ATE439356T1 - Verfahren zur herstellung von chiralen n-aryl piperazinen - Google Patents
Verfahren zur herstellung von chiralen n-aryl piperazinenInfo
- Publication number
- ATE439356T1 ATE439356T1 AT03716384T AT03716384T ATE439356T1 AT E439356 T1 ATE439356 T1 AT E439356T1 AT 03716384 T AT03716384 T AT 03716384T AT 03716384 T AT03716384 T AT 03716384T AT E439356 T1 ATE439356 T1 AT E439356T1
- Authority
- AT
- Austria
- Prior art keywords
- producing chiral
- aryl piperazines
- piperazines
- aryl
- chiral
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36343102P | 2002-03-12 | 2002-03-12 | |
PCT/US2003/007078 WO2003078417A1 (en) | 2002-03-12 | 2003-03-10 | Process for synthesizing chiral n-aryl piperazines |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE439356T1 true ATE439356T1 (de) | 2009-08-15 |
Family
ID=28041762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03716384T ATE439356T1 (de) | 2002-03-12 | 2003-03-10 | Verfahren zur herstellung von chiralen n-aryl piperazinen |
Country Status (23)
Country | Link |
---|---|
US (1) | US6713626B2 (de) |
EP (1) | EP1483255B1 (de) |
JP (1) | JP4391241B2 (de) |
KR (1) | KR20040105765A (de) |
CN (2) | CN1304388C (de) |
AR (1) | AR038930A1 (de) |
AT (1) | ATE439356T1 (de) |
AU (1) | AU2003220094B2 (de) |
BR (1) | BR0308377A (de) |
CA (1) | CA2477892C (de) |
CR (1) | CR7431A (de) |
DE (1) | DE60328756D1 (de) |
EC (1) | ECSP045290A (de) |
ES (1) | ES2329122T3 (de) |
IL (1) | IL163827A0 (de) |
MX (1) | MXPA04008729A (de) |
NO (1) | NO20044050L (de) |
NZ (1) | NZ535168A (de) |
RU (1) | RU2315762C2 (de) |
TW (1) | TW200403231A (de) |
UA (1) | UA79273C2 (de) |
WO (1) | WO2003078417A1 (de) |
ZA (1) | ZA200408202B (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060223824A1 (en) | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
WO2003007956A1 (en) * | 2001-07-20 | 2003-01-30 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
KR20040091119A (ko) * | 2002-03-12 | 2004-10-27 | 와이어쓰 | 키랄 1,4-이치환된 피페라진의 제조방법 |
US7091349B2 (en) * | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
US7361773B2 (en) | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
AU2003220122A1 (en) * | 2002-03-12 | 2003-09-29 | Wyeth | Preparation of n1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
PA8626301A1 (es) * | 2004-03-19 | 2006-12-07 | Wyeth Wyeth | Proceso para preparar derivados de n-aril-piperazina |
US20050215561A1 (en) * | 2004-03-19 | 2005-09-29 | Krishnendu Ghosh | Pharmaceutical dosage forms and compositions |
US20070099931A1 (en) * | 2004-03-19 | 2007-05-03 | Wyeth | Pharmaceutical dosage forms and compositions |
CN101137648A (zh) * | 2005-03-01 | 2008-03-05 | 惠氏公司 | 结晶和非晶4-氰基-n-{(2r)-2-[4-(2,3-二氢-苯并[1,4]二氧杂环己烯-5-基)-哌嗪-1-基]-丙基}-n-吡啶-2-基-苯甲酰胺盐酸盐 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0189612B1 (de) | 1984-12-21 | 1992-11-04 | Duphar International Research B.V | Arzneimittel mit psychotroper Wirkung |
JPH01125357A (ja) | 1987-11-06 | 1989-05-17 | Dainippon Pharmaceut Co Ltd | トリペプチドの誘導体 |
IL101722A (en) * | 1991-05-02 | 1996-05-14 | Wyeth John & Brother Ltd | History of piperazine, their preparation and pharmaceutical preparations containing them |
WO1994024115A1 (en) * | 1993-04-16 | 1994-10-27 | Santen Pharmaceutical Co., Ltd. | Novel piperazine derivative |
GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
WO1995033725A1 (en) | 1994-06-03 | 1995-12-14 | John Wyeth & Brother Limited | Novel processes and intermediates for the preparation of piperazine derivatives |
GB9413772D0 (en) * | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
DE69716900T2 (de) | 1996-04-10 | 2003-07-03 | Merck & Co., Inc. | Alpha v Beta 3 ANTAGONISTEN |
US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
-
2003
- 2003-03-10 WO PCT/US2003/007078 patent/WO2003078417A1/en active Application Filing
- 2003-03-10 NZ NZ535168A patent/NZ535168A/xx unknown
- 2003-03-10 US US10/384,845 patent/US6713626B2/en not_active Expired - Fee Related
- 2003-03-10 TW TW092105097A patent/TW200403231A/zh unknown
- 2003-03-10 MX MXPA04008729A patent/MXPA04008729A/es active IP Right Grant
- 2003-03-10 KR KR10-2004-7014156A patent/KR20040105765A/ko not_active Application Discontinuation
- 2003-03-10 CA CA2477892A patent/CA2477892C/en not_active Expired - Fee Related
- 2003-03-10 JP JP2003576423A patent/JP4391241B2/ja not_active Expired - Fee Related
- 2003-03-10 CN CNB038058413A patent/CN1304388C/zh not_active Expired - Fee Related
- 2003-03-10 CN CNA2007100083292A patent/CN1982307A/zh active Pending
- 2003-03-10 BR BR0308377-2A patent/BR0308377A/pt not_active IP Right Cessation
- 2003-03-10 IL IL16382703A patent/IL163827A0/xx unknown
- 2003-03-10 EP EP03716384A patent/EP1483255B1/de not_active Expired - Lifetime
- 2003-03-10 DE DE60328756T patent/DE60328756D1/de not_active Expired - Lifetime
- 2003-03-10 AU AU2003220094A patent/AU2003220094B2/en not_active Expired - Fee Related
- 2003-03-10 ES ES03716384T patent/ES2329122T3/es not_active Expired - Lifetime
- 2003-03-10 RU RU2004130300/04A patent/RU2315762C2/ru not_active IP Right Cessation
- 2003-03-10 AT AT03716384T patent/ATE439356T1/de not_active IP Right Cessation
- 2003-03-11 AR ARP030100831A patent/AR038930A1/es unknown
- 2003-10-03 UA UA20041008211A patent/UA79273C2/uk unknown
-
2004
- 2004-08-24 CR CR7431A patent/CR7431A/es not_active Application Discontinuation
- 2004-09-10 EC EC2004005290A patent/ECSP045290A/es unknown
- 2004-09-24 NO NO20044050A patent/NO20044050L/no not_active Application Discontinuation
- 2004-10-11 ZA ZA200408202A patent/ZA200408202B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA04008729A (es) | 2005-07-13 |
CA2477892C (en) | 2010-11-23 |
AR038930A1 (es) | 2005-02-02 |
ECSP045290A (es) | 2004-10-26 |
KR20040105765A (ko) | 2004-12-16 |
CR7431A (es) | 2008-07-29 |
US20030187265A1 (en) | 2003-10-02 |
ES2329122T3 (es) | 2009-11-23 |
NO20044050L (no) | 2004-09-24 |
JP4391241B2 (ja) | 2009-12-24 |
JP2005526775A (ja) | 2005-09-08 |
EP1483255A1 (de) | 2004-12-08 |
IL163827A0 (en) | 2005-12-18 |
CA2477892A1 (en) | 2003-09-25 |
US6713626B2 (en) | 2004-03-30 |
BR0308377A (pt) | 2005-01-11 |
EP1483255B1 (de) | 2009-08-12 |
CN1642936A (zh) | 2005-07-20 |
UA79273C2 (en) | 2007-06-11 |
AU2003220094A1 (en) | 2003-09-29 |
TW200403231A (en) | 2004-03-01 |
RU2315762C2 (ru) | 2008-01-27 |
DE60328756D1 (de) | 2009-09-24 |
RU2004130300A (ru) | 2005-04-10 |
NZ535168A (en) | 2006-03-31 |
CN1982307A (zh) | 2007-06-20 |
WO2003078417A1 (en) | 2003-09-25 |
AU2003220094B2 (en) | 2009-04-23 |
CN1304388C (zh) | 2007-03-14 |
ZA200408202B (en) | 2007-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |