ATE471157T1 - Vorrichtung und verfahren zur photodynamischen diagnose von tumorgewebe - Google Patents
Vorrichtung und verfahren zur photodynamischen diagnose von tumorgewebeInfo
- Publication number
- ATE471157T1 ATE471157T1 AT02725145T AT02725145T ATE471157T1 AT E471157 T1 ATE471157 T1 AT E471157T1 AT 02725145 T AT02725145 T AT 02725145T AT 02725145 T AT02725145 T AT 02725145T AT E471157 T1 ATE471157 T1 AT E471157T1
- Authority
- AT
- Austria
- Prior art keywords
- camera
- telescopic device
- proximal end
- filter
- surgical telescopic
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000004020 luminiscence type Methods 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
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- A—HUMAN NECESSITIES
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00186—Optical arrangements with imaging filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
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- A—HUMAN NECESSITIES
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
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- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
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- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
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- A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
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- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
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- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
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- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0012—Surgical microscopes
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- A—HUMAN NECESSITIES
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- A61B1/313—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
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- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3937—Visible markers
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- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
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- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1003—Carbocyclic compounds
- C09K2211/1007—Non-condensed systems
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
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- C09K2211/1011—Condensed systems
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1003—Carbocyclic compounds
- C09K2211/1014—Carbocyclic compounds bridged by heteroatoms, e.g. N, P, Si or B
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1044—Heterocyclic compounds characterised by ligands containing two nitrogen atoms as heteroatoms
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/18—Metal complexes
- C09K2211/187—Metal complexes of the iron group metals, i.e. Fe, Co or Ni
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B20/00—Energy efficient lighting technologies, e.g. halogen lamps or gas discharge lamps
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Materials Engineering (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Oral & Maxillofacial Surgery (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27603601P | 2001-03-16 | 2001-03-16 | |
US33631601P | 2001-10-30 | 2001-10-30 | |
PCT/US2002/007699 WO2002074339A1 (en) | 2001-03-16 | 2002-03-15 | Deveice and method for the photodynamic diagnosis of tumor tissue |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE471157T1 true ATE471157T1 (de) | 2010-07-15 |
Family
ID=26957725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02725145T ATE471157T1 (de) | 2001-03-16 | 2002-03-15 | Vorrichtung und verfahren zur photodynamischen diagnose von tumorgewebe |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1370291B1 (de) |
JP (1) | JP2004525697A (de) |
AT (1) | ATE471157T1 (de) |
CA (2) | CA2771039A1 (de) |
DE (1) | DE60236722D1 (de) |
NZ (1) | NZ528920A (de) |
WO (1) | WO2002074339A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1956752B (zh) * | 2003-05-14 | 2011-12-07 | 光谱治疗股份公司 | 含有用于分配辐射的平移分配器的治疗和诊断***与方法 |
SE527164C2 (sv) * | 2003-05-14 | 2006-01-10 | Spectracure Ab | Anordning och metod för terapi och diagnostik innefattande optiska komponenter för distribution av strålning |
JP4709157B2 (ja) * | 2003-05-14 | 2011-06-22 | スペクトラキュア アクティエボラーグ | 放射線供給のための非機械的ディストリビュータと機械的ディストリビュータを共に備えている治療及び診断用のシステム及び方法 |
JP4663258B2 (ja) * | 2003-06-17 | 2011-04-06 | オリンパス株式会社 | 内視鏡装置 |
JP4663273B2 (ja) * | 2003-08-08 | 2011-04-06 | オリンパス株式会社 | カプセル型光センサー及びそれを用いた診断装置 |
JP5197916B2 (ja) * | 2004-09-08 | 2013-05-15 | オリンパス株式会社 | 内視鏡装置 |
DE102005005984B4 (de) * | 2005-02-09 | 2019-10-24 | Leica Instruments (Singapore) Pte. Ltd. | Fluoreszenz-/Infraroteinrichtung für Operationsmikroskope |
US8140141B2 (en) * | 2006-05-17 | 2012-03-20 | University Of Utah Research Foundation | Devices and methods for fluorescent inspection and/or removal of material in a sample |
DE102007010046A1 (de) * | 2007-03-01 | 2008-09-04 | Siemens Ag | PCa-Nachweisgerät |
CA2678646A1 (en) | 2007-03-05 | 2008-09-12 | Syracuse University | A conjugate of insulin and vitamin b12 for oral delivery |
CN101109699B (zh) * | 2007-07-28 | 2010-09-15 | 中国科学院安徽光学精密机械研究所 | 大气成分垂直分布探测的多轴差分吸收光谱方法与装置 |
CN101609207B (zh) * | 2009-07-17 | 2011-01-05 | 清华大学 | 可留置的荧光显微内窥成像***及成像方法 |
EP2514357B1 (de) * | 2011-04-18 | 2014-10-29 | Karl Storz GmbH & Co. KG | Exoskop |
WO2013150745A1 (ja) * | 2012-04-05 | 2013-10-10 | Sbiファーマ株式会社 | センチネルリンパ節がん転移識別装置 |
JP7083821B2 (ja) * | 2016-06-17 | 2022-06-13 | ソルボンヌ・ユニヴェルシテ | 制御された光強度で対象物を照明するための装置および関連する方法 |
KR101847435B1 (ko) * | 2016-09-30 | 2018-04-10 | 부경대학교 산학협력단 | 부갑상선 실시간 이미징 장치 |
CN108195814B (zh) * | 2018-01-24 | 2023-09-26 | 北京海光仪器有限公司 | 一种用于原子荧光的顺序注射蒸气发生进样*** |
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US4782819A (en) * | 1987-02-25 | 1988-11-08 | Adair Edwin Lloyd | Optical catheter |
JP2862099B2 (ja) * | 1990-10-12 | 1999-02-24 | 旭光学工業株式会社 | 早期癌診断装置 |
JP3487933B2 (ja) * | 1993-12-03 | 2004-01-19 | オリンパス株式会社 | 蛍光観察装置 |
JPH07250812A (ja) * | 1994-03-15 | 1995-10-03 | Olympus Optical Co Ltd | 蛍光診断装置 |
JPH08224240A (ja) * | 1995-02-22 | 1996-09-03 | Olympus Optical Co Ltd | 蛍光診断装置 |
JP3560671B2 (ja) * | 1995-02-23 | 2004-09-02 | オリンパス株式会社 | 蛍光観察装置 |
JP3411737B2 (ja) * | 1995-03-03 | 2003-06-03 | ペンタックス株式会社 | 生体の蛍光診断装置 |
US6212425B1 (en) * | 1995-09-26 | 2001-04-03 | Karl Storz Gmbh & Co., Kg | Apparatus for photodynamic diagnosis |
JP4008184B2 (ja) * | 1996-03-06 | 2007-11-14 | 富士フイルム株式会社 | 蛍光検出装置 |
DE19612536A1 (de) * | 1996-03-29 | 1997-10-02 | Freitag Lutz Dr | Anordnung und Verfahren zur Diagnose von malignem Gewebe durch Fluoreszenzbetrachtung |
JP3654324B2 (ja) * | 1997-02-13 | 2005-06-02 | 富士写真フイルム株式会社 | 蛍光検出装置 |
JPH10243920A (ja) * | 1997-03-07 | 1998-09-14 | Olympus Optical Co Ltd | 蛍光観察内視鏡装置 |
JP3417795B2 (ja) * | 1997-04-30 | 2003-06-16 | ペンタックス株式会社 | 蛍光診断装置 |
US5912735A (en) * | 1997-07-29 | 1999-06-15 | Kla-Tencor Corporation | Laser/white light viewing laser imaging system |
JP2001013422A (ja) * | 1999-06-30 | 2001-01-19 | Olympus Optical Co Ltd | 内視鏡照明光学系 |
DK1226153T3 (da) * | 1999-10-26 | 2010-06-07 | Univ Utah Res Found | Phosphorescerende cobalaminer og anvendelser deraf |
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2002
- 2002-03-15 EP EP02725145A patent/EP1370291B1/de not_active Expired - Lifetime
- 2002-03-15 NZ NZ528920A patent/NZ528920A/en not_active IP Right Cessation
- 2002-03-15 CA CA2771039A patent/CA2771039A1/en not_active Abandoned
- 2002-03-15 CA CA2441107A patent/CA2441107C/en not_active Expired - Fee Related
- 2002-03-15 AT AT02725145T patent/ATE471157T1/de not_active IP Right Cessation
- 2002-03-15 WO PCT/US2002/007699 patent/WO2002074339A1/en active Application Filing
- 2002-03-15 DE DE60236722T patent/DE60236722D1/de not_active Expired - Lifetime
- 2002-03-15 JP JP2002573046A patent/JP2004525697A/ja active Pending
Also Published As
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EP1370291B1 (de) | 2010-06-16 |
JP2004525697A (ja) | 2004-08-26 |
CA2441107C (en) | 2012-06-05 |
EP1370291A1 (de) | 2003-12-17 |
CA2771039A1 (en) | 2002-09-26 |
CA2441107A1 (en) | 2002-09-26 |
WO2002074339A1 (en) | 2002-09-26 |
NZ528920A (en) | 2006-10-27 |
DE60236722D1 (de) | 2010-07-29 |
WO2002074339B1 (en) | 2003-05-22 |
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