ATE412058T1 - Interne ribosomenzugangsstelle-enthaltende zell- spezifische adenovirale vektoren - Google Patents
Interne ribosomenzugangsstelle-enthaltende zell- spezifische adenovirale vektorenInfo
- Publication number
- ATE412058T1 ATE412058T1 AT01920614T AT01920614T ATE412058T1 AT E412058 T1 ATE412058 T1 AT E412058T1 AT 01920614 T AT01920614 T AT 01920614T AT 01920614 T AT01920614 T AT 01920614T AT E412058 T1 ATE412058 T1 AT E412058T1
- Authority
- AT
- Austria
- Prior art keywords
- internal ribosome
- adenoviral vectors
- access site
- containing cell
- vectors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
- C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19215600P | 2000-03-24 | 2000-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE412058T1 true ATE412058T1 (de) | 2008-11-15 |
Family
ID=22708488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01920614T ATE412058T1 (de) | 2000-03-24 | 2001-03-21 | Interne ribosomenzugangsstelle-enthaltende zell- spezifische adenovirale vektoren |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1266022B1 (de) |
JP (1) | JP2004511203A (de) |
AT (1) | ATE412058T1 (de) |
AU (2) | AU2001247648B2 (de) |
CA (1) | CA2404235C (de) |
DE (1) | DE60136268D1 (de) |
WO (1) | WO2001073093A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673614B2 (en) | 2000-06-27 | 2004-01-06 | Cell Genesys, Inc. | Rapid methods and kits for detection and semi-quantitation of anti-adenovirus antibody |
EP1377672A2 (de) | 2001-02-23 | 2004-01-07 | Novartis AG | Vektorkonstrukte |
US8163892B2 (en) | 2002-07-08 | 2012-04-24 | Oncolys Biopharma, Inc. | Oncolytic virus replicating selectively in tumor cells |
JP3867968B2 (ja) | 2002-07-08 | 2007-01-17 | 関西ティー・エル・オー株式会社 | 腫瘍細胞において選択的に増殖する腫瘍融解ウイルス |
US7371570B2 (en) | 2002-11-01 | 2008-05-13 | Cell Genesys, Inc. | Cell-specific adenovirus vector comprising EBV-specific promoter |
JP4478775B2 (ja) | 2003-07-31 | 2010-06-09 | 財団法人名古屋産業科学研究所 | 増殖制御型組換えアデノウイルスベクターの効率的な作製方法及びその作製用キット |
US7482156B2 (en) | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
EP1900749A1 (de) * | 2006-09-12 | 2008-03-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nukleinsäuren zur Expression von Polynukleotiden in Säuger-Krebszellen |
AU2014236207B2 (en) | 2013-03-14 | 2019-05-23 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
CA3013637A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
CN117384961A (zh) | 2016-02-23 | 2024-01-12 | 萨克生物研究学院 | 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达 |
JP7208492B2 (ja) | 2016-03-10 | 2023-01-19 | シージー オンコロジー, インコーポレイテッド | 併用療法によって固形腫瘍又はリンパ系腫瘍を処置する方法 |
WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
US11338003B2 (en) | 2017-04-14 | 2022-05-24 | Cg Oncology, Inc. | Methods of treating bladder cancer with an oncolytic virus |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638762B1 (en) * | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
US6197293B1 (en) * | 1997-03-03 | 2001-03-06 | Calydon, Inc. | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof |
FR2755975B1 (fr) * | 1996-11-15 | 1999-05-07 | Rhone Poulenc Rorer Sa | Virus recombinants bicistroniques utiles pour le traitement de pathologies liees aux dyslipoproteinemies |
US6653132B1 (en) * | 1997-02-25 | 2003-11-25 | Qbi Enterprises, Ltd. | IRES sequences with high translational efficiency and expression vectors containing the sequence |
AU744725B2 (en) * | 1997-03-03 | 2002-02-28 | Cold Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
WO1998039467A2 (en) * | 1997-03-03 | 1998-09-11 | Calydon, Inc. | Adenovirus vectors specific for cells expressing carcinoembryonic antigen and methods of use thereof |
FR2762615B1 (fr) * | 1997-04-28 | 1999-07-16 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes et vecteur le contenant |
EP1002103B1 (de) * | 1997-08-04 | 2007-10-17 | Cell Genesys, Inc. | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
CA2322663A1 (en) * | 1998-03-11 | 1999-09-16 | Board Of Regents, The University Of Texas System | Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery |
JP2002506651A (ja) * | 1998-03-16 | 2002-03-05 | イントロジェン・セラピューティクス,インコーポレイテッド | 多重遺伝子ベクター |
US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
WO2001072341A2 (en) * | 2000-03-24 | 2001-10-04 | Cell Genesys, Inc. | Methods of treating neoplasia with combinations of target cell-specific adenovirus, chemotherapy and radiation |
-
2001
- 2001-03-21 DE DE60136268T patent/DE60136268D1/de not_active Expired - Lifetime
- 2001-03-21 JP JP2001570809A patent/JP2004511203A/ja active Pending
- 2001-03-21 CA CA2404235A patent/CA2404235C/en not_active Expired - Lifetime
- 2001-03-21 WO PCT/US2001/009036 patent/WO2001073093A2/en active Application Filing
- 2001-03-21 AT AT01920614T patent/ATE412058T1/de not_active IP Right Cessation
- 2001-03-21 AU AU2001247648A patent/AU2001247648B2/en not_active Expired
- 2001-03-21 AU AU4764801A patent/AU4764801A/xx active Pending
- 2001-03-21 EP EP01920614A patent/EP1266022B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU4764801A (en) | 2001-10-08 |
WO2001073093A2 (en) | 2001-10-04 |
EP1266022B1 (de) | 2008-10-22 |
JP2004511203A (ja) | 2004-04-15 |
DE60136268D1 (de) | 2008-12-04 |
CA2404235C (en) | 2010-09-21 |
AU2001247648B2 (en) | 2006-03-30 |
WO2001073093A3 (en) | 2002-09-06 |
CA2404235A1 (en) | 2001-10-04 |
EP1266022A2 (de) | 2002-12-18 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |