ATE424448T1 - Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten - Google Patents

Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten

Info

Publication number
ATE424448T1
ATE424448T1 AT03774653T AT03774653T ATE424448T1 AT E424448 T1 ATE424448 T1 AT E424448T1 AT 03774653 T AT03774653 T AT 03774653T AT 03774653 T AT03774653 T AT 03774653T AT E424448 T1 ATE424448 T1 AT E424448T1
Authority
AT
Austria
Prior art keywords
methods
antagonists
condition
test methods
calcium channel
Prior art date
Application number
AT03774653T
Other languages
English (en)
Inventor
Menghang Xia
Thomas Connolly
Paul Bennett
Charles Cohen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE424448T1 publication Critical patent/ATE424448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03774653T 2002-10-10 2003-10-09 Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten ATE424448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41801702P 2002-10-10 2002-10-10

Publications (1)

Publication Number Publication Date
ATE424448T1 true ATE424448T1 (de) 2009-03-15

Family

ID=32094136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03774653T ATE424448T1 (de) 2002-10-10 2003-10-09 Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten

Country Status (6)

Country Link
US (1) US20060014206A1 (de)
EP (1) EP1560915B1 (de)
AT (1) ATE424448T1 (de)
CA (1) CA2501233A1 (de)
DE (1) DE60326482D1 (de)
WO (1) WO2004033647A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270949B2 (en) * 2003-01-07 2007-09-18 Neuromed Pharmaceuticals Ltd. Fluorescence based T-type channel assay
WO2006055927A2 (en) * 2004-11-17 2006-05-26 The Cleveland Clinic Foundation Pathogenic gene and protein associated with paroxysmal dyskinesia and epilepsy
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US9274099B2 (en) * 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
JP2009502140A (ja) 2005-07-22 2009-01-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 光活性化陽イオンチャネルおよびその使用
GB0520405D0 (en) * 2005-10-07 2005-11-16 Imp College Innovations Ltd Biological agents and method
KR100716103B1 (ko) 2005-10-28 2007-05-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제의 세포 기반 고효율 검색 방법
US8398692B2 (en) 2007-01-10 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
RU2010147661A (ru) 2008-04-23 2012-05-27 Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити (Us) Системы, способы и композиции для оптической стимуляции клеток-мишеней
MX2010012986A (es) 2008-05-29 2011-05-25 Univ Leland Stanford Junior Linea de celulas, sistema y metodo para control optico de mensajeros secundarios.
CA2728402A1 (en) 2008-06-17 2009-12-23 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for controlling cellular development
JP2011525130A (ja) 2008-06-17 2011-09-15 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
WO2010151609A1 (en) * 2009-06-24 2010-12-29 Photoswitch Biosciences Inc. Photoswitch-enabled ion channel assay system
US20110144028A1 (en) * 2009-12-11 2011-06-16 Vinod Sharma Modulating cellular electrophysiology
MY175954A (en) 2010-03-17 2020-07-16 The Board Of Trustees Of Leland Stanford Junior Univ Light-sensitive ion-passing molecules
AU2011323237B2 (en) 2010-11-05 2015-11-12 The Board Of Trustees Of The Leland Stanford Junior University Optically-controlled CNS dysfunction
CN106376525A (zh) 2010-11-05 2017-02-08 斯坦福大学托管董事会 记忆功能的控制和表征
ES2625179T3 (es) 2010-11-05 2017-07-18 The Board Of Trustees Of The Leland Stanford Junior University Control optogenético de comportamientos relacionados con la recompensa
EP2635111B1 (de) 2010-11-05 2018-05-23 The Board of Trustees of the Leland Stanford Junior University Stabilisierte opsin-proteine mit stufenfunktion und verwendungsverfahren dafür
CN103313752B (zh) 2010-11-05 2016-10-19 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
EP2635108B1 (de) 2010-11-05 2019-01-23 The Board of Trustees of the Leland Stanford Junior University Lichtaktivierte chimäre opsine und verwendungsverfahren dafür
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CN107936097A (zh) 2011-12-16 2018-04-20 斯坦福大学托管董事会 视蛋白多肽及其使用方法
CA2865296A1 (en) 2012-02-21 2013-08-29 Karl A. DEISSEROTH Compositions and methods for treating neurogenic disorders of the pelvic floor
CA2897005A1 (en) * 2013-01-10 2014-07-17 Tau Therapeutics Llc T-type calcium channel inhibitors for treatment of cancer
JP6594854B2 (ja) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 行動状態の光遺伝学的制御方法
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
CN105431046B (zh) 2013-04-29 2020-04-17 小利兰·斯坦福大学托管委员会 用于靶细胞中的动作电位的光遗传学调节的装置、***和方法
WO2015023782A1 (en) 2013-08-14 2015-02-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for controlling pain
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
WO2020193446A1 (en) * 2019-03-22 2020-10-01 Westfälische Wilhelms-Universität Münster Catsper-activity-test for determining male infertility

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043457A (en) * 1990-04-17 1991-08-27 Allergan, Inc. 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents
US5429921A (en) * 1988-04-04 1995-07-04 The Salk Institute Biotechnology/Industrial Assoc. Inc. Assays for agonists and antagonists of recombinant human calcium channels
US5851824A (en) * 1988-04-04 1998-12-22 Sibia Neurosciences, Inc. Human calcium channel α-1C/α-1D, α-2, β-1, and γsubunits and cells expressing the DNA
US6096514A (en) * 1988-04-04 2000-08-01 Sibia Neurosciences, Inc. Human calcium channel compositions and methods
US5876958A (en) * 1988-04-04 1999-03-02 Sibia Neurosciences, Inc. Assays of cells expressing human calcium channels containing α1 β subunits
US6090623A (en) * 1993-08-11 2000-07-18 Merck & Co., Inc. Recombinant human calcium channel β4 subunits
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
US6117990A (en) * 1999-04-06 2000-09-12 Synaptic Pharmaceutical Corporation DNA encoding SNORF1 receptor
US7399599B2 (en) * 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods

Also Published As

Publication number Publication date
DE60326482D1 (de) 2009-04-16
EP1560915B1 (de) 2009-03-04
EP1560915A2 (de) 2005-08-10
EP1560915A4 (de) 2006-11-15
WO2004033647A2 (en) 2004-04-22
WO2004033647A3 (en) 2004-11-04
CA2501233A1 (en) 2004-04-22
US20060014206A1 (en) 2006-01-19

Similar Documents

Publication Publication Date Title
ATE424448T1 (de) Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten
ATE302951T1 (de) Hochdurchsatz-screening
ATE437370T1 (de) Pharmakodynamische tests mit durchflusszytometrie
DK1483576T3 (da) Hidtil ukendt fremgangsmåde til detektion og analysering af proteininteraktioner in vivo
HK1118337A1 (en) Methods for altering one or more parameters of a measurement system
GB2427468B (en) Cell separation device and method for the detection of EpCAM positive cells
NO20082351L (no) Screeninganalyse med hoy gjennomgang for TRPM5 ionekanalen
DK1766400T3 (da) Fremgangsmåde til at udföre fuldblodsanalyser
TW200622950A (en) Methods of monitoring the concentration of an analyte
ATE468534T1 (de) Verwendung von biomarkern zum nachweis von eierstockkrebs
ATE475171T1 (de) Verfahren und vorrichtung zur erkennung tonaler komponenten von audiosignalen
ATE418729T1 (de) Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie
DK1502102T3 (da) Forbindelser og fremgangsmåder til analysering af proteomet
DE602007000887D1 (de) Reagens, Ausstattung und Verfahren zur Probenanalyse
WO2003106964A3 (en) HIGH EFFICIENCY METHODS AND DEVICES FOR ASSAYING ANALYTES IN A FLUID SAMPLE
TW200722746A (en) Method for detecting sample supply condition, and analyzer
DE602005001465D1 (de) Vorrichtung und Verfahren zur Entnahme von Proben
DE60308259D1 (de) Immunologische Verfahren, Vorrichtungen und Reagenzien
ATE504833T1 (de) Verfahren zur bestimmung des phänotyps von zellen
ATE434760T1 (de) Blutzellen-detektor, blutanalysegerät und blutanalyseverfahren unter verwendung des detektors
MXPA03005234A (es) Un metodo para medir la concetracion total de monoxido de carbono e hidrocarburos en oxigeno por medio de espectrometria de movilidad de ion.
WO2009082533A3 (en) Method of identification of petroleum compounds using frequency mixing on surfaces
SG147316A1 (en) Test methods for determining the intracellular concentration of cyclic nucleotides
DE60327776D1 (de) Sonden zum nachweis von tumorzellen
WO2005082050A3 (en) Analysis and screening of solid forms using the atomic pair distribution function

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties