ATE458808T1 - Verfahren zur herstellung einer voll entwickelten natürlichen killerzelle - Google Patents

Verfahren zur herstellung einer voll entwickelten natürlichen killerzelle

Info

Publication number
ATE458808T1
ATE458808T1 AT06798754T AT06798754T ATE458808T1 AT E458808 T1 ATE458808 T1 AT E458808T1 AT 06798754 T AT06798754 T AT 06798754T AT 06798754 T AT06798754 T AT 06798754T AT E458808 T1 ATE458808 T1 AT E458808T1
Authority
AT
Austria
Prior art keywords
natural killer
killer cell
axl
protein
precursor
Prior art date
Application number
AT06798754T
Other languages
English (en)
Inventor
Hyung Sik Kang
Sang Hyun Kim
Eun Mi Kim
Eun Hee Lee
Hee Jung Yun
Chang Bo Ko
Young Jin Heo
Woo Young Shim
Seong Beom Heo
Ji Yeon Yoon
Original Assignee
Univ Nat Chonnam Ind Found
Good Cell Life Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nat Chonnam Ind Found, Good Cell Life Inc filed Critical Univ Nat Chonnam Ind Found
Priority claimed from PCT/KR2006/003627 external-priority patent/WO2007032634A1/en
Application granted granted Critical
Publication of ATE458808T1 publication Critical patent/ATE458808T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
AT06798754T 2005-09-12 2006-09-12 Verfahren zur herstellung einer voll entwickelten natürlichen killerzelle ATE458808T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR1020050084896 2005-09-12
KR1020050084897 2005-09-12
KR1020050084898 2005-09-12
KR1020060070390A KR100650384B1 (ko) 2005-09-12 2006-07-26 성숙자연살해세포의 분화용 조성물 및 그 제조 방법
PCT/KR2006/003627 WO2007032634A1 (en) 2005-09-12 2006-09-12 A method for production of mature natural killer cell

Publications (1)

Publication Number Publication Date
ATE458808T1 true ATE458808T1 (de) 2010-03-15

Family

ID=37713748

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06798754T ATE458808T1 (de) 2005-09-12 2006-09-12 Verfahren zur herstellung einer voll entwickelten natürlichen killerzelle

Country Status (4)

Country Link
JP (1) JP2009507827A (de)
KR (1) KR100650384B1 (de)
AT (1) ATE458808T1 (de)
DE (1) DE602006012425D1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009104911A2 (en) * 2008-02-22 2009-08-27 Industry Foundation Of Chonnam National University Uses as agents for prophylaxis or treatment of cervical cancer
EP2723376B1 (de) * 2011-06-22 2018-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl-antikörper und verwendungen damit
DE102011106914B4 (de) 2011-07-08 2015-08-27 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
EP3737743A1 (de) * 2018-01-08 2020-11-18 Iovance Biotherapeutics, Inc. Verfahren zur erzeugung von til-produkten, die für tumorantigenspezifische t-zellen angereichert sind
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
US20220025327A1 (en) * 2018-10-01 2022-01-27 Universiteit Gent Accelerated human hematopoeitic stem cell differentiation towards mature natural killer cells with enhanced antibody-dependent cytotoxic activity
CN114736859B (zh) * 2022-06-13 2022-08-19 广东先康达生物科技有限公司 一种脐带血nk细胞的培养液及培养方法

Also Published As

Publication number Publication date
KR100650384B1 (ko) 2006-11-30
DE602006012425D1 (de) 2010-04-08
JP2009507827A (ja) 2009-02-26

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