ATE437893T1 - Fusionsprotein mit angiopoietinrezeptorbindung und einer multimerisationsdomäne - Google Patents

Fusionsprotein mit angiopoietinrezeptorbindung und einer multimerisationsdomäne

Info

Publication number
ATE437893T1
ATE437893T1 AT03760110T AT03760110T ATE437893T1 AT E437893 T1 ATE437893 T1 AT E437893T1 AT 03760110 T AT03760110 T AT 03760110T AT 03760110 T AT03760110 T AT 03760110T AT E437893 T1 ATE437893 T1 AT E437893T1
Authority
AT
Austria
Prior art keywords
fusion protein
receptor binding
multimerization domain
angiopoietin receptor
angiopoietin
Prior art date
Application number
AT03760110T
Other languages
English (en)
Inventor
Gou Young Koh
Original Assignee
Genexel Sein Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genexel Sein Inc filed Critical Genexel Sein Inc
Application granted granted Critical
Publication of ATE437893T1 publication Critical patent/ATE437893T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
AT03760110T 2002-05-21 2003-05-21 Fusionsprotein mit angiopoietinrezeptorbindung und einer multimerisationsdomäne ATE437893T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38254102P 2002-05-21 2002-05-21
US10/273,180 US7081443B2 (en) 2002-05-21 2002-10-18 Chimeric comp-ang1 molecule
PCT/IB2003/003814 WO2003106501A1 (en) 2002-05-21 2003-05-21 Fusion protein comprising angiopoietin receptor-binding and a multimerization domain

Publications (1)

Publication Number Publication Date
ATE437893T1 true ATE437893T1 (de) 2009-08-15

Family

ID=29552950

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03760110T ATE437893T1 (de) 2002-05-21 2003-05-21 Fusionsprotein mit angiopoietinrezeptorbindung und einer multimerisationsdomäne

Country Status (10)

Country Link
US (3) US7081443B2 (de)
EP (1) EP1549679B1 (de)
JP (1) JP4384597B2 (de)
KR (1) KR100611620B1 (de)
AT (1) ATE437893T1 (de)
AU (1) AU2003256001A1 (de)
CA (1) CA2486649C (de)
DE (1) DE60328615D1 (de)
DK (1) DK1549679T3 (de)
WO (1) WO2003106501A1 (de)

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EP2681240B1 (de) 2011-02-28 2017-08-16 F. Hoffmann-La Roche AG Monovalente antigenbindende proteine
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EP2662447B1 (de) * 2012-05-09 2020-02-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Artifizielle Forisomenkörper mit SEO-F-Fusionsproteinen, pflanzliche oder Hefezellen mit Vektoren, die für diese Proteine codieren
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JP6154900B2 (ja) 2012-07-13 2017-06-28 ロシュ グリクアート アクチェンゲゼルシャフト 二重特異性抗ｖｅｇｆ／抗ａｎｇ−２抗体及び眼血管疾患の処置におけるそれらの使用
KR101407730B1 (ko) 2012-11-23 2014-06-12 인하대학교 산학협력단 안지오포이에틴-4 단백질을 유효성분으로 포함하는 발기부전의 예방 또는 치료용 조성물
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KR102196450B1 (ko) 2013-09-17 2020-12-30 삼성전자주식회사 Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제
WO2015052230A1 (en) 2013-10-11 2015-04-16 F. Hoffmann-La Roche Ag Multispecific domain exchanged common variable light chain antibodies
ES2764111T3 (es) 2014-12-03 2020-06-02 Hoffmann La Roche Anticuerpos multiespecíficos
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US10588940B2 (en) 2015-11-06 2020-03-17 Regeneron Pharmaceuticals, Inc. Use of angiopoietins in promoting blood coagulation and in the treatment of blood coagulation disorders
WO2018047856A1 (ja) * 2016-09-06 2018-03-15 学校法人慶應義塾 融合タンパク質、構造体、捕集剤、捕集する方法、ｄｎａ、及びベクター
EP3601367A4 (de) * 2017-03-30 2020-09-16 The University of Queensland Chimäre moleküle und verwendungen davon
CN107033249B (zh) * 2017-05-16 2020-07-14 成都开乐药业有限公司 sTie2融合蛋白、其载体及含有sTie2融合蛋白的药物组合物
KR102005712B1 (ko) * 2018-01-15 2019-07-31 전남대학교산학협력단 다중화 요소 및 가용성 조절 기술의 접목을 통한 재조합 단백질 생산방법 및 이의 용도
EP4110796A1 (de) * 2020-02-28 2023-01-04 Northwestern University Chimäre fusionen zwischen dem c4-bindenden protein-c-terminalen segment und der fibrinogen-ähnlichen domäne von angiopoietin-1 als angiopoietin-mimetika und tie2-agonisten zur behandlung von gefässerkrankungen
WO2021173999A1 (en) * 2020-02-28 2021-09-02 Northwestern University Method of enhancing aqueous humor outflow and reducing intraocular pressure
GB202108761D0 (en) * 2021-06-18 2021-08-04 Ikarovec Ltd Ocular disorders

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Also Published As

Publication number Publication date
US20030220476A1 (en) 2003-11-27
CA2486649C (en) 2014-08-05
JP4384597B2 (ja) 2009-12-16
US20060074230A1 (en) 2006-04-06
US7081443B2 (en) 2006-07-25
JP2006504405A (ja) 2006-02-09
EP1549679B1 (de) 2009-07-29
KR100611620B1 (ko) 2006-09-01
US7309586B2 (en) 2007-12-18
EP1549679A1 (de) 2005-07-06
WO2003106501A1 (en) 2003-12-24
AU2003256001A1 (en) 2003-12-31
DK1549679T3 (da) 2009-10-26
CA2486649A1 (en) 2003-12-24
US20080160574A1 (en) 2008-07-03
US7691366B2 (en) 2010-04-06
EP1549679A4 (de) 2006-06-21
DE60328615D1 (de) 2009-09-10
KR20050004198A (ko) 2005-01-12

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