DE69114476D1 - Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung. - Google Patents
Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung.Info
- Publication number
- DE69114476D1 DE69114476D1 DE69114476T DE69114476T DE69114476D1 DE 69114476 D1 DE69114476 D1 DE 69114476D1 DE 69114476 T DE69114476 T DE 69114476T DE 69114476 T DE69114476 T DE 69114476T DE 69114476 D1 DE69114476 D1 DE 69114476D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclosporin
- pharmaceutical composition
- parts
- production
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008203 oral pharmaceutical composition Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 abstract 1
- ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 108010019249 cyclosporin G Proteins 0.000 abstract 1
- 229940100688 oral solution Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU907653A HU208491B (en) | 1990-11-27 | 1990-11-27 | Process for producing oral pharmaceutical composition containing cyclosporin |
PCT/HU1991/000050 WO1992009299A1 (en) | 1990-11-27 | 1991-11-27 | Oral pharmaceutical composition containing cyclosporin and process for preparing same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69114476D1 true DE69114476D1 (de) | 1995-12-14 |
DE69114476T2 DE69114476T2 (de) | 1996-04-18 |
Family
ID=10972318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69114476T Expired - Fee Related DE69114476T2 (de) | 1990-11-27 | 1991-11-27 | Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5430017A (de) |
EP (1) | EP0512109B1 (de) |
JP (1) | JPH082795B2 (de) |
AT (1) | ATE129898T1 (de) |
AU (1) | AU651154B2 (de) |
CA (1) | CA2072983A1 (de) |
CS (1) | CS230492A3 (de) |
DE (1) | DE69114476T2 (de) |
DK (1) | DK0512109T3 (de) |
FI (1) | FI923385A0 (de) |
HU (1) | HU208491B (de) |
IL (1) | IL100162A (de) |
MX (1) | MX9102243A (de) |
NO (1) | NO922961L (de) |
NZ (1) | NZ240762A (de) |
PT (1) | PT99623A (de) |
WO (1) | WO1992009299A1 (de) |
ZA (1) | ZA919352B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ247516A (en) * | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
DE59510233D1 (de) | 1994-11-03 | 2002-07-11 | Novartis Ag | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
US6022536A (en) * | 1995-08-09 | 2000-02-08 | Schering Corporation | Combined use of interleukin 10 and cyclosporin for immunosuppression therapy |
AU764599B2 (en) * | 1995-08-25 | 2003-08-21 | Sangstat Medical Corporation | Oral cyclosporin formulations |
MX9702809A (es) * | 1995-08-25 | 1998-02-28 | Sangstat Medical Corp | Formulaciones orales de ciclosporina. |
US5766629A (en) * | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
EP0988046B1 (de) | 1997-01-30 | 2004-09-15 | Novartis AG | Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält |
SI0969856T1 (en) * | 1997-03-12 | 2005-06-30 | Abbott Laboratories | Hydrophilic binary systems for the administration of cyclosporine |
US5891845A (en) * | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
JP2002534370A (ja) | 1998-12-30 | 2002-10-15 | デクセル リミテッド | サイクロスポリンを送達するための分散可能な濃縮物 |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE290460C (de) * | ||||
DE2907460A1 (de) * | 1978-03-07 | 1979-09-13 | Sandoz Ag | Neue resorbierbare galenische kompositionen |
CH641356A5 (en) * | 1979-02-27 | 1984-02-29 | Sandoz Ag | Pharmaceutical compositions containing cyclosporin |
GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
CA1323306C (en) * | 1987-03-05 | 1993-10-19 | Mircea C. Popescu | Pharmacological agent-lipid solution preparation |
JP2577049B2 (ja) * | 1987-06-04 | 1997-01-29 | 三共株式会社 | シクロスポリン製剤 |
GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
BE1003009A5 (fr) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base de cyclosporines. |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
-
1990
- 1990-11-27 HU HU907653A patent/HU208491B/hu unknown
-
1991
- 1991-11-27 WO PCT/HU1991/000050 patent/WO1992009299A1/en not_active Application Discontinuation
- 1991-11-27 EP EP92902040A patent/EP0512109B1/de not_active Expired - Lifetime
- 1991-11-27 NZ NZ240762A patent/NZ240762A/xx unknown
- 1991-11-27 PT PT99623A patent/PT99623A/pt not_active Application Discontinuation
- 1991-11-27 MX MX9102243A patent/MX9102243A/es unknown
- 1991-11-27 AT AT92902040T patent/ATE129898T1/de not_active IP Right Cessation
- 1991-11-27 DE DE69114476T patent/DE69114476T2/de not_active Expired - Fee Related
- 1991-11-27 CA CA002072983A patent/CA2072983A1/en not_active Abandoned
- 1991-11-27 IL IL10016291A patent/IL100162A/en not_active IP Right Cessation
- 1991-11-27 AU AU89440/91A patent/AU651154B2/en not_active Ceased
- 1991-11-27 DK DK92902040.2T patent/DK0512109T3/da active
- 1991-11-27 ZA ZA919352A patent/ZA919352B/xx unknown
- 1991-11-27 JP JP4500525A patent/JPH082795B2/ja not_active Expired - Lifetime
-
1992
- 1992-07-23 CS CS922304A patent/CS230492A3/cs unknown
- 1992-07-27 NO NO92922961A patent/NO922961L/no unknown
- 1992-07-27 FI FI923385A patent/FI923385A0/fi not_active Application Discontinuation
-
1993
- 1993-05-20 US US07/915,719 patent/US5430017A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI923385A (fi) | 1992-07-27 |
IL100162A0 (en) | 1992-08-18 |
DE69114476T2 (de) | 1996-04-18 |
IL100162A (en) | 1995-11-27 |
US5430017A (en) | 1995-07-04 |
NZ240762A (en) | 1993-05-26 |
CA2072983A1 (en) | 1992-05-28 |
EP0512109A1 (de) | 1992-11-11 |
NO922961L (no) | 1992-09-23 |
EP0512109B1 (de) | 1995-11-08 |
DK0512109T3 (da) | 1995-12-11 |
FI923385A0 (fi) | 1992-07-27 |
PT99623A (pt) | 1992-12-31 |
AU651154B2 (en) | 1994-07-14 |
AU8944091A (en) | 1992-06-25 |
ZA919352B (en) | 1992-09-30 |
HU907653D0 (en) | 1991-06-28 |
HU208491B (en) | 1993-11-29 |
ATE129898T1 (de) | 1995-11-15 |
JPH082795B2 (ja) | 1996-01-17 |
WO1992009299A1 (en) | 1992-06-11 |
JPH05503306A (ja) | 1993-06-03 |
MX9102243A (es) | 1992-07-08 |
CS230492A3 (en) | 1992-12-16 |
HUT60929A (en) | 1992-11-30 |
NO922961D0 (no) | 1992-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |