ATE414691T1 - Verfahren zum erhalt von enantiomeren und nicht- razemischen mischungen der enantiomere von n-(2,6-dimethylphenyl)-1-propyl-2- piperidinocarbonsäureamid; nicht-razemische mischungen und pharmazeutische zusammenstellungen die diese enthalten. - Google Patents

Verfahren zum erhalt von enantiomeren und nicht- razemischen mischungen der enantiomere von n-(2,6-dimethylphenyl)-1-propyl-2- piperidinocarbonsäureamid; nicht-razemische mischungen und pharmazeutische zusammenstellungen die diese enthalten.

Info

Publication number
ATE414691T1
ATE414691T1 AT02805235T AT02805235T ATE414691T1 AT E414691 T1 ATE414691 T1 AT E414691T1 AT 02805235 T AT02805235 T AT 02805235T AT 02805235 T AT02805235 T AT 02805235T AT E414691 T1 ATE414691 T1 AT E414691T1
Authority
AT
Austria
Prior art keywords
enantiomers
dimethylphenyl
propyl
razemic
mixtures
Prior art date
Application number
AT02805235T
Other languages
English (en)
Inventor
Valter Russo
Elisa Russo
Ogari Pacheco
Original Assignee
Cristalia Prod Quimicos Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cristalia Prod Quimicos Farm filed Critical Cristalia Prod Quimicos Farm
Application granted granted Critical
Publication of ATE414691T1 publication Critical patent/ATE414691T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT02805235T 2001-10-10 2002-10-08 Verfahren zum erhalt von enantiomeren und nicht- razemischen mischungen der enantiomere von n-(2,6-dimethylphenyl)-1-propyl-2- piperidinocarbonsäureamid; nicht-razemische mischungen und pharmazeutische zusammenstellungen die diese enthalten. ATE414691T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0104491A BRPI0104491B8 (pt) 2001-10-10 2001-10-10 n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.

Publications (1)

Publication Number Publication Date
ATE414691T1 true ATE414691T1 (de) 2008-12-15

Family

ID=3948021

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02805235T ATE414691T1 (de) 2001-10-10 2002-10-08 Verfahren zum erhalt von enantiomeren und nicht- razemischen mischungen der enantiomere von n-(2,6-dimethylphenyl)-1-propyl-2- piperidinocarbonsäureamid; nicht-razemische mischungen und pharmazeutische zusammenstellungen die diese enthalten.

Country Status (8)

Country Link
US (1) US7495105B2 (de)
EP (1) EP1434764B1 (de)
AT (1) ATE414691T1 (de)
AU (1) AU2002333074A1 (de)
BR (1) BRPI0104491B8 (de)
DE (1) DE60229968D1 (de)
HK (1) HK1069818A1 (de)
WO (1) WO2003053326A2 (de)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695576A (en) * 1984-07-09 1987-09-22 Astra Lake Medel Aktiebolag L-N-n-propylpipecolic acid-2,6-xylidide
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
US5786484A (en) * 1994-09-23 1998-07-28 Chiroscience Limited Racemization and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
PT788480E (pt) * 1994-10-25 2003-12-31 Darwin Discovery Ltd Cristalizacao de levobupivacaina e seus analogos
ES2203645T3 (es) * 1994-10-25 2004-04-16 Darwin Discovery Limited Procedimiento para la preparacion de levobupivacaina y analogos de losmismos.
US6384227B2 (en) * 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
SE9501808D0 (sv) * 1995-05-16 1995-05-16 Astra Ab New process

Also Published As

Publication number Publication date
WO2003053326B1 (en) 2004-04-08
WO2003053326A3 (en) 2004-03-04
EP1434764B1 (de) 2008-11-19
BR0104491B1 (pt) 2013-11-12
EP1434764A4 (de) 2005-06-01
EP1434764A2 (de) 2004-07-07
HK1069818A1 (en) 2005-06-03
AU2002333074A1 (en) 2003-07-09
BR0104491A (pt) 2003-12-02
BRPI0104491B8 (pt) 2021-05-25
DE60229968D1 (de) 2009-01-02
AU2002333074A8 (en) 2003-07-09
US7495105B2 (en) 2009-02-24
US20040210057A1 (en) 2004-10-21
WO2003053326A2 (en) 2003-07-03

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