ATE464946T1 - Verfahren und vorrichtung zur synthese von dan- sonderanordnungen - Google Patents
Verfahren und vorrichtung zur synthese von dan- sonderanordnungenInfo
- Publication number
- ATE464946T1 ATE464946T1 AT99908351T AT99908351T ATE464946T1 AT E464946 T1 ATE464946 T1 AT E464946T1 AT 99908351 T AT99908351 T AT 99908351T AT 99908351 T AT99908351 T AT 99908351T AT E464946 T1 ATE464946 T1 AT E464946T1
- Authority
- AT
- Austria
- Prior art keywords
- substrate
- array
- synthesis
- active surface
- micromirror
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/0816—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements
- G02B26/0833—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD
- G02B26/0841—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD the reflecting element being moved or deformed by electrostatic means
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
- G03F7/20—Exposure; Apparatus therefor
- G03F7/2002—Exposure; Apparatus therefor with visible light or UV light, through an original having an opaque pattern on a transparent support, e.g. film printing, projection printing; by reflection of visible or UV light from an original such as a printed image
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00436—Maskless processes
- B01J2219/00439—Maskless processes using micromirror arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00529—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00608—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00709—Type of synthesis
- B01J2219/00711—Light-directed synthesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Composite Materials (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7564198P | 1998-02-23 | 1998-02-23 | |
PCT/US1999/003807 WO1999042813A1 (en) | 1998-02-23 | 1999-02-22 | Method and apparatus for synthesis of arrays of dna probes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE464946T1 true ATE464946T1 (de) | 2010-05-15 |
Family
ID=22127097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99908351T ATE464946T1 (de) | 1998-02-23 | 1999-02-22 | Verfahren und vorrichtung zur synthese von dan- sonderanordnungen |
Country Status (11)
Country | Link |
---|---|
US (2) | US6375903B1 (de) |
EP (3) | EP2259046A3 (de) |
JP (1) | JP4698023B2 (de) |
AT (1) | ATE464946T1 (de) |
AU (1) | AU746760B2 (de) |
CA (1) | CA2321070C (de) |
DE (1) | DE69942272D1 (de) |
ES (2) | ES2656439T3 (de) |
IL (1) | IL137901A (de) |
MX (1) | MXPA00008263A (de) |
WO (1) | WO1999042813A1 (de) |
Families Citing this family (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5846717A (en) * | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US7527928B2 (en) * | 1996-11-29 | 2009-05-05 | Third Wave Technologies, Inc. | Reactions on a solid surface |
US7432048B2 (en) * | 1996-11-29 | 2008-10-07 | Third Wave Technologies, Inc. | Reactions on a solid surface |
US20040035690A1 (en) * | 1998-02-11 | 2004-02-26 | The Regents Of The University Of Michigan | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
US6426184B1 (en) * | 1998-02-11 | 2002-07-30 | The Regents Of The University Of Michigan | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
EP2259046A3 (de) * | 1998-02-23 | 2011-11-30 | Wisconsin Alumni Research Foundation | Verfahren zur Synthese von DNA-Sonden-Arrays |
US6271957B1 (en) * | 1998-05-29 | 2001-08-07 | Affymetrix, Inc. | Methods involving direct write optical lithography |
WO1999063385A1 (en) * | 1998-06-04 | 1999-12-09 | Board Of Regents, The University Of Texas System | Digital optical chemistry micromirror imager |
DE19940751A1 (de) * | 1998-08-28 | 2000-03-02 | Febit Ferrarius Biotech Gmbh | Lichtemissions-Detektionseinrichtung |
US6801353B2 (en) * | 1999-02-01 | 2004-10-05 | Production Resource Group Inc. | Pixel based gobo record control format |
EP1180111A4 (de) * | 1999-02-10 | 2003-03-26 | Macrogen Inc | Verfahren und gerät zur herstellung von verbindungsbibliotheken mittels optischem modulator |
DE19932487A1 (de) * | 1999-07-09 | 2001-02-08 | Epigenomics Gmbh | Vorrichtung und Verfahren zur photolithographischen Belichtung von biologischen Stoffen |
US6472588B1 (en) * | 1999-09-10 | 2002-10-29 | Texas Tech University | Transgenic cotton plants with altered fiber characteristics transformed with a sucrose phosphate synthase nucleic acid |
US6315958B1 (en) | 1999-11-10 | 2001-11-13 | Wisconsin Alumni Research Foundation | Flow cell for synthesis of arrays of DNA probes and the like |
DE10027119A1 (de) * | 2000-05-23 | 2001-12-06 | Epigenomics Ag | Vorrichtung und Verfahren zur photolithographischen Belichtung von biologischen Stoffen |
DE10027524A1 (de) * | 2000-06-02 | 2001-12-13 | Max Planck Gesellschaft | Vorrichtung und Verfahren zur Bearbeitung von substratgebundenen Proben |
WO2002002227A2 (en) * | 2000-07-03 | 2002-01-10 | Xeotron Corporation | Devices and methods for carrying out chemical reactions using photogenerated reagents |
WO2002004597A2 (en) * | 2000-07-07 | 2002-01-17 | Nimblegen Systems, Inc. | Method and apparatus for synthesis of arrays of dna probes |
US6567163B1 (en) | 2000-08-17 | 2003-05-20 | Able Signal Company Llc | Microarray detector and synthesizer |
US6545758B1 (en) | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
DE10051396A1 (de) | 2000-10-17 | 2002-04-18 | Febit Ferrarius Biotech Gmbh | Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger |
US6706867B1 (en) | 2000-12-19 | 2004-03-16 | The United States Of America As Represented By The Department Of Health And Human Services | DNA array sequence selection |
US20020075490A1 (en) * | 2000-12-20 | 2002-06-20 | Affymetrix, Inc. | System and method for addressable light-directed microarray printing |
US7211654B2 (en) | 2001-03-14 | 2007-05-01 | Regents Of The University Of Michigan | Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports |
US20020160427A1 (en) * | 2001-04-27 | 2002-10-31 | Febit Ag | Methods and apparatuses for electronic determination of analytes |
CA2447240C (en) | 2001-05-18 | 2013-02-19 | Wisconsin Alumni Research Foundation | Method for the synthesis of dna sequences |
US7049049B2 (en) * | 2001-06-27 | 2006-05-23 | University Of South Florida | Maskless photolithography for using photoreactive agents |
WO2003008943A1 (en) * | 2001-07-19 | 2003-01-30 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
US20030087298A1 (en) * | 2001-11-02 | 2003-05-08 | Roland Green | Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe |
US6790620B2 (en) * | 2001-12-24 | 2004-09-14 | Agilent Technologies, Inc. | Small volume chambers |
US7037659B2 (en) * | 2002-01-31 | 2006-05-02 | Nimblegen Systems Inc. | Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer |
US7422851B2 (en) * | 2002-01-31 | 2008-09-09 | Nimblegen Systems, Inc. | Correction for illumination non-uniformity during the synthesis of arrays of oligomers |
US20040126757A1 (en) * | 2002-01-31 | 2004-07-01 | Francesco Cerrina | Method and apparatus for synthesis of arrays of DNA probes |
US7157229B2 (en) | 2002-01-31 | 2007-01-02 | Nimblegen Systems, Inc. | Prepatterned substrate for optical synthesis of DNA probes |
US7083975B2 (en) * | 2002-02-01 | 2006-08-01 | Roland Green | Microarray synthesis instrument and method |
US20030186301A1 (en) * | 2002-03-25 | 2003-10-02 | The Regents Of The University Of California | Constructing user-defined, long DNA sequences |
US7452666B2 (en) | 2002-03-25 | 2008-11-18 | Lawrence Livermore National Security, Llc | Synthesis of DNA |
US20030180781A1 (en) * | 2002-03-25 | 2003-09-25 | The Regents Of The University Of California | Constructing very long DNA sequences from synthetic DNA molecules |
US20030228598A1 (en) * | 2002-03-25 | 2003-12-11 | The Regents Of The University Of California | DNA/RNA as a write/read medium |
US20070275411A1 (en) | 2006-05-25 | 2007-11-29 | Mcgall Glenn H | Silane mixtures |
US7332273B2 (en) * | 2002-06-20 | 2008-02-19 | Affymetrix, Inc. | Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays |
EP1552003A4 (de) * | 2002-06-28 | 2007-06-13 | Rosetta Inpharmatics Llc | Verfahren zur beurteilung der qualität von mikroarrays |
DE10230320A1 (de) * | 2002-07-05 | 2004-02-05 | Marcel Rogalla | Programmierbare Beleuchtungsvorrichtung zur hochauflösenden, massiv parallelen, räumlichen Systhese und Analyse von Microarrays |
EP1573366B1 (de) * | 2002-08-24 | 2016-11-09 | Chime Ball Technology Co., Ltd. | Kontinuierliche optische direktschreiblithographie |
US7563600B2 (en) | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
AU2003270898A1 (en) * | 2002-09-27 | 2004-04-19 | Nimblegen Systems, Inc. | Microarray with hydrophobic barriers |
US20040110212A1 (en) * | 2002-09-30 | 2004-06-10 | Mccormick Mark | Microarrays with visual alignment marks |
US7482170B2 (en) * | 2002-09-30 | 2009-01-27 | Roche Nimblegen, Inc. | Parallel loading of arrays |
JP2006500954A (ja) * | 2002-10-01 | 2006-01-12 | ニンブルゲン システムズ インコーポレイテッド | 単一のアレイ特徴部に複数のオリゴヌクレオチドを有するマイクロアレイ |
US8069676B2 (en) | 2002-11-13 | 2011-12-06 | Deka Products Limited Partnership | Water vapor distillation apparatus, method and system |
US7090979B2 (en) * | 2002-11-22 | 2006-08-15 | The Regents Of The University Of California | Derivatized versions of ligase enzymes for constructing DNA sequences |
US7871799B2 (en) * | 2002-11-22 | 2011-01-18 | Lawrence Livermore National Security, Llc | Sequential addition of short DNA oligos in DNA-polymerase-based synthesis reactions |
SG121829A1 (en) * | 2002-11-29 | 2006-05-26 | Asml Netherlands Bv | Lithographic apparatus and device manufacturing method |
US20040115336A1 (en) * | 2002-12-12 | 2004-06-17 | Industrial Technology Research Institute | Method of fabricating a grating-based optical biosensor |
US20040115654A1 (en) * | 2002-12-16 | 2004-06-17 | Intel Corporation | Laser exposure of photosensitive masks for DNA microarray fabrication |
US6819469B1 (en) * | 2003-05-05 | 2004-11-16 | Igor M. Koba | High-resolution spatial light modulator for 3-dimensional holographic display |
US7061591B2 (en) * | 2003-05-30 | 2006-06-13 | Asml Holding N.V. | Maskless lithography systems and methods utilizing spatial light modulator arrays |
US6989920B2 (en) * | 2003-05-29 | 2006-01-24 | Asml Holding N.V. | System and method for dose control in a lithographic system |
EP1706488B1 (de) * | 2004-01-12 | 2013-07-24 | Roche NimbleGen, Inc. | Verfahren zur pcr-amplifikation auf einem microarray |
ES2292110T3 (es) * | 2004-01-26 | 2008-03-01 | Nimblegen Systems, Inc. | Programa de ordenador para ayudar en la identificacion de snps (polimorfismos de un solo nucleotido) con microformaciones. |
JP4095968B2 (ja) * | 2004-02-06 | 2008-06-04 | 株式会社日立ハイテクノロジーズ | 液体分注装置、それを用いた自動分析装置、及び液面検出装置 |
CA2557841A1 (en) * | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
CA2562285A1 (en) * | 2004-04-08 | 2006-03-16 | Nimblegen Systems, Inc. | Comparative genomic resequencing |
US7072500B2 (en) * | 2004-05-07 | 2006-07-04 | Wisconsin Alumni Research Foundation | Image locking system for DNA micro-array synthesis |
ATE474936T1 (de) | 2004-06-09 | 2010-08-15 | Wisconsin Alumni Res Found | Schnelle synthese von oligonukleotiden |
EP1766078B1 (de) * | 2004-06-18 | 2012-05-30 | Nimblegen Systems, Inc. | Auswahl von sonden mit unterschiedlicher länge |
WO2006002191A1 (en) * | 2004-06-21 | 2006-01-05 | Nimblegen Systems, Inc. | Probe optimization methods |
US7588892B2 (en) | 2004-07-19 | 2009-09-15 | Entelos, Inc. | Reagent sets and gene signatures for renal tubule injury |
EP1781786B1 (de) * | 2004-08-27 | 2011-01-26 | Wisconsin Alumni Research Foundation | Verfahren zur fehlerverringerung in nukleinsäurepopulationen |
US20060066842A1 (en) * | 2004-09-30 | 2006-03-30 | Saunders Winston A | Wafer inspection with a customized reflective optical channel component |
US7560417B2 (en) * | 2005-01-13 | 2009-07-14 | Wisconsin Alumni Research Foundation | Method and apparatus for parallel synthesis of chain molecules such as DNA |
ATE359500T1 (de) * | 2005-01-18 | 2007-05-15 | Hoffmann La Roche | Fluoreszenzabbildung mittels telezentrizität |
EP1859376B1 (de) * | 2005-02-04 | 2012-05-23 | Nimblegen Systems, Inc. | Optimiertes sondenauswahlverfahren |
US7722824B2 (en) * | 2005-08-02 | 2010-05-25 | Wisconsin Alumni Research Foundation | Synthesis of arrays of oligonucleotides and other chain molecules |
US20070196834A1 (en) * | 2005-09-09 | 2007-08-23 | Francesco Cerrina | Method and system for the generation of large double stranded DNA fragments |
US7994098B2 (en) * | 2005-12-09 | 2011-08-09 | Wisconsin Alumni Research Foundation | Light directed DNA synthesis using inverse capping for error reduction |
CN101553576A (zh) * | 2005-12-13 | 2009-10-07 | 罗氏宁博根有限公司 | 后生修饰的鉴定和监测方法 |
JP2007252249A (ja) * | 2006-03-22 | 2007-10-04 | Oki Electric Ind Co Ltd | 有機化合物合成装置,光照射装置,有機化合物合成用基板および有機化合物の合成方法 |
US20070231823A1 (en) * | 2006-03-23 | 2007-10-04 | Mckernan Kevin J | Directed enrichment of genomic DNA for high-throughput sequencing |
US20070231805A1 (en) * | 2006-03-31 | 2007-10-04 | Baynes Brian M | Nucleic acid assembly optimization using clamped mismatch binding proteins |
US20090087840A1 (en) * | 2006-05-19 | 2009-04-02 | Codon Devices, Inc. | Combined extension and ligation for nucleic acid assembly |
US7759062B2 (en) | 2006-06-09 | 2010-07-20 | Third Wave Technologies, Inc. | T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection |
WO2008027558A2 (en) | 2006-08-31 | 2008-03-06 | Codon Devices, Inc. | Iterative nucleic acid assembly using activation of vector-encoded traits |
CA2665188C (en) | 2006-10-04 | 2014-08-19 | Third Wave Technologies, Inc. | Snap-back primers and detectable hairpin structures |
US20080161204A1 (en) * | 2006-10-06 | 2008-07-03 | Mo-Huang Li | Microwell array for parallel synthesis of chain molecules |
KR100834745B1 (ko) * | 2006-12-20 | 2008-06-09 | 삼성전자주식회사 | 분석 친화적 레이아웃에 기반한 올리고머 프로브 어레이칩, 이의 제조에 사용되는 마스크 및 이의 혼성화 분석방법 |
CA2683804A1 (en) * | 2007-04-13 | 2008-10-23 | Dana Farber Cancer Institute, Inc. | Receptor tyrosine kinase profiling |
ES2529790T3 (es) | 2007-04-13 | 2015-02-25 | Dana-Farber Cancer Institute, Inc. | Métodos de tratamiento de cáncer resistente a agentes terapéuticos de ERBB |
US7778512B2 (en) * | 2007-08-28 | 2010-08-17 | Scenterra, Inc. | Light-pipe array system |
EP2053132A1 (de) | 2007-10-23 | 2009-04-29 | Roche Diagnostics GmbH | Anreicherung und Sequenzanalyse von Genombereichen |
US20090142759A1 (en) * | 2007-11-29 | 2009-06-04 | Erik Larsson | qPCR array with IN SITU primer synthesis |
JP2009191020A (ja) * | 2008-02-14 | 2009-08-27 | Oki Electric Ind Co Ltd | 有機化合物合成装置および有機化合物合成方法 |
US20090246788A1 (en) | 2008-04-01 | 2009-10-01 | Roche Nimblegen, Inc. | Methods and Assays for Capture of Nucleic Acids |
US20100056382A1 (en) * | 2008-05-30 | 2010-03-04 | Sussman Michael R | Dna millichip |
US20100047876A1 (en) * | 2008-08-08 | 2010-02-25 | President And Fellows Of Harvard College | Hierarchical assembly of polynucleotides |
WO2010025310A2 (en) | 2008-08-27 | 2010-03-04 | Westend Asset Clearinghouse Company, Llc | Methods and devices for high fidelity polynucleotide synthesis |
US8796011B2 (en) | 2008-10-20 | 2014-08-05 | Samsung Electronics Co., Ltd. | Apparatus for fabricating and optically detecting biochip |
US20100161607A1 (en) | 2008-12-22 | 2010-06-24 | Jasjit Singh | System and method for analyzing genome data |
US20100331204A1 (en) | 2009-02-13 | 2010-12-30 | Jeff Jeddeloh | Methods and systems for enrichment of target genomic sequences |
US20100292102A1 (en) * | 2009-05-14 | 2010-11-18 | Ali Nouri | System and Method For Preventing Synthesis of Dangerous Biological Sequences |
US9416409B2 (en) | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
EP2494069B1 (de) | 2009-10-30 | 2013-10-02 | Roche Diagniostics GmbH | Verfahren zum nachweis von ausgeglichenen chromosomalen aberrationen in genomen |
WO2011056872A2 (en) | 2009-11-03 | 2011-05-12 | Gen9, Inc. | Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly |
EP3597771A1 (de) | 2009-11-25 | 2020-01-22 | Gen9, Inc. | Verfahren und vorrichtung für chipbasierte dna-fehlerreduktion |
US9216414B2 (en) | 2009-11-25 | 2015-12-22 | Gen9, Inc. | Microfluidic devices and methods for gene synthesis |
US9080140B2 (en) * | 2009-12-01 | 2015-07-14 | Empire Technology Development Llc | Selective conformation of cell culturing support layer |
WO2011085075A2 (en) | 2010-01-07 | 2011-07-14 | Gen9, Inc. | Assembly of high fidelity polynucleotides |
US8716467B2 (en) | 2010-03-03 | 2014-05-06 | Gen9, Inc. | Methods and devices for nucleic acid synthesis |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
CA2794522C (en) | 2010-04-05 | 2019-11-26 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
WO2011128096A1 (en) | 2010-04-16 | 2011-10-20 | Roche Diagnostics Gmbh | Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment |
WO2011143556A1 (en) | 2010-05-13 | 2011-11-17 | Gen9, Inc. | Methods for nucleotide sequencing and high fidelity polynucleotide synthesis |
WO2011150168A1 (en) | 2010-05-28 | 2011-12-01 | Gen9, Inc. | Methods and devices for in situ nucleic acid synthesis |
US20130143214A1 (en) | 2010-06-04 | 2013-06-06 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
CN103119176A (zh) | 2010-06-07 | 2013-05-22 | 霍夫曼-拉罗奇有限公司 | 用于预测对白介素-6受体抑制性单克隆抗体药物治疗的响应的基因表达标记 |
EP3360963B1 (de) | 2010-11-12 | 2019-11-06 | Gen9, Inc. | Verfahren und vorrichtungen für nukleinsäuresynthese |
EP2637780B1 (de) | 2010-11-12 | 2022-02-09 | Gen9, Inc. | Proteinanordnungen und verfahren zu ihrer herstellung und verwendung |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
CN103732744A (zh) | 2011-06-15 | 2014-04-16 | Gen9股份有限公司 | 制备性体外克隆的方法 |
US9752176B2 (en) | 2011-06-15 | 2017-09-05 | Ginkgo Bioworks, Inc. | Methods for preparative in vitro cloning |
LT3594340T (lt) | 2011-08-26 | 2021-10-25 | Gen9, Inc. | Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai |
EP2766498B1 (de) | 2011-10-14 | 2019-06-19 | President and Fellows of Harvard College | Sequenzierung durch strukturanordnung |
PL2768985T3 (pl) | 2011-10-21 | 2019-10-31 | Chronix Biomedical | Biomarkery będące krążącymi kwasami nukleinowymi związane z rakiem jelita grubego |
WO2014163886A1 (en) | 2013-03-12 | 2014-10-09 | President And Fellows Of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
WO2013123125A1 (en) | 2012-02-17 | 2013-08-22 | President And Fellows Of Harvard College | Assembly of nucleic acid sequences in emulsions |
FR2988093B1 (fr) * | 2012-03-14 | 2014-04-25 | Alveole | Dispositif de greffage micro-structure de proteines sur un substrat |
US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
EP2834371B1 (de) | 2012-04-05 | 2019-01-09 | The Regents of The University of California | Genexpressionspaneel für brustkrebsprognose |
EP2841601B1 (de) | 2012-04-24 | 2019-03-06 | Gen9, Inc. | Verfahren zum sortieren von nukleinsäuren und zur multiplexierten, vorbereitenden in-vitro-klonung |
WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
TWM445196U (zh) * | 2012-06-06 | 2013-01-11 | Chin-Feng Wan | 無光罩微影系統 |
TWM445178U (zh) * | 2012-06-25 | 2013-01-11 | Chin-Feng Wan | 結合光學平台之微流體晶片自動化系統 |
LT2864531T (lt) | 2012-06-25 | 2019-03-12 | Gen9, Inc. | Nukleorūgšties konstravimo ir aukšto produktyvumo sekvenavimo būdai |
KR101743846B1 (ko) | 2012-07-19 | 2017-06-05 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산을 이용하여 정보를 저장하는 방법 |
US9476089B2 (en) | 2012-10-18 | 2016-10-25 | President And Fellows Of Harvard College | Methods of making oligonucleotide probes |
EP2722105A1 (de) | 2012-10-22 | 2014-04-23 | Universität Wien | Verfahren zur In-situ-Synthetisierung von Mikroarrays |
US20140274749A1 (en) | 2013-03-15 | 2014-09-18 | Affymetrix, Inc. | Systems and Methods for SNP Characterization and Identifying off Target Variants |
US9879313B2 (en) | 2013-06-25 | 2018-01-30 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US20150141256A1 (en) * | 2013-07-29 | 2015-05-21 | Roche Nimblegen, Inc. | Compositions and methods for bisulfite converted sequence capture |
TWI646230B (zh) | 2013-08-05 | 2019-01-01 | 扭轉生物科技有限公司 | 重新合成之基因庫 |
US20150259743A1 (en) | 2013-12-31 | 2015-09-17 | Roche Nimblegen, Inc. | Methods of assessing epigenetic regulation of genome function via dna methylation status and systems and kits therefor |
CA2975855A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
EP4119677B1 (de) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
CA2998169A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
WO2017093246A1 (en) | 2015-11-30 | 2017-06-08 | F. Hoffmann-La Roche Ag | System and method for identification of protease substrates |
EP3384077A4 (de) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | Funktionalisierte oberflächen und herstellung davon |
US10184939B2 (en) | 2016-02-12 | 2019-01-22 | Roche Sequencing Solutions, Inc. | Detection of neoantigens using peptide arrays |
WO2018033478A1 (en) | 2016-08-15 | 2018-02-22 | F. Hoffmann-La Roche Ag | Method and composition for detection of peptide cyclization using protein tags |
KR102212257B1 (ko) | 2016-08-22 | 2021-02-04 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 핵산 라이브러리 |
CN109963584B (zh) | 2016-09-06 | 2024-03-15 | 豪夫迈·罗氏有限公司 | 结合mhc的肽阵列及其使用方法 |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
US10907274B2 (en) | 2016-12-16 | 2021-02-02 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
US11550939B2 (en) | 2017-02-22 | 2023-01-10 | Twist Bioscience Corporation | Nucleic acid based data storage using enzymatic bioencryption |
US10894959B2 (en) | 2017-03-15 | 2021-01-19 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
US11459618B2 (en) | 2017-03-29 | 2022-10-04 | Crown Bioscience, Inc. (Taicang) | System and method for determining Cetuximab sensitivity on gastric cancer |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
EP3638782A4 (de) | 2017-06-12 | 2021-03-17 | Twist Bioscience Corporation | Verfahren für nahtlose nukleinsäureanordnung |
CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
KR20240024357A (ko) | 2017-10-20 | 2024-02-23 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
US10936953B2 (en) | 2018-01-04 | 2021-03-02 | Twist Bioscience Corporation | DNA-based digital information storage with sidewall electrodes |
EP3814497A4 (de) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | Polynukleotide, reagenzien und verfahren zur nukleinsäurehybridisierung |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
US11492727B2 (en) | 2019-02-26 | 2022-11-08 | Twist Bioscience Corporation | Variant nucleic acid libraries for GLP1 receptor |
EP3987019A4 (de) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-basierte nukleinsäuresequenzanordnung |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
WO2023200259A1 (ko) * | 2022-04-13 | 2023-10-19 | 고려대학교 산학협력단 | 정밀 dna 광학 합성을 위한 시스템 및 방법 |
WO2023200261A1 (ko) * | 2022-04-13 | 2023-10-19 | 고려대학교 산학협력단 | 이미지반전에 의한 자가 정렬 기반 정밀 dna 광학 합성 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2644341C2 (de) | 1976-10-01 | 1984-08-02 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | Verfahren und Anordnungen zur automatischen Verwirklichung des Köhler'schen Beleuchtungsprinzipes |
US4146329A (en) * | 1977-09-14 | 1979-03-27 | The United States Of America As Represented By The Secretary Of The Navy | Autoalignment system for high power laser |
JPS5534490A (en) * | 1978-09-01 | 1980-03-11 | Canon Inc | Alignment device |
US4571603A (en) | 1981-11-03 | 1986-02-18 | Texas Instruments Incorporated | Deformable mirror electrostatic printer |
US4596992A (en) | 1984-08-31 | 1986-06-24 | Texas Instruments Incorporated | Linear spatial light modulator and printer |
US4662746A (en) | 1985-10-30 | 1987-05-05 | Texas Instruments Incorporated | Spatial light modulator and method |
US5096279A (en) | 1984-08-31 | 1992-03-17 | Texas Instruments Incorporated | Spatial light modulator and method |
US4615595A (en) | 1984-10-10 | 1986-10-07 | Texas Instruments Incorporated | Frame addressed spatial light modulator |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US5028939A (en) | 1988-08-23 | 1991-07-02 | Texas Instruments Incorporated | Spatial light modulator system |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
GB8917133D0 (en) | 1989-07-27 | 1989-09-13 | Parry Davis | Child safety seat |
US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5083857A (en) | 1990-06-29 | 1992-01-28 | Texas Instruments Incorporated | Multi-level deformable mirror device |
US5159172A (en) * | 1990-08-07 | 1992-10-27 | International Business Machines Corporation | Optical projection system |
WO1993002992A1 (en) | 1991-08-07 | 1993-02-18 | H & N Instruments, Inc. | Synthesis of chain chemical compounds |
US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
DE69233087T2 (de) | 1991-11-22 | 2003-12-24 | Affymetrix Inc N D Ges D Staat | Verfahren zur Herstellung von Polymerarrays |
US5404783A (en) * | 1992-06-10 | 1995-04-11 | Feiten; Howard B. | Method and apparatus for fully adjusting and intonating an acoustic guitar |
US5324483B1 (en) | 1992-10-08 | 1996-09-24 | Warner Lambert Co | Apparatus for multiple simultaneous synthesis |
US5600388A (en) | 1993-01-11 | 1997-02-04 | Pinnacle Brands, Inc. | Method and apparatus for creating cylindrical three dimensional picture |
US5552922A (en) * | 1993-04-12 | 1996-09-03 | Corning Incorporated | Optical system for projection display |
US5425483A (en) * | 1993-12-17 | 1995-06-20 | Mertes; James S. | Dispensing cap for vessel |
US5583688A (en) | 1993-12-21 | 1996-12-10 | Texas Instruments Incorporated | Multi-level digital micromirror device |
US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US5734498A (en) | 1994-05-09 | 1998-03-31 | The Regents Of The University Of California | Illuminator elements for conventional light microscopes |
US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5504614A (en) | 1995-01-31 | 1996-04-02 | Texas Instruments Incorporated | Method for fabricating a DMD spatial light modulator with a hardened hinge |
US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US5535047A (en) | 1995-04-18 | 1996-07-09 | Texas Instruments Incorporated | Active yoke hidden hinge digital micromirror device |
JP2800731B2 (ja) * | 1995-08-29 | 1998-09-21 | 株式会社ニコン | 走査露光方法、及び走査露光による回路素子製造方法 |
US5815310A (en) | 1995-12-12 | 1998-09-29 | Svg Lithography Systems, Inc. | High numerical aperture ring field optical reduction system |
US5696631A (en) | 1996-02-22 | 1997-12-09 | Anvik Corporation | Unit magnification projection lens system |
US5691541A (en) | 1996-05-14 | 1997-11-25 | The Regents Of The University Of California | Maskless, reticle-free, lithography |
JP3726270B2 (ja) * | 1996-05-23 | 2005-12-14 | 株式会社ニコン | 露光装置及び方法 |
US5870176A (en) | 1996-06-19 | 1999-02-09 | Sandia Corporation | Maskless lithography |
US5768009A (en) * | 1997-04-18 | 1998-06-16 | E-Beam | Light valve target comprising electrostatically-repelled micro-mirrors |
US6426184B1 (en) * | 1998-02-11 | 2002-07-30 | The Regents Of The University Of Michigan | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
EP2259046A3 (de) | 1998-02-23 | 2011-11-30 | Wisconsin Alumni Research Foundation | Verfahren zur Synthese von DNA-Sonden-Arrays |
US6271957B1 (en) | 1998-05-29 | 2001-08-07 | Affymetrix, Inc. | Methods involving direct write optical lithography |
WO1999063385A1 (en) | 1998-06-04 | 1999-12-09 | Board Of Regents, The University Of Texas System | Digital optical chemistry micromirror imager |
-
1999
- 1999-02-22 EP EP10010737A patent/EP2259046A3/de not_active Withdrawn
- 1999-02-22 EP EP99908351A patent/EP1066506B1/de not_active Expired - Lifetime
- 1999-02-22 MX MXPA00008263A patent/MXPA00008263A/es active IP Right Grant
- 1999-02-22 ES ES10001599.9T patent/ES2656439T3/es not_active Expired - Lifetime
- 1999-02-22 ES ES99908351T patent/ES2344772T3/es not_active Expired - Lifetime
- 1999-02-22 CA CA2321070A patent/CA2321070C/en not_active Expired - Lifetime
- 1999-02-22 WO PCT/US1999/003807 patent/WO1999042813A1/en active IP Right Grant
- 1999-02-22 IL IL13790199A patent/IL137901A/en not_active IP Right Cessation
- 1999-02-22 US US09/253,460 patent/US6375903B1/en not_active Expired - Lifetime
- 1999-02-22 JP JP2000532704A patent/JP4698023B2/ja not_active Expired - Lifetime
- 1999-02-22 EP EP10001599.9A patent/EP2180309B1/de not_active Expired - Lifetime
- 1999-02-22 AT AT99908351T patent/ATE464946T1/de not_active IP Right Cessation
- 1999-02-22 DE DE69942272T patent/DE69942272D1/de not_active Expired - Lifetime
- 1999-02-22 AU AU27804/99A patent/AU746760B2/en not_active Expired
-
2006
- 2006-09-20 US US11/524,082 patent/US8030477B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2259046A2 (de) | 2010-12-08 |
EP2180309A3 (de) | 2011-12-07 |
ES2656439T3 (es) | 2018-02-27 |
EP1066506B1 (de) | 2010-04-21 |
EP1066506A1 (de) | 2001-01-10 |
EP1066506A4 (de) | 2005-02-23 |
EP2180309B1 (de) | 2017-11-01 |
JP4698023B2 (ja) | 2011-06-08 |
IL137901A (en) | 2004-07-25 |
CA2321070A1 (en) | 1999-08-26 |
US20100227780A1 (en) | 2010-09-09 |
MXPA00008263A (es) | 2002-04-24 |
DE69942272D1 (de) | 2010-06-02 |
US8030477B2 (en) | 2011-10-04 |
EP2180309A2 (de) | 2010-04-28 |
AU2780499A (en) | 1999-09-06 |
WO1999042813A1 (en) | 1999-08-26 |
IL137901A0 (en) | 2001-10-31 |
CA2321070C (en) | 2010-04-06 |
US6375903B1 (en) | 2002-04-23 |
EP2259046A3 (de) | 2011-11-30 |
AU746760B2 (en) | 2002-05-02 |
ES2344772T3 (es) | 2010-09-06 |
JP2002504679A (ja) | 2002-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE464946T1 (de) | Verfahren und vorrichtung zur synthese von dan- sonderanordnungen | |
DE69623489T2 (de) | Formungsverfahren durch selektiven materialabsatz und vorrichtung zur formung von dreidimensionalen gegenständen mit stützstruktur | |
CA2474601A1 (en) | Pre-patterned substrate, device and method for optical synthesis of dna probes | |
EP0961174A3 (de) | Zusammensetzungen und Verfahren für direkt schreibende optische Lithographie | |
FR2705479B1 (fr) | Procédé et appareil de reconnaissance de formes. | |
ATE156034T1 (de) | Verfahren und vorrichtung zur durchfürung einer vielzahl von chemischen reaktionen auf einer traegerflaeche | |
DE19782096T1 (de) | Immobiliserung von Nucleinsäuren in hoher Dichte | |
DE69609375T2 (de) | Verfahren zum Schreiben von Bildern auf ein keramisches Material | |
ATE162117T1 (de) | Vorrichtung zur reinigung in situ von kronleuchtern mit ultraschallkavitationseffekte | |
DE69608431T2 (de) | Vorrichtung zum Aufspannen von Karosserien diverser Typen | |
DE69605711D1 (de) | Vorrichtung und Verfahren zur Zufuhr von Teig | |
DE69824065D1 (de) | Vorrichtung und Verfahren zum Drucken unter Verwendung von Mehrfachdüsengruppen | |
DE69415123T2 (de) | Vorrichtung zum Vervielfältigen von Bildern | |
DE19523076C5 (de) | Vorrichtung zur Erzielung einer einwandfreien Auflage eines Bedruckstoffs in einer Druckmaschine | |
DE69806625T2 (de) | Vorrichtung zum beleuchten von mustern | |
DE69415155T2 (de) | Vorrichtung zur herstellung von druckplatten zum siebdrucken | |
TW200705546A (en) | Process for forming pattern | |
ATE82983T1 (de) | Verfahren und vorrichtung zur vollautomatischen simultanen synthese mehrerer polypeptide. | |
DE69016823D1 (de) | Vorrichtung zum Aufbringen eines Leiterbahnmusters unter Verwendung eines Rastertunnelmikroskops. | |
DE69022487T2 (de) | Vorrichtung zum Verdampfen von Substanzen. | |
DE59813115D1 (de) | Verfahren und Vorrichtung zum Dekorieren von flachen selbsttragenden Objekten | |
DE59801421D1 (de) | Verfahren zum Besticken von rohrförmigem Nähgut und Vorrichtung zum Besticken von rohrförmigem Nähgut | |
DE68907942T3 (de) | Verfahren zur Steuerung eines Matrixbildschirms und Vorrichtung zur Durchführung dieses Verfahrens. | |
ATE321154T1 (de) | Verfahren und vorrichtung zur herstellung von filmen | |
US20040026229A1 (en) | Method and device for the mask-free production of biopolymers by means of a light diode array |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |