ATE438722T1 - Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein - Google Patents
Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoproteinInfo
- Publication number
- ATE438722T1 ATE438722T1 AT01930179T AT01930179T ATE438722T1 AT E438722 T1 ATE438722 T1 AT E438722T1 AT 01930179 T AT01930179 T AT 01930179T AT 01930179 T AT01930179 T AT 01930179T AT E438722 T1 ATE438722 T1 AT E438722T1
- Authority
- AT
- Austria
- Prior art keywords
- sugar chain
- reduction
- protein
- mannose phosphate
- glycoprotein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000144643 | 2000-05-17 | ||
PCT/JP2001/004070 WO2001088143A1 (fr) | 2000-05-17 | 2001-05-16 | Procede d'elaboration de proteine avec reduction de chaine saccharose acide, et glycoproteine resultante |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE438722T1 true ATE438722T1 (de) | 2009-08-15 |
Family
ID=18651270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01930179T ATE438722T1 (de) | 2000-05-17 | 2001-05-16 | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
Country Status (9)
Country | Link |
---|---|
US (3) | US7198921B2 (de) |
EP (1) | EP1283265B1 (de) |
JP (2) | JP4969011B2 (de) |
AT (1) | ATE438722T1 (de) |
AU (1) | AU2001256762A1 (de) |
DE (1) | DE60139467D1 (de) |
DK (1) | DK1283265T3 (de) |
ES (1) | ES2328106T3 (de) |
WO (1) | WO2001088143A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60139467D1 (de) * | 2000-05-17 | 2009-09-17 | Mitsubishi Tanabe Pharma Corp | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
ZA200306406B (en) | 2001-01-19 | 2004-09-06 | Dow Chemical Co | Method for secretory production of glycoprotein having human-type sugar chain using plant cell. |
US7259007B2 (en) * | 2003-12-24 | 2007-08-21 | Glycofi, Inc. | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins |
AU2005238308B8 (en) * | 2004-04-29 | 2009-10-08 | Glycofi, Inc. | Methods for reducing or eliminating alpha-mannosidase resistant glycans in the production of glycoproteins |
CA2623197A1 (en) * | 2005-09-22 | 2007-03-29 | Prosci Incorporated | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
SG187521A1 (en) * | 2007-03-07 | 2013-02-28 | Glycofi Inc | Production of glycoproteins with modified fucosylation |
EP2508612B1 (de) * | 2007-04-03 | 2017-11-29 | Oxyrane UK Limited | Glycosylierung von Molekülen |
KR101460953B1 (ko) | 2007-04-17 | 2014-11-13 | 스티칭 디엔스트 랜드보위쿤디그 온데조에크 | 비-포유동물 글리코실트랜스퍼라제의 발현에 의한 식물에서의 포유동물형 글리코실화 |
US8637435B2 (en) * | 2007-11-16 | 2014-01-28 | Merck Sharp & Dohme Corp. | Eukaryotic cell display systems |
CN101903531B (zh) | 2007-12-19 | 2013-09-18 | 格利科菲公司 | 用于蛋白质生产的酵母菌株 |
US20100311122A1 (en) * | 2008-02-20 | 2010-12-09 | Glycofi, Inc | Vectors and yeast strains for protein production |
EP2263089B1 (de) * | 2008-03-03 | 2015-01-28 | GlycoFi, Inc. | Oberflächenanzeige rekombinanter proteine bei niederen eukaryoten |
US8067339B2 (en) * | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
AU2009282228A1 (en) | 2008-08-12 | 2010-02-18 | Glycofi, Inc. | Improved vectors and yeast strains for protein production: Ca2+ ATPase overexpression |
KR20110122134A (ko) | 2009-02-25 | 2011-11-09 | 머크 샤프 앤드 돔 코포레이션 | 글리코공학처리된 효모 피키아 파스토리스에서 갈락토스 동화 경로의 대사 공학 |
JP5990102B2 (ja) | 2009-09-29 | 2016-09-07 | ユニフェルシテイト ヘント | ホスホ−6−マンノースへのマンノース−1−ホスホ−6−マンノース結合の加水分解 |
CN102648286A (zh) | 2009-10-16 | 2012-08-22 | 默沙东公司 | 在巴斯德毕赤氏酵母中生产缺乏与针对宿主细胞抗原的抗体的可检测交叉结合活性的蛋白质的方法 |
MX2012004994A (es) | 2009-10-30 | 2012-06-12 | Merck Sharp & Dohme | Metodo para producir proteinas terapeuticas en pichia pastoris que carecen de actividad de dipeptidil aminopeptidasa. |
CA2777487A1 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Methods for the production of recombinant proteins with improved secretion efficiencies |
BR112012011980A2 (pt) | 2009-11-19 | 2021-09-08 | Oxyrane Uk Limited | Métodos de produzir células transformadas de yarrowia lipolytica e proteínas-alvocompreendendo n-glicanos, células transformadas de yarrowia lipolytica e suas culturas, bem como composição compreendendo glicoproteínas |
JP5976549B2 (ja) | 2010-02-24 | 2016-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ピチア・パストリスにおいて産生される治療用糖タンパク質上のn−グリコシル化部位占拠を増加させるための方法 |
BR112012030179A8 (pt) | 2010-05-27 | 2023-03-14 | Merck Sharp & Dohme | Polipeptídeo contendo fc |
CA2812870C (en) | 2010-09-29 | 2020-06-09 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
JP6131190B2 (ja) | 2010-09-29 | 2017-05-17 | オキシレイン ユーケー リミテッド | リン酸化n−グリカンの脱マンノシル化 |
CN110042066A (zh) | 2010-12-01 | 2019-07-23 | 默沙东公司 | 表面锚定的fc-诱饵抗体展示*** |
JP2014518608A (ja) | 2011-02-25 | 2014-08-07 | メルク・シャープ・アンド・ドーム・コーポレーション | 修飾o−グリコシル化を有するタンパク質の製造のための酵母株 |
AU2012258907A1 (en) | 2011-05-25 | 2013-11-07 | Merck Sharp & Dohme Corp. | Method for preparing Fc-containing polypeptides having improved properties |
WO2013062940A1 (en) | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp. | Engineered lower eukaryotic host strains for recombinant protein expression |
AU2013234042B2 (en) | 2012-03-15 | 2017-11-02 | Oxyrane Uk Limited | Methods and materials for treatment of Pompe's disease |
CN104271816A (zh) | 2012-05-11 | 2015-01-07 | 默沙东公司 | 表面锚定的轻链诱饵抗体展示*** |
DK2852610T3 (en) | 2012-05-23 | 2018-09-03 | Glykos Finland Oy | PRODUCTION OF FUCOSYLED GLYCOPROTEIN |
WO2014066134A1 (en) | 2012-10-22 | 2014-05-01 | Merck Sharp & Dohme Corp. | Crz1 mutant fungal cells |
JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | O−グリコシル化カルボキシ末端部分(ctp)ペプチド系のインスリンおよびインスリン類似体 |
WO2016012468A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL82935A0 (en) * | 1986-08-12 | 1987-12-20 | Phillips Petroleum Co | Secretion of heterologous proteins from yeast |
JPH093097A (ja) | 1995-06-16 | 1997-01-07 | Green Cross Corp:The | ピキア属酵母由来の糖鎖伸長タンパク、該蛋白質をコードするdna、修飾該dnaおよび形質転換体 |
JP2770010B2 (ja) | 1996-03-29 | 1998-06-25 | 工業技術院長 | 酵母のマンノース−1−リン酸転移を正に制御する遺伝子ならびにこの遺伝子の欠損変異株を利用する高マンノース型中性糖鎖の製造方法 |
US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
DE60139467D1 (de) * | 2000-05-17 | 2009-09-17 | Mitsubishi Tanabe Pharma Corp | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
US7029872B2 (en) * | 2000-06-28 | 2006-04-18 | Glycofi, Inc | Methods for producing modified glycoproteins |
-
2001
- 2001-05-16 DE DE60139467T patent/DE60139467D1/de not_active Expired - Lifetime
- 2001-05-16 WO PCT/JP2001/004070 patent/WO2001088143A1/ja active Application Filing
- 2001-05-16 AT AT01930179T patent/ATE438722T1/de not_active IP Right Cessation
- 2001-05-16 ES ES01930179T patent/ES2328106T3/es not_active Expired - Lifetime
- 2001-05-16 JP JP2001584525A patent/JP4969011B2/ja not_active Expired - Lifetime
- 2001-05-16 DK DK01930179T patent/DK1283265T3/da active
- 2001-05-16 US US10/276,075 patent/US7198921B2/en not_active Expired - Lifetime
- 2001-05-16 EP EP01930179A patent/EP1283265B1/de not_active Expired - Lifetime
- 2001-05-16 AU AU2001256762A patent/AU2001256762A1/en not_active Abandoned
-
2007
- 2007-02-16 US US11/707,737 patent/US7488591B2/en not_active Expired - Lifetime
-
2008
- 2008-08-01 US US12/184,334 patent/US7872111B2/en not_active Expired - Fee Related
-
2011
- 2011-12-24 JP JP2011282526A patent/JP2012105652A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US7198921B2 (en) | 2007-04-03 |
ES2328106T3 (es) | 2009-11-10 |
AU2001256762A1 (en) | 2001-11-26 |
WO2001088143A1 (fr) | 2001-11-22 |
US7872111B2 (en) | 2011-01-18 |
EP1283265B1 (de) | 2009-08-05 |
EP1283265A4 (de) | 2004-10-20 |
US20070202569A1 (en) | 2007-08-30 |
EP1283265A1 (de) | 2003-02-12 |
US7488591B2 (en) | 2009-02-10 |
DK1283265T3 (da) | 2009-11-09 |
US20090004725A1 (en) | 2009-01-01 |
DE60139467D1 (de) | 2009-09-17 |
JP2012105652A (ja) | 2012-06-07 |
JP4969011B2 (ja) | 2012-07-04 |
US20040014170A1 (en) | 2004-01-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |