ATE461170T1 - Verfahren zur herstellung von bicalutamid und verfahren zur aufreinigung von zwischenprodukten dafür - Google Patents

Verfahren zur herstellung von bicalutamid und verfahren zur aufreinigung von zwischenprodukten dafür

Info

Publication number: ATE461170T1
Authority: AT; Austria
Prior art keywords: compound; producing; formula; bicalutamid; intermediate products
Prior art date: 2003-10-16

Application number

AT04792811T

Other languages

English (en)

Inventor

Tetsuya Shintaku

Tadashi Katsura

Kiyoshi Sugi

Nobushige Itaya

Original Assignee

Sumitomo Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-16

Filing date

2004-10-15

Publication date

2010-04-15

2004-10-15 Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461170T1 publication Critical patent/ATE461170T1/de

Links

238000000034 method Methods 0.000 title abstract 3
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
239000013078 crystal Substances 0.000 abstract 5
SCKXCAADGDQQCS-UHFFFAOYSA-N Performic acid Chemical compound OOC=O SCKXCAADGDQQCS-UHFFFAOYSA-N 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 abstract 1
OKIHXNKYYGUVTE-UHFFFAOYSA-N 4-Fluorothiophenol Chemical compound FC1=CC=C(S)C=C1 OKIHXNKYYGUVTE-UHFFFAOYSA-N 0.000 abstract 1
229960000997 bicalutamide Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/06—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT04792811T 2003-10-16 2004-10-15 Verfahren zur herstellung von bicalutamid und verfahren zur aufreinigung von zwischenprodukten dafür ATE461170T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003357038A JP4322621B2 (ja)	2003-10-16	2003-10-16	４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
PCT/JP2004/015669 WO2005037777A1 (ja)	2003-10-16	2004-10-15	ビカルタミドの製造方法及びその中間体の精製方法

Publications (1)

Publication Number	Publication Date
ATE461170T1 true ATE461170T1 (de)	2010-04-15

Family

ID=34463235

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04792811T ATE461170T1 (de)	2003-10-16	2004-10-15	Verfahren zur herstellung von bicalutamid und verfahren zur aufreinigung von zwischenprodukten dafür

Country Status (15)

Country	Link
US (1)	US20060183934A1 (de)
EP (1)	EP1679306B1 (de)
JP (1)	JP4322621B2 (de)
KR (1)	KR101126948B1 (de)
AT (1)	ATE461170T1 (de)
AU (1)	AU2004282077A1 (de)
BR (1)	BRPI0415347A (de)
CA (1)	CA2542788C (de)
DE (1)	DE602004026088D1 (de)
ES (1)	ES2341008T3 (de)
IL (1)	IL174781A (de)
IS (1)	IS2757B (de)
NZ (1)	NZ546466A (de)
WO (1)	WO2005037777A1 (de)
ZA (1)	ZA200603289B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE521590T1 (de) *	2004-07-14	2011-09-15	Sumitomo Chemical Co	Verfahren zur kristallisation von bicalutamid
EP1863759A1 (de) *	2005-03-29	2007-12-12	Usv Limited	Verfahren zur herstellung von bicalutamid
CA2513356A1 (en) *	2005-07-26	2007-01-26	Apotex Pharmachem Inc.	Process for production of bicalutamide
CZ299577B6 (cs) *	2005-12-20	2008-09-03	Interpharma Praha, A. S.	Zpusob výroby vysoce cistého 4-kyano-3-trifluoromethyl-N-(3-p-fluorfenylsulfonyl-2-hydroxy-2-methylpropionyl) anilinu
AU2006329551A1 (en)	2005-12-27	2007-07-05	Dabur Pharma Limited	An improved process for preparation of Bicalutamide
CN105541680B (zh) *	2016-02-16	2017-12-22	重庆硕奥科技有限公司	一种比卡鲁胺的合成方法
CN106748884B (zh) *	2016-12-13	2021-08-20	山西振东制药股份有限公司	一种比卡鲁胺中间体的制备方法
CN106831509B (zh) *	2017-02-07	2018-05-18	西北师范大学	一种比卡鲁胺的合成方法
CN106905265A (zh) *	2017-03-09	2017-06-30	常州沃腾化工科技有限公司	N‑[4‑氰基‑3‑（三氟甲基）苯基]‑2,3‑环氧‑2‑甲基丙酰胺的制备方法
CN109456227B (zh) *	2018-11-19	2021-11-16	常州新星联生物科技有限公司	一种比卡鲁胺环氧中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU223950B1 (hu)	1999-06-10	2005-03-29	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
KR20020091047A (ko)	1999-10-19	2002-12-05	노벡스 코포레이션	카소덱스, 그의 유도체 및 중간산물의 에난티오머를비대칭 합성하는 방법
AU2001295044A1 (en)	2000-09-21	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
DE60233526D1 (de) *	2001-12-13	2009-10-08	Sumitomo Chemical Co	Bicalutamidkristalle und verfahren zu deren herstellung

2003
- 2003-10-16 JP JP2003357038A patent/JP4322621B2/ja not_active Expired - Fee Related
2004
- 2004-10-15 EP EP04792811A patent/EP1679306B1/de not_active Not-in-force
- 2004-10-15 KR KR1020067009306A patent/KR101126948B1/ko not_active IP Right Cessation
- 2004-10-15 BR BRPI0415347-2A patent/BRPI0415347A/pt not_active IP Right Cessation
- 2004-10-15 NZ NZ546466A patent/NZ546466A/en not_active IP Right Cessation
- 2004-10-15 WO PCT/JP2004/015669 patent/WO2005037777A1/ja active Application Filing
- 2004-10-15 ES ES04792811T patent/ES2341008T3/es active Active
- 2004-10-15 CA CA2542788A patent/CA2542788C/en not_active Expired - Fee Related
- 2004-10-15 ZA ZA200603289A patent/ZA200603289B/en unknown
- 2004-10-15 DE DE602004026088T patent/DE602004026088D1/de active Active
- 2004-10-15 AU AU2004282077A patent/AU2004282077A1/en not_active Abandoned
- 2004-10-15 AT AT04792811T patent/ATE461170T1/de not_active IP Right Cessation
2006
- 2006-04-04 IL IL174781A patent/IL174781A/en not_active IP Right Cessation
- 2006-04-11 US US11/401,262 patent/US20060183934A1/en not_active Abandoned
- 2006-05-11 IS IS8459A patent/IS2757B/is unknown

Also Published As

Publication number	Publication date
EP1679306A1 (de)	2006-07-12
IL174781A0 (en)	2006-08-20
AU2004282077A1 (en)	2005-04-28
BRPI0415347A (pt)	2006-12-05
NZ546466A (en)	2009-08-28
EP1679306A4 (de)	2006-10-11
JP2005120024A (ja)	2005-05-12
CA2542788A1 (en)	2005-04-28
KR20060117948A (ko)	2006-11-17
EP1679306B1 (de)	2010-03-17
IL174781A (en)	2011-05-31
JP4322621B2 (ja)	2009-09-02
AU2004282077A2 (en)	2005-04-28
CA2542788C (en)	2012-01-03
IS2757B (is)	2011-10-15
ES2341008T3 (es)	2010-06-14
ZA200603289B (en)	2007-07-25
WO2005037777A1 (ja)	2005-04-28
US20060183934A1 (en)	2006-08-17
IS8459A (is)	2006-05-11
KR101126948B1 (ko)	2012-03-20
DE602004026088D1 (de)	2010-04-29

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Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties