ATE426603T1 - Acyl- und sulfonylderivative 6,9- disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel - Google Patents
Acyl- und sulfonylderivative 6,9- disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittelInfo
- Publication number
- ATE426603T1 ATE426603T1 AT01987144T AT01987144T ATE426603T1 AT E426603 T1 ATE426603 T1 AT E426603T1 AT 01987144 T AT01987144 T AT 01987144T AT 01987144 T AT01987144 T AT 01987144T AT E426603 T1 ATE426603 T1 AT E426603T1
- Authority
- AT
- Austria
- Prior art keywords
- diaminocyclohexyl
- purines
- disubstituted
- acyl
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24456700P | 2000-10-31 | 2000-10-31 | |
GBGB0117075.2A GB0117075D0 (en) | 2000-10-31 | 2001-07-13 | Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE426603T1 true ATE426603T1 (de) | 2009-04-15 |
Family
ID=26246308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01987144T ATE426603T1 (de) | 2000-10-31 | 2001-10-31 | Acyl- und sulfonylderivative 6,9- disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1377579B1 (de) |
JP (1) | JP4348081B2 (de) |
AT (1) | ATE426603T1 (de) |
AU (2) | AU2002239388B2 (de) |
BR (1) | BR0115080A (de) |
CA (1) | CA2427338C (de) |
DE (1) | DE60138140D1 (de) |
DK (1) | DK1377579T3 (de) |
ES (1) | ES2324763T3 (de) |
IL (1) | IL155590A0 (de) |
MX (1) | MXPA03003774A (de) |
NO (1) | NO20031939L (de) |
NZ (1) | NZ525264A (de) |
WO (1) | WO2002042303A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
FR2851248B1 (fr) * | 2003-02-18 | 2005-04-08 | Aventis Pharma Sa | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
CA2525207A1 (en) * | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | Substituted piperidine carbamates for use as inhibitors of hormone sensitive lipase |
MX2010010975A (es) * | 2008-04-07 | 2010-11-01 | Amgen Inc | Amino piridinas/pirimidinas gem-disustituidas y espirociclicas como inhibidores de ciclo celular. |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
US9382239B2 (en) | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
US10047070B2 (en) | 2013-10-18 | 2018-08-14 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
AU2015371251B2 (en) | 2014-12-23 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2016160617A2 (en) * | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
US11142507B2 (en) | 2015-09-09 | 2021-10-12 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
US11427567B2 (en) | 2019-08-14 | 2022-08-30 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors |
CR20220170A (es) | 2019-10-11 | 2022-10-10 | Incyte Corp | Aminas bicíclicas como inhibidoras de la cdk2 |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6479487B1 (en) * | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
CA2320448C (en) * | 1998-02-26 | 2005-02-01 | Aventis Pharmaceuticals Inc. | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines |
FR2793794B1 (fr) * | 1999-05-21 | 2001-07-27 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
CA2394646A1 (en) * | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Novel purines |
JP2003519232A (ja) * | 2000-01-07 | 2003-06-17 | ウニフェルジテーレ・インステリング・アントウェルペン | プリン誘導体、その製造法およびその使用 |
-
2001
- 2001-10-31 NZ NZ525264A patent/NZ525264A/en not_active IP Right Cessation
- 2001-10-31 EP EP01987144A patent/EP1377579B1/de not_active Expired - Lifetime
- 2001-10-31 ES ES01987144T patent/ES2324763T3/es not_active Expired - Lifetime
- 2001-10-31 BR BR0115080-4A patent/BR0115080A/pt not_active Application Discontinuation
- 2001-10-31 CA CA002427338A patent/CA2427338C/en not_active Expired - Lifetime
- 2001-10-31 DE DE60138140T patent/DE60138140D1/de not_active Expired - Lifetime
- 2001-10-31 AT AT01987144T patent/ATE426603T1/de active
- 2001-10-31 WO PCT/US2001/044835 patent/WO2002042303A2/en active Application Filing
- 2001-10-31 JP JP2002544437A patent/JP4348081B2/ja not_active Expired - Lifetime
- 2001-10-31 MX MXPA03003774A patent/MXPA03003774A/es active IP Right Grant
- 2001-10-31 IL IL15559001A patent/IL155590A0/xx unknown
- 2001-10-31 DK DK01987144T patent/DK1377579T3/da active
- 2001-10-31 AU AU2002239388A patent/AU2002239388B2/en not_active Expired
- 2001-10-31 AU AU3938802A patent/AU3938802A/xx active Pending
-
2003
- 2003-04-29 NO NO20031939A patent/NO20031939L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20031939L (no) | 2003-06-19 |
DE60138140D1 (de) | 2009-05-07 |
CA2427338A1 (en) | 2002-05-30 |
NO20031939D0 (no) | 2003-04-29 |
JP2004517075A (ja) | 2004-06-10 |
EP1377579A2 (de) | 2004-01-07 |
CA2427338C (en) | 2008-06-10 |
AU3938802A (en) | 2002-06-03 |
EP1377579B1 (de) | 2009-03-25 |
MXPA03003774A (es) | 2003-07-28 |
NZ525264A (en) | 2005-12-23 |
AU2002239388B2 (en) | 2006-05-25 |
IL155590A0 (en) | 2003-11-23 |
DK1377579T3 (da) | 2009-08-31 |
ES2324763T3 (es) | 2009-08-14 |
WO2002042303A2 (en) | 2002-05-30 |
BR0115080A (pt) | 2003-09-23 |
WO2002042303A3 (en) | 2003-10-30 |
JP4348081B2 (ja) | 2009-10-21 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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