ATE473747T1 - NEUE VERWENDUNG DES MIFEPRISTON UND DESSEN DERIVATEN ZUR MODULIERUNG DES ßHEDGEHOGß- PROTEINSIGNALWEGES UND DESSEN ANWENDUNGEN - Google Patents
NEUE VERWENDUNG DES MIFEPRISTON UND DESSEN DERIVATEN ZUR MODULIERUNG DES ßHEDGEHOGß- PROTEINSIGNALWEGES UND DESSEN ANWENDUNGENInfo
- Publication number
- ATE473747T1 ATE473747T1 AT04704259T AT04704259T ATE473747T1 AT E473747 T1 ATE473747 T1 AT E473747T1 AT 04704259 T AT04704259 T AT 04704259T AT 04704259 T AT04704259 T AT 04704259T AT E473747 T1 ATE473747 T1 AT E473747T1
- Authority
- AT
- Austria
- Prior art keywords
- steroid
- modulating
- signaling pathway
- protein signaling
- aralkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0300646A FR2850022B1 (fr) | 2003-01-22 | 2003-01-22 | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
PCT/FR2004/000151 WO2004067550A2 (fr) | 2003-01-22 | 2004-01-22 | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE473747T1 true ATE473747T1 (de) | 2010-07-15 |
Family
ID=32605913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04704259T ATE473747T1 (de) | 2003-01-22 | 2004-01-22 | NEUE VERWENDUNG DES MIFEPRISTON UND DESSEN DERIVATEN ZUR MODULIERUNG DES ßHEDGEHOGß- PROTEINSIGNALWEGES UND DESSEN ANWENDUNGEN |
Country Status (8)
Country | Link |
---|---|
US (1) | US8703752B2 (de) |
EP (1) | EP1585526B1 (de) |
JP (1) | JP4667363B2 (de) |
AT (1) | ATE473747T1 (de) |
CA (1) | CA2513717C (de) |
DE (1) | DE602004028098D1 (de) |
FR (1) | FR2850022B1 (de) |
WO (1) | WO2004067550A2 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
US8716479B2 (en) | 2007-12-27 | 2014-05-06 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
AR070047A1 (es) * | 2007-12-27 | 2010-03-10 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer. composicion que comprende un inhibidor de hedgehog. |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
FR2948367A1 (fr) | 2009-07-24 | 2011-01-28 | Centre Nat Rech Scient | Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog |
CN102574791A (zh) | 2009-08-05 | 2012-07-11 | 无限药品股份有限公司 | 环杷明类似物的酶促转氨基反应 |
PL2470173T3 (pl) * | 2009-08-25 | 2016-11-30 | Leczenie skojarzone nanocząstkowymi kompozycjami taksanu i inhibitorów hedgehog | |
US20110065645A1 (en) * | 2009-09-10 | 2011-03-17 | The Regents Of The University Of California | Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance |
AU2010343102B2 (en) | 2009-12-29 | 2016-03-24 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
WO2011150209A1 (en) * | 2010-05-26 | 2011-12-01 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CA2817577A1 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
FR2967498B1 (fr) | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
KR101875720B1 (ko) | 2011-01-10 | 2018-07-09 | 인피니티 파마슈티칼스, 인코포레이티드 | 이소퀴놀린온 및 이의 고체 형태의 제조 방법 |
WO2012138857A2 (en) | 2011-04-08 | 2012-10-11 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing supression of immune function |
JP6027610B2 (ja) | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環式化合物及びその使用 |
KR20140063605A (ko) | 2011-07-19 | 2014-05-27 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
FR2980477B1 (fr) | 2011-09-23 | 2013-10-18 | Centre Nat Rech Scient | Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications |
WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
CA2856291C (en) * | 2011-11-17 | 2020-08-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
US20130274233A1 (en) * | 2012-04-03 | 2013-10-17 | President And Fellow Of Harvard College | Modulators of hedgehog signaling pathway |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
LT2914296T (lt) | 2012-11-01 | 2018-09-25 | Infinity Pharmaceuticals, Inc. | Vėžio gydymas, panaudojant p13 kinazės izoformos moduliatorius |
EP2925363A4 (de) * | 2012-11-29 | 2016-11-09 | Strasspharma Llc | Verfahren zur modulation einer follikelstimulierenden hormonaktivität |
US20160024051A1 (en) | 2013-03-15 | 2016-01-28 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
DK3003309T3 (da) | 2013-05-30 | 2020-12-14 | Infinity Pharmaceuticals Inc | Behandling af cancer med PI3-kinase-isoform modulatorer |
EP3052485B1 (de) | 2013-10-04 | 2021-07-28 | Infinity Pharmaceuticals, Inc. | Heterocyclische verbindungen und verwendungen davon |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015058126A1 (en) | 2013-10-18 | 2015-04-23 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
JP6491202B2 (ja) | 2013-10-18 | 2019-03-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の多環阻害剤 |
WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP4066834A1 (de) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclische verbindungen zur verwendung in der behandlung von pi3k-gamma-vermittelten erkrankungen |
WO2015160986A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
EP3273966B1 (de) | 2015-03-27 | 2023-05-03 | Dana-Farber Cancer Institute, Inc. | Hemmer von cyclinabhängigen kinasen |
AU2016271468B2 (en) | 2015-06-04 | 2020-01-02 | Sol-Gel Technologies Ltd. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
AU2016319125B2 (en) | 2015-09-09 | 2021-04-08 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
WO2017139497A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
TWI814925B (zh) | 2018-10-29 | 2023-09-11 | 美商湛新美國股份有限公司 | 低烘烤粉末塗料樹脂及塗覆基材的方法 |
KR102544591B1 (ko) * | 2023-02-08 | 2023-07-17 | 주식회사 에스씨엘테라퓨틱스 | 신규 화합물 및 이의 용도 |
KR102604396B1 (ko) * | 2023-02-08 | 2023-11-23 | 주식회사 에스씨엘테라퓨틱스 | 신규 화합물 및 이의 용도 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
US5468741A (en) * | 1993-05-28 | 1995-11-21 | The Regents Of The University Of California | Use of low levels of mifepristone to treat leiomyomata |
US5759811A (en) * | 1996-11-13 | 1998-06-02 | The Regents Of The University Of California | Mutant human hedgehog gene |
AU5729098A (en) * | 1996-12-24 | 1998-07-17 | Zymogenetics Inc. | Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes |
US6514686B2 (en) | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
JP2002504895A (ja) * | 1997-04-28 | 2002-02-12 | ザ ユニバーシティー オブ ブリティッシュコロンビア | アミロイド症を調節する方法及び組成 |
CN1218665A (zh) * | 1997-12-03 | 1999-06-09 | 上海市计划生育科学研究所 | 高效米非司酮制剂、其制备方法和用途 |
US6277566B1 (en) * | 1998-02-13 | 2001-08-21 | Phillip A. Beachy | Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor |
AU756818B2 (en) * | 1998-05-15 | 2003-01-23 | Board Of Trustees Of The Leland Stanford Junior University | Glucocorticoid receptor antagonists for the treatment of dementia |
AU4416499A (en) * | 1998-06-03 | 1999-12-20 | President And Fellows Of Harvard College, The | Use of bigenic mouse models and assay systems to identify agents that regulate proliferation and differentiation |
JP2003501395A (ja) * | 1999-06-08 | 2003-01-14 | ローランティス・リミテッド | 治療的使用 |
AU9684401A (en) * | 2000-10-13 | 2002-04-22 | Curis Inc | Hedgehog antagonists, methods and uses related thereto |
-
2003
- 2003-01-22 FR FR0300646A patent/FR2850022B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 US US10/543,004 patent/US8703752B2/en not_active Expired - Fee Related
- 2004-01-22 JP JP2006502119A patent/JP4667363B2/ja not_active Expired - Fee Related
- 2004-01-22 AT AT04704259T patent/ATE473747T1/de not_active IP Right Cessation
- 2004-01-22 WO PCT/FR2004/000151 patent/WO2004067550A2/fr active Application Filing
- 2004-01-22 CA CA2513717A patent/CA2513717C/fr not_active Expired - Fee Related
- 2004-01-22 EP EP04704259A patent/EP1585526B1/de not_active Expired - Lifetime
- 2004-01-22 DE DE602004028098T patent/DE602004028098D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1585526B1 (de) | 2010-07-14 |
DE602004028098D1 (de) | 2010-08-26 |
JP2006516289A (ja) | 2006-06-29 |
CA2513717C (fr) | 2012-04-17 |
JP4667363B2 (ja) | 2011-04-13 |
US20070060546A1 (en) | 2007-03-15 |
WO2004067550A2 (fr) | 2004-08-12 |
EP1585526A2 (de) | 2005-10-19 |
FR2850022A1 (fr) | 2004-07-23 |
CA2513717A1 (fr) | 2004-08-12 |
WO2004067550A3 (fr) | 2004-10-14 |
FR2850022B1 (fr) | 2006-09-08 |
US8703752B2 (en) | 2014-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |