ATE432918T1 - Verfahren zur herstellung von cpla 2-inhibitoren - Google Patents

Verfahren zur herstellung von cpla 2-inhibitoren

Info

Publication number
ATE432918T1
ATE432918T1 AT04778654T AT04778654T ATE432918T1 AT E432918 T1 ATE432918 T1 AT E432918T1 AT 04778654 T AT04778654 T AT 04778654T AT 04778654 T AT04778654 T AT 04778654T AT E432918 T1 ATE432918 T1 AT E432918T1
Authority
AT
Austria
Prior art keywords
cpla
inhibitors
producing
producing cpla
Prior art date
Application number
AT04778654T
Other languages
English (en)
Inventor
Yanzhong Wu
Panolil Raveendranath
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE432918T1 publication Critical patent/ATE432918T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04778654T 2003-07-25 2004-07-19 Verfahren zur herstellung von cpla 2-inhibitoren ATE432918T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49000503P 2003-07-25 2003-07-25
PCT/US2004/023247 WO2005012238A1 (en) 2003-07-25 2004-07-19 Process for the preparation of cpla2 inhibitors

Publications (1)

Publication Number Publication Date
ATE432918T1 true ATE432918T1 (de) 2009-06-15

Family

ID=34115341

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04778654T ATE432918T1 (de) 2003-07-25 2004-07-19 Verfahren zur herstellung von cpla 2-inhibitoren

Country Status (14)

Country Link
US (2) US6891065B2 (de)
EP (1) EP1648861B1 (de)
JP (1) JP4607877B2 (de)
CN (1) CN100577640C (de)
AR (1) AR045089A1 (de)
AT (1) ATE432918T1 (de)
AU (1) AU2004261567A1 (de)
BR (1) BRPI0412904A (de)
CA (1) CA2528174C (de)
DE (1) DE602004021388D1 (de)
ES (1) ES2325265T3 (de)
MX (1) MXPA06000406A (de)
TW (1) TW200510305A (de)
WO (1) WO2005012238A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
TW200510305A (en) 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
AR053410A1 (es) * 2004-08-19 2007-05-09 Wyeth Corp Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios
TW200718687A (en) 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
KR100746342B1 (ko) 2006-04-10 2007-08-03 한국과학기술원 구리 촉매 존재하에서 n―설포닐아미드 화합물의 제조방법
CN100363341C (zh) * 2006-05-12 2008-01-23 北京化工大学 旋光性n-炔丙磺酰胺聚合物及其制备方法
BRPI0718042A2 (pt) * 2006-10-31 2013-11-12 Wyeth Corp Formulações semissólidas de inibidores de enzima fosfolipase
WO2008055136A2 (en) * 2006-10-31 2008-05-08 Wyeth Liquid formulations of phospholipase enzyme inhibitors
US8113207B2 (en) * 2008-08-22 2012-02-14 Kimberly-Clark Worldwide, Inc. Self-conforming sound attenuation earplug
CN102617558A (zh) * 2012-03-26 2012-08-01 上海泛凯生物医药科技有限公司 一种维拉佐酮的制备方法
CN110437125B (zh) * 2019-09-06 2021-03-12 苏州旺山旺水生物医药有限公司 一种Tezacaftor中间体II的制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5461075A (en) 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
DE3826230A1 (de) 1988-08-02 1990-02-08 Hoechst Ag Heterocyclische n-acylsufonamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
US5186736A (en) 1988-08-02 1993-02-16 Hoechst Aktiengesellschaft Heterocyclic N-acylsulfonamides and their use as herbicides or growth regulators
JPH02115157A (ja) * 1988-10-24 1990-04-27 Hokko Chem Ind Co Ltd スルホニルグリシン誘導体および除草剤
CA2017383A1 (en) 1989-06-08 1990-12-08 Raymond R. Martodam Use of vanilloids for the treatment of respiratory diseases or disorders
DE3935277A1 (de) 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
GB9201755D0 (en) 1992-01-28 1992-03-11 British Bio Technology Compounds
CN1100045C (zh) 1993-12-20 2003-01-29 拜尔公司 具有含硫基的n-氰芳基氮杂环化合物
DE4431218A1 (de) 1994-09-02 1996-03-07 Bayer Ag Substituierte Pyrimidin(thi)one
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
DE19601626A1 (de) 1996-01-18 1997-07-24 Bayer Ag Substituierte N-Aryl-Stickstoffheterocyclen
DE19606594A1 (de) 1996-02-22 1997-08-28 Bayer Ag Substituierte 2-Aryl-1,2,4-triazin-3,5-di(thi)one
CA2264020A1 (en) * 1996-08-26 1998-03-05 Jean Bemis Inhibitors of phospholipase enzymes
EA200000868A1 (ru) * 1998-02-25 2001-04-23 Дженетикс Инститьют, Инк. Ингибиторы фосфолипаз
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
EP1316548A4 (de) * 2000-07-05 2004-05-19 Ajinomoto Kk Acylsulfonamidderivate
DE10043790A1 (de) 2000-09-06 2002-03-14 Bayer Ag Substituierte 1-Aryl-pyridin-2-(thi)one
CA2430409A1 (en) 2000-11-28 2002-06-06 Guilford Pharmaceuticals Inc. Bisubstituted carbocyclic cyclophilin binding compounds and their use
US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US20040242456A1 (en) 2001-09-06 2004-12-02 Christoph Luthy Herbicidal n-alkysulfonamino derivatives
US6635771B2 (en) * 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US6797708B2 (en) * 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
ES2401454T3 (es) * 2001-12-03 2013-04-19 Wyeth Llc Inhibidores de la fosfolipasa A2 citosólica
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
TW200510305A (en) 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7582771B2 (en) 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Also Published As

Publication number Publication date
AU2004261567A1 (en) 2005-02-10
AR045089A1 (es) 2005-10-12
JP2007500190A (ja) 2007-01-11
EP1648861A1 (de) 2006-04-26
US6891065B2 (en) 2005-05-10
MXPA06000406A (es) 2006-03-17
US7259277B2 (en) 2007-08-21
WO2005012238A1 (en) 2005-02-10
ES2325265T3 (es) 2009-08-31
CA2528174A1 (en) 2005-02-10
CN1816522A (zh) 2006-08-09
CN100577640C (zh) 2010-01-06
TW200510305A (en) 2005-03-16
BRPI0412904A (pt) 2006-09-26
JP4607877B2 (ja) 2011-01-05
US20050020858A1 (en) 2005-01-27
US20050159613A1 (en) 2005-07-21
CA2528174C (en) 2012-03-13
EP1648861B1 (de) 2009-06-03
DE602004021388D1 (de) 2009-07-16

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