ATE409005T1 - Zellchirurgie unter benutzung konfokaler mikroskopie - Google Patents
Zellchirurgie unter benutzung konfokaler mikroskopieInfo
- Publication number
- ATE409005T1 ATE409005T1 AT98911824T AT98911824T ATE409005T1 AT E409005 T1 ATE409005 T1 AT E409005T1 AT 98911824 T AT98911824 T AT 98911824T AT 98911824 T AT98911824 T AT 98911824T AT E409005 T1 ATE409005 T1 AT E409005T1
- Authority
- AT
- Austria
- Prior art keywords
- tissue
- confocal
- laser
- laser beam
- cells
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/10—Scanning systems
- G02B26/12—Scanning systems using multifaceted mirrors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0012—Surgical microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/20—Surgical microscopes characterised by non-optical aspects
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Electromagnetism (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Laser Surgery Devices (AREA)
- Microscoopes, Condenser (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4105097P | 1997-03-19 | 1997-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE409005T1 true ATE409005T1 (de) | 2008-10-15 |
Family
ID=21914455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98911824T ATE409005T1 (de) | 1997-03-19 | 1998-03-19 | Zellchirurgie unter benutzung konfokaler mikroskopie |
Country Status (8)
Country | Link |
---|---|
US (3) | US5995867A (de) |
EP (1) | EP1003429B1 (de) |
JP (1) | JP4383545B2 (de) |
AT (1) | ATE409005T1 (de) |
AU (1) | AU6569198A (de) |
DE (1) | DE69840046D1 (de) |
ES (1) | ES2313745T3 (de) |
WO (1) | WO1998041158A1 (de) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6745067B1 (en) | 1998-09-14 | 2004-06-01 | Lucid, Inc. | System for marking the locations of imaged tissue with respect to the surface of the tissue |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
JP4383545B2 (ja) * | 1997-03-19 | 2009-12-16 | ルーシド インコーポレーテッド | 共焦点顕微鏡使用法を利用する細胞手術 |
JP4056091B2 (ja) | 1997-05-15 | 2008-03-05 | パロマー・メディカル・テクノロジーズ・インコーポレーテッド | 皮膚科的治療方法及び装置 |
WO2000053261A1 (en) | 1999-03-08 | 2000-09-14 | Asah Medico A/S | An apparatus for tissue treatment and having a monitor for display of tissue features |
JP3554760B2 (ja) * | 1997-12-12 | 2004-08-18 | 横河電機株式会社 | 共焦点顕微鏡装置 |
EP1066488A1 (de) * | 1998-02-26 | 2001-01-10 | Lucid, Inc. | Konfokales mikroskop zur erleichterung der kryochirurgie von geweben |
EP1566149A1 (de) | 1998-03-12 | 2005-08-24 | Palomar Medical Technologies, Inc. | System zur elektromagnetischen Bestrahlung der Haut |
US7227630B1 (en) | 1998-09-14 | 2007-06-05 | Lucid, Inc. | Imaging of surgical biopsies |
WO2000015021A2 (en) * | 1998-09-14 | 2000-03-23 | Lucid, Inc. | Imaging of surgical biopsies |
US6352502B1 (en) | 1998-12-03 | 2002-03-05 | Lightouch Medical, Inc. | Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities |
US6522407B2 (en) | 1999-01-22 | 2003-02-18 | The Regents Of The University Of California | Optical detection dental disease using polarized light |
US6720547B1 (en) | 1999-03-18 | 2004-04-13 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
WO2000055669A1 (en) * | 1999-03-18 | 2000-09-21 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
DE60023236T2 (de) * | 1999-04-14 | 2007-01-11 | Koninklijke Philips Electronics N.V. | Einrichtung zur haarentfernung mit einer steuerbaren laserquelle |
WO2000069333A1 (en) * | 1999-05-19 | 2000-11-23 | The Regents Of The University Of California | Optical detection of dental disease using polarized light |
US6494878B1 (en) * | 2000-05-12 | 2002-12-17 | Ceramoptec Industries, Inc. | System and method for accurate optical treatment of an eye's fundus |
DE10024404A1 (de) * | 2000-05-19 | 2001-11-22 | Leica Microsystems | Verfahren und Vorrichtung zum Abtasten eines Objekts |
US6450949B1 (en) | 2000-06-30 | 2002-09-17 | Inner Vision Imaging, Inc. | Endoscope |
US6530882B1 (en) * | 2000-06-30 | 2003-03-11 | Inner Vision Imaging, L.L.C. | Endoscope having microscopic and macroscopic magnification |
US6613042B1 (en) * | 2000-06-30 | 2003-09-02 | Nikolai Tankovich | Rainbow laser |
CA2413663A1 (en) * | 2000-07-07 | 2002-01-17 | Charles D. Weaver | Electrophysiology configuration suitable for high throughput screening of compounds for drug discovery |
US7359748B1 (en) * | 2000-07-26 | 2008-04-15 | Rhett Drugge | Apparatus for total immersion photography |
US7321394B1 (en) * | 2000-09-29 | 2008-01-22 | Lucid, Inc. | Automatic gain control for a confocal imaging system |
US7003345B1 (en) * | 2000-10-17 | 2006-02-21 | Lucid, Inc. | System and method for enhancing microscope images of tissue using citric acid and agents of the like |
US7139122B1 (en) * | 2000-10-17 | 2006-11-21 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
JP4685229B2 (ja) * | 2000-10-31 | 2011-05-18 | オリンパス株式会社 | レーザ顕微鏡 |
AU2002303863B2 (en) * | 2001-05-23 | 2006-08-31 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
US6687035B2 (en) * | 2001-06-07 | 2004-02-03 | Leica Microsystems Heildelberg Gmbh | Method and apparatus for ROI-scan with high temporal resolution |
FR2834349B1 (fr) * | 2001-12-28 | 2004-04-09 | Mauna Kea Technologies | Appareillage d'imagerie confocale notamment pour endoscope |
WO2003057100A2 (en) * | 2002-01-10 | 2003-07-17 | Katana Technologies Gmbh | Device and procedure for refractive laser surgery |
US7328060B2 (en) | 2002-02-12 | 2008-02-05 | Science & Engineering Associates, Inc. | Cancer detection and adaptive dose optimization treatment system |
US20040133112A1 (en) * | 2002-03-08 | 2004-07-08 | Milind Rajadhyaksha | System and method for macroscopic and confocal imaging of tissue |
US7135033B2 (en) | 2002-05-23 | 2006-11-14 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
WO2004000098A2 (en) | 2002-06-19 | 2003-12-31 | Palomar Medical Technologies, Inc. | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
EP1636625B1 (de) * | 2003-05-20 | 2013-07-10 | Lucid, Inc. | Konfokales mikroskop zur abbildung gewählter stellen des körpers eines patienten |
JP3803673B2 (ja) * | 2004-02-02 | 2006-08-02 | オリンパス株式会社 | 測定方法及び測定装置 |
US7792570B2 (en) * | 2004-04-07 | 2010-09-07 | Northeastern University | Opto-acoustic signal detection with coherent confocal microscopy |
JP2007532225A (ja) * | 2004-04-15 | 2007-11-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 放射線ビームを用いる皮膚の処置に対する装置 |
ATE418294T1 (de) * | 2004-10-05 | 2009-01-15 | Koninkl Philips Electronics Nv | Hautbehandlungsvorrichtung mit strahlungsemissionsschutz |
US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
EP1895905A4 (de) | 2005-05-12 | 2014-05-07 | Lucid Inc | Konfokales abtastmikroskop mit einen in der hand gehaltenen abbildungskopf bereitstellenden optischen abtastsystemen |
US20100181706A1 (en) * | 2005-07-13 | 2010-07-22 | Jari Ruuttu | Radiation Arrangement |
FI118937B (fi) * | 2005-07-13 | 2008-05-15 | Picodeon Ltd Oy | Diodipumppu |
US20070021807A1 (en) * | 2005-07-20 | 2007-01-25 | Eastman Kodak Company | Device for optically stimulating collagen formation in tissue |
JP2007029603A (ja) | 2005-07-29 | 2007-02-08 | Fujinon Corp | 光診断治療装置 |
CA2622560A1 (en) | 2005-09-15 | 2007-03-29 | Palomar Medical Technologies, Inc. | Skin optical characterization device |
US7864996B2 (en) * | 2006-02-17 | 2011-01-04 | Lucid, Inc. | System for macroscopic and confocal imaging of tissue |
US8260401B2 (en) * | 2006-07-26 | 2012-09-04 | University Of Rochester | Non-invasive in-vivo imaging of mechanoreceptors in skin using confocal microscopy |
US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
US8894637B2 (en) * | 2008-01-22 | 2014-11-25 | Board Of Regents, The University Of Texas System | Systems, devices and methods for imaging and surgery |
TR201901658T4 (tr) | 2008-05-20 | 2019-02-21 | Univ Health Network | Floresan bazli görüntüleme ve i̇zleme i̇çi̇n ci̇haz ve metot |
JP2011530082A (ja) | 2008-08-04 | 2011-12-15 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | 細胞ミクロ構造の共焦点画像化のための染料適用 |
JP5581782B2 (ja) * | 2009-04-17 | 2014-09-03 | ソニー株式会社 | 撮像装置 |
WO2010146588A2 (en) * | 2009-06-16 | 2010-12-23 | Technion- Research And Development Foundation Ltd. | Miniature disease diagnostic system |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
JP5452180B2 (ja) * | 2009-11-13 | 2014-03-26 | オリンパス株式会社 | 顕微鏡装置 |
US9333036B2 (en) | 2010-01-22 | 2016-05-10 | Board Of Regents, The University Of Texas System | Systems, devices and methods for imaging and surgery |
CN104254767B (zh) | 2012-02-26 | 2016-10-26 | 克力博成像诊断股份有限公司 | 用于光学切片显微镜的组织样本工作台 |
KR102136901B1 (ko) | 2012-04-18 | 2020-07-22 | 싸이노슈어, 엘엘씨 | 피코초 레이저 장치 및 그를 사용한 표적 조직의 치료 방법 |
CN104704416B (zh) | 2012-08-15 | 2018-07-31 | 卢西德股份有限公司 | 用于对组织进行成像的***和方法 |
US9677869B2 (en) | 2012-12-05 | 2017-06-13 | Perimeter Medical Imaging, Inc. | System and method for generating a wide-field OCT image of a portion of a sample |
WO2014145707A2 (en) | 2013-03-15 | 2014-09-18 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
EP2967755A1 (de) * | 2013-03-15 | 2016-01-20 | Convergent Dental, Inc. | System und verfahren für optische bildgebung, vergrösserung, fluoreszenz und reflexion |
WO2016011534A1 (en) | 2014-07-24 | 2016-01-28 | University Health Network | Collection and analysis of data for diagnostic purposes |
CN107096997B (zh) * | 2017-05-10 | 2019-09-24 | 华中科技大学 | 一种基于连续激光的三维微结构刻写***及方法 |
EP3655748B1 (de) | 2017-07-18 | 2023-08-09 | Perimeter Medical Imaging, Inc. | Probenbehälter zur stabilisierung und ausrichtung exzidierter biologischer gewebeproben zur ex-vivo-analyse |
EP3759770A4 (de) | 2018-02-26 | 2021-12-08 | Cynosure, LLC | Gütegeschalteter cavity-dump-subnanosekundenlaser |
EP3759540A4 (de) | 2018-02-26 | 2022-03-16 | Caliber Imaging & Diagnostics, Inc. | System und verfahren zur makroskopischen und mikroskopischen abbildung von ex-vivo-gewebe |
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US4289378A (en) | 1978-06-21 | 1981-09-15 | Ernst Remy | Apparatus for adjusting the focal point of an operating laser beam focused by an objective |
US4408602A (en) * | 1981-01-14 | 1983-10-11 | Asahi Kogaku Kogyo Kabushiki Kaisha | Laser knife device |
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DE3708511A1 (de) * | 1987-03-16 | 1988-09-29 | Kratzer Michael | Einrichtung zur selektiven zerstoerung von zellen |
US5364390A (en) * | 1988-05-19 | 1994-11-15 | Refractive Laser Research And Development, Inc. | Handpiece and related apparatus for laser surgery and dentistry |
US5200838A (en) * | 1988-05-27 | 1993-04-06 | The University Of Connecticut | Lateral effect imaging system |
US5089384A (en) * | 1988-11-04 | 1992-02-18 | Amoco Corporation | Method and apparatus for selective cell destruction using amplified immunofluorescence |
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US5065008A (en) * | 1989-10-18 | 1991-11-12 | Fuji Photo Film Co., Ltd. | Scanning microscope and scanning mechanism for the same |
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US5203328A (en) * | 1991-07-17 | 1993-04-20 | Georgia Tech Research Corporation | Apparatus and methods for quantitatively measuring molecular changes in the ocular lens |
US5458594A (en) * | 1991-08-28 | 1995-10-17 | Siemens Aktiengesellschaft | Method and apparatus for the treatment of hard biological material, such as hard dental material, using lasers |
WO1993019705A1 (en) * | 1992-03-31 | 1993-10-14 | Massachusetts Institute Of Technology | Apparatus and method for acoustic heat generation and hyperthermia |
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US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
ITFI940095A1 (it) * | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
US5795755A (en) * | 1994-07-05 | 1998-08-18 | Lemelson; Jerome H. | Method of implanting living cells by laser poration at selected sites |
NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
US5848177A (en) * | 1994-12-29 | 1998-12-08 | Board Of Trustees Operating Michigan State University | Method and system for detection of biological materials using fractal dimensions |
WO1996021938A1 (en) * | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Video-rate confocal scanning laser microscope |
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US5608519A (en) * | 1995-03-20 | 1997-03-04 | Gourley; Paul L. | Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells |
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US5788639A (en) * | 1995-07-13 | 1998-08-04 | Lucid Technologies, Inc. | Confocal imaging through thick dermal tissue |
DE69635521T2 (de) * | 1995-09-19 | 2006-08-17 | Cornell Research Foundation, Inc. | Multiphoton-lasermikroskopie |
US5760950A (en) * | 1996-07-25 | 1998-06-02 | Advanced Scanning, Ltd. | Scanning confocal microscope |
US5839445A (en) * | 1996-07-25 | 1998-11-24 | Con-S Ltd. | Method of diagnosis of diseases using confocal microscope |
US6424852B1 (en) | 1996-10-18 | 2002-07-23 | Lucid, Inc. | System for confocal imaging within dermal tissue |
US5832931A (en) * | 1996-10-30 | 1998-11-10 | Photogen, Inc. | Method for improved selectivity in photo-activation and detection of molecular diagnostic agents |
US5829448A (en) * | 1996-10-30 | 1998-11-03 | Photogen, Inc. | Method for improved selectivity in photo-activation of molecular agents |
US5836877A (en) * | 1997-02-24 | 1998-11-17 | Lucid Inc | System for facilitating pathological examination of a lesion in tissue |
JP4383545B2 (ja) * | 1997-03-19 | 2009-12-16 | ルーシド インコーポレーテッド | 共焦点顕微鏡使用法を利用する細胞手術 |
US5874266A (en) * | 1997-03-27 | 1999-02-23 | Palsson; Bernhard O. | Targeted system for removing tumor cells from cell populations |
-
1998
- 1998-03-19 JP JP54079498A patent/JP4383545B2/ja not_active Expired - Fee Related
- 1998-03-19 US US09/044,355 patent/US5995867A/en not_active Expired - Lifetime
- 1998-03-19 ES ES98911824T patent/ES2313745T3/es not_active Expired - Lifetime
- 1998-03-19 WO PCT/US1998/005399 patent/WO1998041158A1/en active Application Filing
- 1998-03-19 EP EP98911824A patent/EP1003429B1/de not_active Expired - Lifetime
- 1998-03-19 AT AT98911824T patent/ATE409005T1/de not_active IP Right Cessation
- 1998-03-19 DE DE69840046T patent/DE69840046D1/de not_active Expired - Lifetime
- 1998-03-19 AU AU65691/98A patent/AU6569198A/en not_active Abandoned
-
1999
- 1999-11-10 US US09/438,065 patent/US6668186B1/en not_active Expired - Lifetime
-
2003
- 2003-10-31 US US10/698,294 patent/US7190990B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1003429A1 (de) | 2000-05-31 |
WO1998041158A1 (en) | 1998-09-24 |
US5995867A (en) | 1999-11-30 |
DE69840046D1 (de) | 2008-11-06 |
US7190990B2 (en) | 2007-03-13 |
EP1003429A4 (de) | 2000-05-31 |
US20040092827A1 (en) | 2004-05-13 |
JP4383545B2 (ja) | 2009-12-16 |
AU6569198A (en) | 1998-10-12 |
EP1003429B1 (de) | 2008-09-24 |
US6668186B1 (en) | 2003-12-23 |
ES2313745T3 (es) | 2009-03-01 |
JP2001517119A (ja) | 2001-10-02 |
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