ATE449791T1 - Inhibierung von c5 komplement-aktivierung für die behandlung und vorbeugung von xeno-transplantat oder akute vaskuläre abstossung - Google Patents

Inhibierung von c5 komplement-aktivierung für die behandlung und vorbeugung von xeno-transplantat oder akute vaskuläre abstossung

Info

Publication number
ATE449791T1
ATE449791T1 AT01977478T AT01977478T ATE449791T1 AT E449791 T1 ATE449791 T1 AT E449791T1 AT 01977478 T AT01977478 T AT 01977478T AT 01977478 T AT01977478 T AT 01977478T AT E449791 T1 ATE449791 T1 AT E449791T1
Authority
AT
Austria
Prior art keywords
inhibition
treatment
acute vascular
xeno
transplant
Prior art date
Application number
AT01977478T
Other languages
English (en)
Inventor
Michael Fung
Bill Sun
Cecily Sun
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE449791T1 publication Critical patent/ATE449791T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01977478T 2000-10-10 2001-10-04 Inhibierung von c5 komplement-aktivierung für die behandlung und vorbeugung von xeno-transplantat oder akute vaskuläre abstossung ATE449791T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23930900P 2000-10-10 2000-10-10
PCT/US2001/031103 WO2002030985A2 (en) 2000-10-10 2001-10-04 Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection

Publications (1)

Publication Number Publication Date
ATE449791T1 true ATE449791T1 (de) 2009-12-15

Family

ID=22901599

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01977478T ATE449791T1 (de) 2000-10-10 2001-10-04 Inhibierung von c5 komplement-aktivierung für die behandlung und vorbeugung von xeno-transplantat oder akute vaskuläre abstossung

Country Status (11)

Country Link
US (1) US6534058B2 (de)
EP (5) EP3031827A1 (de)
AT (1) ATE449791T1 (de)
AU (1) AU2001296594A1 (de)
CA (1) CA2424379C (de)
DE (1) DE60140618D1 (de)
DK (1) DK1325033T3 (de)
ES (2) ES2483991T3 (de)
HK (3) HK1134508A1 (de)
PT (1) PT1325033E (de)
WO (1) WO2002030985A2 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8658773B2 (en) 2011-05-02 2014-02-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
ITMI20021527A1 (it) 2002-07-11 2004-01-12 Consiglio Nazionale Ricerche Anticorpi anti componente c5 del complemento e loro uso
DE60326264D1 (de) * 2002-12-02 2009-04-02 Resistentia Pharmaceuticals Ab Verfahren und materialien zur behandlung von entzündungen unter verwendung eines polypeptides das einen eigenen-c5 aminosaüresegment und einen nicht-eigenen aminosaüresegment enthält
US20070123466A1 (en) * 2003-05-13 2007-05-31 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Method of treating recurrent miscarriages
ATE498010T1 (de) 2004-03-01 2011-02-15 Immune Disease Inst Inc Natürliche igm-antikörper und inhibitoren davon
CA2566716C (en) * 2004-05-14 2014-12-23 Alexion Pharmaceuticals, Inc. Prolongation of survival of an allograft by inhibiting complement activity
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
ES2551202T5 (es) * 2005-11-04 2018-11-30 Genentech, Inc. Uso de inhibidores de la vía del complemento para tratar enfermedades oculares
AU2013200223B2 (en) * 2005-11-04 2015-08-20 Genentech, Inc. Use of Complement Pathway Inhibitors to Treat Ocular Diseases
KR101650264B1 (ko) 2006-03-02 2016-08-22 알렉시온 파마슈티칼스, 인코포레이티드 보체 활성을 저해함으로써 동종이식편의 생존 연장
US20090220508A1 (en) 2006-03-15 2009-09-03 Alexion Pharmaceuticals, Inc. Treatment Of Paroxysmal Nocturnal Hemoglobinuria Patients By An Inhibitor Of Complement
EP4001409A1 (de) 2006-03-31 2022-05-25 Chugai Seiyaku Kabushiki Kaisha Verfahren zur kontrolle der blutkinetik eines antikörpers
PL2061810T3 (pl) * 2006-09-05 2015-05-29 Alexion Pharma Inc Sposoby i kompozycje do leczenia neuropatii zależnych od przeciwciał
EP2097455B1 (de) 2006-11-02 2014-10-22 Genentech, Inc. Humanisierte anti-faktor d-antikörper
EP2979729A3 (de) 2007-02-05 2016-05-11 Apellis Pharmaceuticals, Inc. Compstatin analoga zur behandlung von entzundungserkrankungen der atemwege
ES2595638T3 (es) 2007-09-26 2017-01-02 Chugai Seiyaku Kabushiki Kaisha Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR
KR102084925B1 (ko) 2008-04-11 2020-03-05 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
CN102170906B (zh) * 2008-08-05 2014-07-30 诺华股份有限公司 靶定补体蛋白c5的抗体的组合物和方法
AU2014201433B2 (en) * 2008-08-05 2016-05-26 Novartis Ag Compositions and methods for antibodies targeting complement protein C5
WO2010093395A1 (en) 2009-02-13 2010-08-19 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
CN102482701B (zh) 2009-09-16 2015-05-13 免疫医疗公司 I类抗-cea抗体及其使用
CA2782194C (en) 2009-12-02 2018-01-16 Immunomedics, Inc. Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer
CN108715614A (zh) 2010-11-30 2018-10-30 中外制药株式会社 与多分子的抗原重复结合的抗原结合分子
WO2012178083A1 (en) 2011-06-22 2012-12-27 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
CN104114576B (zh) 2011-12-21 2017-04-05 诺华股份有限公司 用于抗体靶定p因子的组合物和方法
LT2817329T (lt) 2012-02-20 2019-04-10 Swedish Orphan Biovitrum Ab (Publ) Polipeptidai, prisijungiantys prie žmogaus komplemento c5
WO2014028560A2 (en) 2012-08-14 2014-02-20 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
TW201418707A (zh) * 2012-09-21 2014-05-16 Alexion Pharma Inc 補體組分c5拮抗劑之篩選分析
RS62243B9 (sr) 2012-11-15 2022-11-30 Apellis Pharmaceuticals Inc Analozi kompstatina sa produženim trajanjem dejstva i njihove kompozicije i postupci
KR102536723B1 (ko) 2012-12-13 2023-05-30 이뮤노메딕스, 인코오포레이티드 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약
WO2017004144A1 (en) 2015-07-01 2017-01-05 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
RU2018125515A (ru) * 2013-01-31 2018-10-29 СЕУЛ НЭШНЛ ЮНИВЕРСИТИ Ар энд ДиБи ФАУНДЕЙШН Антитело против c5 и способ предупреждения и лечения обусловленных комплементом заболеваний
US10308687B2 (en) 2013-03-15 2019-06-04 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
BR112016002845A2 (pt) 2013-08-12 2017-09-12 Genentech Inc composições e métodos para tratar condições associadas ao complemento
SG11201602679VA (en) 2013-08-28 2016-05-30 Swedish Orphan Biovitrum Ab Publ Stable polypeptides binding to human complement c5
PT3039033T (pt) 2013-08-28 2019-09-06 Affibody Ab Polipéptidos de ligação com um scaffold mutado
EP3107577B1 (de) 2014-02-21 2024-03-20 IBC Pharmaceuticals, Inc. Krankheitstherapie durch induktion einer immunantwort gegen trop-2-exprimierende zellen
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
JP2017515811A (ja) 2014-05-01 2017-06-15 ジェネンテック, インコーポレイテッド 抗d因子抗体変異体及びその使用法
US9580495B2 (en) 2014-06-24 2017-02-28 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
CA2961774C (en) 2014-10-07 2023-05-23 Immunomedics, Inc. Neoadjuvant use of antibody-drug conjugates
CR20170251A (es) 2014-12-19 2017-07-19 Chugai Pharmaceutical Co Ltd Anticuerpos anti-c5 y métodos para su uso
JP2018511557A (ja) 2015-01-22 2018-04-26 中外製薬株式会社 2種以上の抗c5抗体の組み合わせおよび使用方法
CA2981543A1 (en) 2015-04-22 2016-10-27 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
CN107735104B (zh) 2015-06-25 2022-05-03 免疫医疗公司 组合抗hla-dr抗体或抗trop-2抗体与微管抑制剂、parp抑制剂、布鲁顿激酶抑制剂或磷酸肌醇3-激酶抑制剂使癌症治疗结果显著改善
KR20180090785A (ko) 2015-10-07 2018-08-13 아펠리스 파마슈티컬스 인코포레이티드 투여 요법
TW201718014A (zh) 2015-10-12 2017-06-01 諾華公司 C5抑制劑於移植相關微血管病之用途
WO2017075173A2 (en) 2015-10-30 2017-05-04 Genentech, Inc. Anti-factor d antibodies and conjugates
US10654932B2 (en) 2015-10-30 2020-05-19 Genentech, Inc. Anti-factor D antibody variant conjugates and uses thereof
WO2017218515A1 (en) 2016-06-14 2017-12-21 Regeneron Pharmaceuticals, Inc. Anti-c5 antibodies and uses thereof
CA3026050A1 (en) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of il-8 related diseases
CR20220563A (es) 2017-01-31 2022-12-07 Chugai Pharmaceutical Co Ltd Una composición farmacéutica que comprende un anticuerpo anti-c5 contra una enfermedad relacionada con c5 y un producto de la misma
JP2020516607A (ja) 2017-04-07 2020-06-11 アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. 投与レジメンならびに関連組成物および方法
SG11202004662RA (en) 2017-12-13 2020-06-29 Regeneron Pharma Anti-c5 antibody combinations and uses thereof
US20210301004A1 (en) 2018-08-01 2021-09-30 Chugai Seiyaku Kabushiki Kaisha A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease
TW202120125A (zh) 2019-07-31 2021-06-01 瑞士商赫孚孟拉羅股份公司 藉由使用抗c5抗體克羅伐單抗(crovalimab)之治療或預防c5相關疾病之劑量及投藥療程
AU2020319677A1 (en) 2019-07-31 2022-01-06 F. Hoffmann-La Roche Ag Dosage and administration regimen for the treatment or prevention of C5-related diseases by the use of the anti-C5 antibody Crovalimab
US20220356234A1 (en) 2019-10-02 2022-11-10 Alexion Pharmaceuticals, Inc. Complement inhibitors for treating drug-induced complement-mediated response
CN111171149B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的人源化单链抗体及其应用
EP4150338A1 (de) 2020-05-15 2023-03-22 Alexion Pharmaceuticals, Inc. Verfahren zur verwendung von extrazellulären vesikeln zur erkennung von komplementaktivierungen und verwendungen davon zur beurteilung und/oder überwachung der behandlung einer komplementvermittelten erkrankung
CN114149501B (zh) * 2020-12-11 2023-05-26 天士力生物医药股份有限公司 抗c5抗体及其应用
JPWO2022239720A1 (de) 2021-05-10 2022-11-17

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
DE3380726D1 (en) 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5506247A (en) 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
US6395888B1 (en) * 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
US5679546A (en) 1993-09-24 1997-10-21 Cytomed, Inc. Chimeric proteins which block complement activation
EP0751787B1 (de) * 1994-03-23 2005-01-12 Alexion Pharmaceuticals, Inc. Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs
US6074642A (en) * 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5679345A (en) 1994-06-02 1997-10-21 The Johns Hopkins University Method for preventing complement-dependent rejection of organ or tissue transplants
US5546808A (en) 1994-09-06 1996-08-20 Harris Instrument Corporation Apparatus and method for binocular measurement system
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US6319897B1 (en) 1996-03-13 2001-11-20 John D. Lambris Peptides which inhibit complement activation
US5977076A (en) 1997-04-14 1999-11-02 Anderson; Byron E. Method and material for inhibiting complement
AU736549B2 (en) 1997-05-21 2001-08-02 Merck Patent Gesellschaft Mit Beschrankter Haftung Method for the production of non-immunogenic proteins
DK1007092T3 (da) 1997-08-26 2006-10-02 Amgen Fremont Inc En fremgangsmåde til inhibering af komplementaktivering via det alternative forlöb

Also Published As

Publication number Publication date
PT1325033E (pt) 2010-04-15
DK1325033T3 (da) 2010-04-06
AU2001296594A1 (en) 2002-04-22
EP3031827A1 (de) 2016-06-15
WO2002030985A3 (en) 2002-12-05
EP2113516A1 (de) 2009-11-04
HK1211043A1 (en) 2016-05-13
ES2333775T3 (es) 2010-03-01
CA2424379A1 (en) 2002-04-18
HK1134508A1 (en) 2010-04-30
EP2281840A3 (de) 2012-05-23
US20020041875A1 (en) 2002-04-11
CA2424379C (en) 2013-10-01
EP2281840A2 (de) 2011-02-09
HK1225741A1 (zh) 2017-09-15
ES2483991T3 (es) 2014-08-08
EP2896631A1 (de) 2015-07-22
US6534058B2 (en) 2003-03-18
WO2002030985A2 (en) 2002-04-18
EP1325033A2 (de) 2003-07-09
DE60140618D1 (de) 2010-01-07
EP1325033B1 (de) 2009-11-25
EP2113516B1 (de) 2014-05-21

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