ATE439356T1 - Verfahren zur herstellung von chiralen n-aryl piperazinen - Google Patents

Verfahren zur herstellung von chiralen n-aryl piperazinen

Info

Publication number: ATE439356T1
Authority: AT; Austria
Prior art keywords: producing chiral; aryl piperazines; piperazines; aryl; chiral
Prior art date: 2002-03-12

Application number

AT03716384T

Other languages

English (en)

Inventor

Gregg Feigelson

Joseph Zeldis

Ivo Jirkovsky

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-12

Filing date

2003-03-10

Publication date

2009-08-15

2003-03-10 Application filed by Wyeth Corp filed Critical Wyeth Corp

2009-08-15 Application granted granted Critical

2009-08-15 Publication of ATE439356T1 publication Critical patent/ATE439356T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
150000004885 piperazines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

AT03716384T 2002-03-12 2003-03-10 Verfahren zur herstellung von chiralen n-aryl piperazinen ATE439356T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36343102P	2002-03-12	2002-03-12
PCT/US2003/007078 WO2003078417A1 (en)	2002-03-12	2003-03-10	Process for synthesizing chiral n-aryl piperazines

Publications (1)

Publication Number	Publication Date
ATE439356T1 true ATE439356T1 (de)	2009-08-15

Family

ID=28041762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03716384T ATE439356T1 (de)	2002-03-12	2003-03-10	Verfahren zur herstellung von chiralen n-aryl piperazinen

Country Status (23)

Country	Link
US (1)	US6713626B2 (de)
EP (1)	EP1483255B1 (de)
JP (1)	JP4391241B2 (de)
KR (1)	KR20040105765A (de)
CN (2)	CN1304388C (de)
AR (1)	AR038930A1 (de)
AT (1)	ATE439356T1 (de)
AU (1)	AU2003220094B2 (de)
BR (1)	BR0308377A (de)
CA (1)	CA2477892C (de)
CR (1)	CR7431A (de)
DE (1)	DE60328756D1 (de)
EC (1)	ECSP045290A (de)
ES (1)	ES2329122T3 (de)
IL (1)	IL163827A0 (de)
MX (1)	MXPA04008729A (de)
NO (1)	NO20044050L (de)
NZ (1)	NZ535168A (de)
RU (1)	RU2315762C2 (de)
TW (1)	TW200403231A (de)
UA (1)	UA79273C2 (de)
WO (1)	WO2003078417A1 (de)
ZA (1)	ZA200408202B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060223824A1 (en)	2000-11-28	2006-10-05	Wyeth	Serotonergic agents
US20060287335A1 (en) *	2000-11-28	2006-12-21	Wyeth	Serotonergic agents for treating sexual dysfunction
WO2003007956A1 (en) *	2001-07-20	2003-01-30	Psychogenics, Inc.	Treatment for attention-deficit hyperactivity disorder
KR20040091119A (ko) *	2002-03-12	2004-10-27	와이어쓰	키랄 1,4-이치환된 피페라진의 제조방법
US7091349B2 (en) *	2002-03-12	2006-08-15	Wyeth	Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7361773B2 (en)	2002-03-12	2008-04-22	Wyeth	Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
AU2003220122A1 (en) *	2002-03-12	2003-09-29	Wyeth	Preparation of n1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
PA8626301A1 (es) *	2004-03-19	2006-12-07	Wyeth Wyeth	Proceso para preparar derivados de n-aril-piperazina
US20050215561A1 (en) *	2004-03-19	2005-09-29	Krishnendu Ghosh	Pharmaceutical dosage forms and compositions
US20070099931A1 (en) *	2004-03-19	2007-05-03	Wyeth	Pharmaceutical dosage forms and compositions
CN101137648A (zh) *	2005-03-01	2008-03-05	惠氏公司	结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0189612B1 (de)	1984-12-21	1992-11-04	Duphar International Research B.V	Arzneimittel mit psychotroper Wirkung
JPH01125357A (ja)	1987-11-06	1989-05-17	Dainippon Pharmaceut Co Ltd	トリペプチドの誘導体
IL101722A (en) *	1991-05-02	1996-05-14	Wyeth John & Brother Ltd	History of piperazine, their preparation and pharmaceutical preparations containing them
WO1994024115A1 (en) *	1993-04-16	1994-10-27	Santen Pharmaceutical Co., Ltd.	Novel piperazine derivative
GB9411099D0 (en) *	1994-06-03	1994-07-27	Wyeth John & Brother Ltd	Piperazine derivatives
WO1995033725A1 (en)	1994-06-03	1995-12-14	John Wyeth & Brother Limited	Novel processes and intermediates for the preparation of piperazine derivatives
GB9413772D0 (en) *	1994-07-08	1994-08-24	Wyeth John & Brother Ltd	5-HT1A ligands
GB9514901D0 (en) *	1995-07-20	1995-09-20	American Home Prod	Piperazine derivatives
DE69716900T2 (de)	1996-04-10	2003-07-03	Merck & Co., Inc.	Alpha v Beta 3 ANTAGONISTEN
US6469007B2 (en)	2000-11-28	2002-10-22	Wyeth	Serotonergic agents

2003
- 2003-03-10 WO PCT/US2003/007078 patent/WO2003078417A1/en active Application Filing
- 2003-03-10 NZ NZ535168A patent/NZ535168A/xx unknown
- 2003-03-10 US US10/384,845 patent/US6713626B2/en not_active Expired - Fee Related
- 2003-03-10 TW TW092105097A patent/TW200403231A/zh unknown
- 2003-03-10 MX MXPA04008729A patent/MXPA04008729A/es active IP Right Grant
- 2003-03-10 KR KR10-2004-7014156A patent/KR20040105765A/ko not_active Application Discontinuation
- 2003-03-10 CA CA2477892A patent/CA2477892C/en not_active Expired - Fee Related
- 2003-03-10 JP JP2003576423A patent/JP4391241B2/ja not_active Expired - Fee Related
- 2003-03-10 CN CNB038058413A patent/CN1304388C/zh not_active Expired - Fee Related
- 2003-03-10 CN CNA2007100083292A patent/CN1982307A/zh active Pending
- 2003-03-10 BR BR0308377-2A patent/BR0308377A/pt not_active IP Right Cessation
- 2003-03-10 IL IL16382703A patent/IL163827A0/xx unknown
- 2003-03-10 EP EP03716384A patent/EP1483255B1/de not_active Expired - Lifetime
- 2003-03-10 DE DE60328756T patent/DE60328756D1/de not_active Expired - Lifetime
- 2003-03-10 AU AU2003220094A patent/AU2003220094B2/en not_active Expired - Fee Related
- 2003-03-10 ES ES03716384T patent/ES2329122T3/es not_active Expired - Lifetime
- 2003-03-10 RU RU2004130300/04A patent/RU2315762C2/ru not_active IP Right Cessation
- 2003-03-10 AT AT03716384T patent/ATE439356T1/de not_active IP Right Cessation
- 2003-03-11 AR ARP030100831A patent/AR038930A1/es unknown
- 2003-10-03 UA UA20041008211A patent/UA79273C2/uk unknown
2004
- 2004-08-24 CR CR7431A patent/CR7431A/es not_active Application Discontinuation
- 2004-09-10 EC EC2004005290A patent/ECSP045290A/es unknown
- 2004-09-24 NO NO20044050A patent/NO20044050L/no not_active Application Discontinuation
- 2004-10-11 ZA ZA200408202A patent/ZA200408202B/en unknown

Also Published As

Publication number	Publication date
MXPA04008729A (es)	2005-07-13
CA2477892C (en)	2010-11-23
AR038930A1 (es)	2005-02-02
ECSP045290A (es)	2004-10-26
KR20040105765A (ko)	2004-12-16
CR7431A (es)	2008-07-29
US20030187265A1 (en)	2003-10-02
ES2329122T3 (es)	2009-11-23
NO20044050L (no)	2004-09-24
JP4391241B2 (ja)	2009-12-24
JP2005526775A (ja)	2005-09-08
EP1483255A1 (de)	2004-12-08
IL163827A0 (en)	2005-12-18
CA2477892A1 (en)	2003-09-25
US6713626B2 (en)	2004-03-30
BR0308377A (pt)	2005-01-11
EP1483255B1 (de)	2009-08-12
CN1642936A (zh)	2005-07-20
UA79273C2 (en)	2007-06-11
AU2003220094A1 (en)	2003-09-29
TW200403231A (en)	2004-03-01
RU2315762C2 (ru)	2008-01-27
DE60328756D1 (de)	2009-09-24
RU2004130300A (ru)	2005-04-10
NZ535168A (en)	2006-03-31
CN1982307A (zh)	2007-06-20
WO2003078417A1 (en)	2003-09-25
AU2003220094B2 (en)	2009-04-23
CN1304388C (zh)	2007-03-14
ZA200408202B (en)	2007-03-28

Legal Events

Date	Code	Title	Description
2010-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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