ATE468332T1 - Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin- - yi)aminderivate - Google Patents
Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin- - yi)aminderivateInfo
- Publication number
- ATE468332T1 ATE468332T1 AT03762663T AT03762663T ATE468332T1 AT E468332 T1 ATE468332 T1 AT E468332T1 AT 03762663 T AT03762663 T AT 03762663T AT 03762663 T AT03762663 T AT 03762663T AT E468332 T1 ATE468332 T1 AT E468332T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- pyrazole
- pyrimidine
- amine derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0215844.2A GB0215844D0 (en) | 2002-07-09 | 2002-07-09 | Organic compounds |
PCT/EP2003/007350 WO2004005282A1 (en) | 2002-07-09 | 2003-07-08 | PHENYL-[4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE468332T1 true ATE468332T1 (de) | 2010-06-15 |
Family
ID=9940097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03762663T ATE468332T1 (de) | 2002-07-09 | 2003-07-08 | Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin- - yi)aminderivate |
Country Status (13)
Country | Link |
---|---|
US (1) | US7691855B2 (de) |
EP (1) | EP1521749B8 (de) |
JP (1) | JP4478016B2 (de) |
CN (1) | CN1330643C (de) |
AT (1) | ATE468332T1 (de) |
AU (1) | AU2003249993A1 (de) |
BR (1) | BR0312573A (de) |
CA (1) | CA2491635A1 (de) |
DE (1) | DE60332629D1 (de) |
ES (1) | ES2346427T3 (de) |
GB (1) | GB0215844D0 (de) |
PT (1) | PT1521749E (de) |
WO (1) | WO2004005282A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60135676D1 (de) * | 2000-12-05 | 2008-10-16 | Vertex Pharma | Inhibitoren von c-jun n-terminalen kinasen (jnk) und anderen proteinkinasen |
GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
BRPI0413977A (pt) | 2003-08-27 | 2006-11-07 | Osi Eyetech Inc | método para suprimir um distúrbio neovascular, e para tratar um paciente diagnosticado com ou em risco de desenvolver um distúrbio neovascular, composição farmacêutica, e, embalagem farmacêutica |
CN1906188A (zh) * | 2004-01-09 | 2007-01-31 | 诺瓦提斯公司 | 作为igf-1r抑制剂的苯基-[4-(3-苯基-1h-吡唑-4-基)-嘧啶-2-基]-胺衍生物 |
TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
PE20060582A1 (es) * | 2004-10-13 | 2006-08-17 | Wyeth Corp | Analogos de anilino-pirimidina |
US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
JP4278172B2 (ja) * | 2005-07-30 | 2009-06-10 | アストラゼネカ アクチボラグ | 増殖性疾患の治療において使用するためのイミダゾリル−ピリミジン化合物 |
KR20080049130A (ko) | 2005-09-30 | 2008-06-03 | 아스트라제네카 아베 | 세포 증식 억제 활성을 갖는 이미다조 [1,2-a] 피리딘 |
RS54181B9 (sr) | 2005-12-13 | 2020-01-31 | Incyte Holdings Corp | Heteroaril supstituisani pirolo[2,3-b]piridini i pirolo[2,3-b]pirimidini kao inhibitori janus kinaze |
CA2643066A1 (en) * | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
WO2008042639A1 (en) | 2006-10-02 | 2008-04-10 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
JP2010522770A (ja) * | 2007-03-29 | 2010-07-08 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Akt活性の阻害物質 |
MY154969A (en) | 2007-06-13 | 2015-08-28 | Incyte Corp | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
WO2009010455A2 (en) * | 2007-07-13 | 2009-01-22 | Addex Pharma S.A. | Pyrazole derivatives as modulators of metabotropic glutamate receptors |
CA2695114A1 (en) * | 2007-08-01 | 2009-02-05 | Pfizer Inc. | Pyrazole compounds and their use as raf inhibitors |
MX2010005300A (es) * | 2007-11-16 | 2010-06-25 | Incyte Corp | 4-pirazolil-n-arilpirimidin-2-aminas y 4-pirazolil-n-heteroarilpir imidin-2-aminas como inhibidores de cinasas janus. |
US8367687B2 (en) | 2007-12-07 | 2013-02-05 | Novartis Ag | Pyrazole derivatives |
AU2009214440B2 (en) * | 2008-02-15 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases |
EP2400985A2 (de) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Kombination eines anti-igf-1r-antikörpers oder eines igf-bindungsproteins und eines kleinmoleküligen igf-1r-kinase-inhibitors |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
JP2012519281A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
WO2010099364A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
MY156727A (en) * | 2009-05-22 | 2016-03-15 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
MX2011012262A (es) * | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak). |
MX2011012631A (es) * | 2009-05-27 | 2012-03-06 | Abbott Lab | Inhibidores de actividad de cinasa tipo pirimidina. |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
EP2308866A1 (de) * | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
KR102283091B1 (ko) | 2010-03-10 | 2021-07-30 | 인사이트 홀딩스 코포레이션 | Jak1 저해제로서의 피페리딘4일 아제티딘 유도체 |
TWI499421B (zh) | 2010-05-21 | 2015-09-11 | Incyte Corp | Jak抑制劑的局部製劑 |
KR101531448B1 (ko) | 2010-06-04 | 2015-06-24 | 에프. 호프만-라 로슈 아게 | Lrrk2 조절제로서의 아미노피리미딘 유도체 |
PL2638031T3 (pl) | 2010-11-10 | 2018-03-30 | Genentech, Inc. | Pirazolowo-aminopirymidynowe pochodne jako modulatory LRRK2 |
BR112013012502A2 (pt) | 2010-11-19 | 2019-03-06 | Incyte Corporation | pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak |
CA2818545C (en) | 2010-11-19 | 2019-04-16 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
US9382229B2 (en) | 2011-02-15 | 2016-07-05 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 癌薬剤発見、診断、および治療におけるemt遺伝子シグネチャーの使用 |
MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
WO2013071232A1 (en) * | 2011-11-11 | 2013-05-16 | Beta Cat Pharmaceuticals, Llc | Compositions and methods for inhibition of tbl-1 binding to disease-associated molecules |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
WO2013173720A1 (en) | 2012-05-18 | 2013-11-21 | Incyte Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
KR20210037012A (ko) | 2012-11-15 | 2021-04-05 | 인사이트 홀딩스 코포레이션 | 룩솔리티니브의 서방성 제형 |
EP2922828B1 (de) | 2012-11-21 | 2020-07-08 | PTC Therapeutics, Inc. | 4,6-diamino-pyrimidin-derivate als bmi-1 inhibitoren zur behandlung von krebs |
NZ711976A (en) | 2013-03-06 | 2019-01-25 | Incyte Holdings Corp | Processes and intermediates for making a jak inhibitor |
KR20220061248A (ko) | 2013-07-12 | 2022-05-12 | 이베릭 바이오, 인크. | 안과적 질환을 치료하거나 예방하기 위한 방법 |
SG10201801069QA (en) | 2013-08-07 | 2018-03-28 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
WO2015030847A1 (en) | 2013-08-30 | 2015-03-05 | Ptc Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
EP3071553A4 (de) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituierte pyridin- und pyrazin-bmi-1-hemmer |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
JP7083309B2 (ja) * | 2015-08-04 | 2022-06-10 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム エルティーディー. | ピラゾールピリミジン誘導体及びその使用 |
WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
EP3746429B1 (de) | 2018-01-30 | 2022-03-09 | Incyte Corporation | Verfahren zur herstellung von (1-(3-fluor-2-trifluormethyl)isonicotinyl)piperidin-4-on) |
EA202092343A1 (ru) | 2018-03-30 | 2021-01-20 | Инсайт Корпорейшн | Лечение гнойного гидраденита с использованием ингибиторов jak |
CN114423750B (zh) * | 2019-06-28 | 2024-04-19 | 成都赜灵生物医药科技有限公司 | 2,4-二取代嘧啶衍生物及其制备方法和用途 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
JP2024517792A (ja) * | 2021-04-28 | 2024-04-23 | コーネル・ユニバーシティー | 可溶性アデニリルシクラーゼ(sAC)阻害剤及びその使用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL112290A (en) | 1994-01-12 | 1999-01-26 | Novartis Ag | Transformed aryl and the troiryl pyrimidines and herbicides containing them |
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
AP1246A (en) | 1997-05-22 | 2004-02-07 | Searle & Co | Substituted pyrazoles as p38 Kinase inhibitors. |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
JP2002504909A (ja) | 1997-06-13 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | 新規な置換ピラゾールおよびピラゾリン化合物 |
AU6909600A (en) | 1999-08-13 | 2001-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
AU2001237041B9 (en) | 2000-02-17 | 2005-07-28 | Amgen Inc. | Kinase inhibitors |
EP1261327B1 (de) | 2000-02-25 | 2005-04-27 | F.Hoffmann-La Roche Ag | Adenosin-rezeptor modulatoren |
AU783981C (en) | 2000-05-08 | 2007-05-03 | Janssen Pharmaceutica N.V. | HIV replication inhibitors |
DE60135676D1 (de) * | 2000-12-05 | 2008-10-16 | Vertex Pharma | Inhibitoren von c-jun n-terminalen kinasen (jnk) und anderen proteinkinasen |
GB0129476D0 (en) | 2001-12-10 | 2002-01-30 | Syngenta Participations Ag | Organic compounds |
-
2002
- 2002-07-09 GB GBGB0215844.2A patent/GB0215844D0/en not_active Ceased
-
2003
- 2003-07-08 AT AT03762663T patent/ATE468332T1/de not_active IP Right Cessation
- 2003-07-08 AU AU2003249993A patent/AU2003249993A1/en not_active Abandoned
- 2003-07-08 ES ES03762663T patent/ES2346427T3/es not_active Expired - Lifetime
- 2003-07-08 EP EP03762663A patent/EP1521749B8/de not_active Expired - Lifetime
- 2003-07-08 JP JP2004518751A patent/JP4478016B2/ja not_active Expired - Lifetime
- 2003-07-08 CN CNB038163837A patent/CN1330643C/zh not_active Expired - Fee Related
- 2003-07-08 DE DE60332629T patent/DE60332629D1/de not_active Expired - Lifetime
- 2003-07-08 PT PT03762663T patent/PT1521749E/pt unknown
- 2003-07-08 WO PCT/EP2003/007350 patent/WO2004005282A1/en active Application Filing
- 2003-07-08 BR BR0312573-4A patent/BR0312573A/pt not_active IP Right Cessation
- 2003-07-08 CA CA002491635A patent/CA2491635A1/en not_active Abandoned
- 2003-07-08 US US10/520,567 patent/US7691855B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2491635A1 (en) | 2004-01-15 |
JP4478016B2 (ja) | 2010-06-09 |
US20060106027A1 (en) | 2006-05-18 |
CN1668610A (zh) | 2005-09-14 |
EP1521749A1 (de) | 2005-04-13 |
WO2004005282A1 (en) | 2004-01-15 |
EP1521749B8 (de) | 2010-12-22 |
PT1521749E (pt) | 2010-08-18 |
JP2006501183A (ja) | 2006-01-12 |
AU2003249993A1 (en) | 2004-01-23 |
US7691855B2 (en) | 2010-04-06 |
GB0215844D0 (en) | 2002-08-14 |
ES2346427T3 (es) | 2010-10-15 |
EP1521749B1 (de) | 2010-05-19 |
BR0312573A (pt) | 2005-04-26 |
DE60332629D1 (de) | 2010-07-01 |
CN1330643C (zh) | 2007-08-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |