DE69114476D1 - Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung. - Google Patents

Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung.

Info

Publication number: DE69114476D1
Authority: DE; Germany
Prior art keywords: cyclosporin; pharmaceutical composition; parts; production; composition containing
Prior art date: 1990-11-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69114476T

Other languages

English (en)

Other versions

DE69114476T2 (de

Inventor

Ernoe Orban

Laszlone Tomori

Maria Kuerthy

Tibor Balogh

Laszlo Jaszlits

Imre Moravcsik

Istvan Kovacs

Istvanne Jusztin

Sandor Jancso

Erzsebet Takacs

Tamasne Kiss

Antalne Kovacs

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teva Pharmaceutical Works PLC

Original Assignee

Biogal Gyogyszergyar Rt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-27

Filing date

1991-11-27

Publication date

1995-12-14

1991-11-27 Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt

1995-12-14 Application granted granted Critical

1995-12-14 Publication of DE69114476D1 publication Critical patent/DE69114476D1/de

1996-04-18 Publication of DE69114476T2 publication Critical patent/DE69114476T2/de

2011-11-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 4
229930105110 Cyclosporin A Natural products 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
229930182912 cyclosporin Natural products 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000008203 oral pharmaceutical composition Substances 0.000 title 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 abstract 1
ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 abstract 1
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
108010019249 cyclosporin G Proteins 0.000 abstract 1
229940100688 oral solution Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
-1 polyoxyethylene Polymers 0.000 abstract 1
229920001451 polypropylene glycol Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DE69114476T 1990-11-27 1991-11-27 Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung. Expired - Fee Related DE69114476T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU907653A HU208491B (en)	1990-11-27	1990-11-27	Process for producing oral pharmaceutical composition containing cyclosporin
PCT/HU1991/000050 WO1992009299A1 (en)	1990-11-27	1991-11-27	Oral pharmaceutical composition containing cyclosporin and process for preparing same

Publications (2)

Publication Number	Publication Date
DE69114476D1 true DE69114476D1 (de)	1995-12-14
DE69114476T2 DE69114476T2 (de)	1996-04-18

Family

ID=10972318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69114476T Expired - Fee Related DE69114476T2 (de)	1990-11-27	1991-11-27	Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung.

Country Status (18)

Country	Link
US (1)	US5430017A (de)
EP (1)	EP0512109B1 (de)
JP (1)	JPH082795B2 (de)
AT (1)	ATE129898T1 (de)
AU (1)	AU651154B2 (de)
CA (1)	CA2072983A1 (de)
CS (1)	CS230492A3 (de)
DE (1)	DE69114476T2 (de)
DK (1)	DK0512109T3 (de)
FI (1)	FI923385A0 (de)
HU (1)	HU208491B (de)
IL (1)	IL100162A (de)
MX (1)	MX9102243A (de)
NO (1)	NO922961L (de)
NZ (1)	NZ240762A (de)
PT (1)	PT99623A (de)
WO (1)	WO1992009299A1 (de)
ZA (1)	ZA919352B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ247516A (en) *	1993-04-28	1995-02-24	Bernard Charles Sherman	Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
DE59510233D1 (de)	1994-11-03	2002-07-11	Novartis Ag	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
HU215966B (hu) *	1994-11-21	1999-07-28	BIOGAL Gyógyszergyár Rt.	Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US6022536A (en) *	1995-08-09	2000-02-08	Schering Corporation	Combined use of interleukin 10 and cyclosporin for immunosuppression therapy
AU764599B2 (en) *	1995-08-25	2003-08-21	Sangstat Medical Corporation	Oral cyclosporin formulations
MX9702809A (es) *	1995-08-25	1998-02-28	Sangstat Medical Corp	Formulaciones orales de ciclosporina.
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
EP0988046B1 (de)	1997-01-30	2004-09-15	Novartis AG	Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält
SI0969856T1 (en) *	1997-03-12	2005-06-30	Abbott Laboratories	Hydrophilic binary systems for the administration of cyclosporine
US5891845A (en) *	1997-11-21	1999-04-06	Fuisz Technologies Ltd.	Drug delivery systems utilizing liquid crystal structures
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
JP2002534370A (ja)	1998-12-30	2002-10-15	デクセルリミテッド	サイクロスポリンを送達するための分散可能な濃縮物
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE290460C (de) *
DE2907460A1 (de) *	1978-03-07	1979-09-13	Sandoz Ag	Neue resorbierbare galenische kompositionen
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
SE8601624D0 (sv) *	1986-04-11	1986-04-11	Haessle Ab	New pharmaceutical preparations
CA1323306C (en) *	1987-03-05	1993-10-19	Mircea C. Popescu	Pharmacological agent-lipid solution preparation
JP2577049B2 (ja) *	1987-06-04	1997-01-29	三共株式会社	シクロスポリン製剤
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
BE1003009A5 (fr) *	1989-02-09	1991-10-22	Sandoz Sa	Nouvelles compositions pharmaceutiques a base de cyclosporines.
US4996193A (en) *	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine

1990
- 1990-11-27 HU HU907653A patent/HU208491B/hu unknown
1991
- 1991-11-27 WO PCT/HU1991/000050 patent/WO1992009299A1/en not_active Application Discontinuation
- 1991-11-27 EP EP92902040A patent/EP0512109B1/de not_active Expired - Lifetime
- 1991-11-27 NZ NZ240762A patent/NZ240762A/xx unknown
- 1991-11-27 PT PT99623A patent/PT99623A/pt not_active Application Discontinuation
- 1991-11-27 MX MX9102243A patent/MX9102243A/es unknown
- 1991-11-27 AT AT92902040T patent/ATE129898T1/de not_active IP Right Cessation
- 1991-11-27 DE DE69114476T patent/DE69114476T2/de not_active Expired - Fee Related
- 1991-11-27 CA CA002072983A patent/CA2072983A1/en not_active Abandoned
- 1991-11-27 IL IL10016291A patent/IL100162A/en not_active IP Right Cessation
- 1991-11-27 AU AU89440/91A patent/AU651154B2/en not_active Ceased
- 1991-11-27 DK DK92902040.2T patent/DK0512109T3/da active
- 1991-11-27 ZA ZA919352A patent/ZA919352B/xx unknown
- 1991-11-27 JP JP4500525A patent/JPH082795B2/ja not_active Expired - Lifetime
1992
- 1992-07-23 CS CS922304A patent/CS230492A3/cs unknown
- 1992-07-27 NO NO92922961A patent/NO922961L/no unknown
- 1992-07-27 FI FI923385A patent/FI923385A0/fi not_active Application Discontinuation
1993
- 1993-05-20 US US07/915,719 patent/US5430017A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI923385A (fi)	1992-07-27
IL100162A0 (en)	1992-08-18
DE69114476T2 (de)	1996-04-18
IL100162A (en)	1995-11-27
US5430017A (en)	1995-07-04
NZ240762A (en)	1993-05-26
CA2072983A1 (en)	1992-05-28
EP0512109A1 (de)	1992-11-11
NO922961L (no)	1992-09-23
EP0512109B1 (de)	1995-11-08
DK0512109T3 (da)	1995-12-11
FI923385A0 (fi)	1992-07-27
PT99623A (pt)	1992-12-31
AU651154B2 (en)	1994-07-14
AU8944091A (en)	1992-06-25
ZA919352B (en)	1992-09-30
HU907653D0 (en)	1991-06-28
HU208491B (en)	1993-11-29
ATE129898T1 (de)	1995-11-15
JPH082795B2 (ja)	1996-01-17
WO1992009299A1 (en)	1992-06-11
JPH05503306A (ja)	1993-06-03
MX9102243A (es)	1992-07-08
CS230492A3 (en)	1992-12-16
HUT60929A (en)	1992-11-30
NO922961D0 (no)	1992-07-27

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Legal Events

Date	Code	Title	Description
1996-11-07	8339	Ceased/non-payment of the annual fee