ATE457734T1 - Kombinationstherapie zur behandlung von hepatitis b infektionen - Google Patents

Kombinationstherapie zur behandlung von hepatitis b infektionen

Info

Publication number
ATE457734T1
ATE457734T1 AT03077543T AT03077543T ATE457734T1 AT E457734 T1 ATE457734 T1 AT E457734T1 AT 03077543 T AT03077543 T AT 03077543T AT 03077543 T AT03077543 T AT 03077543T AT E457734 T1 ATE457734 T1 AT E457734T1
Authority
AT
Austria
Prior art keywords
hepatitis
combination
alternation
administering
directed
Prior art date
Application number
AT03077543T
Other languages
English (en)
Inventor
Phillip A Furman
George R Painter
David Barry
Franck Rousseau
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of ATE457734T1 publication Critical patent/ATE457734T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03077543T 1998-11-02 1999-11-02 Kombinationstherapie zur behandlung von hepatitis b infektionen ATE457734T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10666498P 1998-11-02 1998-11-02

Publications (1)

Publication Number Publication Date
ATE457734T1 true ATE457734T1 (de) 2010-03-15

Family

ID=22312611

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03077543T ATE457734T1 (de) 1998-11-02 1999-11-02 Kombinationstherapie zur behandlung von hepatitis b infektionen
AT99961553T ATE287268T1 (de) 1998-11-02 1999-11-02 Kombinationstherapie zur behandlung von hepatitis b infektionen
AT03077542T ATE408410T1 (de) 1998-11-02 1999-11-02 Kombinationstherapie zur behandlung von hepatitis b infektionen

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT99961553T ATE287268T1 (de) 1998-11-02 1999-11-02 Kombinationstherapie zur behandlung von hepatitis b infektionen
AT03077542T ATE408410T1 (de) 1998-11-02 1999-11-02 Kombinationstherapie zur behandlung von hepatitis b infektionen

Country Status (16)

Country Link
US (3) US6528515B1 (de)
EP (3) EP1382343B1 (de)
JP (2) JP2002528508A (de)
KR (1) KR100632520B1 (de)
CN (3) CN1173705C (de)
AT (3) ATE457734T1 (de)
AU (1) AU1810600A (de)
CY (2) CY1108635T1 (de)
DE (3) DE69939604D1 (de)
DK (2) DK1382343T3 (de)
ES (3) ES2314157T3 (de)
HK (1) HK1062146A1 (de)
ID (1) ID29471A (de)
IL (3) IL142910A0 (de)
PT (2) PT1380303E (de)
WO (1) WO2000025797A1 (de)

Families Citing this family (11)

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IL142910A0 (en) * 1998-11-02 2002-04-21 Triangle Pharmaceuticals Inc Combination therapy to treat hepatitis b virus
ES2345099T3 (es) * 2002-06-19 2010-09-15 Fideline Feromonas tranquilizantes aviarias para disminuir el estres, la ansiedad y la agresividad.
JP4806187B2 (ja) * 2002-07-15 2011-11-02 ギリード・サイエンシズ・インコーポレーテッド Ｂ型肝炎ウイルスの治療のためのｌ−ｆｍａｕとの併用療法
US20040224916A1 (en) * 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
KR20100127180A (ko) * 2009-05-25 2010-12-03 부광약품 주식회사 클레부딘 및 아데포비어 디피복실을 함유하는 만성 ｂ형 간염 치료용 조성물
CN102917706A (zh) * 2010-05-18 2013-02-06 富光药品株式会社 含有克拉夫定及阿德福韦酯的用于治疗慢性乙型肝炎的组合物
RU2606845C2 (ru) 2010-12-10 2017-01-10 СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
WO2016180691A1 (en) * 2015-05-08 2016-11-17 F. Hoffmann-La Roche Ag Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
CN105943547B (zh) * 2016-05-23 2018-01-19 北京慧宝源生物技术股份有限公司 抗hbv的药物组合物及其应用

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US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
DE3485225D1 (de) 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
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Also Published As

Publication number Publication date
DE69923338D1 (de) 2005-02-24
IL193148A (en) 2011-09-27
EP1382343A1 (de) 2004-01-21
DK1380303T3 (da) 2008-12-01
HK1062146A1 (en) 2004-10-21
KR20010082282A (ko) 2001-08-29
EP1124562B1 (de) 2005-01-19
JP2011079840A (ja) 2011-04-21
JP2002528508A (ja) 2002-09-03
WO2000025797A1 (en) 2000-05-11
EP1382343B1 (de) 2010-02-17
EP1124562A1 (de) 2001-08-22
ES2338642T3 (es) 2010-05-11
AU1810600A (en) 2000-05-22
ES2314157T3 (es) 2009-03-16
CY1110629T1 (el) 2015-04-29
CN1666742A (zh) 2005-09-14
ATE287268T1 (de) 2005-02-15
DE69939604D1 (de) 2008-10-30
IL142910A (en) 2009-06-15
EP1380303B1 (de) 2008-09-17
DE69923338T2 (de) 2006-04-06
ES2237189T3 (es) 2005-07-16
DE69942042D1 (de) 2010-04-01
CN1891221A (zh) 2007-01-10
US7572800B2 (en) 2009-08-11
IL193148A0 (en) 2009-02-11
KR100632520B1 (ko) 2006-10-09
CY1108635T1 (el) 2014-04-09
US6528515B1 (en) 2003-03-04
ID29471A (id) 2001-08-30
EP1380303A1 (de) 2004-01-14
US20090247487A1 (en) 2009-10-01
PT1382343E (pt) 2010-03-10
PT1380303E (pt) 2008-11-03
CN1173705C (zh) 2004-11-03
DK1382343T3 (da) 2010-04-26
IL142910A0 (en) 2002-04-21
US20030158150A1 (en) 2003-08-21
ATE408410T1 (de) 2008-10-15
CN1329497A (zh) 2002-01-02

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