ATE417628T1 - Topisch anwendbare pharmazeutische zubereitung - Google Patents

Topisch anwendbare pharmazeutische zubereitung

Info

Publication number
ATE417628T1
ATE417628T1 AT03755048T AT03755048T ATE417628T1 AT E417628 T1 ATE417628 T1 AT E417628T1 AT 03755048 T AT03755048 T AT 03755048T AT 03755048 T AT03755048 T AT 03755048T AT E417628 T1 ATE417628 T1 AT E417628T1
Authority
AT
Austria
Prior art keywords
pharmaceutical preparation
topically applicable
applicable pharmaceutical
topically
administering
Prior art date
Application number
AT03755048T
Other languages
English (en)
Inventor
Christina Bolle
Rudolf Linder
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Application granted granted Critical
Publication of ATE417628T1 publication Critical patent/ATE417628T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41WEAPONS
    • F41BWEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B5/00Bows; Crossbows
    • F41B5/12Crossbows
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41WEAPONS
    • F41BWEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B5/00Bows; Crossbows
    • F41B5/12Crossbows
    • F41B5/123Compound crossbows
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41WEAPONS
    • F41BWEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B5/00Bows; Crossbows
    • F41B5/14Details of bows; Accessories for arc shooting
    • F41B5/1442Accessories for arc or bow shooting
    • F41B5/1469Bow-string drawing or releasing devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT03755048T 2002-05-28 2003-05-27 Topisch anwendbare pharmazeutische zubereitung ATE417628T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10223828 2002-05-28
EP02011830 2002-05-28
DE10311613 2003-03-14

Publications (1)

Publication Number Publication Date
ATE417628T1 true ATE417628T1 (de) 2009-01-15

Family

ID=29587313

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03730122T ATE485821T1 (de) 2002-05-28 2003-05-27 Ophthalmologische zubereitung enthaltend roflumilast in der behandlung von krankheiten der augen
AT03755048T ATE417628T1 (de) 2002-05-28 2003-05-27 Topisch anwendbare pharmazeutische zubereitung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03730122T ATE485821T1 (de) 2002-05-28 2003-05-27 Ophthalmologische zubereitung enthaltend roflumilast in der behandlung von krankheiten der augen

Country Status (33)

Country Link
US (7) US20060084685A1 (de)
EP (3) EP2020243B1 (de)
JP (3) JP5652983B2 (de)
KR (2) KR101307093B1 (de)
CN (3) CN101491520B (de)
AT (2) ATE485821T1 (de)
AU (2) AU2003240719B2 (de)
BR (2) BR0311337A (de)
CA (2) CA2486910C (de)
CY (2) CY1110312T1 (de)
DE (2) DE60325354D1 (de)
DK (3) DK2020243T3 (de)
EA (2) EA020569B1 (de)
ES (3) ES2354971T3 (de)
HK (2) HK1079437A1 (de)
HR (1) HRP20041211B1 (de)
HU (1) HUE039709T2 (de)
IL (3) IL164935A (de)
IS (1) IS2639B (de)
LT (1) LT2020243T (de)
MA (1) MA27813A1 (de)
ME (1) ME00565A (de)
MX (2) MXPA04011612A (de)
NO (2) NO334882B1 (de)
NZ (3) NZ536920A (de)
PL (3) PL212134B1 (de)
PT (3) PT2020243T (de)
RS (1) RS51104B (de)
SI (2) SI2020243T1 (de)
TR (1) TR201815573T4 (de)
UA (2) UA81910C2 (de)
WO (2) WO2003099278A1 (de)
ZA (2) ZA200408649B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
DK2020243T3 (en) * 2002-05-28 2018-11-19 Astrazeneca Ab Pharmaceutical composition which can be applied topically
EP1542768A1 (de) 2002-09-20 2005-06-22 Alcon, Inc. Verwendung von zytokin-synthesehemmern zur behandlung von erkrankungen mit trockenem auge
FR2851247B1 (fr) * 2003-02-19 2007-06-29 Exonhit Therapeutics Sa Methodes et compositions pour le traitement de pathologies degeneratives oculaires
EP1606261B1 (de) 2003-03-10 2009-11-04 Nycomed GmbH Neues verfahren zur herstellung vonroflumilast
JP2007517893A (ja) * 2004-01-10 2007-07-05 バイオリピッド インコーポレイテッド 脂質組成物及び該脂質組成物の使用方法
DE102004046235A1 (de) * 2004-09-22 2006-03-30 Altana Pharma Ag Arzneimittelzubereitung
DE102004046236A1 (de) * 2004-09-22 2006-03-30 Altana Pharma Ag Arzneimittelzubereitung
AU2006222060B2 (en) * 2005-03-08 2011-09-01 Takeda Gmbh Roflumilast for the treatment of diabetes mellitus
CA2601250C (en) * 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
US20090209599A1 (en) * 2005-06-09 2009-08-20 Yoko Endo Eye drop containing roflumilast
WO2007097317A1 (ja) 2006-02-21 2007-08-30 Eisai R & D Management Co., Ltd. 4-(3-ベンゾイルアミノフェニル)-6,7-ジメトキシ-2-メチルアミノキナゾリン誘導体
AU2008215411B2 (en) 2007-02-16 2012-11-22 Eisai R & D Management Co., Ltd. Crystal, amorphous form and salt of methyl N-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid
CA2696727A1 (en) 2007-08-17 2009-02-26 Eisai R&D Management Co., Ltd. Method for producing quinazoline derivative
CN101687819B (zh) 2007-08-17 2013-03-20 卫材R&D管理有限公司 外用剂
BR112012010179A2 (pt) 2009-10-30 2015-09-29 Nestec Sa métodos para manter a saúde do olho e melhorar as doenças oftálmicas em caninos.
ES2408132B1 (es) * 2010-09-08 2014-04-04 Universidad Miguel Hernández De Elche Composición farmacéutica para el tratamiento de la epífora.
ES2377785B2 (es) * 2010-09-08 2012-09-26 Universidad Miguel Hernández De Elche Composición farmacéutica para el tratamiento del ojo seco.
ES2868231T3 (es) 2011-03-07 2021-10-21 Amgen Europe Gmbh Métodos de tratamiento de enfermedades usando compuestos de isoindolina
CN102793684B (zh) * 2011-05-26 2016-02-17 杭州赛利药物研究所有限公司 罗氟司特液体制剂及其制备方法
PE20141031A1 (es) * 2011-06-28 2014-08-21 Bayer Healthcare Llc Composicion farmaceutica oftalmologica topica que contiene regorafenib
EP2836240B1 (de) * 2012-04-10 2019-03-13 Georgia State University Research Foundation, Inc. Zusammensetzungen und verfahren zur behandlung von mittelohrentzündung und anderen erkrankungen mit cyld-inhibitoren
CN103570610B (zh) * 2012-07-18 2017-08-11 重庆华邦制药有限公司 一种罗氟司特微粒的制备方法
WO2014012954A1 (en) 2012-07-18 2014-01-23 Takeda Gmbh Treatment of partly controlled or uncontrolled severe asthma
US9737521B2 (en) 2012-11-08 2017-08-22 Rhizen Pharmaceuticals Sa Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor
DK3033082T3 (da) 2013-08-16 2021-09-20 Univ Maastricht Behandling af kognitiv svækkelse med pde4-hæmmer
CN105434328A (zh) * 2014-09-01 2016-03-30 天津药物研究院有限公司 一种含罗氟司特固体分散体的固体制剂及其制备方法
EP3210974B1 (de) * 2014-10-24 2020-01-29 Hisamitsu Pharmaceutical Co., Inc. Prodrug von roflumilast
CN104997959A (zh) * 2015-08-21 2015-10-28 蔡宇平 一种用于治疗睑板腺囊肿的中药
CN106148528B (zh) * 2016-07-11 2019-10-01 赵晨 一种遗传性Usher综合征的致病突变及其检测试剂
US20210161870A1 (en) 2017-06-07 2021-06-03 Arcutis Biotherapeutics, Inc. Roflumilast formulations with an improved pharmacokinetic profile
US11129818B2 (en) 2017-06-07 2021-09-28 Arcutis Biotherapeutics, Inc. Topical roflumilast formulation having improved delivery and plasma half life
US12011437B1 (en) 2017-06-07 2024-06-18 Arcutis Biotherapeutics, Inc. Roflumilast formulations with an improved pharmacokinetic profile
US20200155524A1 (en) * 2018-11-16 2020-05-21 Arcutis, Inc. Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
US12042487B2 (en) 2018-11-16 2024-07-23 Arcutis Biotherapeutics, Inc. Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
US9895359B1 (en) 2017-06-07 2018-02-20 Arcutis, Inc. Inhibition of crystal growth of roflumilast
US11534493B2 (en) * 2017-09-22 2022-12-27 Arcutis Biotherapeutics, Inc. Pharmaceutical compositions of roflumilast in aqueous blends of water-miscible, pharmaceutically acceptable solvents
CN108283620A (zh) * 2018-03-13 2018-07-17 兆科药业(广州)有限公司 一种磷酸二酯酶-4抑制剂的局部药物组合物及其制备方法
EP3801461A2 (de) 2018-06-04 2021-04-14 Arcutis, Inc. Verfahren und formulierung zur verbesserung der hautdurchdringungsverzögerungszeit von roflumilast
KR102117525B1 (ko) * 2018-07-09 2020-06-01 건양대학교 산학협력단 Pde4b 저해제를 유효성분으로 함유하는 만성 부비동염에서의 비용종 발생의 예방 및 치료용 약학 조성물
CN115551478A (zh) 2020-01-31 2022-12-30 阿尔库缇斯生物疗法股份有限公司 具有改善递送和血浆半衰期的罗氟司特局部制剂
AU2021268977B2 (en) * 2020-05-07 2024-05-23 Arcutis Biotherapeutics, Inc. Treatment of skin conditions using high Krafft temperature anionic surfactants
WO2022169615A1 (en) 2021-02-05 2022-08-11 Arcutis Biotherapeutics, Inc. Roflumilast formulations with an improved pharmacokinetic profile
AU2022218993A1 (en) * 2021-02-10 2023-08-03 Iolyx Therapeutics, Inc. Methods for ophthalmic delivery of roflumilast
CN116867480A (zh) * 2021-02-10 2023-10-10 洛利克斯治疗有限公司 眼部递送罗氟司特的方法
EP4351612A2 (de) * 2021-06-01 2024-04-17 Eyedea Bio, Llc System zur verabreichung von arzneimitteln mit verlängerter freisetzung für augenarzneimittel und verfahren zur verwendung
AU2022353032A1 (en) * 2021-09-22 2024-03-28 Iolyx Therapeutics, Inc. Methods of treating ocular inflammatory diseases
US20240108609A1 (en) 2022-09-15 2024-04-04 Arcutis Biotherapeutics, Inc. Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753945A (en) * 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US5011843A (en) * 1988-05-31 1991-04-30 Iolab Corporation Treatment of glaucoma using phosphodiesterase inhibitors
US5891904A (en) * 1992-09-14 1999-04-06 Wolf-Georg Forssmann Use of inhibitors of phosphodiesterase IV
ES2176252T3 (es) * 1993-07-02 2002-12-01 Altana Pharma Ag Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos.
CN1128955A (zh) * 1993-08-10 1996-08-14 藤泽药品工业株式会社 经皮吸收制剂
ZA954599B (en) * 1994-06-07 1996-01-26 Allergan Inc Stable gel formulation for topical treatment of skin conditions
HUP0103947A3 (en) * 1998-09-29 2002-06-28 Fujisawa Pharmaceutical Co Novel methanesulfonate salts of pyridopyrazine compound and crystals thereof and their pharmaceutical use
US6395746B1 (en) * 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US20020006418A1 (en) * 1998-10-13 2002-01-17 John Kung Composition to enhance permeation of topical skin agents
DE60015098T2 (de) 1999-03-10 2006-02-02 Altana Pharma Ag 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose
US6174878B1 (en) * 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
JP2003513038A (ja) * 1999-10-29 2003-04-08 スミスクライン・ビーチャム・コーポレイション ホスホジエステラーゼ4阻害剤の投与法
MXPA02007465A (es) * 2000-01-31 2002-12-13 Pfizer Prod Inc Carboxamidas de pirimidina utiles como inhibidores de isozimas pde4.
EP1261331A4 (de) * 2000-02-16 2005-01-05 Univ Nebraska Medical Ct Methoden und zusammenstellungen zur behandlung von fibrotischen erkrankungen
JP2003534328A (ja) * 2000-05-25 2003-11-18 メルク フロスト カナダ アンド カンパニー フルオロアルコキシ置換ベンズアミドジクロロピリジニルn−オキシドpde4阻害剤
CA2427814C (en) * 2000-11-07 2009-06-02 Merck & Co., Inc. A combination of a pde4 inhibitor and a leukotriene antagonist in the treatment of bronchial and respiratory disorders
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US6872382B1 (en) * 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US20030092706A1 (en) * 2001-11-09 2003-05-15 Johannes Barsig Combination
DK2020243T3 (en) * 2002-05-28 2018-11-19 Astrazeneca Ab Pharmaceutical composition which can be applied topically

Also Published As

Publication number Publication date
HRP20041211A2 (hr) 2006-04-30
JP2005529930A (ja) 2005-10-06
PT1511481E (pt) 2011-01-14
DE60325354D1 (de) 2009-01-29
KR101307093B1 (ko) 2013-09-11
EA020569B1 (ru) 2014-12-30
JP2005529928A (ja) 2005-10-06
HUE039709T2 (hu) 2019-01-28
CA2486910C (en) 2011-11-29
SI2020243T1 (sl) 2018-11-30
PL372082A1 (en) 2005-07-11
US20110313005A1 (en) 2011-12-22
JP5683538B2 (ja) 2015-03-11
PL212134B1 (pl) 2012-08-31
CA2486910A1 (en) 2003-12-04
NZ536920A (en) 2007-04-27
NO334882B1 (no) 2014-06-30
NO20045506L (no) 2004-12-16
CN101491520A (zh) 2009-07-29
CA2486917C (en) 2011-11-22
IS7612A (is) 2004-12-23
SI1511516T1 (sl) 2009-06-30
EA200401517A1 (ru) 2005-06-30
BR0311337A (pt) 2005-03-15
EP1511516B1 (de) 2008-12-17
BR0311339A (pt) 2005-03-22
IL165065A (en) 2010-11-30
AU2003232828B2 (en) 2010-06-24
CN101491520B (zh) 2011-03-16
US20210116207A1 (en) 2021-04-22
HRP20041211B1 (hr) 2013-06-30
DK2020243T3 (en) 2018-11-19
LT2020243T (lt) 2018-11-12
US20080280958A1 (en) 2008-11-13
KR20050014844A (ko) 2005-02-07
CA2486917A1 (en) 2003-12-04
ATE485821T1 (de) 2010-11-15
IL164935A (en) 2010-12-30
NZ537308A (en) 2009-09-25
AU2003232828A1 (en) 2003-12-12
PL397021A1 (pl) 2012-03-26
PL211870B1 (pl) 2012-07-31
CY1121133T1 (el) 2019-12-11
WO2003099334A1 (en) 2003-12-04
CN1655823B (zh) 2010-05-26
EP2020243B1 (de) 2018-08-15
PT2020243T (pt) 2018-11-09
CY1110312T1 (el) 2015-01-14
ES2354971T3 (es) 2011-03-21
WO2003099278A1 (en) 2003-12-04
UA88523C2 (ru) 2009-10-26
CN1655782A (zh) 2005-08-17
AU2003240719B2 (en) 2009-12-10
EA200702588A1 (ru) 2008-08-29
AU2003240719A1 (en) 2003-12-12
US20140303215A1 (en) 2014-10-09
EP1511481A1 (de) 2005-03-09
IS2639B (is) 2010-06-15
CN100490804C (zh) 2009-05-27
JP2012229245A (ja) 2012-11-22
HK1079445A1 (en) 2006-04-07
TR201815573T4 (tr) 2018-11-21
HK1079437A1 (en) 2006-04-07
DE60334692D1 (de) 2010-12-09
PL372095A1 (en) 2005-07-11
IL209657A0 (en) 2011-02-28
PT1511516E (pt) 2009-02-20
ZA200408649B (en) 2007-12-27
UA81910C2 (uk) 2008-02-25
RS51104B (sr) 2010-10-31
US20060084684A1 (en) 2006-04-20
US20060084685A1 (en) 2006-04-20
NO20045656L (no) 2004-12-27
ES2693094T3 (es) 2018-12-07
EP1511516A1 (de) 2005-03-09
DK1511481T3 (da) 2011-01-24
IL165065A0 (en) 2005-12-18
EA010416B1 (ru) 2008-08-29
EP1511481B1 (de) 2010-10-27
EP2020243A1 (de) 2009-02-04
DK1511516T3 (da) 2009-04-06
MXPA04011612A (es) 2005-03-07
MA27813A1 (fr) 2006-04-03
JP5652983B2 (ja) 2015-01-14
KR20110122230A (ko) 2011-11-09
RS101404A (en) 2007-02-05
NO334916B1 (no) 2014-07-14
CN1655823A (zh) 2005-08-17
IL164935A0 (en) 2005-12-18
MXPA04011528A (es) 2005-02-14
NZ553731A (en) 2007-07-27
ME00565A (en) 2011-12-20
US20190029956A1 (en) 2019-01-31
ZA200409584B (en) 2006-05-31
ES2319517T3 (es) 2009-05-08

Similar Documents

Publication Publication Date Title
CY1121133T1 (el) Τοπικα εφαρμοσιμο φαρμακευτικο παρασκευασμα
NO20032510D0 (no) Organiske forbindelser
ATE337016T1 (de) Zusammensetzungen zur erhöhung der bioverfügbarkeit von oral verabreichten pharmazeutischen verbindungen
PA8589401A1 (es) Derivados de indolilo
ECSP045447A (es) Preparación farmacéutica que se puede aplicar por vía tópica

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1511516

Country of ref document: EP