ATE410162T1 - Verfahren zur herstellung einer fein selbstemulgierbaren pharmazeutischen zusammensetzung - Google Patents

Verfahren zur herstellung einer fein selbstemulgierbaren pharmazeutischen zusammensetzung

Info

Publication number
ATE410162T1
ATE410162T1 AT03719615T AT03719615T ATE410162T1 AT E410162 T1 ATE410162 T1 AT E410162T1 AT 03719615 T AT03719615 T AT 03719615T AT 03719615 T AT03719615 T AT 03719615T AT E410162 T1 ATE410162 T1 AT E410162T1
Authority
AT
Austria
Prior art keywords
pharmaceutical composition
pharmaceutically acceptable
producing
composition
emulsifiable
Prior art date
Application number
AT03719615T
Other languages
English (en)
Inventor
Ping Gao
Xioarong He
Keith Bolyard
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE410162T1 publication Critical patent/ATE410162T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03719615T 2002-04-09 2003-04-07 Verfahren zur herstellung einer fein selbstemulgierbaren pharmazeutischen zusammensetzung ATE410162T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37120002P 2002-04-09 2002-04-09

Publications (1)

Publication Number Publication Date
ATE410162T1 true ATE410162T1 (de) 2008-10-15

Family

ID=29250656

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03719615T ATE410162T1 (de) 2002-04-09 2003-04-07 Verfahren zur herstellung einer fein selbstemulgierbaren pharmazeutischen zusammensetzung

Country Status (19)

Country Link
US (1) US20030235596A1 (de)
EP (1) EP1492527B1 (de)
JP (1) JP2005529104A (de)
KR (1) KR100779285B1 (de)
CN (1) CN1305470C (de)
AT (1) ATE410162T1 (de)
AU (1) AU2003223485B2 (de)
BR (1) BR0309138A (de)
CA (1) CA2481677A1 (de)
DE (1) DE60323953D1 (de)
ES (1) ES2310653T3 (de)
HK (1) HK1076382A1 (de)
IL (1) IL164163A0 (de)
MX (1) MXPA04009880A (de)
PL (1) PL372807A1 (de)
RS (1) RS87004A (de)
RU (1) RU2299061C2 (de)
WO (1) WO2003086392A2 (de)
ZA (1) ZA200407711B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211801B4 (de) 2002-03-16 2004-09-30 Clariant Gmbh Kosmetische und pharmazeutische Zubereitungen enthaltend einen oxalkylierten Polyglycerinester
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
RU2342953C2 (ru) * 2003-02-24 2009-01-10 Фармасьютикал Продакшенз, Инк. Трансмукозная система доставки лекарственных средств
JP2006232755A (ja) * 2005-02-25 2006-09-07 Dai Ichi Kogyo Seiyaku Co Ltd 油中水型マイクロエマルション
CA2627351C (en) 2005-10-26 2012-05-01 Banner Pharmacaps, Inc. Lipophilic vehicle-based dual controlled release matrix system
US8333989B2 (en) * 2005-10-26 2012-12-18 Banner Pharmacaps, Inc. Hydrophilic vehicle-based dual controlled release matrix system
US20100119601A1 (en) * 2007-04-11 2010-05-13 Pharmaceutical Productions Inc. Melatonin tablet and methods of preparation and use
EP2488022B1 (de) 2009-10-16 2018-01-10 Mochida Pharmaceutical Co., Ltd. Zusammensetzungen
MX2012007229A (es) * 2009-12-22 2012-07-30 Leo Pharma As Composicion cutanea que comprende analogo de vitamina d y mezcla de solvente y tensioactivos.
AT511045A1 (de) 2011-01-28 2012-08-15 Blum Gmbh Julius Möbelteil mit einer drehmomentübertragenden welle
US9119826B2 (en) 2011-02-16 2015-09-01 Pivotal Therapeutics, Inc. Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels
US8951514B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels
US8952000B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
JP6285866B2 (ja) 2011-11-23 2018-02-28 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然複合ホルモン補充製剤および療法
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN103965113A (zh) * 2014-05-06 2014-08-06 四川大学 1-羟乙基-2-取代苯氧甲基苯并咪唑类化合物及其制备方法
KR20170005819A (ko) 2014-05-22 2017-01-16 쎄러퓨틱스엠디, 인코퍼레이티드 천연 복합 호르몬 대체 제형 및 요법
EP3160444B1 (de) 2014-06-25 2021-11-24 Synergia Bio Sciences Private Limited Pharmazeutische öl-in-wasser-nanoemulsion
US11400048B2 (en) 2014-06-25 2022-08-02 Synergia Bio Sciences Private Limited Pharmaceutical oil-in-water nano-emulsion
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
AU2016267685A1 (en) 2015-05-28 2017-12-07 Dr. Reddy's Laboratories Ltd. Oral composition of celecoxib for treatment of pain
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
CN105343002B (zh) * 2015-11-27 2019-07-26 济南康和医药科技有限公司 一种依托考昔口服微乳制剂及其制备方法
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN111729125B (zh) * 2020-07-31 2022-10-04 陕西佰傲再生医学有限公司 骨止血材料
CA3144079A1 (en) * 2020-12-28 2022-06-28 Biodelivery Sciences International, Inc. Methods of treating pain
CN113750043A (zh) * 2021-09-18 2021-12-07 山东省药学科学院 一种塞来昔布自乳化口服液及其制备方法
KR102635930B1 (ko) 2021-10-29 2024-02-14 단국대학교 천안캠퍼스 산학협력단 자가나노유화 약물전달시스템을 이용한 셀레콕시브 함유 경구 투여용 제제 및 이의 제조방법
GB2616663A (en) * 2022-03-18 2023-09-20 Alkaloid Ad Skopje Pharmaceutical formulation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53121923A (en) * 1977-03-29 1978-10-24 Capsugel Ag Production of chain like capsule
JP2564889B2 (ja) * 1988-03-07 1996-12-18 松下電工株式会社 軸流フアン
US5264223A (en) * 1990-03-29 1993-11-23 Japan Elanco Company, Ltd. Hard capsule for pharmaceutical drugs and method for producing the same
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5756123A (en) * 1994-12-01 1998-05-26 Japan Elanco Co., Ltd. Capsule shell
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US5981576A (en) * 1995-10-13 1999-11-09 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
US5861419A (en) * 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
ZA200101994B (en) * 1998-09-09 2002-03-11 Alza Corp Dosage form comprising liquid formulation.
AR035642A1 (es) * 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
TWI232761B (en) * 2000-07-01 2005-05-21 Pharmaceutical Ind Tech & Dev Capsule preparation for oral administration and the preparation method thereof
JP2004503588A (ja) * 2000-07-13 2004-02-05 ファルマシア・コーポレーション 全身性疼痛および頭痛に対する選択的シクロオキシゲナーゼ−２阻害薬および血管調節化合物
US20030105141A1 (en) * 2001-04-17 2003-06-05 Ping Gao Finely self-emulsifiable pharmaceutical composition

Also Published As

Publication number Publication date
KR100779285B1 (ko) 2007-11-28
BR0309138A (pt) 2005-02-01
DE60323953D1 (de) 2008-11-20
CN1658870A (zh) 2005-08-24
AU2003223485A1 (en) 2003-10-27
WO2003086392A3 (en) 2004-03-25
AU2003223485B2 (en) 2007-05-31
US20030235596A1 (en) 2003-12-25
IL164163A0 (en) 2005-12-18
RU2004130291A (ru) 2005-05-27
RU2299061C2 (ru) 2007-05-20
HK1076382A1 (en) 2006-01-20
EP1492527A2 (de) 2005-01-05
ZA200407711B (en) 2006-06-28
KR20070014237A (ko) 2007-02-01
EP1492527B1 (de) 2008-10-08
WO2003086392A2 (en) 2003-10-23
MXPA04009880A (es) 2004-12-07
ES2310653T3 (es) 2009-01-16
JP2005529104A (ja) 2005-09-29
CA2481677A1 (en) 2003-10-23
PL372807A1 (en) 2005-08-08
RS87004A (en) 2006-12-15
CN1305470C (zh) 2007-03-21

Similar Documents

Publication Publication Date Title
DE60323953D1 (de) Verfahren zur herstellung einer fein selbstemulgierbaren pharmazeutischen zusammensetzung
ATE124047T1 (de) Oxazolopyridinderivate, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen zusammensetzungen.
ES2110377T1 (es) Formulacion galenica de fenofibrato y aplicacion de la misma.
ATE355829T1 (de) Einen lipophilen wirkstoff enthaltende feste pharmazeutische zusammensetzung sowie deren herstellung
ATE308890T1 (de) Verfahren zur herstellung einer gereinigten shilajit-zusammensetzung aus nativem shilajit
ATE218359T1 (de) Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
EA200301019A1 (ru) Доставляемая перорально фармацевтическая композиция, включающая препарат с низкой растворимостью в воде (ингибитор cox-2), растворитель, жирную кислоту и органический амин
ATE116979T1 (de) 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsäurederivate, salze und ester, verfahren zu ihrer herstellung, pharmazeutische präparate sowie vorprodukte.
ATE386725T1 (de) Heterocyclylverbindungen
ATE136298T1 (de) Chinoloncarbonsäurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel
ATE137753T1 (de) Codeinsalz einer substituierten carbonsäure, verfahren zu seiner herstellung, seine verwendung und pharmazeutische präparate
DE69114476D1 (de) Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung.
EP0600395A1 (de) Entzündungshemmendes und analgetisches Diclofenac-Gel
PT99563A (pt) Processo para a preparacao de aminas biologicamente activas
DE69808938D1 (de) Verfahren zur herstellung von pharmazeutischen zusammensetzungen
DE3573119D1 (en) 8-alkylthio-2-piperazino-pyrimidoû5,4-d¨pyrimidines, their preparation and medicaments containing them
ATE193297T1 (de) Wasserlösliche derivate epipodophyllotoxine, verfahren zu ihrer herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
ATE152118T1 (de) Kardioaktive 17b-(3-furyl) und 17b-(4- pyridazinyl)-5beta, 14beta-androstan derivate, verfahren zu ihrer herstellung und pharmazeutische präparate davon
ATE25679T1 (de) Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.
MX9400165A (es) Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen.
DE50006842D1 (de) 4-benzylaminochinoline konjugate mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung
ATE287895T1 (de) Substituierte tetrahydropyranderivate sowie verfahren zu deren herstellung
ATE160938T1 (de) Feste orale pharmazeutische zubereitung mit gemfibrozil als aktiver inhaltsstoff und verfahren zur herstellung
DE3770287D1 (de) Neue n-glycosylamidderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
DE69008103D1 (de) Neue 9-g(a)-hydroxy-3-oxo-4,24(25)-stigmastadien-26-säurederivate, verfahren zur herstellung und heilmittel daraus.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties