ATE423114T1 - Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten - Google Patents

Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten

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Publication number
ATE423114T1
ATE423114T1 AT05714101T AT05714101T ATE423114T1 AT E423114 T1 ATE423114 T1 AT E423114T1 AT 05714101 T AT05714101 T AT 05714101T AT 05714101 T AT05714101 T AT 05714101T AT E423114 T1 ATE423114 T1 AT E423114T1
Authority
AT
Austria
Prior art keywords
aminocyclopropane
acid amide
carbonic acid
amide derivatives
bradykinin antagonists
Prior art date
Application number
AT05714101T
Other languages
English (en)
Inventor
Mark Bock
Dong-Mei Feng
Scott Kuduk
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE423114T1 publication Critical patent/ATE423114T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
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AT05714101T 2004-03-02 2005-02-25 Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten ATE423114T1 (de)

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US54937904P 2004-03-02 2004-03-02

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ATE423114T1 true ATE423114T1 (de) 2009-03-15

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Country Status (9)

Country Link
US (1) US20070189865A1 (de)
EP (1) EP1723143B1 (de)
JP (1) JP2007526311A (de)
CN (1) CN1926136A (de)
AT (1) ATE423114T1 (de)
AU (1) AU2005219836A1 (de)
CA (1) CA2557858A1 (de)
DE (1) DE602005012806D1 (de)
WO (1) WO2005085198A2 (de)

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KR20060118442A (ko) * 2003-10-07 2006-11-23 렌즈베이비즈, 엘엘씨 급속 틸트 촬영을 위한 가요성 렌즈 마운트 시스템
US7429604B2 (en) * 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
CL2008002545A1 (es) 2007-08-29 2009-10-23 Boehringer Ingelheim Int Compuestos derivados de fenoxi-bencil-carbamoilo; composicion farmaceutica; procedimiento para preparar la composicion farmaceutica; y su uso en el tratamiento del dolor.
US20090270394A1 (en) * 2008-04-28 2009-10-29 Galemmo Jr Robert Cyclylamine derivatives as calcium channel blockers
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
WO2010031577A1 (en) * 2008-09-18 2010-03-25 Jerini Ag Use of bradykinin b1 receptor antagonists in intestinal fibrosis treatment
WO2010097373A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin b1 antagonisten
UA105923C2 (uk) * 2009-02-26 2014-07-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Сполуки як антагоністи брадикініну b1
AU2015271888B2 (en) * 2010-02-23 2017-06-15 Boehringer Ingelheim International Gmbh Compounds as bradykinin B1 antagonists
CN103980258B (zh) * 2010-02-23 2016-09-07 贝林格尔.英格海姆国际有限公司 作为缓激肽b1拮抗剂的化合物
US8937073B2 (en) 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
WO2012022794A1 (de) * 2010-08-20 2012-02-23 Boehringer Ingelheim International Gmbh Pyridazinderivative als bradykinin b1 rezeptor antagonsiten
HUP1000598A2 (en) * 2010-11-05 2012-09-28 Richter Gedeon Nyrt Indole derivatives
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
US8592426B2 (en) * 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
CN107382844A (zh) * 2017-08-28 2017-11-24 天津科技大学 一种以烟酸胺为原料生产烟酸的方法

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US20070189865A1 (en) 2007-08-16
AU2005219836A1 (en) 2005-09-15
CN1926136A (zh) 2007-03-07
CA2557858A1 (en) 2005-09-15
WO2005085198A3 (en) 2005-11-24
DE602005012806D1 (en) 2009-04-02
JP2007526311A (ja) 2007-09-13
WO2005085198A2 (en) 2005-09-15
EP1723143B1 (de) 2009-02-18

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