AR060795A1 - Moleculas quimericas fusionadas a matrilina 1, de uso terapeutico - Google Patents
Moleculas quimericas fusionadas a matrilina 1, de uso terapeuticoInfo
- Publication number
- AR060795A1 AR060795A1 ARP070101321A ARP070101321A AR060795A1 AR 060795 A1 AR060795 A1 AR 060795A1 AR P070101321 A ARP070101321 A AR P070101321A AR P070101321 A ARP070101321 A AR P070101321A AR 060795 A1 AR060795 A1 AR 060795A1
- Authority
- AR
- Argentina
- Prior art keywords
- fused
- therapeutic use
- matrilina
- protein
- chemical molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Moléculas quiméricas fusionadas al péptido correspondiente al extremo carboxilo-de la Matrilina 1 humana mediante un espaciador flexible que les confiere un mayor tiempo de vida media en sangre y una actividad específica superior respecto a las moléculas no fusionadas. Reivindicacion 1: Proteína quimérica caracterizada porque contiene esencialmente el extremo carboxilo de la Matrilina 1, identificada en el listado de secuencias como Seq. ID. N°:19 desde el aminoácido numero 206 hasta el 246, y una proteína de uso terapéutico, fusionadas mediante un espaciador aminoacídico, la cual tiene una vida media y una actividad específica mayor que la proteína de uso terapéutico no fusionada.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060073 | 2006-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060795A1 true AR060795A1 (es) | 2008-07-16 |
Family
ID=38510311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101321A AR060795A1 (es) | 2006-03-29 | 2007-03-29 | Moleculas quimericas fusionadas a matrilina 1, de uso terapeutico |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR060795A1 (es) |
WO (1) | WO2007110001A2 (es) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993021226A1 (en) * | 1992-04-10 | 1993-10-28 | The General Hospital Corporation | Cartilage matrix protein and methods for use |
US6900292B2 (en) * | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
CU23228A1 (es) * | 2002-04-29 | 2007-09-26 | Ct Ingenieria Genetica Biotech | Fragmentos de anticuerpos especificos para el antigeno carcinoembrionario humano (cea) secuencias de sus regiones variables y vectores para la expresion microbiana de los mismos |
US7081443B2 (en) * | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
FR2856070A1 (fr) * | 2003-06-13 | 2004-12-17 | Bionexis | Molecules pour le ciblage et l'assemblage in situ de proteines therapeutiques et leur utilisation |
-
2007
- 2007-03-29 AR ARP070101321A patent/AR060795A1/es not_active Application Discontinuation
- 2007-03-29 WO PCT/CU2007/000012 patent/WO2007110001A2/es active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2007110001A2 (es) | 2007-10-04 |
WO2007110001A3 (es) | 2007-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20090225A1 (es) | Proteinas de fusion que degradan el peptido beta amiloide | |
UY31123A1 (es) | Proteinas de fusion natriureticas | |
PE20240015A1 (es) | Proteinas de fusion gdf15 y usos de estas | |
PE20090711A1 (es) | Region constante de anticuerpo mutante | |
CL2013003634A1 (es) | Complejo que comprende una proteina de fusion que comprende, un peptido viral, peptido conector, microglobulina beta 2 , peptido conector, dominios extracelulares alfa 1, 2 y 3 de mhc de clase i y un tercer peptido conector; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso | |
AR062030A1 (es) | Proteinas de fusion de exendina | |
MD3292141T2 (ro) | Proteine de fuziune | |
JP2014525901A5 (es) | ||
AR062065A1 (es) | Anticuerpo humanizado | |
NI201200134A (es) | Polipéptidos agonistas que se enlazan a dr5 | |
RU2016146198A (ru) | Терапевтические dll4-связывающие белки | |
DK1761553T3 (da) | MHC molecule-binding tumor-associated peptides | |
ES2571879T3 (es) | Moléculas de una sola cadena de TNFSF | |
RU2014101697A (ru) | Коагонисты рецепторов глюкагона/glp-1 | |
WO2013075066A3 (en) | Variant serum albumin with improved half -life and other properties | |
NO20071592L (no) | GLP-1 og exendinrelatert oppfinnelse | |
ATE474917T1 (de) | Verfahren zur erhöhung der in-vivo-gewinnung therapeutischer polypeptide | |
AR060862A1 (es) | Proteinas de fusion rage, formulaciones y metodos de uso de estas | |
NO20082510L (no) | En fremgangsmate for konsentrasjon av et polypeptid | |
PE20170142A1 (es) | Proteina de fusion que inhibe angiogenesis o crecimiento y uso de la misma | |
PE20130199A1 (es) | Proteina de fusion robo1-fc y su utilizacion en el tratamiento de tumores | |
UA100127C2 (ru) | Пептид cdh3 и лекарственное средство, содержащее его | |
AR088048A1 (es) | Señuelos notch1 humanos | |
NZ724196A (en) | Uti fusion proteins | |
EA202091496A1 (ru) | Вариант инсектицидного гена axmi115 и способы его применения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |