen's University At Kingston Method for treating amyloidosis
EP1060750B1 (de) 1993-03-29 2005-12-07 Queen's University At Kingston Propan-1,3-disulphonsäure und deren pharmazeutisch akzeptable Salze zur Behandlung von Amyloidosis
US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5840294A (en) 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
IT1270846B (it) * 1993-05-10 1997-05-13 Alfa Wassermann Spa Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
US5455044A (en) * 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
AU6836394A (en) * 1993-06-01 1994-12-20 Cortex Pharmaceuticals, Inc. Use of metabotropic receptor agonists in progressive neurodegenerative deseases
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
DE4427813C2 (de) 1994-08-05 1996-07-11 Boewe Systec Ag Papierhandhabungssystem
IT1274351B (it) 1994-10-06 1997-07-17 Alfa Wassermann Spa Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
US5858326A (en) 1995-06-06 1999-01-12 Neurochem, Inc. Methods of increasing amyloid deposition
AU6959896A (en) 1995-09-01 1997-03-27 Howard K. Shapiro Methods and compositions for development of drug screening procedures and diagnostic tools
AU703540B2 (en) * 1996-03-26 1999-03-25 Meddiss, Incorporated Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general
US7030146B2 (en) * 1996-09-10 2006-04-18 University Of South Carolina Methods for treating diabetic neuropathy
US5989592A (en) * 1996-10-03 1999-11-23 Coastside Bio Resources Inhibition of complement pathway by sea cucumber fractions
US6306909B1 (en) * 1997-03-12 2001-10-23 Queen's University At Kingston Anti-epileptogenic agents
NZ550116A (en) 1997-08-18 2008-03-28 Neurochem Int Ltd Phosphono-carboxylate compounds for treating amyloidosis
US5869469A (en) * 1997-08-18 1999-02-09 Queen's University At Kingston Phosphonocarboxylate compounds for treating amyloidosis
US6294583B1 (en) * 1998-01-13 2001-09-25 Synchroneuron, Llc Methods of treating tardive dyskinesia and other movement disorders
US6391922B1 (en) * 1998-01-13 2002-05-21 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
JP2002501887A (ja) 1998-01-28 2002-01-22 ワーナー−ランバート・カンパニー アルツハイマー病の治療方法
CA2320224C (en) 1998-02-11 2008-08-12 Neurochem, Inc. Method for modulating macrophage activation
US20020022657A1 (en) * 1998-02-11 2002-02-21 Francine Gervais Methods for modulating neuronal cell death
US6329356B1 (en) * 1998-04-10 2001-12-11 Neurochem, Inc. Phosphono-carboxylate compounds for treating amyloidosis
US6310073B1 (en) * 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
IT1312107B1 (it) 1999-05-14 2002-04-04 Umberto Cornelli Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
EP1237547A2 (de) * 1999-07-09 2002-09-11 Isis Innovation Limited Verbindungen zur krankheitshemmung und zur bereitung von zellen zur transplantation
KR20090016517A (ko) * 1999-12-23 2009-02-13 벨루스 헬스 (인터내셔널) 리미티드 대뇌 아밀로이드 혈관병증을 조절하는 화합물 및 방법
US6376557B1 (en) * 2000-03-16 2002-04-23 Chanda Bhuwalka Zaveri Methods for treating alopecia
US7259152B2 (en) * 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US20020115717A1 (en) * 2000-07-25 2002-08-22 Francine Gervais Amyloid targeting imaging agents and uses thereof
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
JP2002058016A (ja) * 2000-08-11 2002-02-22 Sanyo Electric Co Ltd 画像蓄積サーバおよびその方法、画像蓄積サーバを用いた遠隔監視システム、撮像装置
IL157845A0 (en) * 2001-03-13 2004-03-28 Univ Kingston Anti-epileptogenic agents
US7501429B2 (en) * 2001-04-11 2009-03-10 Queen's University At Kingston Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
CA2448160A1 (en) * 2001-05-25 2002-12-05 Queen's University At Kingston Heterocyclic beta-amino acids and their use as anti-epileptogenic agents
JP2004533463A (ja) 2001-06-12 2004-11-04 ケリクス・バイオフアーマシユーチカルズ・インコーポレーテツド 腎症の治療のためのグリコサミノグリカンの使用方法
IL160208A0 (en) * 2001-08-31 2004-07-25 Neurochem Int Ltd Amidine derivatives for treating amyloidosis
US20030077833A1 (en) * 2001-09-07 2003-04-24 Queen's University At Kingston Diagnositc methods for determining susceptibility to convulsive conditions
ATE329914T1 (de) 2001-11-21 2006-07-15 Smithkline Beecham Plc Rosiglitazon-edisylate und ihre verwendung als antidiabetika
GEP20094759B (en) 2002-10-24 2009-08-25 Merz Pharma Gmbh & Co Kgaa Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
US20050031651A1 (en) * 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US20060135403A1 (en) 2002-12-24 2006-06-22 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
JP5392980B2 (ja) * 2003-03-27 2014-01-22 チルドレンズ ホスピタル メディカル センター 早発型の腎尿細管細胞障害を検出するための方法およびキット
US7253306B2 (en) * 2003-06-23 2007-08-07 Neurochem (International) Limited Pharmaceutical drug candidates and methods for preparation thereof
CA2529269C (en) 2003-06-23 2012-02-07 Neurochem (International) Limited Improved pharmaceutical drug candidates and methods for preparation thereof
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20050038000A1 (en) * 2003-06-23 2005-02-17 Xianqi Kong Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US20050214294A1 (en) * 2004-02-11 2005-09-29 Allan Flyvbjerg Diabetic nephropathy therapies
JP2008515807A (ja) 2004-10-01 2008-05-15 ケリク ビオファルマセウチカルス インコーポレーテッド 腎臓疾患の治療にグリコサミノグリカンを用いる方法
US20060183800A1 (en) * 2004-11-12 2006-08-17 Xianqi Kong Methods and fluorinated compositions for treating amyloid-related diseases
US20060167057A1 (en) * 2004-11-16 2006-07-27 Xianqi Kong Compounds for the treatment of CNS and amyloid associated diseases
CA2592320C (en) * 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2006121853A1 (en) 2005-05-05 2006-11-16 Keryx Biopharmaceuticals, Inc. Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy
ES2352801T3 (es) 2005-12-22 2011-02-23 Kiacta Sàrl Tratamiento de nefropatía diabética.

Also Published As

Publication number Publication date
EP1968561A2 (de) 2008-09-17
CN101453999A (zh) 2009-06-10
MX2008008213A (es) 2008-09-03
WO2007125385A3 (en) 2008-03-20
BRPI0620637A2 (pt) 2011-11-16
EP1968561B8 (de) 2010-10-20
ES2352801T3 (es) 2011-02-23
DE602006016990D1 (de) 2010-10-28
US8372886B2 (en) 2013-02-12
AU2006342958A1 (en) 2007-11-08
IL192377A0 (en) 2009-08-03
US20070238788A1 (en) 2007-10-11
EP1968561B1 (de) 2010-09-15
WO2007125385A2 (en) 2007-11-08
CA2634871A1 (en) 2007-11-08

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