ATE464389T1 - Transgene huftiere, die zur produktion von menschlichen antikörpern fähig sind - Google Patents
Transgene huftiere, die zur produktion von menschlichen antikörpern fähig sindInfo
- Publication number
- ATE464389T1 ATE464389T1 AT03738939T AT03738939T ATE464389T1 AT E464389 T1 ATE464389 T1 AT E464389T1 AT 03738939 T AT03738939 T AT 03738939T AT 03738939 T AT03738939 T AT 03738939T AT E464389 T1 ATE464389 T1 AT E464389T1
- Authority
- AT
- Austria
- Prior art keywords
- human antibodies
- unfound
- transgenic
- animals
- capability
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 230000002779 inactivation Effects 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 210000004507 artificial chromosome Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8773—Ovine embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38153102P | 2002-05-17 | 2002-05-17 | |
US42505602P | 2002-11-08 | 2002-11-08 | |
PCT/US2003/015937 WO2003097812A2 (en) | 2002-05-17 | 2003-05-19 | Transgenic ungulates capable of human antibody production |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE464389T1 true ATE464389T1 (de) | 2010-04-15 |
Family
ID=29553536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03738939T ATE464389T1 (de) | 2002-05-17 | 2003-05-19 | Transgene huftiere, die zur produktion von menschlichen antikörpern fähig sind |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1513397B1 (de) |
JP (1) | JP2005525817A (de) |
KR (1) | KR20050000558A (de) |
CN (1) | CN1668187A (de) |
AT (1) | ATE464389T1 (de) |
CA (1) | CA2484655A1 (de) |
DE (1) | DE60332111D1 (de) |
IL (1) | IL165088A0 (de) |
NZ (1) | NZ536341A (de) |
WO (1) | WO2003097812A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
NZ550106A (en) * | 2004-04-22 | 2009-06-26 | Kyowa Hakko Kirin Co Ltd | Transgenic animals and uses thereof |
DK1758986T3 (en) * | 2004-06-09 | 2016-01-18 | Univ Edinburgh | Neural stem cells |
NZ554824A (en) * | 2004-10-22 | 2010-10-29 | Revivicor Inc | Porcines that lack endogenous antibody chains and express exogenous immunoglobulins |
EP2048229B1 (de) | 2006-07-07 | 2016-02-17 | Kyowa Hakko Kirin Co., Ltd. | Hac-(human artificial chromosome-)vektor und diesen enthaltendes humanzellen-pharmazeutikum |
EP2348827B1 (de) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunsupprimierte huftiere |
US20100158878A1 (en) | 2008-12-23 | 2010-06-24 | Alexandra Capela | Target populations of oligodendrocyte precursor cells and methods of making and using same |
CN102711804B (zh) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | 包含glp-1激动剂和甲硫氨酸的药物组合物 |
US9315824B2 (en) | 2009-11-17 | 2016-04-19 | Sab, Llc | Human artificial chromosome vector |
WO2014022853A1 (en) * | 2012-08-03 | 2014-02-06 | Sanford Applied Biosciences, L.L.C. | Complex chromosome engineering for production of human antibodies in transgenic animals |
US20160002330A1 (en) * | 2013-02-13 | 2016-01-07 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Cetuximab with modified glycosylation and uses thereof |
ES2894837T3 (es) | 2013-04-18 | 2022-02-16 | Inst Nat Sante Rech Med | Composición con inmunogenicidad reducida |
EA201790558A1 (ru) * | 2014-10-15 | 2017-08-31 | Ксенотера | Композиция с пониженной иммуногенностью |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652373A (en) * | 1990-01-15 | 1997-07-29 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
KR100272077B1 (ko) * | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5789655A (en) * | 1994-05-13 | 1998-08-04 | The Regents Of The University Of California | Transgenic animals expressing artificial epitope-tagged proteins |
KR20050085971A (ko) | 1995-04-27 | 2005-08-29 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
WO1997007671A1 (fr) * | 1995-08-29 | 1997-03-06 | Kirin Beer Kabushiki Kaisha | Animal chimerique et procede de constitution |
EP2314625B1 (de) | 1996-12-03 | 2014-05-07 | Amgen Fremont Inc. | Transgene Säugetiere, die menschliche Ig-loci einschliesslich mehrere VH und Vkappa Regionen enthalten, und davon erhaltene Antikörper |
WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
KR100882030B1 (ko) * | 2000-11-17 | 2009-02-09 | 교와 핫꼬 기린 가부시키가이샤 | 클로닝된 트랜스제닉 유제류에서 이종 (사람)면역글로블린의 발현 |
US20020108132A1 (en) * | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
-
2003
- 2003-05-19 CN CNA038167425A patent/CN1668187A/zh active Pending
- 2003-05-19 JP JP2004506471A patent/JP2005525817A/ja active Pending
- 2003-05-19 DE DE60332111T patent/DE60332111D1/de not_active Expired - Lifetime
- 2003-05-19 IL IL16508803A patent/IL165088A0/xx unknown
- 2003-05-19 EP EP03738939A patent/EP1513397B1/de not_active Expired - Lifetime
- 2003-05-19 NZ NZ536341A patent/NZ536341A/en unknown
- 2003-05-19 AT AT03738939T patent/ATE464389T1/de not_active IP Right Cessation
- 2003-05-19 CA CA002484655A patent/CA2484655A1/en not_active Abandoned
- 2003-05-19 WO PCT/US2003/015937 patent/WO2003097812A2/en active Application Filing
- 2003-05-19 KR KR10-2004-7018599A patent/KR20050000558A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1513397A4 (de) | 2007-10-24 |
DE60332111D1 (de) | 2010-05-27 |
JP2005525817A (ja) | 2005-09-02 |
EP1513397B1 (de) | 2010-04-14 |
IL165088A0 (en) | 2005-12-18 |
AU2003245300A1 (en) | 2003-12-02 |
CN1668187A (zh) | 2005-09-14 |
CA2484655A1 (en) | 2003-11-27 |
WO2003097812A2 (en) | 2003-11-27 |
KR20050000558A (ko) | 2005-01-05 |
EP1513397A2 (de) | 2005-03-16 |
WO2003097812A3 (en) | 2004-02-12 |
NZ536341A (en) | 2008-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |